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1. 发明申请

WO2004010930A3 REDUCED AEROSOL GENERATING FORMULATIONS 审中-公开
标题翻译：减少气溶胶生成配方
公开(公告)号：WO2004010930A3
公开(公告)日：2004-07-01
申请号：PCT/US0323244
申请日：2003-07-23
申请人： GENENCOR INT , BECKER NATHANIEL T , SCHER HERBERT B , WINETZKY DEBORAH S
发明人： BECKER NATHANIEL T , SCHER HERBERT B , WINETZKY DEBORAH S
IPC分类号： A61K8/04 , A61K8/66 , A61K8/72 , A61K8/73 , A61K8/81 , A61K8/86 , A61Q5/02 , A61Q11/00 , A61Q19/00 , A61Q19/10 , C11D1/00 , C11D3/22 , C11D3/37 , C11D3/386 , C11D17/00 , D06M16/00 , A61K7/06 , A61K31/74 , A61K38/43 , C11D3/00
CPC分类号： C11D3/3769 , A61K8/046 , A61K8/66 , A61K8/86 , A61Q11/00 , A61Q19/10 , C11D3/386 , C11D17/0043
摘要： The present invention relates to compositions comprising high molecular weight polymers, particularly polyethylene oxide polymers, wherein the high molecular weight polymer serves as an anti-misting agent to reduce the potential of aerosol generation from a composition when used in a desired environment. The invention further relates to methods of decreasing enzyme exposure from a personal care or cleaning product comprising a high molecular weight polymer.
摘要翻译：本发明涉及包含高分子量聚合物，特别是聚环氧乙烷聚合物的组合物，其中当在期望的环境中使用时，高分子量聚合物用作防雾剂以降低组合物中气溶胶产生的潜力。本发明还涉及减少包含高分子量聚合物的个人护理或清洁产品的酶暴露的方法。

2. 发明申请

WO2007044968A2 STABLE, DURABLE GRANULES WITH ACTIVE AGENTS 审中-公开
标题翻译：活性剂稳定耐用颗粒剂
公开(公告)号：WO2007044968A2
公开(公告)日：2007-04-19
申请号：PCT/US2006040394
申请日：2006-10-12
申请人： GENENCOR INT , BECKER NATHANIEL T , CLARKSON KATHLEEN A , DALE DOUGLAS , FRYKSDALE BETH , GERBERT MARK S , PARTSUF MICHAEL , GRAVESEN TROELS
发明人： BECKER NATHANIEL T , CLARKSON KATHLEEN A , DALE DOUGLAS , FRYKSDALE BETH , GERBERT MARK S , PARTSUF MICHAEL , GRAVESEN TROELS
IPC分类号： A23K1/165 , A61K9/16 , C12N9/96 , C12N9/98
CPC分类号： A61K9/14 , A23K20/189 , A23K40/30 , A23K50/75 , A61K9/16 , A61K9/5073 , A61K38/465 , A61K38/47 , A61K47/02 , C12N9/96 , C12N9/98
摘要： ABSTRACT A stable, durable granule for feed compositions has a core, at least one active agent; and at least one coating. The active agent of the granule retains at least 50% activity, at least 60% activity, at least 70% activity, at least 80% activity after conditions selected from one or more of a) a feed pelleting process, b) a steam-heated feed pretreatment process, c) storage, d) storage as an ingredient in an unpelleted mixture, and e) storage as an ingredient in a feed base mix or a feed premix comprising at least one compound selected from trace minerals, organic acids, reducing sugars, vitamins, choline chloride, and compounds which result in an acidic or a basic feed base mix or feed premix.
摘要翻译：摘要用于饲料组合物的稳定耐用颗粒具有核心，至少一种活性剂; 和至少一个涂层。颗粒的活性剂在选自以下一种或多种条件之后保留至少50％的活性，至少60％的活性，至少70％的活性，至少80％的活性：a）饲料造粒工艺，b）加热的饲料预处理过程，c）储存，d）作为成分储存在未搅拌的混合物中，和e）作为成分储存在饲料基料混合物或饲料预混物中，所述饲料预混物包含至少一种选自微量矿物质，有机酸，糖类，维生素，氯化胆碱，以及导致酸性或碱性饲料基料混合物或饲料预混料的化合物。

