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1. 发明申请

WO2017085167A2 METHODS FOR PRODUCING ISOBUTENE FROM 3-METHYLCROTONIC ACID 审中-公开
标题翻译：从3-甲基丙酮酸生产异丁烯的方法
公开(公告)号：WO2017085167A2
公开(公告)日：2017-05-26
申请号：PCT/EP2016/077956
申请日：2016-11-17
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： ALLARD, Mathieu , ANISSIMOVA, Maria , MARLIERE, Philippe
IPC分类号： C12P5/02 , C12P7/40 , C12N15/52 , C12N9/00 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/88
CPC分类号： C12P5/026 , C12N9/1029 , C12N9/1085 , C12N9/1217 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/40 , C12Y205/01 , C12Y207/02007 , C12Y207/02014 , C12Y207/02015 , C12Y208/03001 , C12Y208/03008 , C12Y301/02001 , C12Y301/02018 , C12Y301/0202 , C12Y401/01006 , C12Y401/01063 , C12Y604/01004 , C12Y604/01005
摘要： Described are methods for the production of isobutene comprising the enzymatic conversion of 3-methylcrotonic acid into isobutene wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-methylcrotonyl-CoA into 3- methylcrotonic acid or wherein said 3-methylcrotonic acid is obtained by the enzymatic conversion of 3-hydroxyisovalerate (HIV) into 3-methylcrotonic acid. It is described that the enzymatic conversion of 3-methylcrotonic acid into isobutene can, e.g., be achieved by making use of a 3-methylcrotonic acid decarboxylase, preferably an FMN-dependent decarboxylase associated with an FMN prenyl transferase, an aconitate decarboxylase (EC 4.1.1.6), a methylcrotonyl-CoA carboxylase (EC 6.4.1.4), or a geranoyl-CoA carboxylase (EC 6.4.1.5).
摘要翻译：描述了用于生产异丁烯的方法，其包括将3-甲基巴豆酸酶促转化为异丁烯，其中所述3-甲基巴豆酸通过将3-甲基巴豆基辅酶A酶促转化为3-甲基巴豆酸或其中所述3-甲基巴豆酸是通过将3-羟基异戊酸（HIV）酶促转化为3-甲基巴豆酸而获得的。据描述，3-甲基巴豆酸到异丁烯的酶促转化可以例如通过利用3-甲基巴豆酸脱羧酶，优选与FMN异戊烯转移酶，乌头酸脱羧酶（EC 4.1）相关的FMN依赖性脱羧酶 1.6），甲基巴豆酰辅酶A羧化酶（EC 6.4.1.4）或ge烯酰辅酶A羧化酶（EC 6.4.1.5）。

2. 发明申请

WO2016097293A1 PROCESS FOR THE ENZYMATIC PRODUCTION OF 1-BUTENE FROM 2-PENTENOYL-COA 审中-公开
标题翻译： 2-PENTENOYL-COA生产1-丁烯的方法
公开(公告)号：WO2016097293A1
公开(公告)日：2016-06-23
申请号：PCT/EP2015/080491
申请日：2015-12-18
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： ALLARD, Mathieu , MARLIERE, Philippe
IPC分类号： C12P5/02 , C12P7/24 , C12P7/64 , C12P11/00 , C12N9/10 , C12N9/12 , C12N9/16
CPC分类号： C12P5/026 , C12N9/88 , C12P7/24 , C12P7/6409 , C12P7/6436 , C12P11/00
摘要： Described is a method for the production of 2-pentenoic acid comprising the enzymatic conversion of 2-pentenoyl-CoA into 2-pentenoic acid comprising two enzymatic steps comprising (i) first enzymatically converting 2-pentenoyl-CoA into 2-pentenoyl phosphate; and (ii) then enzymatically converting the thus obtained 2-pentenoyl phosphate into said 2-pentenoic acid; or a single enzymatic reaction in which 2-pentenoyl-CoA is directly converted into 2-pentenoic acid by making use of a CoA transferase (EC 2.8.3.-), preferably a butyryl-CoA:acetate-CoA transferase (EC 2.8.3.8).
摘要翻译：描述了一种生产2-戊烯酸的方法，其包括将2-戊烯酰辅酶A酶促转化成2-戊烯酸，其包括两个酶步骤，包括（i）首先将2-戊烯酰辅酶A酶促转化为2-戊烯酰磷酸酯; 和（ii）然后将由此获得的2-戊烯酰磷酸酯酶促转化成所述2-戊烯酸; 或通过使用CoA转移酶（EC 2.8.3.-），优选丁酰辅酶A：乙酸酯-CoA转移酶（EC 2.8）直接将2-戊烯酰辅酶A直接转化为2-戊烯酸的单一酶促反应。 3.8）。

