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1. 发明申请

WO2018005511A1 GENERATOR AND A CATHETER WITH AN ELECTRODE AND A METHOD FOR TREATING A LUNG PASSAGEWAY 审中-公开
标题翻译：发生器和具有电极的导管以及治疗肺通道的方法
公开(公告)号：WO2018005511A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/039527
申请日：2017-06-27
申请人： GALA THERAPEUTICS, INC. , WALDSTREICHER, Jonathan Reuben , KRIMSKY, William Sanford , ZARINS, Denise Marie , BEETEL, Robert J., III , FRIEDRICHS, Paul Brian , TAYLOR, Kevin James , TUROVSKIY, Roman , LONG, Gary L.
发明人： WALDSTREICHER, Jonathan Reuben , KRIMSKY, William Sanford , ZARINS, Denise Marie , BEETEL, Robert J., III , FRIEDRICHS, Paul Brian , TAYLOR, Kevin James , TUROVSKIY, Roman , LONG, Gary L.
IPC分类号： A61B18/12 , A61B18/14
摘要： Systems and methods are provided for treating pulmonary tissues via delivery of energy to target tissue using a pulmonary tissue modification system (100) such as an energy delivery catheter (102) system. Example pulmonary tissues include the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage and/or nerves. The system may be used to treat a variety of pulmonary diseases or disorders such as COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD) and/or acute bronchitis.
摘要翻译：提供了系统和方法，用于通过使用诸如能量输送导管（102）系统的肺组织修改系统（100）将能量输送到靶组织来治疗肺组织。肺组织实例包括上皮（杯状细胞，纤毛假复层柱状上皮细胞和基底细胞），固有层，粘膜下层，粘膜下腺，基底膜，平滑肌，软骨和/或神经。该系统可用于治疗各种肺部疾病或病症，例如COPD（例如慢性支气管炎，肺气肿），哮喘，间质性肺纤维化，囊性纤维化，支气管扩张症，原发性纤毛运动障碍（PCD）和/或急性支气管炎。 / p>

2. 发明公开

EP1450896A2 SELF-PROPELLED, INTRALUMINAL DEVICE WITH ELECTRODE CONFIGURATION AND METHOD OF USE 审中-公开
标题翻译：与铅的配置和使用自供电的管腔内装置
公开(公告)号：EP1450896A2
公开(公告)日：2004-09-01
申请号：EP02784409.1
申请日：2002-11-06
申请人： ETHICON ENDO-SURGERY, INC. , Long, Gary L.
发明人： LONG, Gary L.
IPC分类号： A61N1/18
CPC分类号： A61B1/041 , A61B1/0008 , A61B1/00082 , A61B1/00087 , A61B1/00094 , A61B1/00147 , A61B1/015 , A61B1/018 , A61B1/05 , A61B1/273 , A61B1/31 , A61B5/415 , A61B5/418 , A61B5/6885 , A61B2562/168
摘要： A medical device is provided comprising a capsule for introduction into a bodily lumen. The capsule can include a balloon filled with a conductive fluid, or a mechanism for actuating wings supporting electrodes. An umbilicus can attach to the trailing end of the capsule. A control unit controls propulsion of the capsule through the bodily lumen.

3. 发明申请

WO2019133606A1 METHODS, APPARATUSES, AND SYSTEMS FOR THE TREATMENT OF DISEASE STATES AND DISORDERS 审中-公开
公开(公告)号：WO2019133606A1
公开(公告)日：2019-07-04
申请号：PCT/US2018/067501
申请日：2018-12-26
申请人： GALA THERAPEUTICS, INC.
发明人： WALDSTREICHER, Jonathan Reuben , KRIMSKY, William Sanford , ZARINS, Denise M. , BEETEL, Robert J., III. , FRIEDRICHS, Paul Brian , TAYLOR, Kevin James , TUROVSKIY, Roman , LONG, Gary L. , NEAL II, Robert E.
IPC分类号： A61B18/12 , A61B18/14 , A61B18/00
CPC分类号： A61B18/1206 , A61B18/1492 , A61B2018/0022 , A61B2018/00267 , A61B2018/00351 , A61B2018/00541 , A61B2018/00577 , A61B2018/00839 , A61B2018/124 , A61B2018/1253 , A61B2018/1467 , A61B2018/1475
摘要： Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.

