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1. 发明申请

WO2004013299A3 METHODS FOR THE PRODUCTION OF CELLS AND MAMMALS WITH DESIRED GENETIC MODIFICATIONS 审中-公开
标题翻译：用于生产具有所需遗传修饰的细胞和哺乳动物的方法
公开(公告)号：WO2004013299A3
公开(公告)日：2004-08-12
申请号：PCT/US0324322
申请日：2003-08-01
申请人： GEN HOSPITAL CORP , SEED BRIAN , YANG YI
发明人： SEED BRIAN , YANG YI
IPC分类号： C12N15/90 , A01K67/00 , C12N15/00 , G01N33/00
CPC分类号： C12N15/8509 , A01K2217/072 , A01K2217/075 , C12N15/907 , C12N2800/30 , G01N33/5011 , G01N33/5088
摘要： The present invention features novel methods for generating cell lines and mammals with site-specific genetic modifications of interest. The methods involve homologous recombination between an artificial chromosome having a modification of interest and an endogenous chromosome of a cell. The resulting modified cells can be used in standard methods to generate genetically modified mammals. These mammals can be used in a variety of screening methods to identify compounds useful for the treatment or prevention of disease. Additionally, cells that have been modified to eliminate a mutation associated with a disease can be transplanted into patients for the treatment of a disease.
摘要翻译：本发明的特征在于产生具有目的地特异性遗传修饰的细胞系和哺乳动物的新方法。该方法涉及具有感兴趣修饰的人造染色体和细胞的内源性染色体之间的同源重组。所得到的修饰的细胞可用于标准方法以产生转基因哺乳动物。这些哺乳动物可以用于多种筛选方法，以鉴定可用于治疗或预防疾病的化合物。另外，已被修改以消除与疾病相关的突变的细胞可以移植到患者中用于治疗疾病。

2. 发明专利

CA2560937A1 COMPOSITIONS AND METHODS FOR INDUCING ANTI-TUMOR IMMUNITY 未知
公开(公告)号：CA2560937A1
公开(公告)日：2005-10-20
申请号：CA2560937
申请日：2005-03-25
申请人： WASHINGTON RES FOUND , YANG YI
发明人： YANG YI , HELLSTROM INGEGERD , HELLSTROM KARL ERIK
IPC分类号： C12N15/12 , A61K39/00 , C07K14/705 , C07K16/28 , C12N15/13
摘要： Compositions and methods are provided for inducing anti-tumor immunity. More specifically, tumor cells and recombinant constructs are provided that expre ss a cell surface CD83 polypeptide and/or a cell surface expressed antibody tha t specifically binds to an immune cell receptor, particularly an antibody that specifically binds to CD137. The invention also provides recombinant expression constructs comprising polynucleotides that encode a cell surface CD83 polypeptide, a cell surface expressed anti-immune cell receptor antibod y, and/or at least one tumor antigen, and the related expressed products.

3. 发明专利

IL283309D0 Rip1 inhibitors 未知
公开(公告)号：IL283309D0
公开(公告)日：2021-07-29
申请号：IL28330921
申请日：2021-05-19
申请人： SIRONAX LTD , SU YANING , ZHANG ZHIYUAN , YANG YI , WANG GUOZHENG , LIU WENDONG , MA YONGFEN , REN YAN
发明人： SU YANING , ZHANG ZHIYUAN , YANG YI , WANG GUOZHENG , LIU WENDONG , MA YONGFEN , REN YAN
IPC分类号： A61K31/16 , A61P25/00 , A61P25/28 , A61P31/00 , A61P31/12 , A61P35/00 , C07B59/00 , C07F9/09 , C07F9/24
摘要： The invention provides amides that inhibit cellular necrosis including corresponding sulfonamides, prodrugs and pharmaceutically acceptable salts, hydrates and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.

