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1. 发明申请

WO02030543A1 CONTINUOUSLY OPERABLE ROTATING DRUM PRESSURE DIFFERENTIAL FILTER, METHOD AND SYSTEMS 审中-公开
标题翻译：连续可操作的旋转压力差分过滤器，方法和系统
公开(公告)号：WO02030543A1
公开(公告)日：2002-04-18
申请号：PCT/US2001/042303
申请日：2001-09-26
申请人： GENENCOR INTERNATIONAL, INC. , BRAUN, Ryszard , EKBOM, Stefan , KOSOLA, Antti, V.
发明人： BRAUN, Ryszard , EKBOM, Stefan , KOSOLA, Antti, V.
IPC分类号： B01D33/073
CPC分类号： B01D33/073 , B01D33/463 , B01D33/466 , B01D33/58 , B01D33/60 , B01D37/02 , B01D37/025 , B01D37/04 , B01D2201/54
摘要： A rotating drum pressure differential filter is provided whereby a layer of filter medium is continuously refreshed by a spray applicator device after the layer is utilized to filter components from a sample medium and a portion of the layer is subsequently scraped to remove sample medium waste from the layer. Methods of filtration using the device are also provided as are systems employing two or more such filters. A spray applicator device useful for refreshing a layer of filter medium on the outer surface of a rotating drum pressure differential filter is also provided as is a retro fit kit useful in modifying existing rotating drum pressure differential filters to enable the continuous formation of a refreshed filter medium layer. The continuously refreshed filter and filter systems provide a minimized down time of the filter and system operations. Multiple-stage filtration processes are also provided and are particularly useful in the recovery of enzymes from fermentation broths.
摘要翻译：提供旋转鼓压力差压过滤器，其中一层过滤介质在用于从样品介质中过滤组分之后通过喷涂装置连续刷新，并且该层的一部分随后被刮除以从样品介质废物中除去样品介质废物层。使用该装置的过滤方法也可以采用采用两种或更多种这样的过滤器的系统。还提供了一种用于刷新旋转鼓压差滤波器的外表面上的过滤介质层的喷涂器装置，其可用于修改现有的旋转鼓压力差压滤波器以使连续形成更新过滤器中层。持续更新的过滤器和过滤系统提供过滤器和系统操作的最小化停机时间。还提供了多级过滤方法，并且特别可用于从发酵液中回收酶。

2. 发明申请

WO0213977A2 SYMMETRICAL FLUIDIZATION COATER FOR HIGH CAPACITY MANUFACTURING 审中-公开
标题翻译：用于高容量制造的对称流化涂层
公开(公告)号：WO0213977A2
公开(公告)日：2002-02-21
申请号：PCT/US0125142
申请日：2001-08-10
申请人： GENENCOR INT , KOSOLA ANTTI , BRAUN RYSZARD , BECKER NATHANIEL T , CHRISTENSEN ROBERT I JR , KYLAEKOSKI VILLE , GAERTNER ALFRED L
发明人： KOSOLA ANTTI , BRAUN RYSZARD , BECKER NATHANIEL T , CHRISTENSEN ROBERT I JR , KYLAEKOSKI VILLE , GAERTNER ALFRED L
IPC分类号： B01J2/00 , B01J2/16 , B05D
CPC分类号： B01J2/16 , B01J2/006
摘要： A fluidized bed coating apparatus is provided and includes a fluid inlet adapted to be connected to a source of fluidizing fluid. The fluid inlet has an entrance opening having a first diameter and an exit opening downstream of the entrance opening. The exit opening has a second diameter that is larger than the first diameter. The inlet also includes an expanding inlet section, between the entrance opening and the exit opening, that has an average diameter that increases in a direction from said entrance opening to said exit opening. A fluid distribution plate is provided adjacent the exit opening and includes a plurality of through-passages to allow the even and distributed passage of a fluidizing fluid therethrough. A chamber having a chamber inlet and a chamber outlet is provided and the fluid distribution plate is positioned between the exit opening and the chamber inlet. The chamber includes at least a first diverging section having an average diameter that increases in the direction from the chamber inlet downstream toward the chamber outlet. The symmetrical design of the coater provides an evenly distributed flow of fluid that enables efficient and complete fluidization and coating of very large particle beds.
摘要翻译：提供了一种流化床涂覆设备，并包括适于连接到流化流体源的流体入口。流体入口具有入口，其具有第一直径和入口开口下游的出口。出口具有大于第一直径的第二直径。入口还包括在入口和出口之间的扩张入口部分，其具有在从所述入口到所述出口的方向上增加的平均直径。流体分配板邻近出口设置并且包括多个通道以允许流化流体均匀分布通过其中。提供具有室入口和室出口的室，并且流体分配板位于出口和室入口之间。该腔室至少包括第一发散部分，该第一发散部分具有在从腔室入口下游朝向腔室出口的方向上增加的平均直径。涂布机的对称设计提供均匀分布的流体流动，能够高效，完全地流化和涂覆非常大的颗粒床。