4. 发明申请

WO2013143609A1 DEVICES AND METHODS FOR THE TREATMENT OF METABOLIC DISORDERS 审中-公开
标题翻译：用于治疗代谢性疾病的装置和方法
公开(公告)号：WO2013143609A1
公开(公告)日：2013-10-03
申请号：PCT/EP2012/055834
申请日：2012-03-30
申请人： ETHICON ENDO-SURGERY, INC. , FELDER, Kevin D. , LONG, Gary L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S.
发明人： FELDER, Kevin D. , LONG, Gary L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S.
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0509 , A61N1/36007
摘要： A system for stimulating the release of satiety hormone in a subject comprises a stimulus device (1 1 ) having an electrical pulse generator (2) and multiple stimulus electrodes (3) adapted to apply electrical stimuli to a tissue of a gastrointestinal system of the subject, the stimulus electrodes (3) being arranged at a distance to one another in multiple positions and the stimulus device (1 ) being configured to time-dependently switch selected ones of the stimulus electrodes (3) from an energized state to a non-energized state and vice versa for time-dependently changing the location of application of the stimulus.
摘要翻译：用于刺激受试者中饱腹感激素释放的系统包括具有电脉冲发生器（2）的刺激装置（11）和适于对受试者的胃肠系统的组织施加电刺激的多个刺激电极（3）刺激电极（3）在多个位置彼此间隔一定距离地布置，并且刺激装置（1）构造成将刺激电极（3）中的所选择的激励电极从激励状态时间依赖地切换到非通电状态，反之亦然，从而随时改变刺激应用的位置。

5. 发明申请

WO2013143603A1 DEVICES AND METHODS FOR THE TREATMENT OF METABOLIC DISORDERS 审中-公开
标题翻译：用于治疗代谢性疾病的装置和方法
公开(公告)号：WO2013143603A1
公开(公告)日：2013-10-03
申请号：PCT/EP2012/055813
申请日：2012-03-30
申请人： ETHICON ENDO-SURGERY, INC. , FELDER, Kevin D. , LONG, Gary L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S.
发明人： FELDER, Kevin D. , LONG, Gary L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S.
IPC分类号： A61N1/05 , A61N1/04 , A61N1/36
CPC分类号： A61N1/0509 , A61N1/0408 , A61N1/0476 , A61N1/36007
摘要： A system for stimulating the release of satiety hormone in a subject includes a stimulus device (1) having an electrical pulse generator (2) and stimulus electrodes (3) adapted to apply an electrical stimulus to a tissue, the stimulus device (1) being adapted to be endoluminally introduced in a gastrointestinal system of the subject, and means (9, 16, 17, 42) for anchoring the stimulus device permanently in a target location inside the gastrointestinal system in a position in which the stimulus electrodes engage a tissue of said gastrointestinal system.
摘要翻译：用于刺激受试者中饱腹感激素释放的系统包括具有电脉冲发生器（2）的刺激装置（1）和适于对组织施加电刺激的刺激电极（3），刺激装置（1）为适于在受试者的胃肠系统中被内窥镜引入，以及用于将刺激装置永久地固定在胃肠系统内的目标位置中的装置（9,16,17,42），其中刺激电极接合刺激电极的组织说胃肠系统。