4. 发明申请

WO2011029190A1 MANUAL INSTRUMENTED MEDICAL TOOL SYSTEM 审中-公开
标题翻译：手动仪器医疗工具系统
公开(公告)号：WO2011029190A1
公开(公告)日：2011-03-17
申请号：PCT/CA2010001409
申请日：2010-09-09
申请人： ENGINEERING SERVICES INC , UNIV HEALTH NETWORK , GOLDENBERG ANDREW A , TRACHTENBERG JOHN , YANG YI , MA LIANG
发明人： GOLDENBERG ANDREW A , TRACHTENBERG JOHN , YANG YI , MA LIANG
IPC分类号： A61B19/00 , A61B5/055 , A61B8/00
CPC分类号： A61B5/055 , A61B8/0833 , A61B8/0841 , A61B8/12 , A61B8/4209 , A61B8/5238 , A61B90/11 , A61B2034/2059 , A61B2090/364 , A61B2090/374 , A61B2090/378 , A61N5/1007
摘要： A medical device is for use in association with a medical image of the gland or organ having a known reference point. The medical device comprises a structural frame, a horizontal joint, a vertical joint, a pan join, a tilt joint a medical instrument assembly and a control system. The medical device is positioned at a predetermined location relative to the medical image reference point. Each of the horizontal joint, the vertical joint, the pan joint and the tilt joint have a position sensor and are operably connected to the frame. The medical instrument assembly is operably connected to a sensor and to the horizontal joint, the vertical joint, the pan joint and the tilt joint. The control system is operably connected to the other elements whereby the control system determines the position of a predetermined location on the medical instrument assembly relative to the structural frame.
摘要翻译：医疗装置用于与具有已知参考点的腺体或器官的医学图像相关联。医疗设备包括结构框架，水平接头，垂直接头，平底接头，医疗器械组件和控制系统的倾斜接头。医疗设备被定位在相对于医学图像参考点的预定位置处。水平关节，垂直关节，平底关节和倾斜关节中的每一个都具有位置传感器并且可操作地连接到框架。医疗器械组件可操作地连接到传感器以及水平关节，垂直关节，平底关节和倾斜关节。控制系统可操作地连接到其他元件，由此控制系统相对于结构框架确定医疗器械组件上的预定位置的位置。

5. 发明申请

WO2008060679A3 SYNTHESIS OF NICKEL NANOPOWDERS 审中-公开
标题翻译：镍纳米粒子的合成
公开(公告)号：WO2008060679A3
公开(公告)日：2008-07-03
申请号：PCT/US2007068216
申请日：2007-05-04
申请人： FERRO CORP , YANG YI , FENG XIANGDONG , XIANG YANG
发明人： YANG YI , FENG XIANGDONG , XIANG YANG
IPC分类号： B82B3/00 , B22F9/24 , C01G53/00
CPC分类号： C22B23/0461 , B22F9/24 , B22F2998/00 , C22B5/00 , B22F1/0018
摘要： The invention relates to a method of making a nickel powder having an average particle size of less than about 100 nanometers, comprising contacting, at a temperature of about 5O°C to about 95°C, a reduction solution with a nickel solution to form a reaction mixture. The reduction solution comprises a base and a reducing agent. The nickel solution comprises a nickel compound water, a nucleation agent, a surfactant or dispersant, and combinations thereof. The yield of nickel nanoparticles is greater than about 90% relative to starting moles of nickel compound. The nickel powder is suitable for use in electronics applications and sintered metal applications.
摘要翻译：本发明涉及一种制备平均粒度小于约100纳米的镍粉的方法，包括在约50℃至约95℃的温度下，与镍溶液接触还原溶液以形成反应混合物。还原溶液包含碱和还原剂。镍溶液包含镍化合物水，成核剂，表面活性剂或分散剂及其组合。相对于镍化合物的起始摩尔数，镍纳米颗粒的产率大于约90％。镍粉适用于电子应用和烧结金属应用。

