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1. 发明申请

WO2007028394A3 USE OF A GLP-1 MOLECULE FOR TREATMENT OF BILIARY DYSKINESIA AND/OR BILIARY PAIN/DISCOMFORT 审中-公开
标题翻译： GLP-1分子在治疗胆管性痛和/或胆红素疼痛/挫伤中的应用
公开(公告)号：WO2007028394A3
公开(公告)日：2007-09-20
申请号：PCT/DK2006000496
申请日：2006-09-06
申请人： GASTROTECH PHARMA AS , NIELSEN TINA GERITZ , NILSSON HENRIK , HANSEN CHRISTIAN , SCHAMBYE HANS T
发明人： NIELSEN TINA GERITZ , NILSSON HENRIK , HANSEN CHRISTIAN , SCHAMBYE HANS T
IPC分类号： A61K38/26 , A61P1/16 , G01N33/50
CPC分类号： A61K38/26 , G01N2333/605 , G01N2500/02 , G01N2800/08
摘要： The present invention relates to molecules, compositions and methods suitable for the treatment or prevention of biliary dyskinesia and/or pain and/or discomfort originating from the biliary tree. The peptide hormone glucagon-like peptide-1 (GLP-1) has both anti-secretory effects and smooth muscle relaxatory properties in the gastrointestinal tract. GLP-1 exists in several forms, where the natural occurring GLP-1 molecules are GLP-1 (1- 37), GLP-1 (7-37), and the amidated versions GLP-1 (1-36)amide, GLP-1 (7- 36)amide. Other molecules capable of binding to and activating the GLP-1 receptor is herein included in the tern GLP-1 molecules. GLP-1 molecules may be naturally occurring or homologues of GLP-1 having one or more amino acid substitutions or modifications. The GLP-1 molecules are used for the manufacture of a medicament for the treatment or prevention of biliary dyskinesia and/or pain and/or discomfort originating from the biliary tree.
摘要翻译：本发明涉及适用于治疗或预防源自胆管树的胆道运动障碍和/或疼痛和/或不适的分子，组合物和方法。肽激素胰高血糖素样肽-1（GLP-1）在胃肠道中具有抗分泌作用和平滑肌松弛性质。 GLP-1以几种形式存在，其中天然存在的GLP-1分子是GLP-1（1-37），GLP-1（7-37）和酰胺化形式GLP-1（1-36）酰胺，GLP- -1（7-36）酰胺。其他能够结合并激活GLP-1受体的分子在本文中包括在tern GLP-1分子中。 GLP-1分子可以是天然存在的或具有一个或多个氨基酸取代或修饰的GLP-1的同源物。 GLP-1分子用于制造用于治疗或预防胆道运动障碍和/或源自胆管树的疼痛和/或不适的药物。

2. 发明申请

WO2005097173A3 USE OF GHRELIN FOR THE TREATMENT OF HYPERTHYROIDISM 审中-公开
标题翻译：使用GHRELIN治疗高血糖症
公开(公告)号：WO2005097173A3
公开(公告)日：2005-12-29
申请号：PCT/DK2005000237
申请日：2005-04-07
申请人： GASTROTECH PHARMA AS , NILSSON HENRIK , LANGE BIRGITTE HOLST , POST CLAES , NIELSEN TINA GERITZ
发明人： NILSSON HENRIK , LANGE BIRGITTE HOLST , POST CLAES , NIELSEN TINA GERITZ
IPC分类号： A61K38/25 , A61P3/00 , A61P5/14
CPC分类号： A61K38/25
摘要： The present invention relates to the use of a growth hormone (GH) secretagogue, such as a ghrelin-like compound, for the preparation of a medicament for the prophylaxis or treatment of ghrelin deficiency, and/or undesirable symptoms associated therewith, in an individual at risk of acquiring partial or complete ghrelin deficiency resulting from a medical treatment and/or from a pathological condition. The present invention also relates to use of a secretagogue compound for the preparation of a medicament for the prophylaxis or treatment of one or more of: loss of fat mass, loss of lean body mass, weight loss, cachexia, loss of appetite, immunological dysfunction, malnutrition, disrupted sleep pattern, sleepiness, reduction in intestinal absorption and/or intestinal mobility problems in an individual suffering from, or at risk of suffering from, ghrelin deficiency. Furthermore, the present invention relates to the use of a secretagogue, such as a ghrelin-like compound, for the production of a medicament for preventing weight increase in an individual either: a) being converted from a hyperthyroidic state to euthyroid state, or b) in remission from being converted from a hyperthyroidic state to euthyroid state.
摘要翻译：本发明涉及生长激素（GH）促分泌素如生长素释放肽样化合物在个体中用于预防或治疗生长素释放肽缺乏症和/或与之相关的不良症状的药物的用途有获得由医疗和/或病理状况引起的部分或完全的生长素释放肽缺乏的风险。本发明还涉及促分泌素化合物在制备用于预防或治疗以下中的一种或多种的药物中的用途：脂肪量的损失，瘦体重的减少，体重减轻，恶病质，食欲不振，免疫功能障碍，营养不良，睡眠模式紊乱，困倦，减少肠道吸收和/或肠道运动问题，或者有遭受生长素释放肽缺乏症的个体。此外，本发明涉及促分泌素如生长素释放肽样化合物在制备用于预防个体体重增加的药物中的用途：a）从甲状腺功能亢进状态转变为甲状腺功能状态，或b ）缓解从甲状腺功能亢进状态转变为甲状腺功能状态。

