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1. 发明专利

JP2010270125A Pharmaceutical composition for treating functional dyspepsia and/or irritable bowel syndrome and new use of substance therein 审中-公开
标题翻译：用于治疗功能性血症和/或有用的皮肤病综合征的药物组合物及其物质的新用途
公开(公告)号：JP2010270125A
公开(公告)日：2010-12-02
申请号：JP2010151403
申请日：2010-07-01
申请人： Gastrotech Pharma As , ガストロテックファルマア−/エス
发明人： HELLSTROEM PER , EFENDIC SUAD
IPC分类号： A61K38/26 , A61K38/04 , A61K38/31 , A61P1/00 , A61P1/04 , A61P1/06 , A61P1/14 , A61P43/00
CPC分类号： A61K38/26 , A61K38/31 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide new use of gastrointestinal peptide hormones or derivatives thereof, a pharmaceutical composition for treating functional dyspepsia and/or irritable bowel syndrome, and methods for such treatments.
SOLUTION: The pharmaceutical composition for treating functional dyspepsia and/or irritable bowel syndrome using gastrointestinal peptide hormones having anti-secretory effects and smooth muscle relaxatory properties in the gastrointestinal tract, and selected from the class consisting of glucagon-like peptide-1 (GLP-1) and derivatives thereof, is provided. The pharmaceutical composition comprising a combination of at least one member selected from the class consisting of GLP-1 and derivatives thereof with one or more other gastrointestinal peptide hormones or derivative(s) thereof together with pharmacologically acceptable additives is also provided. The methods for treating functional dyspepsia or irritable bowel syndrome or both of them by administering an effective amount of at least one member of the class consisting of GLP-1 and derivatives thereof are also provided.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供胃肠肽激素或其衍生物的新用途，用于治疗功能性消化不良和/或肠易激综合征的药物组合物，以及用于这些治疗的方法。解决方案：使用在胃肠道中具有抗分泌作用和平滑肌松弛性质的胃肠肽激素治疗功能性消化不良和/或肠易激综合征的药物组合物，并且选自由胰高血糖素样肽-1 （GLP-1）及其衍生物。还提供了包含选自GLP-1和其衍生物与一种或多种其它胃肠肽激素或其衍生物的组合中的至少一种与药理学上可接受的添加剂的组合的药物组合物。还提供了通过施用有效量的由GLP-1及其衍生物组成的至少一种成员治疗功能性消化不良或肠易激综合症或其二者的方法。版权所有（C）2011，JPO＆INPIT

2. 发明专利

JP2004277402A Use of ghrelin for treating low body weight and low body fat amount of individual received gastrectomy 有权
公开(公告)号：JP2004277402A
公开(公告)日：2004-10-07
申请号：JP2003352592
申请日：2003-10-10
申请人： Gastrotech Pharma As , ガストロテックファーマアクティーゼルスカブ
发明人： JANSSON JOHN-OLOV
IPC分类号： A61K38/00 , A61K31/417 , A61K31/5575 , A61K35/38 , A61K38/17 , A61K38/22 , A61K38/25 , A61P1/14 , A61P3/00 , A61P7/00 , C07K14/47
CPC分类号： A61K38/1709 , A61K38/25
摘要： PROBLEM TO BE SOLVED: To provide a method for using ghrelin for treating a low body weight and low body fat amount of an individual who has received gastrectomy. SOLUTION: This medicinal agent used for ≥1 of the treatment of losses of body weight and body fat of the individual who has received the gastrectomy, the prevention and treatment of cachexia, the promotion of appetite, the acceleration of food ingestion, the acceleration of the body weight or the increase of the body fat amount, etc., contains the ghrelin or its analog as an active ingredient. COPYRIGHT: (C)2005,JPO&NCIPI

