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1. 发明授权

US06413474B1 Measuring device 失效
标题翻译：测量工具
公开(公告)号：US06413474B1
公开(公告)日：2002-07-02
申请号：US09441769
申请日：1999-11-17
申请人： Günter Igel , Ulrich Sieben , Jürgen Giehl , Bernhard Wolf
发明人： Günter Igel , Ulrich Sieben , Jürgen Giehl , Bernhard Wolf
IPC分类号： G01N1506
CPC分类号： G01L19/147 , H01L2224/16225 , H01L2924/00014 , H01L2224/0401
摘要： A measuring device (1) has a semiconductor arrangement, which includes a semiconductor chip (2) connected to a carrier (4) having at least one through-hole (3). The semiconductor chip (2) has at least one sensor (6) with an active sensor surface (5) facing the through-hole (3). The semiconductor chip (2) has electrical terminal points (9), which are connected using flip-chip connections (10) to terminal contacts (11) facing the terminal points (9) and located on the carrier (4). The carrier (4) has electrical strip conductors (12), which connect the terminal contacts (11) to contact elements (13) located on the carrier. To the rear side of the carrier (4) having the contact elements (13) a strip conductor carrier (16) is provided, which has strip conductors (12) connected to opposing contacts (14). The opposing contacts (14) are each electrically connected using flip-chip connections (17), to a contact element (13), which are allocated to each of them. The semiconductor chip (2) and the carrier (4) enclose a measuring chamber. Between the carrier (4) and the semiconductor chip (2) a seal (7) is arranged, which is constructed to be porous or semi-porous, at least in certain areas, or is constructed as a selectively permeable membrane, for bringing a substance into the measuring chamber.
摘要翻译：测量装置（1）具有半导体装置，其包括连接到具有至少一个通孔（3）的载体（4）的半导体芯片（2）。半导体芯片（2）具有至少一个具有面向通孔（3）的有源传感器表面（5）的传感器（6）。半导体芯片（2）具有电气端点（9），它们使用倒装芯片连接（10）连接到面向终端点（9）并位于载体（4）上的端子触点（11）。载体（4）具有将端子触点（11）连接到位于载体上的接触元件（13）的电条导体（12）。在具有接触元件（13）的载体（4）的后侧设置带状导体载体（16），该带状导体载体（16）具有连接到相对触点（14）的带状导体（12）。每个相对的触点（14）都使用倒装芯片连接（17）电连接到分配给它们中的每一个的接触元件（13）。半导体芯片（2）和载体（4）包围测量室。在载体（4）和半导体芯片（2）之间，至少在某些区域中布置密封件（7），其被构造为多孔或半孔的，或被构造为选择性渗透膜，用于使物质进入测量室。

2. 发明授权

US06288440B1 Chip arrangement 失效
标题翻译：芯片布置
公开(公告)号：US06288440B1
公开(公告)日：2001-09-11
申请号：US09342697
申请日：1999-06-29
申请人： Ulrich Sieben , Günter Igel , Mirko Lehmann , Hans-Jürgen Gahle , Bernhard Wolf , Werner Baumann , Ralf Ehret
发明人： Ulrich Sieben , Günter Igel , Mirko Lehmann , Hans-Jürgen Gahle , Bernhard Wolf , Werner Baumann , Ralf Ehret
IPC分类号： H01L23495
CPC分类号： H01L23/5385 , A61B5/14532 , A61B5/1473 , G01N33/48707 , H01L2924/0002 , H01L2924/00
摘要： A chip arrangement (1) has a substrate board (2) with an opening (3), into which a carrier chip (4) is inserted, which has an electrical or electronic structural component (5). At least one conductor path (7) is integrated into the carrier chip (4), which connects the structural component (5) to the electrical connection contact (8). The carrier chip (4) is inserted into the opening (3) in such a way that its ends project beyond the opposite-facing, flat-sided surfaces (9, 9′) of the substrate board (2), and thereby form overhangs (10, 10′). Here, the structural component is arranged on the overhang (10) projecting beyond the one surface (9), and the connection contact (8) is arranged on the overhang (10′) projecting beyond the other surface (9′), and the conductor path (7) connecting the structural component (5) and the connection contact (8) passes through the opening (3). A seal is arranged between the substrate board (2) and the carrier chip (4).
摘要翻译：芯片装置（1）具有带有开口（3）的基板（2），其中插入有载体芯片（4），其具有电或电子结构部件（5）。至少一个导体路径（7）集成到载体芯片（4）中，其将结构部件（5）连接到电连接触点（8）。载体芯片（4）以这样的方式插入到开口（3）中，使得其端部突出超过衬底板（2）的相对面对的平坦表面（9,9'），从而形成突出部（10,10'）。这里，结构部件布置在突出超过一个表面（9）的伸出部（10）上，并且连接触点（8）布置在突出超过另一个表面（9'）的伸出部（10'）上，并且连接结构部件（5）和连接触点（8）的导体路径（7）穿过开口（3）。在基板（2）和载体芯片（4）之间设置密封件。

