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1. 发明申请

WO2009088482A1 AMINOTRANSFERASE AND OXIDOREDUCTASE NUCLEIC ACIDS AND POLYPEPTIDES AND METHODS OF USING 审中-公开
标题翻译：氨基转移酶和氧化还原酶核酸和多肽及其使用方法
公开(公告)号：WO2009088482A1
公开(公告)日：2009-07-16
申请号：PCT/US2008/014137
申请日：2008-12-31
申请人： CARGILL, INCORPORATED , DE SOUZA, Mervyn L. , HICKS, Paula M. , KOLLMANN, Sherry R. , LAPLAZA, José M. , LUNDORFF, Joshua M. , MCFARLAN, Sara C. , MARASCO, Erin , NIU, Wei , SANCHEZ-RIERA, Fernando A. , SOLHEID, Christopher , WEINER, David P. , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin
发明人： DE SOUZA, Mervyn L. , HICKS, Paula M. , KOLLMANN, Sherry R. , LAPLAZA, José M. , LUNDORFF, Joshua M. , MCFARLAN, Sara C. , MARASCO, Erin , NIU, Wei , SANCHEZ-RIERA, Fernando A. , SOLHEID, Christopher , WEINER, David P. , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin
IPC分类号： C12P21/06 , C12N9/10
CPC分类号： C12P13/227 , C12N9/0004 , C12N9/1096 , C12P17/10
摘要： The invention provides for aminotransferase and oxidoreductase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such aminotransferase and oxidoreductase nucleic acids and polypeptides.
摘要翻译：本发明提供氨基转移酶和氧化还原酶多肽以及编码这种多肽的核酸。还提供了使用这种氨基转移酶和氧化还原酶核酸和多肽的方法。

2. 发明申请

WO2009088442A2 ISOMERASES AND EPIMERASES AND METHODS OF USING 审中-公开
标题翻译：异构体和硫化物及其使用方法
公开(公告)号：WO2009088442A2
公开(公告)日：2009-07-16
申请号：PCT/US2008/013968
申请日：2008-12-22
申请人： CARGILL, INCORPORATED , DE SOUZA, Mervyn L. , NIU, Wei , LAPLAZA, Jose M. , SOLHEID, Christopher , KOLLMANN, Sherry R. , LUNDORFF, Joshua M. , HICKS, Paula M. , MCFARLAN, Sara C. , SANCHEZ-RIERA, Fernando A. , WEINER, David P. , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin
发明人： DE SOUZA, Mervyn L. , NIU, Wei , LAPLAZA, Jose M. , SOLHEID, Christopher , KOLLMANN, Sherry R. , LUNDORFF, Joshua M. , HICKS, Paula M. , MCFARLAN, Sara C. , SANCHEZ-RIERA, Fernando A. , WEINER, David P. , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin
IPC分类号： C12P13/04
CPC分类号： C12P13/04 , C12P13/227
摘要： The invention provides for isomerase (e.g., racemase) and epimerase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such isomerase (e.g., racemase) and epimerase nucleic acids and polypeptides.
摘要翻译：本发明提供异构酶（例如消旋酶）和差向异构酶多肽以及编码这种多肽的核酸。还提供了使用这种异构酶（例如消旋酶）和差向异构酶核酸和多肽的方法。

3. 发明申请

WO2011002469A1 ISOMERASES AND EPIMERASES AND METHODS OF USING 审中-公开
标题翻译：异构体和硫化物及其使用方法
公开(公告)号：WO2011002469A1
公开(公告)日：2011-01-06
申请号：PCT/US2009/049599
申请日：2009-07-02
申请人： CARGILL, INCORPORATED , DE SOUZA, Mervyn L. , NIU, Wei , LAPLAZA, Jose , SOLDHEID, Christopher , KOLLMANN, Sherry R. , LUNDORFF, Joshua M. , HICKS, Paula M. , MCFARLAN, Sara C. , SANCHEZ-RIERA, Fernando A. , WEINER, David P. , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin
发明人： DE SOUZA, Mervyn L. , NIU, Wei , LAPLAZA, Jose , SOLDHEID, Christopher , KOLLMANN, Sherry R. , LUNDORFF, Joshua M. , HICKS, Paula M. , MCFARLAN, Sara C. , SANCHEZ-RIERA, Fernando A. , WEINER, David P. , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin
IPC分类号： C12P7/40 , C12N15/00
CPC分类号： C12N9/90 , C12P13/06 , C12P13/22 , C12P17/10
摘要： The invention provides for isomerase (e.g., racemase) and epimerase polypeptides and nucleic acids encoding such polypeptides. Also provided are methods of using such isomerase (e.g., racemase) and epimerase nucleic acids and polypeptides.
摘要翻译：本发明提供异构酶（例如消旋酶）和差向异构酶多肽以及编码这种多肽的核酸。还提供了使用这种异构酶（例如消旋酶）和差向异构酶核酸和多肽的方法。