3. 发明申请

WO2005097174A3 USES OF A COMBINATION OF GHRELIN AND SOMATOTROPIN FOR THE TREATMENT OF CACHEXIA 审中-公开
标题翻译：使用GHRELIN和SOMATOTROPIN治疗CACHEXIA
公开(公告)号：WO2005097174A3
公开(公告)日：2005-12-29
申请号：PCT/DK2005000242
申请日：2005-04-07
申请人： GASTROTECH PHARMA AS , LANGE BIRGITTE HOLST , POST CLAES , ISAKSSON OLOF GUSTAV PAULUS , NIELSEN TINA GERITZ
发明人： LANGE BIRGITTE HOLST , POST CLAES , ISAKSSON OLOF GUSTAV PAULUS , NIELSEN TINA GERITZ
IPC分类号： A61K38/24 , A61K38/25 , A61K38/27 , A61K38/35 , A61P3/00
CPC分类号： A61K38/35 , A61K38/24 , A61K38/25 , A61K38/27 , A61K2300/00
摘要： The present invention relates to the use of a secretagogue, such as a ghrelin-like compound, in combination with a growth hormone, such as somatotropin or a variant thereof, for the production of a medicament for the treatment of an individual in need thereof, and to a method of treating or preventing cachexia, stimulating appetite, food intake and/or weight gain in an individual in need thereof by administering a ghrelin-like compound. Furthermore, the invention relates to pharmaceutical compositions comprising at least one secretagogue and at least one growth hormone, and medical packagings comprising one or more of said pharmaceutical composition. In another aspect, the present invention relates to a method of treating an individual in need thereof, such as an individual suffering from cachexia, by administering at least one secretagogue, such as a ghrelin-like compound, in combination with at least one growth hormone.
摘要翻译：本发明涉及促分泌素如生长素释放肽样化合物与生长激素如生长激素或其变体的组合在制备用于治疗有需要的个体的药物中的用途，以及通过施用生长素释放肽样化合物来治疗或预防有需要的个体的恶病质，刺激食欲，摄食和/或体重增加的方法。此外，本发明涉及包含至少一种促分泌素和至少一种生长激素的药物组合物和包含一种或多种所述药物组合物的医用包装。另一方面，本发明涉及通过将至少一种促分泌素如生长素释放肽样化合物与至少一种生长激素组合来治疗有需要的个体，例如患有恶病质的个体的方法。

4. 发明申请

WO2006045319A3 USES OF GROWTH HORMONE SECRETAGOGUES IN THE TREATMENT OF INDIVIDUALS SUFFERING FROM RENAL AND/OR LIVER FAILURE 审中-公开
标题翻译：使用生长激素秘密分泌物治疗个体从肾脏和/或肝脏失败中消失
公开(公告)号：WO2006045319A3
公开(公告)日：2006-09-28
申请号：PCT/DK2005000694
申请日：2005-10-27
申请人： GASTROTECH PHARMA AS , LANGE BIRGITTE HOLST , SCHAMBYE HANS T , NIELSEN TINA GERITZ
发明人： LANGE BIRGITTE HOLST , SCHAMBYE HANS T , NIELSEN TINA GERITZ
IPC分类号： A61K38/22 , A61P1/16 , A61P13/12
CPC分类号： A61K38/25 , A61K38/2264 , A61K38/27 , A61K38/30 , A61K45/06 , A61K2300/00
摘要： The invention relates to the use of a secretagogue compound for the preparation of a medicament for treatment of an individual suffering from renal failure and/or liver failure. Furthemore, the invention relates to a method for stimulating appetite, food intake and/or weight gain in an individual suffering from liver failure and/or renal failure, said method comprising administration of a secretagogue to said patient.
摘要翻译：本发明涉及促分泌素化合物在制备用于治疗患有肾衰竭和/或肝衰竭的个体的药物中的用途。因此，本发明涉及一种刺激患有肝衰竭和/或肾衰竭的个体的食欲，食物摄取和/或体重增加的方法，所述方法包括向所述患者施用促分泌素。

