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1. 发明申请

WO0036102A3 SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
标题翻译：分泌型和跨膜型多肽与编码相同的核酸
公开(公告)号：WO0036102A3
公开(公告)日：2000-11-09
申请号：PCT/US9928634
申请日：1999-12-01
申请人： GENENTECH INC , BOTSTEIN DAVID , DESNOYERS LUC , FERRARA NAPOLEONE , FONG SHERMAN , GAO WEI QIANG , GODDARD AUDREY , GURNEY AUSTIN L , PAN JAMES , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I
发明人： BOTSTEIN DAVID , DESNOYERS LUC , FERRARA NAPOLEONE , FONG SHERMAN , GAO WEI-QIANG , GODDARD AUDREY , GURNEY AUSTIN L , PAN JAMES , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I
IPC分类号： C12N15/09 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/02 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12R1/91
CPC分类号： C12N9/001 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译：本发明涉及新的多肽和编码这些多肽的核酸分子。本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的抗体以及产生本发明多肽的方法发明。

2. 发明申请

WO0140466A3 SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
公开(公告)号：WO0140466A3
公开(公告)日：2002-05-10
申请号：PCT/US0032678
申请日：2000-12-01
申请人： GENENTECH INC , BAKER KEVIN P , BERESINI MAUREEN , DEFORGE LAURA , DESNOYERS LUC , FILVAROFF ELLEN , GAO WEI QIANG , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , SHERWOOD STEVEN , SMITH VICTORIA , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I , ZHANG ZEMIN
发明人： BAKER KEVIN P , BERESINI MAUREEN , DEFORGE LAURA , DESNOYERS LUC , FILVAROFF ELLEN , GAO WEI-QIANG , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , SHERWOOD STEVEN , SMITH VICTORIA , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： C12N15/09 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61K51/00 , A61P35/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/46 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/07 , C12N5/071 , C12N5/077 , C12N5/078 , C12N5/10 , C12N15/12 , C12N15/62 , C12N15/63 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

3. 发明申请

WO0056889A3 SECRETED AND TRANSMEMBRANE POLYPEPTIDES AND NUCLEIC ACIDS ENCODING THE SAME 审中-公开
公开(公告)号：WO0056889A3
公开(公告)日：2001-04-26
申请号：PCT/US0005601
申请日：2000-03-01
申请人： GENENTECH INC , DESNOYERS LUC , EATON DAN L , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , PAN JAMES , STEWART TIMOTHY A , WATANABE COLIN K , WOOD WILLIAM I , ZHANG ZEMIN
发明人： DESNOYERS LUC , EATON DAN L , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , PAN JAMES , STEWART TIMOTHY A , WATANABE COLIN K , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/08 , A61P3/10 , A61P7/00 , A61P13/12 , A61P17/00 , A61P19/08 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/02 , A61P39/06 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/645 , C12R1/91 , C12N9/02
CPC分类号： C07K14/70578 , C07K14/47 , C07K2319/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

4. 发明申请

WO0053758A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES 审中-公开
标题翻译：用于治疗免疫相关疾病的组合物和方法
公开(公告)号：WO0053758A3
公开(公告)日：2001-02-08
申请号：PCT/US0005841
申请日：2000-03-02
申请人： GENENTECH INC , ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HEBERT CAROLINE , HENZEL WILLIAM , KABAKOFF RHONA C , LU YANMEI , PAN JAMES , PENNICA DIANE , SHELTON DAVID L , SMITH VICTORIA , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I , YAN MINHONG
发明人： ASHKENAZI AVI J , BAKER KEVIN P , GODDARD AUDREY , GURNEY AUSTIN L , HEBERT CAROLINE , HENZEL WILLIAM , KABAKOFF RHONA C , LU YANMEI , PAN JAMES , PENNICA DIANE , SHELTON DAVID L , SMITH VICTORIA , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I , YAN MINHONG
IPC分类号： G01N33/50 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61P1/16 , A61P3/10 , A61P5/14 , A61P11/00 , A61P11/02 , A61P17/00 , A61P19/02 , A61P25/00 , A61P29/02 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/06 , C07K14/47 , C07K14/705 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/10 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577
CPC分类号： C12N15/10 , A61K38/00 , C07K14/4703 , C07K14/70578 , C07K16/18 , C12N2799/026 , C12Q1/686 , C12Q2531/113 , C12Q2521/331
摘要： The present invention relates to a composition containing novel proteins and methods for the diagnosis and treatment of immune related diseases.
摘要翻译：本发明涉及包含用于诊断和治疗免疫相关疾病的新型蛋白质和方法的组合物。

