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1. 发明申请

WO2011109059A1 COMPOUNDS FOR TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的化合物
公开(公告)号：WO2011109059A1
公开(公告)日：2011-09-09
申请号：PCT/US2010/062418
申请日：2010-12-29
申请人： GTX, INC. , UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , DALTON, James, T. , MILLER, Duane, D. , AHN, Sunjoo , CHEN, Jianjun , DUKE, Charles , LI, Chien-ming , LI, Wei , LU, Yan , WANG, Zhao
发明人： DALTON, James, T. , MILLER, Duane, D. , AHN, Sunjoo , CHEN, Jianjun , DUKE, Charles , LI, Chien-ming , LI, Wei , LU, Yan , WANG, Zhao
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D233/64 , A61K31/4164 , A61K31/425 , A61K45/06 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/56 , C07D417/04 , A61K2300/00
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.
摘要翻译：本发明涉及具有抗癌活性的新化合物，制备这些化合物的方法及其用于治疗癌症和药物抗性肿瘤的用途，例如，黑素瘤，转移性黑素瘤，耐药性黑素瘤，前列腺癌和耐药前列腺癌。

2. 发明申请

WO2012027481A9 COMPOUNDS FOR TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2012027481A9
公开(公告)日：2012-03-01
申请号：PCT/US2011/048980
申请日：2011-08-24
申请人： GTX, INC. , UNIVERSITY OF TENNESSEE REASEARCH FOUNDATION , DALTON, James, T. , MILLER, Duane, D. , LI, Chien-Ming , AHN, Sunjoo , LU, Yan , WANG, Zhao , CHEN, Jianjun , LI, Wei , DUKE, Charles
发明人： DALTON, James, T. , MILLER, Duane, D. , LI, Chien-Ming , AHN, Sunjoo , LU, Yan , WANG, Zhao , CHEN, Jianjun , LI, Wei , DUKE, Charles
IPC分类号： A01N43/50 , A61K31/415
摘要： The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.

3. 发明申请

WO2008127717A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS FOR TREATING DIABETES 审中-公开
标题翻译：用于治疗糖尿病的选择性安定剂受体调节剂
公开(公告)号：WO2008127717A1
公开(公告)日：2008-10-23
申请号：PCT/US2008/004816
申请日：2008-04-14
申请人： UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , DALTON, James, T. , MILLER, Duane, D.
发明人： DALTON, James, T. , MILLER, Duane, D.
IPC分类号： A61K31/675 , A61K31/66 , A61K31/47
CPC分类号： A61K31/167 , A61K31/277 , A61K31/32 , A61K31/404 , A61K31/47 , A61K31/555 , A61K31/66 , A61K31/675
摘要： This invention provides use of a SARM compound or a composition comprising the same in treating a variety of diseases or conditions in a subject, including, inter-alia , a diabetes disease, and/or disorder such as cardiovascular disease, atherosclerosis, cerebrovascular conditions, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy.
摘要翻译：本发明提供了SARM化合物或其组合物在治疗受试者中的多种疾病或病症中的用途，包括尤其是糖尿病疾病和/或病症如心血管疾病，动脉粥样硬化，脑血管病症，糖尿病性肾病，糖尿病性神经病变和糖尿病性视网膜病变。

4. 发明申请

WO2007126988A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF 审中-公开
标题翻译：选择性雄激素受体调节剂及其使用方法
公开(公告)号：WO2007126988A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/007813
申请日：2007-03-29
申请人： UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , DALTON, James, T. , MILLER, Duane, D. , MARHEFKA, Craig, A. , GAO, Wenqing
发明人： DALTON, James, T. , MILLER, Duane, D. , MARHEFKA, Craig, A. , GAO, Wenqing
IPC分类号： A61K31/66 , A61K31/277 , A61K31/433 , A61K31/426 , A61K31/421 , A61K31/557 , A61K31/275
CPC分类号： A61K31/275 , A61K31/277 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/433 , A61K31/44 , A61K31/505 , A61K31/557 , A61K31/65 , A61K31/66 , C07C255/60 , C07D211/72 , C07D233/44 , C07D239/02
摘要： This invention provides a class of androgen receptor targeting agents (ARTA). The compounds are selective androgen receptor modulators (SARM) useful for, inter-alia , suppressing spermatogenesis, treating a subject having a hormone related condition, treating a subject suffering from prostate cancer, delaying the progression of prostate cancer, preventing the recurrence of prostate cancer, and treating the recurrence of prostate cancer.
摘要翻译：本发明提供一类雄激素受体靶向剂（ARTA）。这些化合物是选择性雄激素受体调节剂（SARM），其用于除其他外抑制精子发生，治疗具有激素相关病症的受试者，治疗患有前列腺癌的受试者，延缓前列腺癌的进展，预防前列腺癌的复发，并治疗前列腺癌的复发。