3. 发明授权

US06638743B2 Method for measuring a state variable 失效
公开(公告)号：US06638743B2
公开(公告)日：2003-10-28
申请号：US10119354
申请日：2002-04-09
申请人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jörg Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
发明人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jörg Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
IPC分类号： C12N1300
CPC分类号： C12N15/89 , C12M35/02 , C12M35/04 , C12M35/08 , C12N13/00
摘要： A method is provided for measuring a state variable of a biological cell (3) located in a nutrient medium (2) and supported on and adhering to a support area (5). Within the support area (5) for the cell (3) and at a distance from the support area edge, an opening is made in the membrane of the cell (3). The edge of the cell membrane that surrounds the opening and adheres to the support area (5) seals off the liquid found inside the cell (3) from the nutrient medium (2). Through the opening the state variable (2) is measured. An apparatus for performing the method is also provided.

4. 发明授权

US06475760B1 Method for intracellular manipulation of a biological cell 有权
标题翻译：细胞内操作生物细胞的方法
公开(公告)号：US06475760B1
公开(公告)日：2002-11-05
申请号：US09321051
申请日：1999-05-27
申请人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
发明人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
IPC分类号： C12N1300
CPC分类号： C12N15/89 , C12M35/02 , C12M35/04 , C12M35/08 , C12N13/00
摘要： A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane of the cell (3) is created spaced from its support edge. The edge of the cell membrane surrounding the opening, adhering to the support area (5), thus seals off the cell fluid situated in the interior of the cell (3) from the culture medium (2) and insulates the cell fluid against the culture medium (2). The interior of the cell (3) is manipulated through the opening. An apparatus for implementing the process is also provided, including an object carrier (4) with a support area (5) for adhering the cell and a poration tool (6) for creating the opening in the cell membrane. The poration tool (6) may be any of various chemical, mechanical and/or electrical devices.
摘要翻译：提供了一种用于细胞内操作生物细胞（3）的方法，所述生物细胞（3）定位为粘附在培养基（2）中的支持区域（5）。在电池（3）的支撑区域（5）的内部，与电池（3）的隔膜形成的开口与其支撑边缘间隔开。围绕开口的细胞膜的边缘附着在支撑区域（5）上，从而将位于细胞（3）内部的细胞液体与培养基（2）密封并使细胞液体抵抗培养物中等（2）。电池（3）的内部通过开口被操纵。还提供了一种用于实现该方法的装置，包括具有用于粘附细胞的支撑区域（5）的物体载体（4）和用于在细胞膜中形成开口的引锭工具（6）。引锭工具（6）可以是各种化学，机械和/或电气装置中的任何一种。

5. 发明授权

US06368851B1 Method and apparatus for measuring a state variable 有权
标题翻译：用于测量状态变量的方法和装置
公开(公告)号：US06368851B1
公开(公告)日：2002-04-09
申请号：US09321458
申请日：1999-05-27
申请人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
发明人： Werner Baumann , Ralf Ehret , Mirko Lehmann , Günter Igel , Hans-Jürgen Gahle , Bernhard Wolf , Ulrich Sieben , Ingo Freund , Martin Brischwein
IPC分类号： C12M142
CPC分类号： C12N15/89 , C12M35/02 , C12M35/04 , C12M35/08 , C12N13/00
摘要： A method is provided for measuring a state variable of a biological cell (3) located in a nutrient medium (2) and supported on and adhering to a support area (5). Within the support area (5) for the cell (3) and at a distance from the support area edge, an opening is made in the membrane of the cell (3). The edge of the cell membrane that surrounds the opening and adheres to the support area (5) seals off the liquid found inside the cell (3) from the nutrient medium (2). Through the opening the state variable (2) is measured. An apparatus for performing the method is also provided.
摘要翻译：提供了一种用于测量位于营养介质（2）中并被支撑并附着到支撑区域（5）上的生物体（3）的状态变量的方法。在电池（3）的支撑区域（5）内并且距离支撑区域边缘一定距离处，在电池（3）的膜中形成开口。围绕开口并附着到支撑区域（5）的细胞膜的边缘将从细胞（3）内发现的液体与营养培养基（2）密封。通过打开状态变量（2）进行测量。还提供了一种用于执行该方法的装置。

