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1. 发明申请

WO9743272A3 BENZOFURANS AND BENZOPYRANS AS CHRONOBIOLOGICAL AGENTS 审中-公开
标题翻译：苯并呋喃和苯并噻吩作为慢性代谢物
公开(公告)号：WO9743272A3
公开(公告)日：1998-03-26
申请号：PCT/EP9702402
申请日：1997-05-13
申请人： GLAXO GROUP LTD , ELLIS FRANK , PANCHAL TERENCE AARON , NORTH PETER CHARLES , COOKE JASON WILLIAM BEAMES , DOLAN SIMON CHARLES
发明人： ELLIS FRANK , PANCHAL TERENCE AARON , NORTH PETER CHARLES , COOKE JASON WILLIAM BEAMES , DOLAN SIMON CHARLES
IPC分类号： A61K31/00 , A61K31/34 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/353 , A61P1/00 , A61P1/04 , A61P25/28 , A61P27/00 , A61P27/06 , A61P35/00 , C07C33/26 , C07C215/48 , C07C233/18 , C07C233/60 , C07D307/79 , C07D311/04 , C07D311/58 , C07D405/12
CPC分类号： C07D307/79 , C07C33/26 , C07C215/48 , C07C233/18 , C07C233/60 , C07C2601/02 , C07D311/58 , C07D405/12
摘要： A compound of formula (I), wherein R?1 and R2¿ which may be the same or different represent H, C¿1-6? alkyl, C3-7 cycloalkyl or aryl; R?3, and R4¿ which may be the same or different represent H, halogen, C¿1-6? alkyl; or substituted aryl; R?5¿ represents H or C¿1-6? alkyl or; n is an integer 0, 1 or 2 and m is an integer 1, 2, 3 or 4; the dotted line indicates the presence or absence of an additional bond; and pharmaceutically acceptable solvates thereof.

2. 发明专利

ES2202615T3 未知
公开(公告)号：ES2202615T3
公开(公告)日：2004-04-01
申请号：ES97923868
申请日：1997-05-13
申请人： GLAXO GROUP LTD
发明人： ELLIS FRANK , PANCHAL TERENCE AARON , NORTH PETER CHARLES , COOKE JASON WILLIAM BEAMES , DOLAN SIMON CHARLES
IPC分类号： A61K31/00 , A61K31/34 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/353 , A61P1/00 , A61P1/04 , A61P25/28 , A61P27/00 , A61P27/06 , A61P35/00 , C07C33/26 , C07C215/48 , C07C233/18 , C07C233/60 , C07D307/79 , C07D311/04 , C07D311/58 , C07D405/12
摘要： PCT No. PCT/EP97/02402 Sec. 371 Date Nov. 6, 1998 Sec. 102(e) Date Nov. 6, 1998 PCT Filed May 13, 1997 PCT Pub. No. WO97/43272 PCT Pub. Date Nov. 20, 1997The invention thus provides compounds of Formula (I) wherein R1 and R2 which may be the same or different represent H, C1-6 alkyl or substituted alkyl or C3-7 cycloalkyl; or aryl; R3, and R4 which may be the same or different represent H, halogen, C1-6 alkyl; or substituted aryl; R5 is H or C1-6 alkyl; n is an integer 0, 1 or 2 and m is an integer 1, 2, 3, or 4; the dotted line indicates the presence or absence of an additional bond; and pharmaceutically acceptable solvates (e.g. hydrates) thereof.

4. 发明专利

DK0901483T3 未知
公开(公告)号：DK0901483T3
公开(公告)日：2003-11-03
申请号：DK97923868
申请日：1997-05-13
申请人： GLAXO GROUP LTD
发明人： ELLIS FRANK , PANCHAL TERENCE AARON , NORTH PETER CHARLES , COOKE JASON WILLIAM BEAMES , DOLAN SIMON CHARLES
IPC分类号： A61K31/00 , A61K31/34 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/353 , A61P1/00 , A61P1/04 , A61P25/28 , A61P27/00 , A61P27/06 , A61P35/00 , C07C33/26 , C07C215/48 , C07C233/18 , C07C233/60 , C07D307/79 , C07D311/04 , C07D311/58 , C07D405/12
摘要： PCT No. PCT/EP97/02402 Sec. 371 Date Nov. 6, 1998 Sec. 102(e) Date Nov. 6, 1998 PCT Filed May 13, 1997 PCT Pub. No. WO97/43272 PCT Pub. Date Nov. 20, 1997The invention thus provides compounds of Formula (I) wherein R1 and R2 which may be the same or different represent H, C1-6 alkyl or substituted alkyl or C3-7 cycloalkyl; or aryl; R3, and R4 which may be the same or different represent H, halogen, C1-6 alkyl; or substituted aryl; R5 is H or C1-6 alkyl; n is an integer 0, 1 or 2 and m is an integer 1, 2, 3, or 4; the dotted line indicates the presence or absence of an additional bond; and pharmaceutically acceptable solvates (e.g. hydrates) thereof.