3. 发明申请

WO0230543A9 CONTINUOUSLY OPERABLE ROTATING DRUM PRESSURE DIFFERENTIAL FILTER, METHOD AND SYSTEMS 审中-公开
标题翻译：连续可操作的旋转压力差分过滤器，方法和系统
公开(公告)号：WO0230543A9
公开(公告)日：2003-02-13
申请号：PCT/US0142303
申请日：2001-09-26
申请人： GENENCOR INT , BRAUN RYSZARD , EKBOM STEFAN , KOSOLA ANTTI V
发明人： BRAUN RYSZARD , EKBOM STEFAN , KOSOLA ANTTI V
IPC分类号： C12N9/00 , B01D24/46 , B01D33/06 , B01D33/073 , B01D33/44 , B01D33/58 , B01D37/02 , B01D33/46 , B01D33/60 , B01D37/04
CPC分类号： B01D33/073 , B01D33/463 , B01D33/466 , B01D33/58 , B01D33/60 , B01D37/02 , B01D37/025 , B01D37/04 , B01D2201/54
摘要： A rotating drum pressure differential filter is provided whereby a layer of filter medium is continuously refreshed by a spray applicator device after the layer is utilized to filter components from a sample medium and a portion of the layer is subsequently scraped to remove sample medium waste from the layer. Methods of filtration using the device are also provided as are systems employing two or more such filters. A spray applicator device useful for refreshing a layer of filter medium on the outer surface of a rotating drum pressure differential filter is also provided as is a retro fit kit useful in modifying existing rotating drum pressure differential filters to enable the continuous formation of a refreshed filter medium layer. The continuously refreshed filter and filter systems provide a minimized down time of the filter and system operations. Multiple-stage filtration processes are also provided and are particularly useful in the recovery of enzymes from fermentation broths.
摘要翻译：提供旋转鼓压力差压过滤器，其中一层过滤介质在用于从样品介质中过滤组分之后通过喷涂装置连续刷新，并且该层的一部分随后被刮除以从样品介质废物中除去样品介质废物层。使用该装置的过滤方法也可以采用采用两种或更多种这样的过滤器的系统。还提供了一种用于刷新旋转鼓压差滤波器的外表面上的过滤介质层的喷涂器装置，其可用于修改现有的旋转鼓压力差压滤波器以使得能够连续形成更新过滤器中层。持续更新的过滤器和过滤系统提供过滤器和系统操作的最小化停机时间。还提供了多级过滤方法，并且特别可用于从发酵液中回收酶。

4. 发明申请

WO0208398A3 STABILIZATION OF ENZYMES 审中-公开
标题翻译：酶的稳定
公开(公告)号：WO0208398A3
公开(公告)日：2002-08-29
申请号：PCT/US0123076
申请日：2001-07-20
申请人： GENENCOR INT , BECKER NATHANIEL T , BOTT RICHARD T , BOWDEN SHAUNA L , HENG MENG HONG , PAECH CHRISTIAN , KOSOLA ANTTI V
发明人： BECKER NATHANIEL T , BOTT RICHARD T , BOWDEN SHAUNA L , HENG MENG HONG , PAECH CHRISTIAN , KOSOLA ANTTI V
IPC分类号： C12N9/54 , C12N9/96 , C11D3/386
CPC分类号： C11D3/38663 , C12N9/54 , C12N9/96
摘要： Enzyme-containing formulations having improved stability and enzymatic activity in liquid medium, comprising one or more protease enzymes produced from any Bacillus bacteria, at least about 5 % alkali metal halide salt, and at least about 50 % polyol. Also disclosed are methods for making such formulations.
摘要翻译：含有液体培养基中具有改善的稳定性和酶活性的含酶制剂，其包含由任何芽孢杆菌属细菌产生的一种或多种蛋白酶，至少约5％的碱金属卤化物盐和至少约50％的多元醇。还公开了制备这种制剂的方法。

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