6. 发明授权

US06656678B1 Method for examination of a surface layer 失效
标题翻译：表层检查方法
公开(公告)号：US06656678B1
公开(公告)日：2003-12-02
申请号：US09585146
申请日：2000-06-01
申请人： Bernhard Wolf , Hans-Jürgen Gahle , Günter Igel , Werner Baumann , Ralf Ehret , Mirko Lehmann
发明人： Bernhard Wolf , Hans-Jürgen Gahle , Günter Igel , Werner Baumann , Ralf Ehret , Mirko Lehmann
IPC分类号： C12Q100
CPC分类号： H01L22/24 , G01B11/30 , G01N21/94
摘要： In a method for examination of the surface of an object for a topographic and/or a chemical property, the object-surface is impinged with surface-structure selective biocomponents for examination of a topographic property and/or with chemoselective biocomponents for the examination of a chemical property, together with a nutrient medium and/or an osmotic protective medium for the biocomponents. The biocomponents contained in the nutrient medium and/or the osmotic protective medium are in contact with the object-surface or are spaced from the object surface by less than the detection range of the biocomponents. The object surface is then examined with the biocomponents contained in the nutrient medium and/or the osmotic protective medium by determining at least one examination measurement value. The examination measurement value is compared with a reference measurement value, and conclusions can be drawn about the topographic and/or chemical properties of the object from the result of the comparison. Using the method, an object surface can be examined for a topographic and/or chemical property in a simple manner with a high measuring sensitivity.
摘要翻译：在用于检查地形和/或化学性质的物体的表面的方法中，物体表面与表面结构选择性生物组分碰撞以检查地形性质和/或化学选择性生物成分用于检查化学性质，以及生物组分的营养培养基和/或渗透保护介质。包含在营养培养基和/或渗透保护介质中的生物成分与物体表面接触或与物体表面间隔小于生物成分的检测范围。然后通过确定至少一个检查测量值用包含在营养培养基和/或渗透保护介质中的生物组分检查物体表面。将检查测量值与参考测量值进行比较，并从比较结果中得出关于物体的地形和/或化学性质的结论。使用该方法，可以以高测量灵敏度的简单方式检查物体表面的地形和/或化学特性。

7. 发明授权

US06210977B1 Measuring device and method for making same 失效
标题翻译：测量装置及其制作方法
公开(公告)号：US06210977B1
公开(公告)日：2001-04-03
申请号：US09468449
申请日：1999-12-21
申请人： Ulrich Sieben , Bernhard Wolf , Hellmut Haberland , Christoph Cremer
发明人： Ulrich Sieben , Bernhard Wolf , Hellmut Haberland , Christoph Cremer
IPC分类号： G01N33543
CPC分类号： G01N27/4145 , H01L2924/0002 , Y10S436/805 , H01L2924/00
摘要： A measuring device for measuring or examining physiological parameters on biocomponents includes an FET sensor 5 whose electrical protective layer 12 is roughened or has a structured coating 15. The structuring of the active sensor contact surface 12 is adapted to the outer contour and topography of the biocomponent in question, so that a better possibility is available for anchoring the biocomponents to the contact surface 24 forming the FET protective layer of the sensor 5.
摘要翻译：用于测量或检查生物组件上的生理参数的测量装置包括FET传感器5，其电保护层12被粗糙化或具有结构化涂层15.主动传感器接触表面12的结构适用于生物组件的外轮廓和形貌因此有可能将生物组分锚定到形成传感器5的FET保护层的接触表面24上。