6. 发明申请

WO9921845A2 4-AMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES 审中-公开
标题翻译： 4-氨基噻唑衍生物，它们的制备及其作为依赖于细胞周期蛋白依赖性激酶的抑制剂的用途
公开(公告)号：WO9921845A2
公开(公告)日：1999-05-06
申请号：PCT/US9822809
申请日：1998-10-27
申请人： AGOURON PHARMA , CHONG WESLEY K M , CHU SHAO SONG , DUVADIE ROHIT R , LI LIN , XIAO WEI , YANG YI
发明人： CHONG WESLEY K M , CHU SHAO SONG , DUVADIE ROHIT R , LI LIN , XIAO WEI , YANG YI
IPC分类号： C07D277/20 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/551 , A61P35/00 , A61P43/00 , C07D213/00 , C07D235/00 , C07D277/42 , C07D277/56 , C07D333/00 , C07D417/06 , C07D417/12 , C07D417/14 , C07D521/00 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/50
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D277/42 , C07D417/06 , C07D417/12 , C07D417/14
摘要： This invention is directed to aminothiazole compounds of formula (I) wherein R is a substituted or unsubstituted group selected from: C1-6-alkyl; C1-6-alkenyl; C1-6-alkynyl; C1-6-alkoxyl; C1-6-alcohol; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, cycloalkyl; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, aryl; carbonyl; ether; (C1-6-alkyl)-carbonyl; (C1-6-alkyl)-aryl; (C1-6-alkyl)-cycloalkyl; (C1-6-alkyl)-(C1-6-alkoxyl); aryl-(C1-6-alkoxyl); thioether; thiol; and sulfonyl; wherein when R is substituted, each substituent independently is a halogen; haloalkyl; C1-6-alkyl; C1-6-alkenyl; C1-6-alkynyl; hydroxyl; C1-6-alkoxyl; amino; nitro; thiol; thioether; imine; cyano; amido; phosphonato; phosphine; carboxyl; thiocarbonyl; sulfonyl; sulfonamide; ketone; aldehyde; ester; oxygen; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, cycloalkyl; or carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, aryl; and R is a carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, ring structure having a substituent at the position adjacent to the point of attachment, which ring structure is optionally further substituted, where each substituent of R independently is a halogen; haloalkyl; C1-6-alkyl; C1-6-alkenyl; C1-6-alkynyl; hydroxyl; C1-6-alkoxyl; amino; nitro; thiol; thioether; imine; cyano; amido; phosphonato; phosphine; carboxyl; thiocarbonyl; sulfonyl; sulfonamide; ketone; aldehyde; ester; oxygen; carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, cycloalkyl; or carbocyclic or heterocyclic, monocyclic or fused or non-fused polycyclic, aryl; or a pharmaceutically acceptable salt of a compound of formula (I), or a prodrug or pharmaceutically active metabolite of a compound of formula (I) or pharmaceutically acceptable salt thereof, for inhibiting cyclin-dependent kinases (CDKs), such as CDK1, CDK2, CDK4, and CDK6. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds and to methods of treating malignancies and other disorders by administering effective amounts of such compounds.
摘要翻译：本发明涉及式（I）的氨基噻唑化合物，其中R 1是取代或未取代的选自以下的基团：C 1-6 - 烷基; C 1-6 - 链烯基; C 1-6 - 炔基; C 1-6 - 烷氧基取代; C 1-6 - 醇; 碳环或杂环，单环或稠合或非稠合多环，环烷基; 碳环或杂环，单环或稠合或非稠合多环，芳基; 羰; 醚; （C 1-6 - 烷基）羰基; （C 1-6 - 烷基） - 芳基; （C 1-6 - 烷基） - 环烷基; （C 1-6 - 烷基） - （C 1-6 - 烷氧基）; 芳基 - （C 1-6 - 烷氧基）; 硫醚; 巯基; 和磺酰基; 其中当R 1被取代时，每个取代基独立地为卤素; 卤代; C 1-6 - 烷基; C 1-6 - 链烯基; C 1-6 - 炔基; 羟; C 1-6 - 烷氧基取代; 氨基; 硝基; 巯基; 硫醚; 亚胺; 氰基; 酰胺基; 膦酸; 膦; 羧基; 硫代羰基; 磺酰基; 磺胺; 酮; 醛; 酯; 氧; 碳环或杂环，单环或稠合或非稠合多环，环烷基; 或碳环或杂环，单环或稠合或非稠合的多环芳基; 并且R 2是碳环或杂环的单环或稠合或非稠合的多环环结构，其在与连接点相邻的位置上具有取代基，该环结构任选进一步被取代，其中R 2的每个取代基 >独立地为卤素; 卤代; C 1-6 - 烷基; C 1-6 - 链烯基; C 1-6 - 炔基; 羟; C 1-6 - 烷氧基取代; 氨基; 硝基; 巯基; 硫醚; 亚胺; 氰基; 酰胺基; 膦酸; 膦; 羧基; 硫代羰基; 磺酰基; 磺胺; 酮; 醛; 酯; 氧; 碳环或杂环，单环或稠合或非稠合多环，环烷基; 或碳环或杂环，单环或稠合或非稠合的多环芳基; 或式（I）化合物的药学上可接受的盐，或式（I）化合物或其药学上可接受的盐的前药或药学活性代谢物用于抑制细胞周期蛋白依赖性激酶（CDK）如CDK1，CDK2 ，CDK4和CDK6。本发明还涉及含有这些化合物的药物组合物的治疗或预防用途以及通过施用有效量的这些化合物治疗恶性肿瘤和其他病症的方法。