5. 发明专利

YU81000A DERIVATI 2-(PURIN-9-IL)-TETRAHIDROFURAN-3,4 DIOLA 未知
公开(公告)号：YU81000A
公开(公告)日：2003-10-31
申请号：YU81000
申请日：1999-06-23
申请人： GLAXO GROUP LTD
发明人： ALLEN DAVID GEORGE , CHAN CHUEN , COOK CAROLINE MARY , COUSINS RICHARD PETER CHARLES , COX BRIAN , DYKE HAZEL JOAN , ELLIS FRANK , GEDEN JOANNA VICTORIA , HOBBS HEATHER , REDGRAVE JUDITH ALISON , SWANSON STEPHEN , BAYS DAVID
IPC分类号： A61K31/7028 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P11/00 , A61P11/06 , A61P29/00 , C07H15/04 , C07H15/26 , C07H19/16
摘要： U skladu sa ovim pronalaskom daju se nova jedinjenja formule (I) u kojoj su R1, R2, R3, Z1, Z2, Z3 i Z4 definisani u opisu ove prijave, postupci za njihovo dobijanje i njihova upotreba u postupku dobijanja leka za tretiranje inflamatornih bolesti.[There are provided according to the invention novel compounds of formula (I), wherein R1, R2, R3, Z1, Z2, Z3 and Z4 are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

6. 发明专利

AT249474T 未知
公开(公告)号：AT249474T
公开(公告)日：2003-09-15
申请号：AT99934530
申请日：1999-06-23
申请人： GLAXO GROUP LTD
发明人： ALLEN DAVID GEORGE , CHAN CHUEN , COOK CAROLINE MARY , COUSINS RICHARD PETER CHARLES , COX BRIAN , DYKE HAZEL JOAN , ELLIS FRANK , GEDEN JOANNA VICTORIA , HOBBS HEATHER , REDGRAVE ALISON JUDITH , SWANSON STEPHEN , BAYS DAVID
IPC分类号： A61K31/7028 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P11/00 , A61P11/06 , A61P29/00 , C07H15/04 , C07H15/26 , C07H19/16 , C07H19/167 , A61K31/70
摘要： There are provided according to the invention novel compounds of formula (I), wherein R , R , R , Z , Z , Z and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

7. 发明专利

AT223429T 未知
公开(公告)号：AT223429T
公开(公告)日：2002-09-15
申请号：AT99906229
申请日：1999-02-12
申请人： GLAXO GROUP LTD
发明人： CHAN CHUEN , COOK CAROLINE MARY , COX BRIAN , COUSINS RICHARD PETER C , DYKE HAZEL JOAN , ELLIS FRANK , GEDEN JOANNA V , SWANSON STEPHEN , BAYS DAVID
IPC分类号： A61K20060101 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P25/00 , A61P25/28 , A61P29/00 , C07D20060101 , C07H19/16 , A61K31/70
摘要： There are disclosed according to the invention, compounds of formula (I) wherein R1, R2 and R3 are defined in the specification. Additionally, processes of preparing the compounds of formula (I), formulations containing same, and the administration of said compounds or formulations thereof in the treatment of inflammatory diseases are also disclosed.

