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1. 发明申请

WO0002621A9 SKIN AND MUSCLE-TARGETED GENE THERAPY BY PULSED ELECTRICAL FIELD 审中-公开
标题翻译：皮肤和肌肉靶向基因治疗的脉冲电场
公开(公告)号：WO0002621A9
公开(公告)日：2000-03-23
申请号：PCT/US9915755
申请日：1999-07-13
申请人： GENETRONICS INC , DEV NAGENDU B , HOFMANN GUNTER A , NOLAN EDWARD , RABUSSAY DIETMAR , TONNESSEN ARNT , WIDERA GEORG , ZHANG LEI
发明人： DEV NAGENDU B , HOFMANN GUNTER A , NOLAN EDWARD , RABUSSAY DIETMAR , TONNESSEN ARNT , WIDERA GEORG , ZHANG LEI
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/327 , A61N1/0424 , A61N1/0452 , A61N1/306 , A61N1/325
摘要： The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.
摘要翻译：本发明描述了一种体内方法，其使用脉冲电场将治疗剂递送到皮肤和肌肉细胞中进行局部和全身治疗。具体而言，治疗剂包括裸露或配制的核酸，多肽和化学治疗剂。

2. 发明申请

WO0067837A9 METHOD OF ELECTROPORATION-ENHANCED DELIVERY OF ACTIVE AGENTS 审中-公开
标题翻译：电活化剂增强方法
公开(公告)号：WO0067837A9
公开(公告)日：2002-07-04
申请号：PCT/US0012657
申请日：2000-05-08
申请人： GENTRONICS INC , HOFMANN GUNTER A , RABUSSAY DIETMAR , ZHANG LEI
发明人： HOFMANN GUNTER A , RABUSSAY DIETMAR , ZHANG LEI
IPC分类号： A61N1/32 , A61N1/30
CPC分类号： A61N1/327 , A61N1/0412 , A61N1/0424 , A61N1/0428 , A61N1/0476 , A61N1/30 , A61N1/306 , A61N1/325 , Y10S977/906
摘要： The present invention provides methods for introducing a biologically active agent into cells of a subject by introducing the agent in a form suitable for electrotransports into a region of tissue of the subject using one or more needle free injectors (2, 4), and applying a pulsed electric field to the region of tissue, thereby causing electroporation. The combination of a needle free injection by needle free injectors (2, 4), and electroporation by creating electrical fields with electrode (14) is sufficient to introduce the agent (6, 8) into the cell.
摘要翻译：本发明提供了通过使用一种或多种无针注射器（2,4）将适合于电转运到受试者的组织区域中的药剂引入到受试者的细胞中来引入生物活性剂的方法，脉冲电场到组织区域，从而引起电穿孔。通过无针注射器（2,4）进行无针注射和通过用电极（14）产生电场进行电穿孔的组合足以将试剂（6,8）引入细胞中。

3. 发明申请

WO2008063555A3 METHODS OF ENHANCING IMMUNE RESPONSE USING ELECTROPORATION-ASSISTED VACCINATION AND BOOSTING 审中-公开
标题翻译：利用电子辅助接种和促进增强免疫反应的方法
公开(公告)号：WO2008063555A3
公开(公告)日：2008-11-06
申请号：PCT/US2007024051
申请日：2007-11-16
申请人： GENETRONICS INC , MATHIESEN IACOB , TJELLE ELISABETH TORUNN , KJEKEN RUNE , RABUSSAY DIETMAR , LIN FENG
发明人： MATHIESEN IACOB , TJELLE ELISABETH TORUNN , KJEKEN RUNE , RABUSSAY DIETMAR , LIN FENG
IPC分类号： A61K39/00
CPC分类号： A61K39/00 , A61K2039/545
摘要： Disclosed are methods of enhancing immune responses. Such methods involve the administration of vaccine compositions to different tissues to elicit an enhanced immune response. The enhanced response arises from the vaccination and boosting route of administration in two separate patient tissues, for example, by first administering a priming vaccination into skin and later administering a boost vaccination in muscle. In each case, priming and boosting, the administration of the vaccine composition is preferably carried out using contemporaneous electroporation-assisted delivery of the antigenic agent.
摘要翻译：公开了增强免疫应答的方法。这些方法涉及将疫苗组合物给予不同的组织以引起增强的免疫应答。增强的反应来自两种分开的患者组织中的接种和加强给药途径，例如首先给予皮肤初免接种并随后在肌肉中施用加强免疫接种。在每种情况下，引发和加强，疫苗组合物的施用优选使用同时的电穿孔辅助递送抗原剂进行。

