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1. 发明申请

WO2010141920A2 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL AND RELATED METHODS 审中-公开
标题翻译：用于生产1,4-丁二醇的微生物及相关方法
公开(公告)号：WO2010141920A2
公开(公告)日：2010-12-09
申请号：PCT/US2010/037544
申请日：2010-06-04
申请人： GENOMATICA, INC. , VAN DIEN, Stephen, J. , BURGARD, Anthony, P. , HASELBECK, Robert , PUJOL-BAXLEY, Catherine, J. , NIU, Wei , TRAWICK, John, D. , YIM, Harry , BURK, Mark, J. , OSTERHOUT, Robin, E. , SUN, Jun
发明人： VAN DIEN, Stephen, J. , BURGARD, Anthony, P. , HASELBECK, Robert , PUJOL-BAXLEY, Catherine, J. , NIU, Wei , TRAWICK, John, D. , YIM, Harry , BURK, Mark, J. , OSTERHOUT, Robin, E. , SUN, Jun
IPC分类号： C12P7/18
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/001 , C12N9/13 , C12N9/16 , C12N9/88 , C12N9/93 , C12N15/52
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed in a sufficient amount to produce BDO and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO.
摘要翻译：本发明提供包含1,4-丁二醇（BDO）途径的非天然存在的微生物生物，其包含至少一种编码足够量的BDO途径酶的外源核酸以产生BDO并进一步优化BDO的表达。本发明还提供了使用这种微生物生产BDO的方法。

2. 发明申请

WO2011066076A1 MICROORGANISMS AND METHODS FOR THE COPRODUCTION OF 1,4-BUTANEDIOL AND GAMMA-BUTYROLACTONE 审中-公开
标题翻译：共聚1,4-丁二醇和γ-丁内酯的微生物和方法
公开(公告)号：WO2011066076A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/055524
申请日：2010-11-04
申请人： GENOMATICA, INC. , SUN, Jun , BURK, Mark, J. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , NIU, Wei , TRAWICK, John, D. , HASELBECK, Robert
发明人： SUN, Jun , BURK, Mark, J. , BURGARD, Anthony, P. , OSTERHOUT, Robin, E. , NIU, Wei , TRAWICK, John, D. , HASELBECK, Robert
IPC分类号： C12P7/38 , C12P7/16 , C12N1/20
CPC分类号： C12P17/04 , C12N1/20 , C12N15/52 , C12P7/18
摘要： The invention provides non-naturally occurring microbial organisms comprising 1,4- butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
摘要翻译：本发明提供包含1,4-丁二醇（14-BDO）和γ-丁内酯（GBL）途径的非天然存在的微生物生物，其包含至少一种编码14-BDO和GBL途径酶的外源核酸，其以足够的量表达，生产14-BDO和GBL。本发明另外提供了使用这种微生物生物来生产14-BDO和GBL的方法。

3. 发明申请

WO2011047101A1 MICROORGANISMS FOR THE PRODUCTION OF 1,4-BUTANEDIOL, 4-HYDROXYBUTANAL, 4-HYDROXYBUTYRYL-COA, PUTRESCINE AND RELATED COMPOUNDS, AND METHODS RELATED THERETO 审中-公开
标题翻译：用于生产1,4-丁二醇，4-羟基吡啶，4-羟基丁酰氯，聚氨酯和相关化合物的微生物及其相关方法
公开(公告)号：WO2011047101A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052570
申请日：2010-10-13
申请人： GENOMATICA, INC. , HASELBECK, Robert , TRAWICK, John, D. , NIU, Wei , BURGARD, Anthony, P.
发明人： HASELBECK, Robert , TRAWICK, John, D. , NIU, Wei , BURGARD, Anthony, P.
IPC分类号： C12P7/26 , C12N1/20
CPC分类号： C12P7/18 , C12P7/24 , C12P7/42 , C12P13/001 , C12P19/40
摘要： The invention provides non-naturally occurring microbial organisms comprising a 1,4- butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, A- hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.
摘要翻译：本发明提供了包含1,4-丁二醇（BDO），4-羟基丁酰辅酶A，4-羟基丁醛或腐胺途径的非天然存在的微生物生物，其包含至少一种编码BDO，4-羟基丁酰辅酶A， - 羟基丁醛或腐胺途径酶以足够的量表达以产生BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺，并进一步优化BDO的表达。本发明另外提供了使用这种微生物生物制备BDO，4-羟基丁酰辅酶A，4-羟基丁醛或腐胺的方法。