5. 发明申请

WO2006058539A3 GROWTH HORMONE SECRETAGOGUE RECEPTOR 1A LIGANDS 审中-公开
标题翻译：生长激素SECRETAGOGUE受体1A配体
公开(公告)号：WO2006058539A3
公开(公告)日：2006-10-26
申请号：PCT/DK2005000763
申请日：2005-11-29
申请人： GASTROTECH PHARMA AS , SCHAMBYE HANS T , LANGE BIRGITTE HOLST , JENSEN PETER HOLME
发明人： SCHAMBYE HANS T , LANGE BIRGITTE HOLST , JENSEN PETER HOLME
IPC分类号： C07K14/60 , A61K38/04 , A61K38/25 , C07K5/087 , C07K5/103 , C07K5/107
CPC分类号： C07K5/1016 , C07K5/0812 , C07K5/101 , C07K14/60
摘要： The present invention relates to new growth hormone secretagogue receptor 1A (GHS-R 1A) ligands, and pharmaceutical compositions comprising any of the new GHS-R1 A ligands. The ligands are suitable for a wide range of applications, and thus the present invention also relates to use of the GHS-R1 A ligands according to the present invention in the manufacture of a medicament for the treatment of an individual in need thereof. In another aspect, the present invention relates to a method of treatment of an individual in need thereof, comprising administering to said individual one or more of the GHS-R1A ligands disclosed herein, such as e.g. for treatment of cancer cachexia.
摘要翻译：本发明涉及新的生长激素促分泌素受体1A（GHS-R1A）配体和包含任何新的GHS-R1A配体的药物组合物。配体适用于广泛的应用，因此本发明还涉及根据本发明的GHS-R1A配体在制备用于治疗有需要的个体的药物中的用途。另一方面，本发明涉及治疗有需要的个体的方法，其包括向所述个体施用本文公开的一种或多种GHS-R1A配体，例如，用于治疗癌症恶病质。

6. 发明申请

WO2006045313A2 USES OF SECRETAGOGUES FOR TREATMENT OF ORGAN TRANSPLANT PATIENTS 审中-公开
标题翻译： SECRETAGOGUES用于治疗器官移植患者的用途
公开(公告)号：WO2006045313A2
公开(公告)日：2006-05-04
申请号：PCT/DK2005000688
申请日：2005-10-26
申请人： GASTROTECH PHARMA AS , LANGE BIRGITTE HOLST , SCHAMBYE HANS T , NIELSEN TINA GERITZ
发明人： LANGE BIRGITTE HOLST , SCHAMBYE HANS T , NIELSEN TINA GERITZ
IPC分类号： A61K38/22 , A61P1/14
CPC分类号： A61K38/25
摘要： The invention relates to the use of a GH secretagogue compound for the preparation of a medicament for the stimulation of appetite, food intake and/or weight gain in an organ transplantation patient in need of such treatment. Furthermore, the invention relates to a method for stimulating appetite, food intake and/or weight gain in an organ transplantation patient, said method comprising administration of a secretagogue to said patient.
摘要翻译：本发明涉及GH促分泌素化合物在制备用于刺激需要这种治疗的器官移植患者的食欲，食物摄取和/或体重增加的药物中的用途。此外，本发明涉及用于刺激器官移植患者的食欲，食物摄取和/或体重增加的方法，所述方法包括向所述患者施用促分泌素。

