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1. 发明专利

RU2690848C2 СПОСОБ РАДИОМЕЧЕНИЯ 未知
公开(公告)号：RU2690848C2
公开(公告)日：2019-06-06
申请号：RU2016148821
申请日：2014-12-16
申请人： GE HEALTHCARE LTD
发明人： WYNN DUNCAN GEORGE , FAIRWAY STEVEN MICHAEL , GLASER MATTHIAS EBERHARD , NEWINGTON IAN , SMITH GARETH EDWIN , KHAN IMTIAZ AHMED , GRIGG JULIAN
IPC分类号： B01D11/00 , A61K31/47 , A61K31/4709 , A61K49/00 , A61K51/00 , A61P43/00 , C07D215/12
摘要： Изобретениеотноситсяк областирадиофармпрепаратовдляполучения in vivo изображений, вчастностиавтоматическимспособамполученияи очисткиF-меченыхрадиофармпрепаратовдляполученияизображенийтау-белка. Крометого, предложенызаменяемыекассеты, применяемыев этихспособах, иприменениеустройствдляавтоматическогосинтезаи кассетв этихспособах. 9 н. и 5 з.п. ф-лы, 2 ил., 4 пр.

2. 发明专利

AU2019246403B2 Solid phase purification 未知
公开(公告)号：AU2019246403B2
公开(公告)日：2022-11-17
申请号：AU2019246403
申请日：2019-03-29
申请人： GE HEALTHCARE LTD
发明人： ENGELL TORGRIM , JACKSON ALEXANDER , KHAN IMTIAZ AHMED , CLARKE ALAN P , MCROBBIE GRAEME , GRIGG JULIAN
IPC分类号： C07B59/00 , B01J19/00 , C07D237/16
摘要： The present invention provides a method for the synthesis of an injectable composition comprising a [

3. 发明专利

AU2020409577A1 Apparatus and method for solid phase extraction 未知
公开(公告)号：AU2020409577A1
公开(公告)日：2022-08-11
申请号：AU2020409577
申请日：2020-12-17
申请人： GE HEALTHCARE LTD
发明人： MCROBBIE GRAEME WALTER , KHAN IMTIAZ AHMED , SHALES JONATHAN ROBERT
IPC分类号： C07B59/00
摘要： The present invention provides a cassette for determining optimised solid phase extraction (SPE) purification conditions, wherein said cassette comprises: (i) a flowpath comprising a first end and a second end; and (ii) a plurality of valves oriented along said flowpath, wherein each of said plurality of valves is selectively fluidly connected to one of a number of components, wherein said components comprise: (a) 1-5 composition vials; (b) 1-3 SPE cartridges; (c) 4-10 solvent vials; (d) a water vial; and (e) a transfer line. The present invention also provides a method for determining optimised SPE purification conditions for a compound from a composition, the method comprising: (i) provision of a cassette as defined in any of claims 1 to 7; (ii) the cassette comprising a composition of the compound in said composition vial(s) or addition of such a composition to said crude reaction vial(s); (iii) passing an aliquot of said composition into each of said 1-3 SPE cartridges; (iv) passing a particular combination of aliquots of solvent from at least 4 of said 4-10 solvent vials into one or more of the SPE cartridges, wherein the solvent in each of said 4-10 solvent vials is either a different solvent or the same solvent at different concentration; (v) eluting the compound to be purified from the or each SPE cartridge; (vi) evaluating the eluted products of step (v); and (vii) determining the optimised purification conditions by comparing the eluted products of step (v) from each cartridge and each solvent.

4. 发明专利

AU2020369122A1 Use of cyclodextrins as a radiostabilizer 未知
公开(公告)号：AU2020369122A1
公开(公告)日：2022-05-05
申请号：AU2020369122
申请日：2020-10-21
申请人： GE HEALTHCARE LTD
发明人： WIKENE KRISTINE , KHAN IMTIAZ AHMED , MCROBBIE GRAEME
IPC分类号： A61K51/00 , C07B59/00
摘要： The present invention provides a radiopharmaceutical composition comprising the following four components: (i) a radio-labelled compound; (ii) ethanol; (iii) a stabilizer of the radio-labelled compound; and (iv) a cyclodextrin. The present invention also provides a radiopharmaceutical composition comprising: (i) a radio-labelled compound; (ii) a stabilizer of the radio-labelled compound, wherein the stabilizer comprises: ascorbic acid, aspartic acid, cysteine, maleic acid, gentisic acid, glutathione, glutamic acid, mannitol, nicotinamide, calcium chloride, N-t-butyl-alpha-phenylnitrone (PBN), tartaric acid, para-aminobenzoic acid (pABA), chloride ions or salts or combinations thereof; and (iii) a cyclodextrin.

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