3. 发明申请

WO0213977A2 SYMMETRICAL FLUIDIZATION COATER FOR HIGH CAPACITY MANUFACTURING 审中-公开
标题翻译：用于高容量制造的对称流化涂层
公开(公告)号：WO0213977A2
公开(公告)日：2002-02-21
申请号：PCT/US0125142
申请日：2001-08-10
申请人： GENENCOR INT , KOSOLA ANTTI , BRAUN RYSZARD , BECKER NATHANIEL T , CHRISTENSEN ROBERT I JR , KYLAEKOSKI VILLE , GAERTNER ALFRED L
发明人： KOSOLA ANTTI , BRAUN RYSZARD , BECKER NATHANIEL T , CHRISTENSEN ROBERT I JR , KYLAEKOSKI VILLE , GAERTNER ALFRED L
IPC分类号： B01J2/00 , B01J2/16 , B05D
CPC分类号： B01J2/16 , B01J2/006
摘要： A fluidized bed coating apparatus is provided and includes a fluid inlet adapted to be connected to a source of fluidizing fluid. The fluid inlet has an entrance opening having a first diameter and an exit opening downstream of the entrance opening. The exit opening has a second diameter that is larger than the first diameter. The inlet also includes an expanding inlet section, between the entrance opening and the exit opening, that has an average diameter that increases in a direction from said entrance opening to said exit opening. A fluid distribution plate is provided adjacent the exit opening and includes a plurality of through-passages to allow the even and distributed passage of a fluidizing fluid therethrough. A chamber having a chamber inlet and a chamber outlet is provided and the fluid distribution plate is positioned between the exit opening and the chamber inlet. The chamber includes at least a first diverging section having an average diameter that increases in the direction from the chamber inlet downstream toward the chamber outlet. The symmetrical design of the coater provides an evenly distributed flow of fluid that enables efficient and complete fluidization and coating of very large particle beds.
摘要翻译：提供了一种流化床涂覆设备，并包括适于连接到流化流体源的流体入口。流体入口具有入口，其具有第一直径和入口开口下游的出口。出口具有大于第一直径的第二直径。入口还包括在入口和出口之间的扩张入口部分，其具有在从所述入口到所述出口的方向上增加的平均直径。流体分配板邻近出口设置并且包括多个通道以允许流化流体均匀分布通过其中。提供具有室入口和室出口的室，并且流体分配板位于出口和室入口之间。该腔室至少包括第一发散部分，该第一发散部分具有在从腔室入口下游朝向腔室出口的方向上增加的平均直径。涂布机的对称设计提供均匀分布的流体流动，能够高效，完全地流化和涂覆非常大的颗粒床。

4. 发明申请

WO0204923A3 REPEATED IMPACT APPARATUS AND METHOD FOR CHARACTERIZING GRANULE STRENGTH 审中-公开
标题翻译：重复冲击装置和表征颗粒强度的方法
公开(公告)号：WO0204923A3
公开(公告)日：2002-07-18
申请号：PCT/US0141294
申请日：2001-07-06
申请人： GENENCOR INT , GEBERT MARK S , PITCHUMANI RAMANAN , BEEKMAN WILLEM J , MEESTERS GABRIEL M H , SCARLETT BRIAN , BECKER NATHANIEL T
发明人： GEBERT MARK S , PITCHUMANI RAMANAN , BEEKMAN WILLEM J , MEESTERS GABRIEL M H , SCARLETT BRIAN , BECKER NATHANIEL T
IPC分类号： G01N3/00 , G01N3/56 , G01N15/02 , G01N33/00
CPC分类号： G01N3/56 , G01N3/565 , G01N15/0272 , G01N2015/0261 , G01N2015/0288 , G01N2033/0091 , G01N2203/0005 , G01N2203/0037
摘要： The present invention provides methods and devices for measuring granule impact strength and granule attrition rates by vibrating a small container of granules at a well-controlled amplitude in order to inflict reproducible damage to the granules. Damage to the granules is measured as a function of time and amplitude and attrition rates are measured in terms of dust generate per number of collisions versus mass of the granules. The measurements obtained yield a highly reproducible means for characterizing granule attrition, attrition rates, and fragmentation.
摘要翻译：本发明提供了通过以良好控制的振幅振动小容器的颗粒来测量颗粒冲击强度和颗粒磨损率的方法和装置，以便对颗粒造成可重复的损害。根据时间和幅度来测量颗粒的损害，并且根据每次碰撞产生的粉尘相对于颗粒的质量来测量磨损率。所获得的测量结果表现出高度可重复的用于表征颗粒磨损，磨损率和碎裂的方法。

5. 发明申请

WO03000625A2 HIGHLY IMPACT-RESISTANT GRANULES 审中-公开
标题翻译：高抗冲击颗粒
公开(公告)号：WO03000625A2
公开(公告)日：2003-01-03
申请号：PCT/US0219518
申请日：2002-06-20
申请人： GENENCOR INT , BECKER NATHANIEL T , GEBERT MARK S , MAZEAUD ISABELLE
发明人： BECKER NATHANIEL T , GEBERT MARK S , MAZEAUD ISABELLE
IPC分类号： C11D3/22 , C11D3/37 , C11D3/38 , C11D3/386 , C11D17/00 , C07B
CPC分类号： C11D3/38 , C11D3/222 , C11D3/3753 , C11D3/38672 , C11D17/0039
摘要： The present invention provides highly impact-resistant, water-soluble or water dispersible, low-dust granules comprising an active ingredient and methods for obtaining the same.
摘要翻译：本发明提供包含活性成分的高抗冲击性，水溶性或水分散性低粉尘颗粒及其获得方法。