4. 发明申请

WO2008115840A2 COMPOSITIONS AND METHODS FOR THE BIOSYNTHESIS OF 1,4-BUTANEDIOL AND ITS PRECURSORS 审中-公开
标题翻译： 1,4-丁二醇及其前体的生物合成的组合物和方法
公开(公告)号：WO2008115840A2
公开(公告)日：2008-09-25
申请号：PCT/US2008/057168
申请日：2008-03-14
申请人： GENOMATICA, INC. , BURK, Mark, J. , VAN DIEN, Stephen, J. , BURGARD, Anthony , NIU, Wei
发明人： BURK, Mark, J. , VAN DIEN, Stephen, J. , BURGARD, Anthony , NIU, Wei
IPC分类号： C12N1/21
CPC分类号： C12N15/52 , B01D3/002 , C12N9/0006 , C12N9/0008 , C12N9/88 , C12N9/93 , C12N15/70 , C12N15/81 , C12P7/18 , C12P7/42 , C12P7/52 , C12P17/04 , C12Y101/01061 , C12Y102/01076 , C12Y401/01071 , C12Y602/01004 , Y02P20/52
摘要： The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce monomeric 4-hydroxybutanoic acid (4-HB). Also provided is a non-naturally occurring microbial biocatalyst including a microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (BDO) biosynthetic pathways, the pathways include at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:CoA transferase, 4-butyrate kinase, phosphotransbutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce 1,4- butanediol (BDO). Additionally provided is a method for the production of 4-HB. The method includes culturing a non-naturally occurring microbial organism having a A- hydroxybutanoic acid (4-HB) biosynthetic pathway including at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase or α-ketoglutarate decarboxylase under substantially anaerobic conditions for a sufficient period of time to produce monomeric A- hydroxybutanoic acid (4-HB). Further provided is a method for the production of BDO. The method includes culturing a non-naturally occurring microbial biocatalyst, comprising a microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (BDO) biosynthetic pathways, the pathways including at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, 4-hydroxybutyrate:CoA transferase, 4-hydroxybutyrate kinase, phosphotranshydroxybutyrylase, α-ketoglutarate decarboxylase, aldehyde dehydrogenase, alcohol dehydrogenase or an aldehyde/alcohol dehydrogenase for a sufficient period of time to produce 1,4-butanediol (BDO). The 4-HB and/or BDO products can be secreted into the culture medium.
摘要翻译：本发明提供一种非天然存在的微生物生物催化剂，其包括具有4-羟基丁酸（4-HB）生物合成途径的微生物生物，其具有至少一种编码4-羟基丁酸脱氢酶的外源核酸，琥珀酰辅酶A合成酶，CoA依赖性琥珀酸半醛脱氢酶或α-酮戊二酸脱羧酶，其中外源核酸以足够的量表达以产生单体4-羟基丁酸（4-HB）。还提供了非天然存在的微生物生物催化剂，其包括具有4-羟基丁酸（4-HB）和1,4-丁二醇（BDO）生物合成途径的微生物生物，该途径包括至少一种编码4-羟基丁酸脱氢酶的外源核酸，琥珀酰辅酶A合成酶，CoA依赖性琥珀酸半醛脱氢酶，4-羟基丁酸酯：CoA转移酶，4-丁酸激酶，磷酸转移酶，α-酮戊二酸脱羧酶，醛脱氢酶，醇脱氢酶或醛/醇脱氢酶，其中外源核酸为表达量足以生产1,4-丁二醇（BDO）。另外提供了用于生产4-HB的方法。所述方法包括培养具有4-羟基丁酸（4-HB）生物合成途径的非天然存在的微生物生物，其包含至少一种编码4-羟基丁酸脱氢酶的外源核酸，琥珀酰辅酶A合成酶，辅酶A依赖性琥珀酸半醛脱氢酶或 - 酮戊二酸脱羧酶在充分的厌氧条件下持续足够的时间以产生单体的4-羟基丁酸（4-HB）。进一步提供一种生产BDO的方法。该方法包括培养非天然存在的微生物生物催化剂，其包含具有4-羟基丁酸（4-HB）和1,4-丁二醇（BDO）生物合成途径的微生物生物，所述途径包括至少一种编码4- 羟基丁酸脱氢酶，琥珀酰辅酶A合成酶，CoA依赖性琥珀酸脱氢酶，4-羟基丁酸酯：CoA转移酶，4-羟基丁酸酯激酶，磷酸转移羟基丁酸酶，α-酮戊二酸脱羧酶，醛脱氢酶，醇脱氢酶或醛/醇脱氢酶，时间来生产1,4-丁二醇（BDO）。 4-HB和/或BDO产物可以分泌到培养基中。