4. 发明申请

WO2007103070A3 METHOD AND DEVICE FOR TREATING MICROSCOPIC RESIDUAL TUMORS REMAINING IN TISSUES FOLLOWING SURGICAL RESECTION 审中-公开
标题翻译：用于治疗依赖于外科治疗的组织中的微创残留肿瘤的方法和装置
公开(公告)号：WO2007103070A3
公开(公告)日：2008-08-28
申请号：PCT/US2007005133
申请日：2007-03-02
申请人： GENETRONICS INC , GOLDFARB PAUL , RABUSSAY DIETMAR
发明人： GOLDFARB PAUL , RABUSSAY DIETMAR
IPC分类号： A61N1/30
CPC分类号： A61N1/327 , A61K9/0009 , A61K38/14 , A61M5/19 , A61M5/20
摘要： This invention concerns treating apparently normal tissue surrounding sites of cancerous tumors so as to reduce both the probability of a recurrence of cancer at and near the site of a cancerous tissue, and to reduce the amount of apparently healthy tissue that is usually excised along with the tumor, thereby providing a substantial benefit to the cancer patient by eliminating or delaying tumor recurrence and sparing normal tissue for its functionality and for avoiding unnecessary disfigurement.
摘要翻译：本发明涉及治疗癌性肿瘤周围部位的正常正常组织，以减少在癌组织的位点附近或其附近的癌症复发的可能性，并减少通常切除的明显健康组织的量肿瘤，从而通过消除或延迟肿瘤复发和保留正常组织的功能并避免不必要的损伤，为癌症患者提供实质性益处。

5. 发明申请

WO9962592A9 FLOW-THROUGH ELECTROPORATION SYSTEM FOR EX VIVO GENE THERAPY 审中-公开
标题翻译：用于EX VIVO基因治疗的流动电穿孔系统
公开(公告)号：WO9962592A9
公开(公告)日：2000-03-09
申请号：PCT/US9912136
申请日：1999-06-01
申请人： GENETRONICS INC
发明人： HOFMANN GUNTER A , RABUSSAY DIETMAR
IPC分类号： C12N15/09 , A61K48/00 , A61N1/32 , C12M1/00 , A61N1/30
CPC分类号： A61N1/327 , A61N1/306 , A61N1/325 , C12M35/02
摘要： This invention is a method, and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule, and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating electric fields which introduce transient pores in the living cell without killing the cell. The rotating electric fields are provided in a flow through chamber apparatus (100) having more than two electrodes (150). A three step pulse process, e.g., collection, electroporation, electrophoresis, is used to introduce the preselected molecule into the cell. A mechanical means (710) of repositioning cells between successive pulses is also provided. The apparatus can also provide a means (540) to pulse cells at different temperatures, and then after pulsing, let the cells recover for a specified residence time at another temperature.
摘要翻译：本发明是一种通过使细胞与预选分子接触并将多个电脉冲施加到细胞而将预选分子引入活细胞的方法和装置。该方法可以离体使用。多个电脉冲产生旋转电场，其在活细胞中引入瞬时孔而不杀死细胞。旋转电场设置在具有多于两个电极（150）的流通室装置（100）中。使用三步脉冲过程，例如收集，电穿孔，电泳，将预选分子引入细胞。还提供了在连续脉冲之间重新定位电池的机械装置（710）。该装置还可以提供在不同温度下脉冲细胞的装置（540），然后在脉冲之后让细胞在另一个温度恢复指定的停留时间。