6. 发明申请

WO2008115917A1 ELECTRODE DOME AND METHOD OF USE 审中-公开
标题翻译：电极球和使用方法
公开(公告)号：WO2008115917A1
公开(公告)日：2008-09-25
申请号：PCT/US2008/057349
申请日：2008-03-18
申请人： ETHICON ENDO-SURGERY, INC , BAKOS, Gregory J. , LONG, Gary L.
发明人： BAKOS, Gregory J. , LONG, Gary L.
IPC分类号： A61B18/12 , A61B18/14
CPC分类号： A61B18/1482 , A61B18/14 , A61B2018/00291 , A61B2018/00577 , A61B2018/1405
摘要： Methods and devices are provided for dissecting tissue. In one embodiment, an electro-surgical device is provided having a housing with a hollow interior adapted to receive tissue, such as an organ. The housing can be adapted to couple to a pressure source for suctioning tissue into the housing, and to an energy source for delivering energy to the tissue. The various elements of the device can be adapted such that the initially dispersed energy is passed through the tissue and is concentrated at a location, e.g., connective tissue, having a surface area that is less than a surface area of the electrode, thereby allowing the connective tissue to be dissected. Exemplary methods for dissecting tissue are also provided.
摘要翻译：提供了解剖组织的方法和装置。在一个实施例中，提供电外科装置，其具有适于接纳诸如器官的组织的具有中空内部的壳体。壳体可以适于联接到用于将组织吸入壳体的压力源，以及用于将能量传递到组织的能量源。装置的各种元件可以适于使得初始分散的能量通过组织并且集中在具有小于电极的表面积的表面积的表面积的位置，例如结缔组织，从而允许要解剖的结缔组织。还提供了用于解剖组织的示例性方法。

7. 发明申请

WO2009091696A1 IN-LINE ELECTROSURGICAL FORCEPS 审中-公开
标题翻译：在线静电力
公开(公告)号：WO2009091696A1
公开(公告)日：2009-07-23
申请号：PCT/US2009/030747
申请日：2009-01-12
申请人： ETHICON ENDO-SURGERY, INC. , LONG, Gary L. , VAKHARIA, Omar J. , BAKOS, Gregory J.
发明人： LONG, Gary L. , VAKHARIA, Omar J. , BAKOS, Gregory J.
IPC分类号： A61B18/14
CPC分类号： A61B18/1447 , A61B2018/00404 , A61B2018/00601 , A61B2018/1422
摘要： An electrosurgical apparatus, system, and method are disclosed. The apparatus, includes an elongate member defines a longitudinal opening. An elongate actuator member is slideably movable within the longitudinal opening. A proximal jaw member having a proximal portion is fixedly coupled to a distal end of the elongate flexible member. A distal jaw member has a proximal portion fixedly coupled to a distal end of the elongate actuator member. A first aperture is defined between the distal portion of the distal jaw member and the proximal portion of the distal jaw member. The distal jaw member is slideably movable relative to the proximal jaw member. The system includes a handle portion to receive a proximal end of the elongate actuator member of the apparatus. A method includes preparing the apparatus for surgery.
摘要翻译：公开了电外科设备，系统和方法。该装置包括细长构件限定纵向开口。细长致动器构件可在纵向开口内可滑动地移动。具有近侧部分的近侧颚构件固定地联接到细长柔性构件的远端。远侧钳口构件具有固定地联接到细长致动器构件的远端的近端部分。第一孔限定在远端钳口构件的远侧部分和远端钳口构件的近端部分之间。远端钳口构件可相对于近端钳口构件可滑动地移动。该系统包括用于接收该装置的细长致动器构件的近端的手柄部分。一种方法包括准备手术装置。