5. 发明申请

WO9954467A9 SH2 DOMAIN-CONTAINING PEPTIDES 审中-公开
标题翻译： SH2含域蛋白
公开(公告)号：WO9954467A9
公开(公告)日：1999-12-16
申请号：PCT/US9908847
申请日：1999-04-23
申请人： GENENTECH INC , STEWART TIMOTHY A , LU YANMEI
发明人： STEWART TIMOTHY A , LU YANMEI
IPC分类号： G01N33/53 , C07K14/47 , C07K16/18 , C07K16/42 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/68 , C12N15/11 , C12N15/62
CPC分类号： C07K14/47 , C07K2319/02
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, antagonists and agonists vectors and host cells expressing, and immunoadhesions and antibodies to PRO201, PRO308 or PRO309 polypeptides. The invention further relates to compositions and method for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based in part on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain tumors (e.g. cancer) and may act as predictors of the prognosis of tumor treatment.
摘要翻译：本发明涉及核苷酸序列，包括表达序列标签（ESTs），寡核苷酸探针，多肽，拮抗剂和激动剂载体以及表达PRO101，PRO308或PRO309多肽的免疫粘附和抗体的宿主细胞。本发明还涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的组合物和方法。本发明部分基于在肿瘤细胞基因组中扩增的基因的鉴定。预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。因此，被扩增的基因编码的蛋白质被认为是用于某些肿瘤（例如癌症）的诊断和/或治疗（包括预防））的有用靶标，并且可以作为肿瘤治疗预后的预测因子。

6. 发明专利

JP2006101880A Secreted and transmembrane polypeptide and nucleic acid encoding the same 有权
标题翻译：分泌和转运蛋白多糖和核酸编码它们
公开(公告)号：JP2006101880A
公开(公告)日：2006-04-20
申请号：JP2005333994
申请日：2005-11-18
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： DESNOYERS LUC , EATON DAN L , GODDARD AUDREY , PAUL J GODOWSKI , GURNEY AUSTIN L , PAN JAMES , STEWART TIMOTHY A , WATANABE COLIN K , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/08 , A61P3/10 , A61P7/00 , A61P13/12 , A61P17/00 , A61P19/08 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/02 , A61P39/06 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/46 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/645 , C12R1/91
CPC分类号： C07K14/70578 , C07K14/47 , C07K2319/00
摘要： PROBLEM TO BE SOLVED: To provide a new DNA and a new polypeptide. SOLUTION: This invention provides new polypeptides and a nucleic acid molecule encoding these polypeptides. The invention further provides a vector and a host cell containing these nucleic acid sequences, a chimeric polypeptide molecule containing a polypeptide fused to a heterologous polypeptide sequence, an antibody binding to the polypeptide, and a method for the production of the polypeptide. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供新的DNA和新的多肽。解决方案：本发明提供新的多肽和编码这些多肽的核酸分子。本发明进一步提供了含有这些核酸序列的载体和宿主细胞，含有与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及产生多肽的方法。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2006051032A Secreted and transmembrane polypeptide and nucleic acid encoding the same 审中-公开
标题翻译：分泌和转运蛋白多糖和核酸编码它们
公开(公告)号：JP2006051032A
公开(公告)日：2006-02-23
申请号：JP2005238274
申请日：2005-08-19
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： ASHKENAZI AVI J , BAKER KEVIN P , BOTSTEIN DAVID , DESNOYERS LUC , EATON DAN L , FERRARA NAPOLEONE , FONG SHERMAN , GAO WEI-QIANG , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , KLJAVIN IVAR J , MOTHER JENNIE P , NAPIER MARY A , PAN JAMES , PAONI NICHOLAS F , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： C12N15/09 , G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07K14/00 , C07K14/47 , C07K14/52 , C07K14/705 , C07K16/18 , C07K16/24 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , G01N33/566 , G01N33/577 , G01N33/58
CPC分类号： C07K14/495 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To clarify the structure of a new secreted/transmembrane polypeptide and a nucleic acid molecule encoding the polypeptide (an amino acid sequence and a base sequence, its intermolecular homology, etc., including a signal sequence, an extracellular domain, etc.), and provide basic information for the development of medicines/diagnostic methods. SOLUTION: The invention provides a vector and a host cell containing the base sequence of a nucleic acid encoding a number of polypeptides including new peptides such as chemokine and EGF family, a chimera molecule fused to a heterologous polypeptide, a binding antibody and a method for producing these substances. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：为了阐明新的分泌/跨膜多肽和编码多肽的核酸分子的结构（氨基酸序列和碱基序列，其分子间同源性等，包括信号序列，细胞外结构域等），为药物/诊断方法的开发提供基础信息。解决方案：本发明提供了载体和宿主细胞，其含有编码多种多肽的核酸的碱基序列，所述多肽包括新的肽，例如趋化因子和EGF家族，与异源多肽融合的嵌合体分子，结合抗体和这些物质的制造方法。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2005304500A Medicine comprising polypeptide 审中-公开
标题翻译：包含多肽的药物
公开(公告)号：JP2005304500A
公开(公告)日：2005-11-04
申请号：JP2005117472
申请日：2005-03-14
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： ASHKENAZI AVI J , BAKER KEVIN P , BOTSTEIN DAVID , DESNOYERS LUC , EATON DAN L , FERRARA NAPOLEONE , FONG SHERMAN , GERBER HANSPETER , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GRIMALDI J CHRISTOPHER , GURNEY AUSTIN L , KLJAVIN IVAR J , NAPIER MARY A , PAN JAMES , PAONI NICHOLAS F , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WILLIAMS P MICKEY , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K51/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02
摘要： PROBLEM TO BE SOLVED: To provide a medicine comprising a new polypeptide available to angiogenesis, wound healing and so on. SOLUTION: Disclosed is a medicine comprising an isolated polypeptide having at least 80% sequence identity to disclosed amino acid sequences or to amino acid sequences encoded by a nucleic acid molecule deposited by ATCC Accession No. 203091. A vector containing a nucleic acid encoding the polypeptide and an antibody or antibody fragment inhibiting an ability promoting the growth of endothelial cells through binding to the polypeptide are also available. Furthermore a method for identifying an agonist or antagonist of the polypeptide is provided. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供包含可用于血管发生，伤口愈合等的新多肽的药物。解决方案：公开了一种药物，其包含与公开的氨基酸序列具有至少80％序列同一性的分离多肽或由ATCC保藏号203091保藏的核酸分子编码的氨基酸序列。含有核酸的载体编码多肽和抑制通过结合多肽促进内皮细胞生长的能力的抗体或抗体片段也是可用的。此外，提供了鉴定多肽的激动剂或拮抗剂的方法。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2008167749A Secreted and transmembrane polypeptide and nucleic acid encoding the same 审中-公开
标题翻译：分泌和转运蛋白多糖和核酸编码它们
公开(公告)号：JP2008167749A
公开(公告)日：2008-07-24
申请号：JP2007326424
申请日：2007-12-18
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： BAKER KEVIN P , BERESINI MAUREEN , DEFORGE LAURA , DESNOYERS LUC , FILVAROFF ELLEN , GAO WEI-QIANG , GERRITSEN MARY E , GODDARD AUDREY , GODOWSKI PAUL J , GURNEY AUSTIN L , SHERWOOD STEVEN , SMITH VICTORIA , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I , ZHANG ZEMIN
IPC分类号： C12N15/09 , A61K31/7105 , A61K31/711 , A61K38/00 , A61K38/17 , A61K39/395 , A61K45/00 , A61K48/00 , A61K51/00 , A61P35/00 , C07K14/46 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/07 , C12N5/071 , C12N5/077 , C12N5/078 , C12N5/10 , C12N15/12 , C12N15/62 , C12N15/63 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/574 , G01N37/00
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47
摘要： PROBLEM TO BE SOLVED: To provide existence and function identification of new extracellular proteins of human, and to provide a nucleic acid molecule sequence encoding the proteins. SOLUTION: New polypeptides and nucleic acid molecules encoding the polypeptides are provided. Further, provided herein are vectors and host cells comprising the nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and production of the polypeptides. COPYRIGHT: (C)2008,JPO&INPIT