4. 发明申请

WO2007133184A2 POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS FOR THE PRODUCTION OF STEREOISOMERS OF MONATIN AND THEIR PRECURSORS 审中-公开
标题翻译：用于生产MONATIN及其前体的立体异构体的多肽和生物活性途径
公开(公告)号：WO2007133184A2
公开(公告)日：2007-11-22
申请号：PCT/US2006/015930
申请日：2006-04-26
申请人： CARGILL, INCORPORATED , BRAZEAU, Brian J. , BURKE, Ellen , DE SOUZA, Mervyn , GORT, Steven J. , HICKS, Paula M. , KOLLMAN, Sherry R. , LUGINBUHL, Peter , MCFARLAN, Sara, C. , RICHARDSON, Toby , SANCHEZ-RIERA, Fernando A. , SOLHEID, Christopher , WEINER, David , ZHAO, Lishan
发明人： BRAZEAU, Brian J. , BURKE, Ellen , DE SOUZA, Mervyn , GORT, Steven J. , HICKS, Paula M. , KOLLMAN, Sherry R. , LUGINBUHL, Peter , MCFARLAN, Sara, C. , RICHARDSON, Toby , SANCHEZ-RIERA, Fernando A. , SOLHEID, Christopher , WEINER, David , ZHAO, Lishan
IPC分类号： H04L9/00
CPC分类号： C12N9/1096 , C12N9/90 , C12P17/10
摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.
摘要翻译：使用多肽和生物合成途径产生莫纳甜和莫纳甜的某些立体异构体，例如R，R莫纳甜和S，R莫纳甜及其盐。这些多肽和生物合成途径也可用于生产在特定莫纳甜合成途径中形成的包括一些生物合成途径的中间体R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸。

5. 发明申请

WO2007133183A2 POLYPEPTIDES AND BIOSYNTHETIC PATHWAYS FOR THE PRODUCTION OF STEREOISOMERS OF MONATIN AND THEIR PRECURSORS 审中-公开
标题翻译：用于生产MONATIN立体异构体及其前体的多肽和生物合成途径
公开(公告)号：WO2007133183A2
公开(公告)日：2007-11-22
申请号：PCT/US2006/015913
申请日：2006-04-27
申请人： CARGILL, INCORPORATED , BRAZEAU, Brian J. , BURKE, Ellen , DE SOUZA, Mervyn , GORT, Steven J. , HICKS, Paula M. , KOLLMAN, Sherry R. , LUGINBUHL, Peter , MCFARLAN, Sara C. , RICHARDSON, Toby , SANCHEZ-RIERA, Fernando A. , SOLHEID, Christopher , WEINER, David , ZHAO, Lishan
发明人： BRAZEAU, Brian J. , BURKE, Ellen , DE SOUZA, Mervyn , GORT, Steven J. , HICKS, Paula M. , KOLLMAN, Sherry R. , LUGINBUHL, Peter , MCFARLAN, Sara C. , RICHARDSON, Toby , SANCHEZ-RIERA, Fernando A. , SOLHEID, Christopher , WEINER, David , ZHAO, Lishan
IPC分类号： H04L9/00
CPC分类号： C12P17/10 , C12N9/1096 , C12N9/90
摘要： Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.
摘要翻译：使用多肽和生物合成途径产生莫纳甜和莫纳甜的某些立体异构体，例如R，R莫纳甜和S，R莫纳甜及其盐。这些多肽和生物合成途径也可用于生产R-2-羟基-2-（吲哚-3-基甲基）-4-酮戊二酸，一种在某些monatin合成途径（包括一些生物合成途径）中形成的中间体。