3. 发明申请

WO2016075244A1 ALKENOL DEHYDRATASE VARIANTS 审中-公开
公开(公告)号：WO2016075244A1
公开(公告)日：2016-05-19
申请号：PCT/EP2015/076450
申请日：2015-11-12
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： MAZALEYRAT, Sabine , DELCOURT, Marc , MARLIERE, Philippe
IPC分类号： C12N9/88
CPC分类号： C12P5/026 , C12N9/88 , C12Y402/01127
摘要： Described are alkenol dehydratase variants having improved activity in catalyzing the conversion of prenol into isoprene, methods for the production of isoprene using such enzyme variants and their uses in the production of isoprene from prenol.
摘要翻译：描述了具有改善的活性来催化前醇醇转化成异戊二烯的烯醇脱水酶变体，使用这种酶变体生产异戊二烯的方法及其在从异戊二烯生产异戊二烯的用途。

4. 发明申请

WO2015000981A2 METHOD FOR THE ENZYMATIC PRODUCTION OF 3-BUTEN-2-ONE 审中-公开
标题翻译： 3-BUTEN-2-ONE生产酶的方法
公开(公告)号：WO2015000981A2
公开(公告)日：2015-01-08
申请号：PCT/EP2014/064102
申请日：2014-07-02
申请人： SCIENTIST OF FORTUNE S.A. , GLOBAL BIOENERGIES
发明人： MARLIERE, Philippe , ANISSIMOVA, Maria , ALLARD, Mathieu
IPC分类号： C12P5/02 , C12P7/26 , C12P7/16 , C12N1/00
CPC分类号： C12P7/16 , C12N1/00 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/88 , C12N15/52 , C12N15/70 , C12P5/026 , C12P7/04 , C12P7/26 , C12P19/32 , C12Y101/01001 , C12Y101/0103 , C12Y101/01034 , C12Y101/01184 , C12Y102/0105 , C12Y103/08001 , C12Y402/01017 , C12Y402/01018 , C12Y402/01055 , C12Y402/01059 , C12Y402/01074 , C12Y402/01116 , C12Y402/01127 , Y02E50/10
摘要： Described is a method for the production of 3-buten-2-one comprising the enzymatic conversion of 4-hydroxy-2-butanone into 3-buten-2-one by making use of an enzyme catalyzing 4-hydroxy-2-butanone dehydration, wherein said enzyme catalyzing 4-hydroxy-2-butanone dehydration is (a) a 3-hydroxypropiony-CoA dehydratase (EC 4.2.1.116), (b) a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55), (c) an enoyl-CoA hydratase (EC 4.2.1.17), (d) a 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59), (e) a crotonyl-[acyl-carrier-protein] hydratase (EC 4.2.1.58), (f) a 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60), (g) a 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61 ), (h) a long-chain-enoyl-CoA hydratase (EC 4.2.1.74), or (i) a 3-methylglutaconyl-CoA hydratase (EC 4.2.1.18). The produced 3-buten-2-one can be further converted into 3-buten-2-ol and finally into 1,3-butadiene.
摘要翻译：描述了用于生产3-丁烯-2-酮的方法，其包括通过利用酶催化将4-羟基-2-丁酮转化为3-丁烯-2-酮其中所述催化4-羟基-2-丁酮脱水的酶是（a）3-羟基丙酸-CoA脱水酶（EC 4.2.1.116），（b）3-羟基丁酰-CoA脱水酶（4-羟基-2-丁酮脱水酶 EC 4.2.1.55），（c）烯酰-CoA水合酶（EC 4.2.1.17），（d）3-羟基辛酰基 - [酰基 - 载体 - 蛋白]脱水酶（EC 4.2.1.59），（e）巴豆酰 - （EC 4.2.1.58），（f）3-羟基癸酰基 - [酰基 - 载体 - 蛋白]脱水酶（EC 4.2.1.60），（g）3-羟基棕榈酰基 - [酰基 - 载体（EC 4.2.1.61），（h）长链烯酰-CoA水合酶（EC 4.2.1.74）或（i）3-甲基戊烯酰-CoA水合酶（EC 4.2.1.18）。生成的3-丁烯-2-酮可以进一步转化成3-丁烯-2-醇，最后转化为1,3-丁二烯。