7. 发明申请

WO2005014032B1 USE OF SECRETAGOGUES LIKE GHRELIN IN CANCER CACHEXIA AND FOR STIMULATING APPETITE 审中-公开
标题翻译：在癌症CACHEXIA中使用秘密肽类似GHRELIN并用于刺激感染
公开(公告)号：WO2005014032B1
公开(公告)日：2005-04-28
申请号：PCT/DK2004000529
申请日：2004-08-06
申请人： GASTROTECH PHARMA AS , LANGE BIRGITTE HOLST , HANSEN CHRISTIAN , NILSSON HENRIK
发明人： LANGE BIRGITTE HOLST , HANSEN CHRISTIAN , NILSSON HENRIK
IPC分类号： A61K38/25 , A61P1/14 , C07K14/60 , G01N33/74
CPC分类号： A61K38/25 , G01N2333/4745 , G01N2333/475 , G01N2333/65
摘要： The present invention relates, in one aspect, to the use of a secretagogue compound for the preparation of a medicament for the prophylaxis or treatment of cancer cachexia in an individual in need of such treatment. In another aspect, the present invention relates to the use of a ghrelin-like compound for the preparation of a medicament for prophylaxis or treatment of cachexia in an individual by administering a subcutaneous dosage of said medicament to the individual. In a further aspect, the present invention relates to the use of a ghrelin-like compound or a pharmaceutically acceptable salt thereof for the preparation of a medicament for stimulation of appetite in an individual by administering a subcutaneous dosage of said medicament to the individual. Furthermore, the present invention relates to a number of new ghrelin-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin-like compounds.
摘要翻译：本发明在一个方面涉及促分泌素化合物在制备用于预防或治疗需要这种治疗的个体中的癌症恶病质的药物中的用途。另一方面，本发明涉及生长素释放肽样化合物在制备用于预防或治疗个体中恶病质的药物中的用途，其通过向个体施用皮下剂量的所述药物。在另一方面，本发明涉及生长素释放肽样化合物或其药学上可接受的盐在制备通过向个体施用皮下剂量的所述药物的个体中刺激个体食欲的药物中的用途。此外，本发明涉及许多新的生长素释放肽样化合物及其用途，以及包含新的生长素释放肽样化合物的药物组合物和医药包装。

8. 发明申请

WO2007028394A3 USE OF A GLP-1 MOLECULE FOR TREATMENT OF BILIARY DYSKINESIA AND/OR BILIARY PAIN/DISCOMFORT 审中-公开
标题翻译： GLP-1分子在治疗胆管性痛和/或胆红素疼痛/挫伤中的应用
公开(公告)号：WO2007028394A3
公开(公告)日：2007-09-20
申请号：PCT/DK2006000496
申请日：2006-09-06
申请人： GASTROTECH PHARMA AS , NIELSEN TINA GERITZ , NILSSON HENRIK , HANSEN CHRISTIAN , SCHAMBYE HANS T
发明人： NIELSEN TINA GERITZ , NILSSON HENRIK , HANSEN CHRISTIAN , SCHAMBYE HANS T
IPC分类号： A61K38/26 , A61P1/16 , G01N33/50
CPC分类号： A61K38/26 , G01N2333/605 , G01N2500/02 , G01N2800/08
摘要： The present invention relates to molecules, compositions and methods suitable for the treatment or prevention of biliary dyskinesia and/or pain and/or discomfort originating from the biliary tree. The peptide hormone glucagon-like peptide-1 (GLP-1) has both anti-secretory effects and smooth muscle relaxatory properties in the gastrointestinal tract. GLP-1 exists in several forms, where the natural occurring GLP-1 molecules are GLP-1 (1- 37), GLP-1 (7-37), and the amidated versions GLP-1 (1-36)amide, GLP-1 (7- 36)amide. Other molecules capable of binding to and activating the GLP-1 receptor is herein included in the tern GLP-1 molecules. GLP-1 molecules may be naturally occurring or homologues of GLP-1 having one or more amino acid substitutions or modifications. The GLP-1 molecules are used for the manufacture of a medicament for the treatment or prevention of biliary dyskinesia and/or pain and/or discomfort originating from the biliary tree.
摘要翻译：本发明涉及适用于治疗或预防源自胆管树的胆道运动障碍和/或疼痛和/或不适的分子，组合物和方法。肽激素胰高血糖素样肽-1（GLP-1）在胃肠道中具有抗分泌作用和平滑肌松弛性质。 GLP-1以几种形式存在，其中天然存在的GLP-1分子是GLP-1（1-37），GLP-1（7-37）和酰胺化形式GLP-1（1-36）酰胺，GLP- -1（7-36）酰胺。其他能够结合并激活GLP-1受体的分子在本文中包括在tern GLP-1分子中。 GLP-1分子可以是天然存在的或具有一个或多个氨基酸取代或修饰的GLP-1的同源物。 GLP-1分子用于制造用于治疗或预防胆道运动障碍和/或源自胆管树的疼痛和/或不适的药物。