10. 发明专利

JP2007312779A Secreted and transmembrane polypeptides and nucleic acids encoding the same 审中-公开
标题翻译：分泌和转运蛋白多核苷酸和编码其的核酸
公开(公告)号：JP2007312779A
公开(公告)日：2007-12-06
申请号：JP2007156006
申请日：2007-06-13
申请人： Genentech Inc , ジェネンテック・インコーポレーテッドGenentech,Inc.
发明人： BOTSTEIN DAVID , DESNOYERS LUC , FERRARA NAPOLEONE , FONG SHERMAN , GAO WEI-QIANG , GODDARD AUDREY , GURNEY AUSTIN L , PAN JAMES , ROY MARGARET ANN , STEWART TIMOTHY A , TUMAS DANIEL , WATANABE COLIN K , WOOD WILLIAM I
IPC分类号： C12N15/09 , A61K45/00 , A61P29/00 , A61P37/00 , C07K14/18 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/02 , C12N15/12 , C12N15/62 , C12P21/02 , C12P21/08 , C12R1/91
CPC分类号： C12N9/001 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28
摘要： PROBLEM TO BE SOLVED: To provide novel secreted and transmembrane polypeptides, and to provide nucleic acid molecules encoding those polypeptides. SOLUTION: The nucleic acids isolated from cDNA clones having at least 80% of homology to nucleic acids encoding the novel secreted and transmembrane polypeptides. Vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. COPYRIGHT: (C)2008,JPO&INPIT

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