8. 发明申请

WO2020061359A1 SYSTEMS, APPARATUSES, AND METHODS FOR DELIVERY OF PULSED ELECTRIC FIELD ABLATIVE ENERGY TO ENDOCARDIAL TISSUE 审中-公开
公开(公告)号：WO2020061359A1
公开(公告)日：2020-03-26
申请号：PCT/US2019/051998
申请日：2019-09-19
申请人： FARAPULSE, INC. , VISWANATHAN, Raju , LONG, Gary L. , PAGEARD, Jean-Luc , THIBAULT, Benoit
发明人： VISWANATHAN, Raju , LONG, Gary L. , PAGEARD, Jean-Luc , THIBAULT, Benoit
IPC分类号： A61B18/14 , A61B18/00
摘要： Systems, devices, and methods for electroporation ablation therapy are disclosed herein, including an inflatable member for positioning an ablation device within a pulmonary vein ostium. An apparatus can include first and second shafts moveable relative to one another, first and second electrodes configured to generate an electric field for ablating tissue, and an inflatable member disposed between the first and second electrodes. In some embodiments, the inflatable member is configured to transition from an undeployed configuration to a deployed configuration in response to movement of the first and second shafts. In some embodiments, the inflatable member in the deployed configuration can engage a wall of a pulmonary vein ostium and direct the electric field generated by the first and second electrodes toward the wall.

9. 发明申请

WO2008101086A2 ELECTROPORATION ABLATION APPARATUS, SYSTEM, AND METHOD 审中-公开
标题翻译：电气化装置，系统和方法
公开(公告)号：WO2008101086A2
公开(公告)日：2008-08-21
申请号：PCT/US2008/053973
申请日：2008-02-14
申请人： ETHICON ENDO-SURGERY, INC , LONG, Gary L.
发明人： LONG, Gary L.
CPC分类号： A61B18/1492 , A61B1/018 , A61B1/04 , A61B1/06 , A61B18/1482 , A61B2018/00482 , A61B2018/00577 , A61B2018/00613 , A61N1/306 , A61N1/327
摘要： A surgical instrument, such as an endoscopic or laparoscopic instrument, includes an ablation device. The ablation device includes an elongate relatively flexible member having a proximal end and a distal end, the flexible member includes at least a first working channel. A first and second electrode extends from a working channel at the distal end of the flexible member. The first and second electrodes are adapted to be endoscopically located in a tissue treatment region. The first and second electrodes are adapted to couple to an electrical waveform generator to receive an irreversible electroporation electrical waveform sufficient to ablate tissue located between the first and second electrodes.
摘要翻译：诸如内窥镜或腹腔镜仪器的手术器械包括消融装置。消融装置包括具有近端和远端的细长相对柔性的构件，所述柔性构件至少包括第一工作通道。第一和第二电极从柔性构件的远端处的工作通道延伸。第一和第二电极适于内窥镜地位于组织治疗区域中。第一和第二电极适于耦合到电波形发生器以接收足以消融位于第一和第二电极之间的组织的不可逆电穿孔电波形。

10. 发明申请

WO2013143599A1 DEVICES AND METHODS FOR THE TREATMENT OF METABOLIC DISORDERS. 审中-公开
标题翻译：用于治疗代谢性疾病的装置和方法。
公开(公告)号：WO2013143599A1
公开(公告)日：2013-10-03
申请号：PCT/EP2012/055795
申请日：2012-03-30
申请人： ETHICON ENDO-SURGERY, INC. , FELDER, Kevin D. , LONG, Gary L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S.
发明人： FELDER, Kevin D. , LONG, Gary L. , ORTIZ, Mark Steven , PASTORELLI, Alessandro , D'ARCANGELO, Michele , BORK, Toralf , CRIVELLI, Rocco , MIGURAS, Mathilde , PFLEIDERER, Martin , TARDY, Yanik S.
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36067 , A61N1/0509
摘要： A system for stimulating the release of satiety hormone in a subject comprises a stimulus device (1) having an electrical pulse generator (2) and stimulus electrodes (3) adapted to apply an electrical stimulus to a tissue, the stimulus device (1) being configured to time dependently move at least one of the stimulus electrodes (3) for time-dependently changing the location of application of the stimulus.
摘要翻译：用于刺激受试者中饱腹感激素释放的系统包括具有电脉冲发生器（2）和刺激电极（3）的刺激装置（1），刺激电极（3）适于对组织施加电刺激，刺激装置（1）被配置为时间依赖地移动至少一个所述刺激电极（3）以随时改变所述刺激的施加位置。

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