7. 发明申请

WO2011027249A2 BENZIMIDAZOLE DERIVATIVES 审中-公开
标题翻译：苯并咪唑衍生物
公开(公告)号：WO2011027249A2
公开(公告)日：2011-03-10
申请号：PCT/IB2010053634
申请日：2010-08-11
申请人： PFIZER , NAIR SAJIV KRISHNAN , PLANKEN SIMON PAUL , PLEWE MICHAEL BRUNO , VERNIER WILLIAM FRANCOIS , YANG YI , ZHU HUICHUN
发明人： NAIR SAJIV KRISHNAN , PLANKEN SIMON PAUL , PLEWE MICHAEL BRUNO , VERNIER WILLIAM FRANCOIS , YANG YI , ZHU HUICHUN
IPC分类号： C07D401/04 , A61K31/444 , A61K31/496 , A61K31/506 , A61P35/00 , C07D401/14 , C07D403/04 , C07D413/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08 , C07D513/04
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D513/04
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1A, R1B, R1C, R2, R3, R4, R5, RA, RB, RC and X are as defined herein. These novel benzimidazole derivatives are useful in therapy, in particular for treating diseases or conditions mediated by SMO, including the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R1A，R1B，R1C，R2，R3，R4，R5，RA，RB，RC和X如本文所定义。这些新的苯并咪唑衍生物可用于治疗，特别是用于治疗哺乳动物中由SMO介导的疾病或病症，包括治疗异常细胞生长，如癌症。本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。

8. 发明申请

WO2005010682A3 SYSTEM AND METHOD FOR EXCHANGING AWARENESS INFORMATION IN A NETWORK ENVIRONMENT 审中-公开
标题翻译：在网络环境中交换意识信息的系统和方法
公开(公告)号：WO2005010682A3
公开(公告)日：2006-06-08
申请号：PCT/US2004022764
申请日：2004-07-14
申请人： CISCO TECH INC , CHANDRA MADHAVI W , COOK DAVID A , RETANA ALVARO E , WHITE RUSSELL I , YANG YI
发明人： CHANDRA MADHAVI W , COOK DAVID A , RETANA ALVARO E , WHITE RUSSELL I , YANG YI
IPC分类号： H04L12/56 , G06F20060101
CPC分类号： H04L45/02 , H04L45/26 , H04W40/248
摘要： A method for communicating packets in a network environment (10) is provided that includes receiving a packet at a network element and identifying a sequence number (316) included in the packet that correlates to awareness information associated with one or more adjacent network elements. A table included in the network element may be updated (312, 314) in order to account for the awareness information included within the packet that has not been accounted for by the network element. In cases where the awareness information included in the packet has already been accounted for, the packet may be ignored.
摘要翻译：提供了一种用于在网络环境（10）中传送分组的方法，包括在网络元件处接收分组并且识别与包含在与一个或多个相邻网络元素相关联的识别信息相关联的分组中的序列号（316）。包括在网络元件中的表可以被更新（312,314），以便考虑包括在网络元件尚未被考虑的分组内的识别信息。在分组中包含的识别信息已经被考虑的情况下，分组可以被忽略。

