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1. 发明申请

WO2012027481A1 COMPOUNDS FOR TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的化合物
公开(公告)号：WO2012027481A1
公开(公告)日：2012-03-01
申请号：PCT/US2011048980
申请日：2011-08-24
申请人： GTX INC , UNIV TENNESSEE REASEARCH FOUNDATION , DALTON JAMES T , MILLER DUANE D , LI CHIEN-MING , AHN SUNJOO , LU YAN , WANG ZHAO , CHEN JIANJUN , LI WEI , DUKE CHARLES
发明人： DALTON JAMES T , MILLER DUANE D , LI CHIEN-MING , AHN SUNJOO , LU YAN , WANG ZHAO , CHEN JIANJUN , LI WEI , DUKE CHARLES
IPC分类号： A01N43/50 , A61K31/415
CPC分类号： A61K31/415 , C07D233/60 , C07D263/32 , C07D277/24 , C07D277/42 , C07D403/04 , C07D403/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
摘要翻译：本发明涉及具有抗癌活性的新化合物，制备这些化合物的方法及其用于治疗癌症和药物抗性肿瘤的用途，例如，黑素瘤，转移性黑素瘤，耐药性黑素瘤，前列腺癌和耐药前列腺癌。

2. 发明公开

EP2542081A4 COMPOUNDS FOR TREATMENT OF CANCER 审中-公开
标题翻译： VERBINDUNGEN ZUR KREBSBEHANDLUNG
公开(公告)号：EP2542081A4
公开(公告)日：2013-07-31
申请号：EP10847161
申请日：2010-12-29
申请人： GTX INC , UNIV TENNESSEE RES FOUNDATION
发明人： DALTON JAMES T , MILLER DUANE D , AHN SUNJOO , CHEN JIANJUN , DUKE CHARLES , LI CHIEN-MING , LI WEI , LU YAN , WANG ZHAO
IPC分类号： A61K31/425 , A61K45/06 , A61P35/00 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/56 , C07D417/04
CPC分类号： C07D233/64 , A61K31/4164 , A61K31/425 , A61K45/06 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/56 , C07D417/04 , A61K2300/00

3. 发明申请

WO2014011220A3 A METHOD OF TREATING ANDROGEN RECEPTOR (AR)-POSITIVE BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATOR (SARMS) 审中-公开
标题翻译：用选择性的雄激素受体调节剂（SARMS）治疗雄激素受体（AR） - 乳腺癌的方法
公开(公告)号：WO2014011220A3
公开(公告)日：2015-03-05
申请号：PCT/US2013029667
申请日：2013-03-07
申请人： GTX INC
发明人： DALTON JAMES T , STEINER MITCHELL S , NARAYANAN RAMESH , AHN SUNJOO
IPC分类号： A01N37/34
CPC分类号： C07C271/02 , A61K31/167 , A61K31/325 , A61K45/06
摘要： This invention relates to the treatment of androgen receptor-positive breast cancer in a subject, for example a female subject. Accordingly, this invention provides methods of: a) treating a subject suffering from breast cancer; b) treating a subject suffering from metastatic breast cancer; c) treating a subject suffering from refractory breast cancer; d) treating a subject suffering from AR-positive breast cancer; e) treating a subject suffering from AR-positive refractory breast cancer; f) treating a subject suffering from AR-positive metastatic breast cancer; g) treating a subject suffering from AR-positive and ER-positive breast cancer; h) treating a subject suffering from triple negative breast cancer; i) treating a subject suffering from advanced breast cancer
摘要翻译：本发明涉及治疗受试者中雄激素受体阳性乳腺癌，例如女性受试者。因此，本发明提供了以下方法：a）治疗患有乳腺癌的受试者; b）治疗患有转移性乳腺癌的受试者; c）治疗难治性乳腺癌患者; d）治疗患有AR阳性乳腺癌的受试者; e）治疗患有AR阳性难治性乳腺癌的受试者; f）治疗患有AR阳性转移性乳腺癌的受试者; g）治疗患有AR阳性和ER阳性乳腺癌的受试者; h）治疗患有三阴性乳腺癌的受试者; i）治疗患有晚期乳腺癌的受试者