5. 发明申请

WO2010144746A2 MICROORGANISMS AND METHODS FOR CARBON-EFFICIENT BIOSYNTHESIS OF MEK AND 2-BUTANOL 审中-公开
标题翻译：用于碳氢化合物和2-丁醇的高效生物合成的微生物和方法
公开(公告)号：WO2010144746A2
公开(公告)日：2010-12-16
申请号：PCT/US2010/038230
申请日：2010-06-10
申请人： GENOMATICA, INC. , OSTERHOUT, Robin, E. , NIU, Wei , BURGARD, Anthony, P.
发明人： OSTERHOUT, Robin, E. , NIU, Wei , BURGARD, Anthony, P.
IPC分类号： C12P7/26 , C12N1/00 , C12P7/16
CPC分类号： C12P7/26 , C12N15/52 , C12P7/16 , Y02E50/10
摘要： A non-naturally occurring microbial organism has at least one exogenous nucleic acid encoding a MEK pathway enzyme expressed in a sufficient amount to produce MEK. The MEK pathway includes an enzyme selected from an acetoacetyl-CoA dehydrogenase (bifunctional), an acetoacetyl-CoA aldehyde dehydrogenase, a 3-oxobutyraldehyde reductase, a 3-oxobutanol dehydratase, an MEK oxidoreductase, a 3-oxobutyraldehyde aminotransferase, a 4-aminobutan-2-one deaminase, a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP aminotransferase, a 2,4-dioxopentanoate decarboxylase, an AKP deaminase, an acetylacrylate decarboxylase, an AKP decarboxylase, a glutamate dehydrogenase, a 3-oxobutyraldehyde oxidoreductase (aminating) and an AKP oxidoreductase (aminating). A 2-butanol pathway further includes an MEK reductase. A method for producing MEK or 2-butanol includes culturing these organisms under conditions and for a sufficient period of time to produce MEK or 2-butanol.
摘要翻译：非天然存在的微生物有至少一种编码MEK途径酶的外源核酸，其表达量足以产生MEK。 MEK途径包括选自乙酰乙酰辅酶A脱氢酶（双功能），乙酰乙酰辅酶A醛脱氢酶，3-氧代丁醛还原酶，3-氧代丁醇脱水酶，MEK氧化还原酶，3-氧代丁醛氨基转移酶，4-氨基丁酸 -2-酮脱氨酶，2-氨基-4-酮戊酸酯（AKP）硫解酶，AKP氨基转移酶，2,4-二氧代戊酸脱羧酶，AKP脱氨酶，乙酰丙酸酯脱羧酶，AKP脱羧酶，谷氨酸脱氢酶，氧化丁醛氧化还原酶（胺化）和AKP氧化还原酶（胺化）。 2-丁醇途径还包括MEK还原酶。包括生产MEK或2-丁醇的方法包括在条件和足够的时间内培养这些生物体以产生MEK或2-丁醇。