8. 发明授权

US06245057B1 Device for treating malignant, tumorous tissue areas 失效
标题翻译：用于治疗恶性肿瘤组织区域的装置
公开(公告)号：US06245057B1
公开(公告)日：2001-06-12
申请号：US09425598
申请日：1999-10-22
申请人： Ulrich Sieben , Bernhard Wolf
发明人： Ulrich Sieben , Bernhard Wolf
IPC分类号： A61K922
CPC分类号： A61B5/145 , A61B5/14539 , A61B5/1473 , A61M31/002
摘要： A device (1) functions for treating malignant, tumorous tissue areas. The device has at least one measuring sensor for determining chemical or physical signal patterns in the immediate vicinity of the tumor cells or similar tissue part, a control unit and at least one treatment assembly, which has as an active agent release element for chemically influencing and/or treatment electrodes for physically influencing the tumorous tissue area to be treated. The sensor(s), the active agent release element, and the treatment electrodes are connected to the control unit for a physical and/or chemical treatment of the tumorous tissue area, controlled as a function of the measured values of the tumor cells. The device is constructed in the form of a swallowable capsule or dragée, and a sensor is provided for detecting release parameters. The control unit is designed with a threshold value switch for activating the active agent release element and/or the electrodes when a predetermined target value is exceeded.
摘要翻译：装置（1）用于治疗恶性肿瘤组织区域。该装置具有至少一个用于确定肿瘤细胞或类似组织部分附近的化学或物理信号图案的测量传感器，控制单元和至少一个处理组件，其具有用于化学影响的活性剂释放元件和 /或用于物理影响待治疗的肿瘤组织区域的治疗电极。传感器，活性剂释放元件和处理电极连接到控制单元，用于根据肿瘤细胞的测量值来控制肿瘤组织区域的物理和/或化学处理。该装置以吞咽胶囊或拖把的形式构造，并且提供用于检测释放参数的传感器。当超过预定目标值时，控制单元设计有用于激活活性剂释放元件和/或电极的阈值开关。

9. 发明授权

US6104495A Measuring apparatus 失效
标题翻译：测量装置
公开(公告)号：US6104495A
公开(公告)日：2000-08-15
申请号：US86111
申请日：1998-05-27
申请人： Ulrich Sieben , Bernhard Wolf
发明人： Ulrich Sieben , Bernhard Wolf
IPC分类号： G01N33/48 , C12M1/34 , G01N21/27 , G01N33/483 , G01N21/59
CPC分类号： C12M41/46
摘要： A measuring apparatus (1) for measuring physiological and/or chemical and/or physical properties of at least one living cell (3) contains, in addition to further sensors (4.1, 4.2), a plurality of optical sensors (4) on a support (2), particularly a support made of semiconductor material. By means of a controller (6) and a switching facility (8) which are integrated on the same support (2), the individual optical sensors (4) and the further sensors (4.1, 4.2) can be selectively interrogated. An external signal-analyzing facility (7) with a screen represents a sort of near-field microscope.
摘要翻译：用于测量至少一个活细胞（3）的生理和/或化学和/或物理性质的测量装置（1）除了还有传感器（4.1,4.2）之外还包含多个光学传感器（4）支撑件（2），特别是由半导体材料制成的支撑件。通过集成在同一支撑件（2）上的控制器（6）和切换设备（8），可以选择性询问各个光学传感器（4）和另外的传感器（4.1,4.2）。具有屏幕的外部信号分析设备（7）表示一种近场显微镜。

10. 发明授权

US06376233B1 Device for conducting research on cell specimens and similar materials 有权
标题翻译：对细胞标本和类似材料进行研究的装置
公开(公告)号：US06376233B1
公开(公告)日：2002-04-23
申请号：US09310003
申请日：1999-05-11
申请人： Bernhard Wolf , Ulrich Sieben
发明人： Bernhard Wolf , Ulrich Sieben
IPC分类号： C12M134
CPC分类号： G01N35/028 , B01J2219/00315 , B01J2219/00317 , B01J2219/00653 , B01J2219/00659 , B01L3/5085 , B01L3/50851 , B01L2200/147 , B01L2300/0645 , B01L2300/0663 , B01L2300/1827 , C40B60/14
摘要： A device (1) serves for conducting investigations on cell specimens, wherein the device has a microtiter plate or similar receiving device with a plurality of individual containers for the cell specimens. Furthermore, a measuring facility for recording changes in individual specimens is provided. On the underside the microtiter plate or similar receiving device has a measuring structure which carries at least one sensor allocated to each receiving vessel. The measuring structure can either be combined with a bottomless upper part of a conventional microtiter plate, or instead it is a semiconductor substrate plate (2) with a plurality of bowl-shaped receptacle depressions (3) situated therein and provided as containers. At least one sensor is allocated to each depression.
摘要翻译：装置（1）用于对细胞试样进行研究，其中装置具有微量滴定板或类似的接收装置，其具有用于细胞样品的多个单独的容器。此外，提供了用于记录各个样本的变化的测量设备。在底侧，微量滴定板或类似的接收装置具有承载分配给每个接收容器的至少一个传感器的测量结构。测量结构可以与常规微量滴定板的无底上部组合，或者替代地是具有位于其中并且设置为容器的多个碗形容器凹部（3）的半导体衬底板（2）。至少有一个传感器被分配给每个凹陷。

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