专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06663757B1 Method and device for the convective movement of liquids in microsystems 失效
标题翻译：微系统中液体对流运动的方法和装置
公开(公告)号：US06663757B1
公开(公告)日：2003-12-16
申请号：US09868199
申请日：2001-08-06
申请人： Günter Führ , Torsten Müller , Thomas Schnelle , Rolf Hagedorn
发明人： Günter Führ , Torsten Müller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： B01L300
CPC分类号： B01F13/0076 , B01F3/1235 , B01F13/0077 , F15D1/02
摘要： The aim of the invention is to convectively move at least one liquid in a channel of a microsystem which comprises a predetermined channel direction. To this end, the liquid is, in a partial section of the channel, subjected to an electric field gradient and optionally to a thermal gradient. The gradients are generated in the partial section corresponding to a predetermined field direction, whereby the field direction differs from the channel direction.
摘要翻译：本发明的目的是对流地移动包括预定通道方向的微系统的通道中的至少一个液体。为此，液体在通道的部分部分中经历电场梯度并且任选地经受热梯度。在对应于预定场方向的部分部分中生成梯度，由此场方向与频道方向不同。

2. 发明申请

US20120305398A1 METHODS AND DEVICES FOR SEPARATING PARTICLES IN A LIQUID FLOW 有权
标题翻译：用于在液体流中分离颗粒的方法和装置
公开(公告)号：US20120305398A1
公开(公告)日：2012-12-06
申请号：US13586988
申请日：2012-08-16
申请人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
发明人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： B01D43/00
CPC分类号： B03C5/005
摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.
摘要翻译：描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）相对于液体沿偏转方向移动被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒在不同的流动区域（11,12）中发生不同的电，磁或几何特性。

3. 发明授权

US09149813B2 Methods and devices for separating particles in a liquid flow 有权
标题翻译：用于分离液体流中的颗粒的方法和装置
公开(公告)号：US09149813B2
公开(公告)日：2015-10-06
申请号：US13586988
申请日：2012-08-16
申请人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
发明人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： G01N27/447 , B03C5/00
CPC分类号： B03C5/005
摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.
摘要翻译：描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）在偏转方向上相对于液体移动被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒在不同的流动区域（11,12）中发生不同的电，磁或几何特性。

4. 发明授权

US06727451B1 Method and device for manipulating microparticles in fluid flows 有权
标题翻译：用于操纵流体流中微粒的方法和装置
公开(公告)号：US06727451B1
公开(公告)日：2004-04-27
申请号：US09673034
申请日：2000-11-30
申请人： Günter Fuhr , Rolf Hagedorn , Torsten Müller , Thomas Schnelle , Gabriele Gradl
发明人： Günter Fuhr , Rolf Hagedorn , Torsten Müller , Thomas Schnelle , Gabriele Gradl
IPC分类号： B01D5702
CPC分类号： B03C5/026 , C12M47/04
摘要： To manipulate microparticles in a fluid that intersects a first channel or several first channels as a stream, one or more microparticles (14) are exposed to electrical field barriers that change their direction from the direction of flow toward the edge of the flow to a lateral hole (17) of the respective first channel. As a result, microparticles can be moved back and forth between streaming fluids. Preferred applications include treatment, separating, sorting or confinement procedures.
摘要翻译：为了操纵在与第一通道或多个第一通道相交的流体中的微粒作为流，一个或多个微粒暴露于电场屏障，其将其方向从流动方向朝向流动边缘改变为侧向（17）。结果，微粒可以在流动流体之间来回移动。优选的应用包括处理，分离，分选或限制程序。

5. 发明授权

US08262883B2 Methods and devices for separating particles in a liquid flow 有权
标题翻译：用于分离液体流中的颗粒的方法和装置
公开(公告)号：US08262883B2
公开(公告)日：2012-09-11
申请号：US10549886
申请日：2004-03-17
申请人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
发明人： Torsten Müller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： B01D57/02
CPC分类号： B03C5/005
摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.
摘要翻译：描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）在偏转方向上相对于液体移动被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒在不同的流动区域（11,12）中发生不同的电，磁或几何特性。