6. 发明申请

WO2007103389A2 ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： ALDOLASES，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：WO2007103389A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005718
申请日：2007-03-07
申请人： CARGILL, INCORPORATED , BURKE, Ellen , GORT, Steven, John , HICKS, Paula, M. , LUGINBUHL, Peter , MCFARLAN, Sara, C. , RICHARDSON, Toby , SOLHEID, Christopher , WEINER, David , ZHAO, Lishan
发明人： BURKE, Ellen , GORT, Steven, John , HICKS, Paula, M. , LUGINBUHL, Peter , MCFARLAN, Sara, C. , RICHARDSON, Toby , SOLHEID, Christopher , WEINER, David , ZHAO, Lishan
IPC分类号： C12P17/00 , C07D209/20 , C12N9/88 , A23L1/22
CPC分类号： C12P17/10 , C12N9/88 , C12P13/001 , Y02P20/52
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R3R and S5R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性（包括热稳定性和耐热活性），以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种制药，农业和工业环境中。在一些实施方案中，本发明提供了用于生产R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体诸如R的多肽和生物合成途径，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，如R3R和S5R构型及其盐。

7. 发明申请

WO2009088753A1 ISOMERASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：异构体，编码它们的核酸及其制备和使用它们的方法
公开(公告)号：WO2009088753A1
公开(公告)日：2009-07-16
申请号：PCT/US2008/088066
申请日：2008-12-22
申请人： VERENIUM CORPORATION , WEINER, David , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin , DE SOUZA, Mervyn, L. , KOLLMANN, Sherry
发明人： WEINER, David , BURKE, Ellen , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin , DE SOUZA, Mervyn, L. , KOLLMANN, Sherry
IPC分类号： C12Q1/533 , C12N9/90 , C12N15/61 , A61K38/52 , C07K16/40
CPC分类号： C12N9/90 , A01K67/0275 , A01K2217/05 , A01K2227/10 , A23G3/366 , A23G4/123 , A23G4/14 , A23K20/189 , A23L29/06 , A23V2002/00 , A61K38/00 , A61K38/52 , C12Q1/533 , C12Y501/00 , C12Y501/01
摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re¬ arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.
摘要翻译：本发明一般涉及酶，编码酶的多核苷酸，这种多核苷酸和多肽的用途，更具体地涉及具有异构酶活性的酶，例如消旋酶活性，例如氨基酸消旋酶活性，丙氨酸消旋酶活性和/或差向异构酶活性，和/或催化分子内原子的重新排列，催化一种异构体转化为另一种异构体，催化光学活性底物转变成光学无活性的外消旋催化底物对映异构体的相互转化，催化立体化学在仅具有一个不对称中心的底物中的不对称碳原子周围反转，催化具有多于一个不对称中心的底物中不对称碳原子周围的构型的立体化学反转，和/或催化氨基酸的外消旋化。因此，本发明提供了用于生产药物组合物，药物中间体，抗生素，甜味剂，肽酶，肽激素，燃料和燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂的酶，组合物，药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆和洗涤剂，其包含根据本发明的多肽或多核苷酸。

8. 发明申请

WO2007103989A2 ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： ALDOLASES，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：WO2007103989A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/063515
申请日：2007-03-07
申请人： VERENIUM CORPORATION , BURKE, Ellen , HICKS, Paula, M. , LUGINBUHL, Peter , RICHARDSON, Toby , WEINER, David, P. , ZHAO, Lishan
发明人： BURKE, Ellen , HICKS, Paula, M. , LUGINBUHL, Peter , RICHARDSON, Toby , WEINER, David, P. , ZHAO, Lishan
IPC分类号： C12N9/10
CPC分类号： C12N9/88 , A01K2217/05 , A61K38/00 , C07K2317/92 , C12N9/1022 , C12N15/8243 , C12P17/10 , C12Y401/03016 , C12Y401/03017 , Y02E50/16 , Y02E50/17