9. 发明申请

WO2005097173A3 USE OF GHRELIN FOR THE TREATMENT OF HYPERTHYROIDISM 审中-公开
标题翻译：使用GHRELIN治疗高血糖症
公开(公告)号：WO2005097173A3
公开(公告)日：2005-12-29
申请号：PCT/DK2005000237
申请日：2005-04-07
申请人： GASTROTECH PHARMA AS , NILSSON HENRIK , LANGE BIRGITTE HOLST , POST CLAES , NIELSEN TINA GERITZ
发明人： NILSSON HENRIK , LANGE BIRGITTE HOLST , POST CLAES , NIELSEN TINA GERITZ
IPC分类号： A61K38/25 , A61P3/00 , A61P5/14
CPC分类号： A61K38/25
摘要： The present invention relates to the use of a growth hormone (GH) secretagogue, such as a ghrelin-like compound, for the preparation of a medicament for the prophylaxis or treatment of ghrelin deficiency, and/or undesirable symptoms associated therewith, in an individual at risk of acquiring partial or complete ghrelin deficiency resulting from a medical treatment and/or from a pathological condition. The present invention also relates to use of a secretagogue compound for the preparation of a medicament for the prophylaxis or treatment of one or more of: loss of fat mass, loss of lean body mass, weight loss, cachexia, loss of appetite, immunological dysfunction, malnutrition, disrupted sleep pattern, sleepiness, reduction in intestinal absorption and/or intestinal mobility problems in an individual suffering from, or at risk of suffering from, ghrelin deficiency. Furthermore, the present invention relates to the use of a secretagogue, such as a ghrelin-like compound, for the production of a medicament for preventing weight increase in an individual either: a) being converted from a hyperthyroidic state to euthyroid state, or b) in remission from being converted from a hyperthyroidic state to euthyroid state.
摘要翻译：本发明涉及生长激素（GH）促分泌素如生长素释放肽样化合物在个体中用于预防或治疗生长素释放肽缺乏症和/或与之相关的不良症状的药物的用途有获得由医疗和/或病理状况引起的部分或完全的生长素释放肽缺乏的风险。本发明还涉及促分泌素化合物在制备用于预防或治疗以下中的一种或多种的药物中的用途：脂肪量的损失，瘦体重的减少，体重减轻，恶病质，食欲不振，免疫功能障碍，营养不良，睡眠模式紊乱，困倦，减少肠道吸收和/或肠道运动问题，或者有遭受生长素释放肽缺乏症的个体。此外，本发明涉及促分泌素如生长素释放肽样化合物在制备用于预防个体体重增加的药物中的用途：a）从甲状腺功能亢进状态转变为甲状腺功能状态，或b ）缓解从甲状腺功能亢进状态转变为甲状腺功能状态。

10. 发明申请

WO2006045314A2 USE OF A GROWTH HORMONE SECRETATOGUE FOR INCREASING OR MAINTAINING LEAN BODY MASS AND/OR FOR TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 审中-公开
标题翻译：使用生长激素分泌物增加或维持体质量和/或治疗慢性阻塞性肺动脉疾病
公开(公告)号：WO2006045314A2
公开(公告)日：2006-05-04
申请号：PCT/DK2005000689
申请日：2005-10-26
申请人： GASTROTECH PHARMA AS , LANGE BIRGITTE HOLST , SCHAMBYE HANS T , NIELSEN TINA GERITZ
发明人： LANGE BIRGITTE HOLST , SCHAMBYE HANS T , NIELSEN TINA GERITZ
CPC分类号： A61K38/25
摘要： The present invention relates to a method for increasing or maintaining lean body mass in an individual in need thereof, by administering a secretagogue. The present invention also relates in another aspect to the use of a secretagogue for the production of a medicament for use in increasing or maintaining an individual's lean body mass, preferably in an individual suffering from, or at risk of suffering from, cachexia, such as cancer cachexia.
摘要翻译：本发明涉及通过施用促分泌素来增加或维持有需要的个体中的瘦体重的方法。本发明的另一方面还涉及使用促分泌素来生产用于增加或维持个体的瘦体重的药物，优选地在患有或有遭受恶病质危险的个体中，例如癌症恶病质。

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