5. 发明申请

WO2008011072A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS, ANALOGS AND DERIVATIVES THEREOF AND USES THEREOF 审中-公开
标题翻译：选择性雄激素受体调节剂，类似物及其衍生物及其用途
公开(公告)号：WO2008011072A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/016311
申请日：2007-07-19
申请人： OSURF (OHIO STATE UNIVERSITY RESEARCH FOUNDATION) , UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , DALTON, James, T. , MILLER, Duane, D. , RAKOV, Igor , BOHL, Casey , MOHLER, Michael, L.
发明人： DALTON, James, T. , MILLER, Duane, D. , RAKOV, Igor , BOHL, Casey , MOHLER, Michael, L.
IPC分类号： A61K31/501
CPC分类号： C07D241/04 , C07C255/54 , C07C255/58 , C07C255/60 , C07C317/46 , C07C323/60 , C07C335/18 , C07D233/86
摘要： This invention provides new compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia , prostate cancer, muscle wasting diseases and/or disorders or a bone-related diseases and/or disorders.
摘要翻译：本发明提供了新化合物及其用于治疗受试者中的多种疾病或病症，包括尤其是前列腺癌，肌肉萎缩疾病和/或病症或与骨有关的疾病和/或疾病。

6. 发明申请

WO2004035736A2 HALOGENATED SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF 审中-公开
标题翻译：卤化选择性雄激素受体调节剂及其使用方法
公开(公告)号：WO2004035736A2
公开(公告)日：2004-04-29
申请号：PCT/US2003/032507
申请日：2003-10-14
申请人： UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , DALTON, James, T. , MILLER, Duane, D. , YIN, Donghua , HE, Yali , STEINER, Mitchell, S. , VEVERKA, Karen, A.
发明人： DALTON, James, T. , MILLER, Duane, D. , YIN, Donghua , HE, Yali , STEINER, Mitchell, S. , VEVERKA, Karen, A.
IPC分类号： C12N
CPC分类号： C07D215/227 , A61K31/165 , A61K31/404 , A61K31/4706 , A61K31/661 , C07C235/16 , C07C235/24 , C07C255/60 , C07C335/18 , C07D209/08 , C07D271/12
摘要： This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. The SARM compounds, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of acute and/or chronic muscular wasting conditions; e) preventing and/or treating dry eye conditions; f) oral androgen replacement therapy; g) decreasing the incidence of, halting or causing a regression of prostate cancer; and/or h) inducing apoptosis in a cancer cell.
摘要翻译：本发明提供了一类雄激素受体靶向剂（ARTA）。代理商定义了一类新的化合物，它们是选择性雄激素受体调节剂（SARM）。已经发现几种SARM化合物具有雄激素受体的非甾体配体的意想不到的雄激素和合成代谢活性。已经发现其他SARM化合物对雄激素受体的非甾体配体具有出乎意料的抗雄激素活性。 SARM化合物单独或作为组合物可用于a）男性避孕; b）治疗多种激素相关病症，例如与衰老男性（ADAM）中的雄激素降低相关的病症，例如疲劳，抑郁症，性欲减退，性功能障碍，勃起功能障碍，性腺机能减退，骨质疏松症，脱发，贫血，肥胖症，肌肉减少症，骨质减少症，骨质疏松症，良性前列腺增生症，情绪和认知改变以及前列腺癌; c）治疗与女性雄激素降低（ADIF）有关的病症，例如性功能障碍，性欲减退，性腺功能减退症，肌肉减少症，骨质减少症，骨质疏松症，认知和情绪改变，抑郁症，贫血，脱发，肥胖症，子宫内膜异位症，乳房癌症，子宫癌和卵巢癌; d）治疗和/或预防急性和/或慢性肌肉萎缩症状; e）预防和/或治疗干眼症; f）口服雄激素替代疗法; g）降低前列腺癌的发病率，停止或导致其消退; 和/或h）诱导癌细胞凋亡。