5. 发明申请

WO2017017124A1 HIV KINASE VARIANTS 审中-公开
标题翻译：艾滋病毒激素变种
公开(公告)号：WO2017017124A1
公开(公告)日：2017-02-02
申请号：PCT/EP2016/067865
申请日：2016-07-27
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： MAZALEYRAT, Sabine , BARBAROUX, Jean-Baptiste , DELCOURT, Marc , STRICHER, Francois , MARLIERE, Philippe
IPC分类号： C12P5/02
CPC分类号： C12N9/12 , C12N9/88 , C12P5/02 , C12Y401/01033
摘要： Described are HIV kinase variants showing an improved activity in converting 3- hydroxyisovalerate (HIV) into 3-phosphonoxyisovalerate (PIV), methods for the production of PIV using such enzyme variants as well as methods for the production isobutene in a subsequent reaction.
摘要翻译：描述了显示出将3-羟基异戊酸酯（HIV）转化为3-膦酸异戊酸酯（PIV）的改善的活性的HIV激酶变体，使用这种酶变体生产PIV的方法以及在后续反应中生产异丁烯的方法。

6. 发明申请

WO2013150100A1 METHOD FOR THE ENZYMATIC PRODUCTION OF ISOPRENOL USING MEVALONATE AS A SUBSTRATE 审中-公开
标题翻译：使用甲基丙烯酸酯作为底物生产异丙苯的方法
公开(公告)号：WO2013150100A1
公开(公告)日：2013-10-10
申请号：PCT/EP2013/057108
申请日：2013-04-04
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： DELCOURT, Marc , ANISSIMOVA, Maria , MARLIERE, Philippe
IPC分类号： C12P7/04 , C12P5/00 , C12N1/00 , C12N9/88
CPC分类号： C12P7/04 , C12N9/88 , C12P5/007 , C12Y401/01033
摘要： Described is a method for generating isoprenol through a biological process. More specifically, described is a method for producing isoprenol from mevalonate.
摘要翻译：描述了通过生物过程产生异戊二烯醇的方法。更具体地，描述了从甲羟戊酸生产异戊二烯醇的方法。

7. 发明申请

WO2016097289A1 ENZYMATIC PRODUCTION OF ACRYLYL-COA OR ETHYLENE FROM GLYCEROL 审中-公开
标题翻译：丙二醇或乙酸乙烯酯的生产
公开(公告)号：WO2016097289A1
公开(公告)日：2016-06-23
申请号：PCT/EP2015/080482
申请日：2015-12-18
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： ALLARD, Mathieu , MARLIERE, Philippe
IPC分类号： C12P5/02 , C12N9/08 , C12N9/02 , C12P7/62
CPC分类号： C12P5/026 , C12N9/0008 , C12N9/001 , C12N9/88 , C12P7/62
摘要： Described is a method for the production of acrylyl-CoA from glycerol comprising the following steps: (a) the enzymatic conversion of glycerol into 3-hydroxypropionaldehyde; (b) the enzymatic conversion of said 3-hydroxypropionaldehyde into 3-hydroxypropionyl-CoA; and (c) the enzymatic conversion of said 3-hydroxypropionyl-CoA into acrylyl-CoA. Further enzymatic conversion of acrylyl-CoA into other products are disclosed. Further described is a method for the production of ethylene comprising the enzymatic conversion of propionic acid into ethylene. It is described that the enzymatic conversion of propionic acid into ethylene can be achieved by making use of a cytochrome P450 fatty acid decarboxylase or a non-heme iron oxygenase. Further, it is described that said propionic acid can be obtained by the enzymatic conversion of acrylyl-CoA into said propionic acid.
摘要翻译：描述了由甘油制备丙烯酰辅酶A的方法，包括以下步骤：（a）将甘油酶促转化为3-羟基丙醛; （b）将所述3-羟基丙醛酶促转化成3-羟基丙酰辅酶A; 和（c）所述3-羟基丙酰辅酶A的酶促转化为丙烯酰辅酶A。公开了将丙烯酰辅酶A进一步酶促转化成其它产物。进一步描述了一种生产乙烯的方法，其包括将丙酸酶促转化成乙烯。描述了丙酸进入乙烯的酶促转化可以通过使用细胞色素P450脂肪酸脱羧酶或非血红素铁加氧酶来实现。此外，描述了所述丙酸可以通过将丙烯酰辅酶A酶促转化成所述丙酸而获得。