8. 发明专利

DE69711868D1 未知
公开(公告)号：DE69711868D1
公开(公告)日：2002-05-16
申请号：DE69711868
申请日：1997-05-13
申请人： GLAXO GROUP LTD
发明人： ELLIS FRANK , SWANSON STEPHEN , COUSINS PETER , COX BRIAN , PENNELL MICHAEL , ELDRED DAVID
IPC分类号： C07H19/167 , A61K31/7076 , A61P9/00 , A61P25/00 , C07H15/04 , C07H19/16 , A61K31/70
摘要： PCT No. PCT/EP97/02403 Sec. 371 Date Nov. 6, 1998 Sec. 102(e) Date Nov. 6, 1998 PCT Filed May 13, 1997 PCT Pub. No. WO97/43300 PCT Pub. Date Nov. 20, 1997This invention relates to novel adenosine derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine. Thus the invention provides compounds of formula (I) which are agonists at the adenosine A1 receptor. wherein R1 represents phenyl optionally substituted by one or more substituents selected from halogen, C1-3alkyl, trifluoromethyl, nitro, cyano, -CO2Ra1-CONRaRb, -CORa, -SORc, -SO2Rc, -SO3H, -SO2NRaRb, -ORa, -NHSO2Rc, -NHCORa and -NRaRb, R2 represents a C1-6alkyl or C3-6alkenyl group; R3 represents C1-3alkyl; Ra and Rb may each independently represent hydrogen or C1-3alkyl or, when -NRaRb is directly attached to said phenyl, Ra and Rb together with the nitrogen atom may form a -5 or -6 or membered heterocyclic ring optionally containing a second heteroatom selected from oxygen or nitrogen, which second nitrogen heteroatom may optionally be further substituted by hydrogen or C1-3alkyl; Rc represents C1-3alkyl; and salts and solvates thereof, in particular physiologically acceptable salts and solvates thereof.

9. 发明专利

AT215958T 未知
公开(公告)号：AT215958T
公开(公告)日：2002-04-15
申请号：AT97923051
申请日：1997-05-13
申请人： GLAXO GROUP LTD
发明人： ELLIS FRANK , SWANSON STEPHEN , COUSINS RICHARD PETER CHARLES , COX BRIAN , PENNELL ANDREW MICHAEL KENNETH , ELDRED COLIN DAVID
IPC分类号： C07H19/167 , A61K31/7076 , A61P9/00 , A61P25/00 , C07H15/04 , C07H19/16 , A61K31/70
摘要： PCT No. PCT/EP97/02403 Sec. 371 Date Nov. 6, 1998 Sec. 102(e) Date Nov. 6, 1998 PCT Filed May 13, 1997 PCT Pub. No. WO97/43300 PCT Pub. Date Nov. 20, 1997This invention relates to novel adenosine derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine. Thus the invention provides compounds of formula (I) which are agonists at the adenosine A1 receptor. wherein R1 represents phenyl optionally substituted by one or more substituents selected from halogen, C1-3alkyl, trifluoromethyl, nitro, cyano, -CO2Ra1-CONRaRb, -CORa, -SORc, -SO2Rc, -SO3H, -SO2NRaRb, -ORa, -NHSO2Rc, -NHCORa and -NRaRb, R2 represents a C1-6alkyl or C3-6alkenyl group; R3 represents C1-3alkyl; Ra and Rb may each independently represent hydrogen or C1-3alkyl or, when -NRaRb is directly attached to said phenyl, Ra and Rb together with the nitrogen atom may form a -5 or -6 or membered heterocyclic ring optionally containing a second heteroatom selected from oxygen or nitrogen, which second nitrogen heteroatom may optionally be further substituted by hydrogen or C1-3alkyl; Rc represents C1-3alkyl; and salts and solvates thereof, in particular physiologically acceptable salts and solvates thereof.

10. 发明专利

HU0102454A2 ANTI INFLAMMATORY 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES 未知
公开(公告)号：HU0102454A2
公开(公告)日：2002-01-28
申请号：HU0102454
申请日：1999-06-23
申请人： GLAXO GROUP LTD
发明人： ALLEN DAVID GEORGE , BAYS DAVID , CHAN CHUEN , COOK CAROLINE MARY , COUSINS RICHARD PETER CHARLES , COX BRIAN , DYKE HAZEL JOAN , ELLIS FRANK , GEDEN JOANNA VICTORIA , HOBBS HEATHER , REDGRAVE ALISON JUDITH , SWANSON STEPHEN
IPC分类号： A61K31/7028 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P11/00 , A61P11/06 , A61P29/00 , C07H15/04 , C07H15/26 , C07H19/16 , C07H19/167
摘要： There are provided according to the invention novel compounds of formula (I), wherein R , R , R , Z , Z , Z and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

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