7. 发明申请

WO2011119544A1 SARMS AND METHOD OF USE THEREOF 审中-公开
标题翻译： SARMS及其使用方法
公开(公告)号：WO2011119544A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/029336
申请日：2011-03-22
申请人： UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , DALTON, James, T. , MILLER, Duane, D. , KEARBEY, Jeffrey
发明人： DALTON, James, T. , MILLER, Duane, D. , KEARBEY, Jeffrey
IPC分类号： A01N37/18 , A61K31/16
CPC分类号： C07C255/60 , A23K20/111 , A23K50/10 , A23K50/30
摘要： This invention is directed to a feed composition and methods of affecting the carcass composition of an animal by the administration of Selective Androgen Receptor Modulators (SARM) acylanilide compounds. According to this invention, SARMs improve meat production in feedlot animals by increasing the lean mass, reducing the fat mass and/or percent fat mass, improving feed efficiency and modulation of meat quality of an animal wherein said animal is a feedlot animal or a finishing livestock such as beef cattle or swine.
摘要翻译：本发明涉及通过施用选择性雄激素受体调节剂（SARM）酰基酰苯胺化合物影响动物的屠体组成的饲料组合物和方法。根据本发明，SARM通过增加瘦肉质量，减少脂肪量和/或脂肪重量百分数，提高饲料效率和调节动物的肉质来改善饲养动物的肉类生产，其中所述动物是饲养动物或整理牲畜如肉牛或猪。

8. 发明申请

WO2008036067A2 THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS 审中-公开
标题翻译：噻唑烷酮酰胺，噻唑烷羧酸和氨基酸，包括其中的聚氨酯结合物，作为选择性抗癌剂
公开(公告)号：WO2008036067A2
公开(公告)日：2008-03-27
申请号：PCT/US2006/027763
申请日：2006-07-19
申请人： THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , OHIO STATE UNIVERSITY RESEARCH FOUNDATION , MILLER, Duane, D. , GUDUDURU, Veeresa , DALTON, James, T. , HURH, Eunju
发明人： MILLER, Duane, D. , GUDUDURU, Veeresa , DALTON, James, T. , HURH, Eunju
IPC分类号： A61K31/427 , A61K31/426 , C07D417/02
CPC分类号： C07D417/04 , A61K31/426 , A61K31/427 , C07D277/06
摘要： Substituted thiazolidinone carboxylic acid amides and substituted thiazolidine carboxylic acid amides according to formulae (I) and (II) are disclosed where the various substituent groups are as defined in the specification. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.
摘要翻译：公开了根据式（I）和（II）的取代的噻唑烷酮羧酸酰胺和取代的噻唑烷羧酸酰胺，其中各种取代基如说明书中所定义。还公开了制备这些化合物的方法，含有这些化合物的药物组合物及其用途，特别是用于治疗或预防癌症的方法。

9. 发明申请

WO2005120483A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHODS OF USE THEREOF 审中-公开
标题翻译：选择性雄激素受体调节剂及其使用方法
公开(公告)号：WO2005120483A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/019788
申请日：2005-06-07
申请人： UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , DALTON, James, T. , MILLER, Duane, D. , VEVERKA, Karen, A.
发明人： DALTON, James, T. , MILLER, Duane, D. , VEVERKA, Karen, A.
IPC分类号： A61K31/17
CPC分类号： C07C255/60 , A61K31/17 , A61K31/663 , C07B2200/07 , C07C235/24 , A61K2300/00
摘要： This invention provides SARM compounds and their use in treating a variety of diseases or conditions in a subject, including, inter-alia , a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.
摘要翻译：本发明提供了SARM化合物及其在治疗受试者中的各种疾病或病症的用途，包括特别是肌肉消耗疾病和/或病症或骨相关疾病和/或病症。

10. 发明申请

WO2008024456A2 SUBSTITUTED ACYLANILIDES AND METHODS OF USE THEREOF 审中-公开
标题翻译：取代的ACYILILIDES及其使用方法
公开(公告)号：WO2008024456A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/018686
申请日：2007-08-24
申请人： UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION , DALTON, James, T. , MILLER, Duane, D.
发明人： DALTON, James, T. , MILLER, Duane, D.
IPC分类号： A61K31/675 , A61K31/555 , A61K31/4709 , A61K31/405 , A61K31/4704 , A61K31/32 , A61K31/277 , A61K31/165
CPC分类号： C07C255/60 , C07B2200/07
摘要： This invention provides SARM compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia , a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.
摘要翻译：本发明提供了SARM化合物及其用于治疗受试者中的多种疾病或病症的方法，包括肌肉萎缩疾病和/或病症或其他疾病或病症骨相关疾病和/或疾病。

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