9. 发明申请

WO2008095033A2 ENZYMES FOR THE TREATMENT OF LIGNOCELLULOSICS, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：用于处理木质纤维体的酶，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：WO2008095033A2
公开(公告)日：2008-08-07
申请号：PCT/US2008/052517
申请日：2008-01-30
申请人： VERENIUM CORPORATION , SYNGENTA PARTICIPATIONS AG , CHANG, Cathy , STEGE, Justin, T. , ABOUSHADI, Nahla , DJORDJEVIC, Gordana , BURKE, Ellen , LUGINBUHL, Peter , DYCAICO, Mark , RICHARDSON, Toby , POLAND, John , HEFNER, Ying , MILES, Stacy, Marie
发明人： STEGE, Justin, T. , ABOUSHADI, Nahla , DJORDJEVIC, Gordana , BURKE, Ellen , LUGINBUHL, Peter , DYCAICO, Mark , RICHARDSON, Toby , POLAND, John , HEFNER, Ying , MILES, Stacy, Marie
CPC分类号： C12P19/14 , C12N9/2437 , C12N9/2445 , C12P7/04 , C12P19/02 , C12Y302/01021 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta- glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a β- xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts; for example, the invention provides a multi-enzyme system that can hydrolyze polysaccharides in a bagasse component of sugarcane processed in sugar mills. The invention provides enzymes for the bioconversion of lignocellulosic residues into fermentable sugars; and these sugars can be used as a chemical feedstock for the production of ethanol and fuels, including biofuels such as bioethanol, biopropanol, biobutanol and biodiesels.
摘要翻译：
本发明提供了一种具有木质纤维素酶活性，例如，糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解，β-葡糖苷酶，木聚糖酶，甘露聚糖酶，木糖苷酶的多肽（例如，β - 木糖苷酶），阿拉伯呋喃糖苷酶和/或葡萄糖氧化酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一个方面，本发明提供了能够酶处理（水解）甘蔗渣，即用于甘蔗渣降解或用于生物质处理的多肽，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。在一个实施方案中，本发明提供了本发明的热稳定和耐热形式的多肽。本发明的多肽可以用于各种制药，农业和工业领域; 例如，本发明提供了一种多酶体系，其能够水解在糖厂中加工的甘蔗的甘蔗渣组分中的多糖。本发明提供了用于将木质纤维素残基生物转化成可发酵糖的酶; 这些糖可以用作生产乙醇和燃料的化学原料，包括生物燃料，如生物乙醇，生物丙醇，生物丁醇和生物柴油。

10. 发明申请

WO2008080093A2 AMYLASES AND GLUCOAMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： AMYLASES和GLUCOAMYLASES，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：WO2008080093A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/088631
申请日：2007-12-21
申请人： VERENIUM CORPORATION , SYNGENTA PARTICIPATIONS AG , SLUPSKA, Malgorzata , HAZLEWOOD, Geoff , CHANG, Cathy , LUGINBUHL, Peter , BURKE, Ellen , CAYOUETTE, Michelle , GUNAVARDENA, Uvini , GHASSEMIAN, Majid , SILVERSTONE, Aron , ZHANG, Yan
发明人： SLUPSKA, Malgorzata , HAZLEWOOD, Geoff , CHANG, Cathy , LUGINBUHL, Peter , BURKE, Ellen , CAYOUETTE, Michelle , GUNAVARDENA, Uvini , GHASSEMIAN, Majid , SILVERSTONE, Aron , ZHANG, Yan
IPC分类号： C12N9/28
CPC分类号： C12N9/96 , C12N9/2408 , C12N9/2414 , C12N9/2425 , C12N9/2428 , Y02E50/16 , Y02E50/17
摘要： In one aspect, the invention is directed to polypeptides having an amylase and/or glucoamylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of polysaccharide, oligosaccharide or starch into sugars. In one aspect, the invention provides delayed release compositions comprising an desired ingredient coated by a latex polymer coating. In alternative embodiments, enzymes are used to make biofuels, e.g., ethanol, butanol, propanol, or a gasoline-ethanol mix, including a bioethanol, biopropanol, biobutanol, or a biodiesel, or for any form of fuel or biomass processing.
摘要翻译：一方面，本发明涉及具有淀粉酶和/或葡糖淀粉酶活性的多肽，编码所述多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一个方面，本发明的多肽可以用作淀粉酶，例如α-淀粉酶，以催化多糖，寡糖或淀粉水解成糖。在一个方面，本发明提供了包含通过胶乳聚合物涂层涂覆的期望成分的延迟释放组合物。在替代实施方案中，使用酶来制造生物燃料，例如乙醇，丁醇，丙醇或汽油 - 乙醇混合物，包括生物乙醇，生物丙醇，生物丁醇或生物柴油，或用于任何形式的燃料或生物质处理。

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