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    • 9. 发明申请
    • CONTROLLED RELEASE HYDROGEL FORMULATION
    • 控制释放水凝胶制剂
    • WO2008039615A3
    • 2008-12-11
    • PCT/US2007076551
    • 2007-08-22
    • BIOKEY INCCHOW SAN-LAUNGWONG DAVIDGARCIA DAMIAN
    • CHOW SAN-LAUNGWONG DAVIDGARCIA DAMIAN
    • A61K31/47A61K9/14A61K31/496
    • A61K9/2054A61K9/2027A61K9/2095A61K31/47A61K31/496
    • Embodiments of the invention generally provide pharmaceutical drug compositions, methods of preparing oral drug compositions, such as controlled release dosage compositions for hydrophobic active ingredients. In one aspect, the invention provides a pharmaceutical formulation comprising a therapeutically effective amount of a hydrophobic drug, an adjustable ratio of a non-cross linked hydrogel polymer and a non-gelling insoluble polymer. One example is a controlled release pharmaceutical composition which includes 1% to 80% of a therapeutically amount of cilostazol, 4% to 80% of a water-swelling hydrogel polymer, and 4% to 80% of a non-gelling insoluble polymer. In another aspect, a constant release profile of the pharmaceutical formulation is obtained. In another aspect, a zero degree release profile of the pharmaceutical formulation is obtained. Further, a method for treating intermittent claudication using the pharmaceutical formulation is provided.
    • 本发明的实施方案通常提供药物组合物,制备口服药物组合物的方法,例如用于疏水性活性成分的控释剂组合物。 一方面,本发明提供了包含治疗有效量的疏水性药物,非交联水凝胶聚合物和非胶凝不溶性聚合物的可调节比例的药物制剂。 一个实例是控释药物组合物,其包含1%至80%的治疗量的西洛他唑,4%至80%的水溶胀性水凝胶聚合物和4%至80%的非胶凝不溶性聚合物。 在另一方面,获得药物制剂的恒定释放曲线。 另一方面,获得药物制剂的零度释放曲线。 此外,提供了使用药物制剂治疗间歇性跛行的方法。