4. 发明专利

CA2879049C A METHOD OF TREATING ANDROGEN RECEPTOR (AR)-POSITIVE BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATOR (SARMS) 未知
公开(公告)号：CA2879049C
公开(公告)日：2021-02-23
申请号：CA2879049
申请日：2013-03-07
申请人： GTX INC
发明人： DALTON JAMES T , STEINER MITCHELL S , NARAYANAN RAMESH , AHN SUNJOO
IPC分类号： A61K31/277 , A61K31/167 , A61P5/26 , A61P35/00 , A61P35/04 , C07C235/24 , C07C255/60
摘要： This invention relates to the treatment of androgen receptor-positive breast cancer in a subject, for example a female subject. Accordingly, this invention provides methods of: a) treating a subject suffering from breast cancer; b) treating a subject suffering from metastatic breast cancer; c) treating a subject suffering from refractory breast cancer; d) treating a subject suffering from AR-positive breast cancer; e) treating a subject suffering from AR-positive refractory breast cancer; f) treating a subject suffering from AR-positive metastatic breast cancer; g) treating a subject suffering from AR-positive and ER-positive breast cancer; h) treating a subject suffering from triple negative breast cancer; i) treating a subject suffering from advanced breast cancer; j) treating a subject suffering from breast cancer that has failed SERM (tamoxifen, toremifene), aromatase inhibitor, trastuzumab (Herceptin, ado-trastuzumab emtansine), pertuzumab (Perjeta), lapatinib, exemestane (Aromasin), bevacizumab (Avastin), and/or fulvestrant treatments; k) treating, preventing, suppressing or inhibiting metastasis in a subject suffering from breast cancer; 1) prolonging survival of a subject with breast cancer, and/or m) prolonging the progression-free survival of a subject with breast cancer; comprising administering to the subject a therapeutically effective amount of a selective androgen receptor modulator (SARM) compound, comprising administering to the subject a therapeutically effective amount of a SARM compound of this invention.

5. 发明专利

AU2015202828A1 Compounds for treatment of cancer 未知
公开(公告)号：AU2015202828A1
公开(公告)日：2015-06-11
申请号：AU2015202828
申请日：2015-05-25
申请人： GTX INC , UNIV TENNESSEE RES FOUNDATION
发明人： DALTON JAMES T , MILLER DUANE D , LI CHIEN-MING , AHN SUNJOO , LU YAN , WANG ZHAO , CHEN JIANJUN , LI WEI , DUKE CHARLES
IPC分类号： A01N43/50 , A61K31/415
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.

6. 发明专利

CA3030689A1 COMPOUNDS FOR TREATMENT OF CANCER 未知
公开(公告)号：CA3030689A1
公开(公告)日：2012-03-01
申请号：CA3030689
申请日：2011-08-24
申请人： GTX INC , UNIV TENNESSEE RES FOUND
发明人： DALTON JAMES T , MILLER DUANE D , LI CHIEN-MING , AHN SUNJOO , LU YAN , CHEN JIANJUN , LI WEI , WANG ZHAO , DUKE CHARLES
IPC分类号： C07D417/12 , A61K31/427 , A61P35/00
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.

7. 发明公开

EP2608671A4 COMPOUNDS FOR TREATMENT OF CANCER 有权
标题翻译：癌症治疗组合物
公开(公告)号：EP2608671A4
公开(公告)日：2013-08-07
申请号：EP11820603
申请日：2011-08-24
申请人： GTX INC , UNIV TENNESSEE RES FOUNDATION
发明人： DALTON JAMES T , MILLER DUANE D , LI CHIEN-MING , AHN SUNJOO , LU YAN , WANG ZHAO , CHEN JIANJUN , LI WEI , DUKE CHARLES
IPC分类号： A61K31/415 , A61P35/00 , C07D233/60 , C07D263/32 , C07D277/24 , C07D277/42 , C07D403/04 , C07D403/12 , C07D417/04 , C07D417/12 , C07D417/14
CPC分类号： A61K31/415 , C07D233/60 , C07D263/32 , C07D277/24 , C07D277/42 , C07D403/04 , C07D403/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.

8. 发明专利

RU2717835C2 СПОСОБ ЛЕЧЕНИЯ АНДРОГЕН-РЕЦЕПТОР(AR)-ПОЛОЖИТЕЛЬНЫХ ФОРМ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ С ИСПОЛЬЗОВАНИЕМ СЕЛЕКТИВНЫХ МОДУЛЯТОРОВ АНДРОГЕННЫХ РЕЦЕПТОРОВ (SARM) 未知
公开(公告)号：RU2717835C2
公开(公告)日：2020-03-26
申请号：RU2017141776
申请日：2013-03-07
申请人： GTX INC
发明人： DALTON JAMES T , STEINER MITCHELL S , NARAYANAN RAMESH , AHN SUNJOO
IPC分类号： A61K31/165 , A61P35/00
摘要： Изобретениеотноситсяк медицине, аименнок онкологии, иможетбытьиспользованодлялечениясубъекта, страдающего HER2-положительнымракоммолочнойжелезы. Дляэтогосубъектувводятселективныймодуляторандрогенногорецептора (SARM). Изобретениеобеспечиваетлечение HER2-положительногоракамолочнойжелезыу субъекта. 4 з.п. ф-лы, 14 ил., 4 табл., 17 пр.