6. 发明申请

WO2008127240A1 COMPOSITIONS AND METHODS OF PRODUCING METHIONINE 审中-公开
标题翻译：组合物和生产甲硫氨酸的方法
公开(公告)号：WO2008127240A1
公开(公告)日：2008-10-23
申请号：PCT/US2007/009146
申请日：2007-04-11
申请人： CARGILL, INCORPORATED , CJ CORPORATION , BRAZEAU, Brian , CHANG, Jin-Sook , CHO, Kwang, Myung , CHO, Young, Wook , DESOUZA, Mervyn , JESSEN, Holly, J. , KIM, So-Young , NIU, Wei , SANCHEZ-RIERA, Fernando, A. , SHIN, Yong-Uk , UM, Hyewon
发明人： BRAZEAU, Brian , CHANG, Jin-Sook , CHO, Kwang, Myung , CHO, Young, Wook , DESOUZA, Mervyn , JESSEN, Holly, J. , KIM, So-Young , NIU, Wei , SANCHEZ-RIERA, Fernando, A. , SHIN, Yong-Uk , UM, Hyewon
IPC分类号： C12N9/10 , C12P13/12
CPC分类号： C12P13/12 , C12N9/1029 , C12N15/63 , C12N15/70 , C12N15/74 , C12Y203/01046 , Y02P20/52
摘要： Described herein are microorganisms that produce methionine and related products from endogenous genes in a transsulfuration pathway, as well as from exogenous genes providing a direct sulfhydrylation pathway. Novel genes that are useful for methionine and SAMe production are disclosed.
摘要翻译：这里描述的是从转基因途径中的内源基因以及提供直接巯基化途径的外源基因产生甲硫氨酸和相关产物的微生物。公开了可用于甲硫氨酸和SAMe生产的新型基因。

7. 发明申请

WO2008091288A2 MICROBIAL SYNTHESIS OF D-1,2,4-BUTANETRIOL 审中-公开
标题翻译： D-1,2,4-BUTANETRIOL的微观合成
公开(公告)号：WO2008091288A2
公开(公告)日：2008-07-31
申请号：PCT/US2007/016384
申请日：2007-07-19
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY , FROST, John, W. , NIU, Wei
发明人： FROST, John, W. , NIU, Wei
CPC分类号： C12P7/18 , C12N9/0006 , C12N9/0008 , C12N9/88
摘要： Improved enzyme systems, recombinant cells, and processes employing the same to produce biosynthetic D-1,2,4-butanetriol; D-1,2,4-butanetriol prepared thereby and derivatives thereof; D-1,2,4-butanetriol trinitrate prepared therefrom; and enzymes and genes useful in the enzyme systems and recombinant cells.
摘要翻译：改进的酶系统，重组细胞和使用其的方法生产生物合成D-1,2,4-丁三醇的方法; 由此制备的D-1,2,4-丁三醇及其衍生物; 由其制备的D-1,2,4-丁三醇三硝酸酯; 以及可用于酶系统和重组细胞的酶和基因。

8. 发明申请

WO2011002469A1 ISOMERASES AND EPIMERASES AND METHODS OF USING 审中-公开
标题翻译：异构体和硫化物及其使用方法
公开(公告)号：WO2011002469A1
公开(公告)日：2011-01-06
申请号：PCT/US2009/049599
申请日：2009-07-02
申请人： CARGILL, INCORPORATED , DE SOUZA, Mervyn L. , NIU, Wei , LAPLAZA, Jose , SOLDHEID, Christopher , KOLLMANN, Sherry R. , LUNDORFF, Joshua M. , HICKS, Paula M. , MCFARLAN, Sara C. , SANCHEZ-RIERA, Fernando A. , WEINER, David P. , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin
发明人： DE SOUZA, Mervyn L. , NIU, Wei , LAPLAZA, Jose , SOLDHEID, Christopher , KOLLMANN, Sherry R. , LUNDORFF, Joshua M. , HICKS, Paula M. , MCFARLAN, Sara C. , SANCHEZ-RIERA, Fernando A. , WEINER, David P. , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin
IPC分类号： C12P7/40 , C12N15/00
CPC分类号： C12N9/90 , C12P13/06 , C12P13/22 , C12P17/10
摘要： The invention provides for isomerase (e.g., racemase) and epimerase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such isomerase (e.g., racemase) and epimerase nucleic acids and polypeptides.
摘要翻译：本发明提供异构酶（例如消旋酶）和差向异构酶多肽以及编码这种多肽的核酸。还提供了使用这种异构酶（例如消旋酶）和差向异构酶核酸和多肽的方法。