8. 发明申请

WO2015101493A1 3-HYDROXYISOVALERATE (HIV) SYNTHASE VARIANTS 审中-公开
标题翻译： 3-HYDROXYISOVALERATE（HIV）SYNTHASE VARIANTS
公开(公告)号：WO2015101493A1
公开(公告)日：2015-07-09
申请号：PCT/EP2014/078120
申请日：2014-12-17
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： MARLIERE, Philippe , DELCOURT, Marc , MAZALEYRAT, Sabine , BARBAROUX, Jean-Baptiste
IPC分类号： C12N9/10 , C12N9/88 , C12P7/42 , C12P7/52
CPC分类号： C12N9/1025 , C12N9/88 , C12P5/026 , C12P7/42 , C12Y203/0301 , C12Y401/03004 , Y02E50/343
摘要： Described are 3-hydroxyisovalerate (HIV) synthase variants having improved activity in converting acetone and a compound which provides an activated acetyl group into 3-hydroxyisovalerate (HIV). Moreover, described are in particular methods for the production of 3-hydoxyisovalerate and methods for the production of isobutene from acetone utilizing the HIV synthase variants of the present invention.
摘要翻译：描述了具有改善的丙酮转化活性的3-羟基异戊酸（HIV）合酶变体和向3-羟基异戊酸酯（HIV）提供活化的乙酰基的化合物。此外，特别地描述了生产3-羟基异戊酸的方法和使用本发明的HIV合酶变体从丙酮生产异丁烯的方法。

9. 发明申请

WO2014064198A1 PRODUCTION OF ALKENES FROM 3-HYDROXY-1-CARBOXYLIC ACIDS VIA 3-SULFONYLOXY-1-CARBOXYLIC ACIDS 审中-公开
标题翻译：从3-羟基-1-羧酸的3-羟基-1-羧酸生产烯烃
公开(公告)号：WO2014064198A1
公开(公告)日：2014-05-01
申请号：PCT/EP2013/072278
申请日：2013-10-24
申请人： SCIENTIST OF FORTUNE S.A. , GLOBAL BIOENERGIES
发明人： MARLIERE, Philippe , ANISSIMOVA, Maria , ALLARD, Mathieu
IPC分类号： C12P5/02 , C12N9/10
CPC分类号： C12P5/026 , C12N9/13
摘要： The application describes a method for producing alkenes (for example propylene, ethylene, 1-butylene, isobutylene, isoamylene, butadiene or isoprene) from 3- hydroxy-1-carboxylic acids via 3-sulfonyloxy-1-carboxylic acids.
摘要翻译：本申请描述了通过3-磺酰氧基-1-羧酸从3-羟基-1-羧酸生产烯烃（例如丙烯，乙烯，1-丁烯，异丁烯，异戊烯，丁二烯或异戊二烯）的方法。

10. 发明申请

WO2017162738A1 METHOD FOR PRODUCING ISOBUTENE FROM 3-METHYLCROTONYL-COA 审中-公开
标题翻译：由3-甲基烟酰基-CoA制备异丁烯的方法
公开(公告)号：WO2017162738A1
公开(公告)日：2017-09-28
申请号：PCT/EP2017/056822
申请日：2017-03-22
申请人： GLOBAL BIOENERGIES , SCIENTIST OF FORTUNE S.A.
发明人： ALLARD, Mathieu , MARLIERE, Philippe
IPC分类号： C12P5/02
摘要： Described is a method for the production of isobutene from 3-methylcrotonyl-CoA comprising the steps of: (a) enzymatically converting 3-methylcrotonyl-CoA into 3-methylbutyric acid; and (b) further enzymatically converting the thus produced 3-methylbutyric acid into isobutene. The conversion of 3-methylcrotonyl-CoA into 3-methylbutyric acid can be achieved by first enzymatically converting 3-methylcrotonyl-CoA into 3-methylbutyryl-CoA and further enzymatically converting the thus produced 3-methylbutyryi-CoA into 3-methylbutyric acid. Alternatively, the conversion of 3-methylcrotonyl-CoA into 3-methylbutyric acid can be achieved by first enzymatically converting 3- methylcrotonyl-CoA into 3-methylcrotonic acid and then further enzymatically converting the thus produced 3-methylcrotonic acid into 3-methylbutyric acid.
摘要翻译：描述了由3-甲基巴豆酰辅酶A生产异丁烯的方法，其包括以下步骤：（a）将3-甲基巴豆酰辅酶A酶促转化为3-甲基丁酸; 和（b）将由此产生的3-甲基丁酸进一步酶促转化为异丁烯。 3-甲基巴豆酰辅酶A向3-甲基丁酸的转化可以通过首先将3-甲基巴豆酰辅酶A酶促转化为3-甲基丁酰辅酶A并进一步酶促将如此产生的3-甲基丁酰辅酶A转化成3-甲基丁酸来实现。或者，3-甲基巴豆酰辅酶A向3-甲基丁酸的转化可以通过首先将3-甲基巴豆酰辅酶A酶促转化成3-甲基巴豆酸然后将由此产生的3-甲基巴豆酸进一步酶促转化成3-甲基丁酸来实现。

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