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1. 发明公开

KR20200138771A 방사성 의약품의 합성 방법 审中-公开
公开(公告)号：KR20200138771A
公开(公告)日：2020-12-10
申请号：KR20207030760
申请日：2019-03-29
申请人： GE HEALTHCARE LTD , GEN ELECTRIC
发明人： JACKSON ALEXANDER , SHALES JONATHAN ROBERT , GOLDEN DAVID ALKO , GRIGG JULIAN , NEMETH SZILARD
IPC分类号： G16C20/30 , G16C20/10 , G16C20/90
摘要： 본발명은실행동안자동화무선합성기를모니터링하는방법에관한것으로, 무선합성기는작동가능하게연관된다수의개별활성검출기를갖는다. 방법은각각의활성검출기로부터활성데이터를기록하는단계(S10); 데이터저장장치로부터이력데이터에액세스하는단계(S20); 이력데이터에기초하여기록된활성데이터에서수율저하의전조를검출하는단계(S30); 검출된수율저하의전조에기초하여무선합성기로트레이서를합성할때 수율을예측하는단계(S40); 및예측된수율레벨과관련된조치를시작하는단계(S50)를포함한다.

2. 发明专利

CA3095599A1 METHOD OF SYNTHESIZING A RADIOPHARMACEUTICAL 未知
公开(公告)号：CA3095599A1
公开(公告)日：2019-10-03
申请号：CA3095599
申请日：2019-03-29
申请人： GE HEALTHCARE LTD , GEN ELECTRIC
发明人： JACKSON ALEXANDER , SHALES JONATHAN ROBERT , GOLDEN DAVID ALKO , GRIGG JULIAN , NEMETH SZILARD
IPC分类号： G16C20/10
摘要： The present invention relates a method of monitoring an automated radiosynthesizer during a run and the radiosynthesizer having a number of individual activity detectors operably associated therewith. The method comprises the steps of recording S10 activity data from each activity detector; accessing S20 historic data from a data storage; detecting S30 precursor of yield drop in the recorded activity data based on the historic data; predicting (S40 yield when synthesizing a tracer with the radiosynthesizer based on the detected precursor of yield drop; and initiating S50 actions related to a level of predicted yield.

3. 发明专利

PL3084774T3 Sposoby i układy do opróżniania zbiornika na odpady 未知
公开(公告)号：PL3084774T3
公开(公告)日：2020-11-02
申请号：PL14824838
申请日：2014-12-19
申请人： GE HEALTHCARE LTD
发明人： OSBORN NIGEL JOHN , GRIGG JULIAN , HORN ERIC , SHALES JONATHAN ROBERT
IPC分类号： G21F9/06 , A61J1/20 , A61J3/00 , B65B3/00 , G21F9/20 , G21F9/22

4. 发明专利

DK3084774T3 FREMGANGSMÅDER OG SYSTEMER TIL TØMNING AF EN AFFALDSBEHOLDER 未知
公开(公告)号：DK3084774T3
公开(公告)日：2020-07-06
申请号：DK14824838
申请日：2014-12-19
申请人： GE HEALTHCARE LTD
发明人： HORN ERIC , OSBORN NIGEL JOHN , GRIGG JULIAN , SHALES JONATHAN ROBERT
IPC分类号： G21F9/06 , A61J1/20 , A61J3/00 , B65B3/00 , G21F9/20 , G21F9/22

5. 发明专利

AU2020409577A1 Apparatus and method for solid phase extraction 未知
公开(公告)号：AU2020409577A1
公开(公告)日：2022-08-11
申请号：AU2020409577
申请日：2020-12-17
申请人： GE HEALTHCARE LTD
发明人： MCROBBIE GRAEME WALTER , KHAN IMTIAZ AHMED , SHALES JONATHAN ROBERT
IPC分类号： C07B59/00
摘要： The present invention provides a cassette for determining optimised solid phase extraction (SPE) purification conditions, wherein said cassette comprises: (i) a flowpath comprising a first end and a second end; and (ii) a plurality of valves oriented along said flowpath, wherein each of said plurality of valves is selectively fluidly connected to one of a number of components, wherein said components comprise: (a) 1-5 composition vials; (b) 1-3 SPE cartridges; (c) 4-10 solvent vials; (d) a water vial; and (e) a transfer line. The present invention also provides a method for determining optimised SPE purification conditions for a compound from a composition, the method comprising: (i) provision of a cassette as defined in any of claims 1 to 7; (ii) the cassette comprising a composition of the compound in said composition vial(s) or addition of such a composition to said crude reaction vial(s); (iii) passing an aliquot of said composition into each of said 1-3 SPE cartridges; (iv) passing a particular combination of aliquots of solvent from at least 4 of said 4-10 solvent vials into one or more of the SPE cartridges, wherein the solvent in each of said 4-10 solvent vials is either a different solvent or the same solvent at different concentration; (v) eluting the compound to be purified from the or each SPE cartridge; (vi) evaluating the eluted products of step (v); and (vii) determining the optimised purification conditions by comparing the eluted products of step (v) from each cartridge and each solvent.

6. 发明专利

ES2802973T3 Métodos y sistemas para vaciar un envase de desperdicios 未知
公开(公告)号：ES2802973T3
公开(公告)日：2021-01-22
申请号：ES14824838
申请日：2014-12-19
申请人： GE HEALTHCARE LTD
发明人： OSBORN NIGEL JOHN , GRIGG JULIAN , HORN ERIC , SHALES JONATHAN ROBERT
IPC分类号： G21F9/06 , A61J1/20 , A61J3/00 , B65B3/00 , G21F9/20 , G21F9/22
摘要： Un método para dirigir un fluido de desperdicios desde un dispositivo de síntesis de radiofármacos (12) a un envase de desperdicios que comprende las etapas de: conectar en serie (502) un envase primario de desperdicios (30) a un envase secundario de desperdicios (50) con un conducto alargado de fluido (40), que incluye una válvula de desperdicios (60) conectada al conducto de fluido (40) que se extiende entre el envase primario de desperdicios (30) y el envase secundario de desperdicios (50), en donde el envase primario de desperdicios (30) incluye un conducto alargado de descarga (34) que se extiende sustancialmente a una superficie más baja (32a) dentro del envase primario de desperdicios (30) de manera que el conducto de descarga (34) se conecta al conducto de fluido (40); abrir (504) la válvula de desperdicios (60) para permitir comunicación de fluidos entre cavidades (35, 55) de los envases primario y secundario de desperdicios (30, 50); aspirar (506) una presión baja en ambos envases de desperdicios (30, 50), en donde la presión baja en el envase secundario de desperdicios (50) es aspirada a través del envase primario de desperdicios (30); cerrar (508) la válvula de desperdicios (60) para aislar para trasmisión de fluidos el envase secundario de desperdicios (50) del envase primario de desperdicios (30); descargar (510) el fluido de desperdicios a través de una válvula de bomba al envase primario de desperdicios (30), y abrir (512) la válvula de desperdicios (60) de modo que la presión baja en el envase secundario de desperdicios (50) evacúa el fluido de desperdicios desde el envase primario de desperdicios (30) al envase secundario de desperdicios (50).

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