6. 发明专利

DE69927388T2 未知
公开(公告)号：DE69927388T2
公开(公告)日：2006-07-13
申请号：DE69927388
申请日：1999-05-14
申请人： GENETRONICS INC
发明人： HOFFMAN A , RABUSSAY DIETMAR , TONNESSEN ARNT
IPC分类号： A61N1/32 , C12N15/09 , A61M37/00 , A61N1/30 , C12M1/00 , C12Q1/68
摘要： An electrode assembly for an apparatus for trans-surface molecular includes a non-conductive carrier having a proximal surface, a distal surface, and a plurality of through holes from the proximal surface to the distal surface, a plurality of first electrodes disposed on the proximal surface, a first conductor disposed on at least a first portion of the distal surface and extending through at least a first portion of the plurality of through holes and connected to the first electrodes on the proximal surface, a plurality of second electrodes disposed on the proximal surface, and a second conductor disposed on at least a second portion of the distal surface and extending through at least a second portion of the plurality of through holes and connected to the second electrodes on the proximal surface, wherein the first electrodes and the second electrodes are configured and disposed in closely spaced relation on the proximal surface for engaging the tissue surface and applying an electric field.

7. 发明专利

AU746484B2 Flow-through electroporation system for ex vivo gene therapy 未知
公开(公告)号：AU746484B2
公开(公告)日：2002-05-02
申请号：AU4226699
申请日：1999-06-01
申请人： GENETRONICS INC
发明人： HOFMANN GUNTER A , RABUSSAY DIETMAR
IPC分类号： C12N15/09 , A61K48/00 , A61N1/32 , C12M1/00 , A61N1/30
摘要： A method and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating electric fields which introduce transient pores in the living cell without killing the cell. The rotating electric fields are provided in a flow through chamber apparatus having more than two electrodes. A three-step pulse process, e.g. collection, electroporation, electrophoresis, is used to introduce the preselected molecule into the cell. A mechanical means of repositioning cells between successive pulses is also provided. The apparatus can also provide a means to pulse cells at different temperatures and then after pulsing, let the cells recover for a specified residence time at another temperature.

8. 发明专利

AU4226699A Flow-through electroporation system for (ex vivo) gene therapy 未知
公开(公告)号：AU4226699A
公开(公告)日：1999-12-20
申请号：AU4226699
申请日：1999-06-01
申请人： GENETRONICS INC
发明人： HOFMANN GUNTER A , RABUSSAY DIETMAR
IPC分类号： C12N15/09 , A61K48/00 , A61N1/32 , C12M1/00 , A61N1/30
摘要： A method and apparatus for introducing a preselected molecule into a living cell by contacting the cell with the preselected molecule and applying a multiple series of electrical pulses to the cell. The method can be utilized ex vivo. The multiple electrical pulses generate rotating electric fields which introduce transient pores in the living cell without killing the cell. The rotating electric fields are provided in a flow through chamber apparatus having more than two electrodes. A three-step pulse process, e.g. collection, electroporation, electrophoresis, is used to introduce the preselected molecule into the cell. A mechanical means of repositioning cells between successive pulses is also provided. The apparatus can also provide a means to pulse cells at different temperatures and then after pulsing, let the cells recover for a specified residence time at another temperature.

9. 发明专利

AU2007322075B2 Methods of enhancing immune response using electroporation-assisted vaccination and boosting 未知
公开(公告)号：AU2007322075B2
公开(公告)日：2013-07-25
申请号：AU2007322075
申请日：2007-11-16
申请人： GENETRONICS INC
发明人： KJEKEN RUNE , MATHIESEN IACOB , RABUSSAY DIETMAR , TJELLE ELISABETH TORUNN , LIN FENG
IPC分类号： A61K39/00
摘要： Disclosed are methods of enhancing immune responses. Such methods involve the administration of vaccine compositions to different tissues to elicit an enhanced immune response. The enhanced response arises from the vaccination and boosting route of administration in two separate patient tissues, for example, by first administering a priming vaccination into skin and later administering a boost vaccination in muscle. In each case, priming and boosting, the administration of the vaccine composition is preferably carried out using contemporaneous electroporation-assisted delivery of the antigenic agent.

10. 发明专利

CA2337652C SKIN AND MUSCLE-TARGETED GENE THERAPY BY PULSED ELECTRICAL FIELD 未知
公开(公告)号：CA2337652C
公开(公告)日：2013-03-26
申请号：CA2337652
申请日：1999-07-13
申请人： GENETRONICS INC
发明人： DEV NAGENDU B , HOFMANN GUNTER A , NOLAN EDWARD , RABUSSAY DIETMAR , TONNESSEN ARNT , WIDERA GEORG , ZHANG LEI
IPC分类号： A61N1/30 , A61M37/00 , A61N1/32
摘要： The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

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