3. 发明申请

WO2005014032A3 USE OF SECRETAGOGUES LIKE GHRELIN IN CANCER CACHEXIA AND FOR STIMULATING APPETITE 审中-公开
标题翻译：使用胃肠激素在胃癌中的作用和刺激胃癌
公开(公告)号：WO2005014032A3
公开(公告)日：2005-03-17
申请号：PCT/DK2004000529
申请日：2004-08-06
申请人： GASTROTECH PHARMA AS , LANGE BIRGITTE HOLST , HANSEN CHRISTIAN , NILSSON HENRIK
发明人： LANGE BIRGITTE HOLST , HANSEN CHRISTIAN , NILSSON HENRIK
IPC分类号： A61K38/25 , A61P1/14 , C07K14/60 , G01N33/74
CPC分类号： A61K38/25 , G01N2333/4745 , G01N2333/475 , G01N2333/65
摘要： The present invention relates, in one aspect, to the use of a secretagogue compound for the preparation of a medicament for the prophylaxis or treatment of cancer cachexia in an individual in need of such treatment. In another aspect, the present invention relates to the use of a ghrelin-like compound for the preparation of a medicament for prophylaxis or treatment of cachexia in an individual by administering a subcutaneous dosage of said medicament to the individual. In a further aspect, the present invention relates to the use of a ghrelin-like compound or a pharmaceutically acceptable salt thereof for the preparation of a medicament for stimulation of appetite in an individual by administering a subcutaneous dosage of said medicament to the individual. Furthermore, the present invention relates to a number of new ghrelin-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin-like compounds.
摘要翻译：一方面，本发明涉及促分泌素化合物在制备用于预防或治疗需要这种治疗的个体中的癌症恶病质的药物中的用途。另一方面，本发明涉及生长激素释放肽样化合物在制备用于预防或治疗个体恶病质的药物中的用途，其通过向个体施用所述药物的皮下剂量来进行。另一方面，本发明涉及生长激素释放肽样化合物或其药学上可接受的盐在制备用于刺激个体食欲的药物中的用途，其通过向个体施用所述药物的皮下剂量来进行。此外，本发明涉及许多新的生长激素释放肽样化合物及其用途，以及包含新生长素释放肽样化合物的药物组合物和医药包装。

4. 发明申请

WO2005014032B1 USE OF SECRETAGOGUES LIKE GHRELIN IN CANCER CACHEXIA AND FOR STIMULATING APPETITE 审中-公开
标题翻译：在癌症CACHEXIA中使用秘密肽类似GHRELIN并用于刺激感染
公开(公告)号：WO2005014032B1
公开(公告)日：2005-04-28
申请号：PCT/DK2004000529
申请日：2004-08-06
申请人： GASTROTECH PHARMA AS , LANGE BIRGITTE HOLST , HANSEN CHRISTIAN , NILSSON HENRIK
发明人： LANGE BIRGITTE HOLST , HANSEN CHRISTIAN , NILSSON HENRIK
IPC分类号： A61K38/25 , A61P1/14 , C07K14/60 , G01N33/74
CPC分类号： A61K38/25 , G01N2333/4745 , G01N2333/475 , G01N2333/65
摘要： The present invention relates, in one aspect, to the use of a secretagogue compound for the preparation of a medicament for the prophylaxis or treatment of cancer cachexia in an individual in need of such treatment. In another aspect, the present invention relates to the use of a ghrelin-like compound for the preparation of a medicament for prophylaxis or treatment of cachexia in an individual by administering a subcutaneous dosage of said medicament to the individual. In a further aspect, the present invention relates to the use of a ghrelin-like compound or a pharmaceutically acceptable salt thereof for the preparation of a medicament for stimulation of appetite in an individual by administering a subcutaneous dosage of said medicament to the individual. Furthermore, the present invention relates to a number of new ghrelin-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin-like compounds.
摘要翻译：本发明在一个方面涉及促分泌素化合物在制备用于预防或治疗需要这种治疗的个体中的癌症恶病质的药物中的用途。另一方面，本发明涉及生长素释放肽样化合物在制备用于预防或治疗个体中恶病质的药物中的用途，其通过向个体施用皮下剂量的所述药物。在另一方面，本发明涉及生长素释放肽样化合物或其药学上可接受的盐在制备通过向个体施用皮下剂量的所述药物的个体中刺激个体食欲的药物中的用途。此外，本发明涉及许多新的生长素释放肽样化合物及其用途，以及包含新的生长素释放肽样化合物的药物组合物和医药包装。

5. 发明专利

CA2603295A1 USE OF GHRELIN FOR THE TREATMENT OF HYPERTHYROIDISM 未知
公开(公告)号：CA2603295A1
公开(公告)日：2006-10-20
申请号：CA2603295
申请日：2005-04-07
申请人： GASTROTECH PHARMA AS
发明人： NIELSEN TINA GERITZ , LANGE BIRGITTE HOLST , POST CLAES , NILSSON HENRIK
IPC分类号： A61K38/25 , A61P3/00 , A61P5/14

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