6. 发明申请

WO0234871A3 PARTICLE WITH SUBSTITUTED POLYVINYL ALCOHOL COATING 审中-公开
标题翻译：具有取代的聚乙烯醇涂料的颗粒
公开(公告)号：WO0234871A3
公开(公告)日：2002-09-12
申请号：PCT/US0142170
申请日：2001-09-12
申请人： GENENCOR INT , BECKER NATHANIEL T , FLYNN MATTHEW J , GEBERT MARK S
发明人： BECKER NATHANIEL T , FLYNN MATTHEW J , GEBERT MARK S
IPC分类号： C08F8/00 , C11D3/04 , C11D3/16 , C11D3/37 , C11D3/386 , C11D3/39 , C11D17/00
CPC分类号： C11D3/38672 , C11D3/166 , C11D3/3753 , C11D3/386 , C11D3/3942 , C11D17/0039
摘要： The present invention provides an improved coating material for use with particles, such as enzyme granules, and the like. In particular, the present invention provides a modified PVA, as well as particles or granules that include such coating. The PVA is modified by substituting hydrophilic moieties for the hydroxyl or alcohol groups of the PVA. Substitution may be achieved with hydrophilic acids, amines, thiols, or combinations thereof. Detergent compositions comprising said particles with coating in combination with borates or perborates.
摘要翻译：本发明提供一种用于颗粒如酶颗粒等的改进的涂料。特别地，本发明提供了改性PVA，以及包括这种涂层的颗粒或颗粒。通过用亲水部分代替PVA的羟基或醇基来修饰PVA。用亲水酸，胺，硫醇或其组合可以进行取代。洗涤剂组合物，其包含具有与硼酸盐或过硼酸盐组合的涂层的所述颗粒。

7. 发明申请

WO0208398A3 STABILIZATION OF ENZYMES 审中-公开
标题翻译：酶的稳定
公开(公告)号：WO0208398A3
公开(公告)日：2002-08-29
申请号：PCT/US0123076
申请日：2001-07-20
申请人： GENENCOR INT , BECKER NATHANIEL T , BOTT RICHARD T , BOWDEN SHAUNA L , HENG MENG HONG , PAECH CHRISTIAN , KOSOLA ANTTI V
发明人： BECKER NATHANIEL T , BOTT RICHARD T , BOWDEN SHAUNA L , HENG MENG HONG , PAECH CHRISTIAN , KOSOLA ANTTI V
IPC分类号： C12N9/54 , C12N9/96 , C11D3/386
CPC分类号： C11D3/38663 , C12N9/54 , C12N9/96
摘要： Enzyme-containing formulations having improved stability and enzymatic activity in liquid medium, comprising one or more protease enzymes produced from any Bacillus bacteria, at least about 5 % alkali metal halide salt, and at least about 50 % polyol. Also disclosed are methods for making such formulations.
摘要翻译：含有液体培养基中具有改善的稳定性和酶活性的含酶制剂，其包含由任何芽孢杆菌属细菌产生的一种或多种蛋白酶，至少约5％的碱金属卤化物盐和至少约50％的多元醇。还公开了制备这种制剂的方法。

8. 发明申请

WO2009035700A3 FILTRATION WITH INTERNAL FOULING CONTROL 审中-公开
标题翻译：带内部污染控制的过滤
公开(公告)号：WO2009035700A3
公开(公告)日：2009-04-30
申请号：PCT/US2008010737
申请日：2008-09-12
申请人： DANISCO US INC GENENCOR DIV , BECKER NATHANIEL T , BRAUN RYSZARD , CHRISTENSEN ROBERT I , EKBOM STEFAN , FONG ROBIN , SCHULER ALEXANDRA
发明人： BECKER NATHANIEL T , BRAUN RYSZARD , CHRISTENSEN ROBERT I , EKBOM STEFAN , FONG ROBIN , SCHULER ALEXANDRA
IPC分类号： B01D61/14 , B01D63/10 , B01D65/02 , B01D65/08
CPC分类号： B01D65/00 , B01D61/14 , B01D63/10 , B01D65/02 , B01D65/08 , B01D2311/06 , B01D2313/19 , B01D2321/02 , B01D2321/04 , B01D2321/10 , B01D2321/12 , B01D2321/20 , B01D2321/2008 , B01D2321/2083 , B01D2311/14 , B01D2311/165
摘要： Filtration processes and systems are provided for the separation of a filterable fluid stream by a filtration membrane module with uniform transmembrane pressure and flux along the membrane and internal control of membrane fouling via intermittent periodic reduction of the pressure differential between the permeate and retentate sides of the membrane and/or backwashing cycles during separation, recovery, and/or purification of proteins, peptides, nucleic acids, biologically produced polymers and other compounds or materials from aqueous fluids.
摘要翻译：提供了过滤方法和系统，用于通过膜过滤膜组件分离可过滤的流体流，膜组件具有均匀的跨膜压力和沿膜的通量以及通过间歇性地定期减少膜污染物的渗透侧和滞留侧之间的压力差来控制膜污染在从含水流体中分离，回收和/或纯化蛋白质，肽，核酸，生物产生的聚合物和其它化合物或物质期间进行膜和/或反洗循环。