9. 发明申请

WO2009088482A1 AMINOTRANSFERASE AND OXIDOREDUCTASE NUCLEIC ACIDS AND POLYPEPTIDES AND METHODS OF USING 审中-公开
标题翻译：氨基转移酶和氧化还原酶核酸和多肽及其使用方法
公开(公告)号：WO2009088482A1
公开(公告)日：2009-07-16
申请号：PCT/US2008/014137
申请日：2008-12-31
申请人： CARGILL, INCORPORATED , DE SOUZA, Mervyn L. , HICKS, Paula M. , KOLLMANN, Sherry R. , LAPLAZA, José M. , LUNDORFF, Joshua M. , MCFARLAN, Sara C. , MARASCO, Erin , NIU, Wei , SANCHEZ-RIERA, Fernando A. , SOLHEID, Christopher , WEINER, David P. , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin
发明人： DE SOUZA, Mervyn L. , HICKS, Paula M. , KOLLMANN, Sherry R. , LAPLAZA, José M. , LUNDORFF, Joshua M. , MCFARLAN, Sara C. , MARASCO, Erin , NIU, Wei , SANCHEZ-RIERA, Fernando A. , SOLHEID, Christopher , WEINER, David P. , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin
IPC分类号： C12P21/06 , C12N9/10
CPC分类号： C12P13/227 , C12N9/0004 , C12N9/1096 , C12P17/10
摘要： The invention provides for aminotransferase and oxidoreductase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such aminotransferase and oxidoreductase nucleic acids and polypeptides.
摘要翻译：本发明提供氨基转移酶和氧化还原酶多肽以及编码这种多肽的核酸。还提供了使用这种氨基转移酶和氧化还原酶核酸和多肽的方法。

10. 发明申请

WO2009088442A2 ISOMERASES AND EPIMERASES AND METHODS OF USING 审中-公开
标题翻译：异构体和硫化物及其使用方法
公开(公告)号：WO2009088442A2
公开(公告)日：2009-07-16
申请号：PCT/US2008/013968
申请日：2008-12-22
申请人： CARGILL, INCORPORATED , DE SOUZA, Mervyn L. , NIU, Wei , LAPLAZA, Jose M. , SOLHEID, Christopher , KOLLMANN, Sherry R. , LUNDORFF, Joshua M. , HICKS, Paula M. , MCFARLAN, Sara C. , SANCHEZ-RIERA, Fernando A. , WEINER, David P. , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin
发明人： DE SOUZA, Mervyn L. , NIU, Wei , LAPLAZA, Jose M. , SOLHEID, Christopher , KOLLMANN, Sherry R. , LUNDORFF, Joshua M. , HICKS, Paula M. , MCFARLAN, Sara C. , SANCHEZ-RIERA, Fernando A. , WEINER, David P. , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin
IPC分类号： C12P13/04
CPC分类号： C12P13/04 , C12P13/227
摘要： The invention provides for isomerase (e.g., racemase) and epimerase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such isomerase (e.g., racemase) and epimerase nucleic acids and polypeptides.
摘要翻译：本发明提供异构酶（例如消旋酶）和差向异构酶多肽以及编码这种多肽的核酸。还提供了使用这种异构酶（例如消旋酶）和差向异构酶核酸和多肽的方法。

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