9. 发明申请

WO2014033644A3 METHODS OF NUCLEASE-BASED GENETIC ENGINEERING 审中-公开
标题翻译：基于核酸的遗传工程方法
公开(公告)号：WO2014033644A3
公开(公告)日：2014-07-10
申请号：PCT/IB2013058083
申请日：2013-08-28
申请人： NOVARTIS AG , YANG YI , MARESCA MARCELLO
发明人： YANG YI , MARESCA MARCELLO
IPC分类号： C12N15/90
CPC分类号： C12N15/90 , A01K2217/00 , C12N15/102 , C12N15/85 , C12N2800/80
摘要： The present invention relates to genetic techniques employing the direct Iigatation of an external DNA fragment generated in situ by the same ZFNs that target the genome. ObLiGaRe, i.e., the obligated ligation-gated recombination, is a new method for genetic engineering using custom designed nucleases, and a strategy of site-specific gene insertion utilizing the NHEJ pathway. It applies a similar logic to the one used in unidirectional loxP sites(Oberdoerffer et al., 2003) but maintains all the advantages and flexibility of CDNs.
摘要翻译：本发明涉及使用通过靶向基因组的相同ZFN原位产生的外部DNA片段的直接染色的遗传技术。 ObLiGaRe，即有义连接门控重组，是使用定制设计的核酸酶的遗传工程的新方法，以及利用NHEJ途径的位点特异性基因插入的策略。它对于单向loxP站点（Oberdoerffer等人，2003）应用了类似的逻辑，但是保持了CDN的所有优点和灵活性。

10. 发明申请

WO2012040740A3 LAMP CONNECTORS 审中-公开
标题翻译：灯管连接器
公开(公告)号：WO2012040740A3
公开(公告)日：2012-05-18
申请号：PCT/US2011053333
申请日：2011-09-26
申请人： OSRAM SYLVANIA INC , LI MING , YANG YI , HARRIOTT DOUGLAS , HARRISON ROBERT
发明人： LI MING , YANG YI , HARRIOTT DOUGLAS , HARRISON ROBERT
IPC分类号： H01R33/08 , F21V21/08
CPC分类号： H01J5/54 , F21V23/06 , H01K1/46
摘要： Lamp connectors are provided. The lamp connectors include a swinging connector and a rotatable connector. The swinging connector is coupled to a pivot connection point disposed on a first exterior surface of a lamp. The swinging connector is operative to pivot between a first position close in proximity to the lamp and a second position at distance away from the lamp. A portion of the swinging connector may be received and retained by a second exterior surface of the lamp, when the lamp is in the first position. The rotatable connector is attached to an end of a lamp via a rotation mechanism. The rotation mechanism is disposed on the end of the lamp. The rotatable connector includes a surface and a pin protruding therefrom. The pin is offset from a central portion of the end of the lamp.
摘要翻译：提供灯连接器。灯连接器包括摆动连接器和可旋转连接器。摆动连接器联接到设置在灯的第一外表面上的枢转连接点。摆动连接器可操作以在靠近灯的第一位置与远离灯的距离处的第二位置之间枢转。当灯处于第一位置时，摆动连接器的一部分可被灯的第二外表面接收和保持。可旋转连接器通过旋转机构附接到灯的端部。旋转机构设置在灯的端部。可旋转连接器包括表面和从其突出的销。引脚偏离灯端部的中心部分。

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