9. 发明专利

MX2015000572A METODO PARA TRATAR CANCERES DE MAMA POSITIVOS A RECEPTOR DE ANDROGENO (AR) CON MODULADOR DE RECEPTOR DE ANDROGENO SELECTIVO (SARMS). 未知
公开(公告)号：MX2015000572A
公开(公告)日：2015-09-23
申请号：MX2015000572
申请日：2013-03-07
申请人： GTX INC
发明人： DALTON JAMES T , STEINER MITCHELL S , NARAYANAN RAMESH , AHN SUNJOO
IPC分类号： C07C271/02 , A61K31/325 , A61K45/06
摘要： Esta invención se refiere al tratamiento del cáncer de mama positivo a receptor de andrógeno en un sujeto, por ejemplo una mujer. Por consiguiente, esta invención proporciona métodos para: a) tratar a un sujeto que padece cáncer de mama; b) tratar a un sujeto que padece cáncer de mama metastásico; c) tratar a un sujeto que padece cáncer de mama refractario; d) tratar a un sujeto que padece cáncer de mama positivo a AR; e) tratar a un sujeto que padece cáncer de mama refractario positivo a AR; f) tratar a un sujeto que padece cáncer de mama metastásico positivo para AR; g) tratar a un sujeto que padece cáncer de mama positivo a AR y positivo a ER; h) tratar a un sujeto que padece cáncer de mama triple negativo; i) tratar a un sujeto que padece cáncer mama avanzado; j) tratar a un sujeto que padece cáncer de mama que ha fallado a tratamientos con SERM (tamixifeno, toromifeno), un inhibidor de aromatasa, trastuzumab (Herceptin, ado-trastuzumab emtansina), pertuzumab (Perjeta), lapatinib, exemestano (Aromasin), bevacizumab (Avastin) y/o fulvestrant; k) tratar, prevenir, suprimir o inhibir metástasis en un sujeto que padece cáncer de mama; 1) prolongar la supervivencia de un sujeto con cáncer de mama; y/o prolongar la supervivencia libre de progresión de un sujeto con cáncer de mama; que comprende administrar al sujeto una cantidad terapéuticamente efectiva de un compuesto modulador de receptor de andrógeno selectivo (SARM), que comprende administrar al sujeto una cantidad terapéuticamente efectiva de un compuesto SARM de esta invención.

10. 发明专利

CA2879049A1 A METHOD OF TREATING ANDROGEN RECEPTOR (AR)-POSITIVE BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATOR (SARMS) 未知
公开(公告)号：CA2879049A1
公开(公告)日：2014-01-16
申请号：CA2879049
申请日：2013-03-07
申请人： GTX INC
发明人： DALTON JAMES T , STEINER MITCHELL S , NARAYANAN RAMESH , AHN SUNJOO
IPC分类号： C07C271/02 , A61K31/325 , A61K45/06
摘要： This invention relates to the treatment of androgen receptor-positive breast cancer in a subject, for example a female subject. Accordingly, this invention provides methods of: a) treating a subject suffering from breast cancer; b) treating a subject suffering from metastatic breast cancer; c) treating a subject suffering from refractory breast cancer; d) treating a subject suffering from AR-positive breast cancer; e) treating a subject suffering from AR-positive refractory breast cancer; f) treating a subject suffering from AR-positive metastatic breast cancer; g) treating a subject suffering from AR-positive and ER-positive breast cancer; h) treating a subject suffering from triple negative breast cancer; i) treating a subject suffering from advanced breast cancer; j) treating a subject suffering from breast cancer that has failed SERM (tamoxifen, toremifene), aromatase inhibitor, trastuzumab (Herceptin, ado-trastuzumab emtansine), pertuzumab (Perjeta), lapatinib, exemestane (Aromasin), bevacizumab (Avastin), and/or fulvestrant treatments; k) treating, preventing, suppressing or inhibiting metastasis in a subject suffering from breast cancer; 1) prolonging survival of a subject with breast cancer, and/or m) prolonging the progression-free survival of a subject with breast cancer; comprising administering to the subject a therapeutically effective amount of a selective androgen receptor modulator (SARM) compound, comprising administering to the subject a therapeutically effective amount of a SARM compound of this invention.

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