9. 发明申请

WO2012121944A1 ENZYME GRANULE BLENDS CONSISTING ESSTENTIALLY OF SODIUM SULFATE 审中-公开
标题翻译： ENSYY硫酸钠的酵母颗粒混合物
公开(公告)号：WO2012121944A1
公开(公告)日：2012-09-13
申请号：PCT/US2012027073
申请日：2012-02-29
申请人： DANISCO US INC , BECKER NATHANIEL T
发明人： BECKER NATHANIEL T
IPC分类号： A23K1/165 , C11D3/386 , C11D17/06 , C12N9/98
CPC分类号： C12N9/52 , A23K20/189 , A23K20/22 , A23K40/10 , A23K40/30 , C11D3/046 , C11D3/386 , C11D3/38672 , C11D17/06 , C12N9/16 , C12N9/48 , C12N9/98 , C12Y301/03 , C12Y304/21062
摘要： The present teachings provide ways of improving the distribution of high payload enzyme granules by reducing their size, and by mixing them with size-matched dummy particles containing sodium sulfate. The present teachings also provide methods of using the mixtures.
摘要翻译：本教导提供了通过减小高有效载荷的酶颗粒的大小，并将它们与尺寸匹配的含有硫酸钠的假颗粒混合来改进高有效载荷酶颗粒的分布的方法。本教导还提供使用该混合物的方法。

10. 发明授权

US6423517B2 Granule containing protein and salt layered on an inert particle 有权
标题翻译：含有蛋白质和盐的颗粒层叠在惰性颗粒上
公开(公告)号：US6423517B2
公开(公告)日：2002-07-23
申请号：US21508698
申请日：1998-12-18
申请人： GENENCOR INT
发明人： BECKER NATHANIEL T , CHRISTENSEN JR ROBERT I , GROS ERNST H
IPC分类号： C11D3/386 , C12N9/98 , C12N9/99 , A61K9/16 , C07K17/00 , C12N9/96 , C12N11/00
CPC分类号： C12N9/98 , C11D3/38672 , C12N9/99 , Y10S530/81 , Y10S530/811 , Y10S530/813 , Y10S530/815
摘要： Granules are prepared containing an admixture of protein and salt layered over an inert particle. A preferred amount of salt is about between 63.7 and 84.3% of the total weight of the admixture. Proteins include pharmaceutically important proteins such as hormones, or industrially important proteins such as enzymes including proteases, amylases, lipases and cellulases capable of hydrolyzing substrates such as stains. Inert particles include inorganic salts, sugars, sugar alcohols, small organic molecules such as organic acids or salts, and minerals such as clays or silicates. A binder such as starch or polyethylene oxide may be mixed in with the admixture. A barrier material such as an inorganic salt or organic acid or salt may be in the admixture or coated over the admixture layer. A coating layer of a soluble or water dispersible film-forming polymer may be between the inert particle and admixture layer and/or over the admixture layer. The granules may also contain plasticizers, extenders, lubricants, pigments and anti-agglomeration agents. A preferred method for preparing the granules is by spraying a solution or slurry of the admixture onto the inert particles while fluidized in a fluid-bed coater.
摘要翻译：制备的颗粒含有层叠在惰性颗粒上的蛋白质和盐的混合物。优选的盐的量约占混合物总重量的63.7％至84.3％。蛋白质包括药学上重要的蛋白质，例如激素或工业上重要的蛋白质，例如酶，包括蛋白酶，淀粉酶，脂肪酶和能够水解底物如污渍的纤维素酶。惰性颗粒包括无机盐，糖，糖醇，小有机分子如有机酸或盐，以及矿物质如粘土或硅酸盐。粘合剂如淀粉或聚环氧乙烷可与混合物混合。阻挡材料如无机盐或有机酸或盐可以混合或涂覆在混合层上。可溶性或水分散性成膜聚合物的涂层可以在惰性颗粒和混合层之间和/或混合层之上。颗粒还可以含有增塑剂，增量剂，润滑剂，颜料和抗附聚剂。制备颗粒的优选方法是通过在流化床涂布机中流化的同时将混合物的溶液或浆料喷雾到惰性颗粒上。

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