6. 发明授权

US06749736B1 Electrode arrangement for the dielectrophoretic diversion of particles 有权
标题翻译：用于介电电泳转移颗粒的电极布置
公开(公告)号：US06749736B1
公开(公告)日：2004-06-15
申请号：US09720222
申请日：2001-02-22
申请人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
发明人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
IPC分类号： G01N27453
CPC分类号： B03C5/026 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2300/0825 , B01L2400/0409 , B01L2400/0415 , B01L2400/0424 , B01L2400/0457 , B03C5/005 , B03C2201/26 , C12M33/00 , C12M35/02 , C12M47/04
摘要： Electrode arrangement (10) in a microsystem adapted for dielectrophoretic manipulation of particles (30) in a suspension fluid in a channel (21), wherein at least one electrode (11, 11a, 11b, 12) is arranged on a lateral wall of the channel (21), the electrode (11, 11a, 11b, 12) consisting of a plurality of electrode segments adapted to generate at least one field gradient for influencing the movement paths of the particles (30) in the channel (21). In one embodiment of the invention, the particles are moved in the microsystem by exposure to centrifugal and/or gravitational forces.
摘要翻译：在微系统中的电极装置（10），其适用于在通道（21）中的悬浮液中的颗粒（30）的介电电泳操作，其中至少一个电极（11,11a，11b，12）布置在所述通道通道（21），由多个电极段组成的电极（11,11a，11b，12），其适于产生用于影响通道（21）中的颗粒（30）的运动路径的至少一个场梯度。在本发明的一个实施方案中，颗粒通过暴露于离心和/或重力而在微系统中移动。

7. 发明授权

US07070684B1 Electrode arrangement for generating functional field barriers in microsystems 失效
标题翻译：用于在微系统中产生功能场屏障的电极装置
公开(公告)号：US07070684B1
公开(公告)日：2006-07-04
申请号：US09720275
申请日：1999-06-28
申请人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
发明人： Günter Fuhr , Thomas Schnelle , Rolf Hagedorn , Torsten Müller
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01F13/0076 , B01F13/0077 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2400/0409 , B01L2400/0415 , B03C5/026 , C12M33/00 , C12M47/04
摘要： A microsystem adapted for dielectrophoretic manipulation of particles in a suspension liquid wherein the microsystem has a channel with channel walls and a longitudinal extension. An electrode arrangement is present which has at least one microelectrode on at least one of the channel walls. This acts to generate a field barrier which crosses the channel at least partly. The microelectrode has a band-shape or has a multitude of straight electrode sections connected to each other. The band-shape has a predetermined curvature or the straight electrode sections are arranged with predetermined different angles so that the field barrier has a predetermined curvature relative to the longitudinal extension of the channel.
摘要翻译：一种适用于悬浮液中颗粒的介电电泳操作的微系统，其中微系统具有通道壁和纵向延伸的通道。存在在至少一个通道壁上具有至少一个微电极的电极布置。这用于产生至少部分穿过通道的场屏障。微电极具有带状或具有彼此连接的多个直电极部分。带状具有预定的曲率或直线电极部分以预定的不同角度布置，使得场屏障相对于通道的纵向延伸具有预定的曲率。

8. 发明授权

US07439075B2 Method and device for withdrawing suspended microparticles from a fluidic microsystem 失效
标题翻译：从流体微系统中取出悬浮微粒的方法和装置
公开(公告)号：US07439075B2
公开(公告)日：2008-10-21
申请号：US10203168
申请日：2001-02-08
申请人： Gunter Fuhr , Stephen Graham Shirley , Torsten Muller , Thomas Schnelle , Rolf Hagedorn
发明人： Gunter Fuhr , Stephen Graham Shirley , Torsten Muller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： G01N1/10 , G01N15/06 , G01N21/00 , G01N31/00 , G01N33/00 , G01N27/26 , B01D57/02 , B01D59/42 , B01D59/50 , B01D61/42 , B01D61/58 , G01L9/18 , G01L1/20 , G01F1/64 , C02F1/469 , C02F1/40 , C02F11/00 , C07K1/26 , C08F2/58 , C25B7/00 , C25B15/00
CPC分类号： B01L3/5027 , B01J19/0093 , B01J2219/00891 , B01L3/0241 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , G01N15/1404 , G01N27/44791 , G01N2015/1409 , Y10T436/2575
摘要： A method of discharging a fluid flow with suspended microparticles from a fluidic microsystem (10) is described, whereby the fluid flow converges with at least one output flow to form a discharge flow at the end of a discharge channel (14) of the microsystem, and the discharge flow is delivered through a conduction element (19). A microsystem with a flow output device for implementation of this method is also described.
摘要翻译：描述了从流体微系统（10）排出具有悬浮微粒的流体流的方法，由此流体流与至少一个输出流收敛以在微系统的排放通道（14）的端部处形成排出流，并且通过导电元件（19）输送排出流。还描述了具有用于实现该方法的流输出装置的微系统。

9. 发明申请

US20060289341A1 Methods and devices for separting particles in a liquid flow 有权
标题翻译：在液体流中分离颗粒的方法和装置
公开(公告)号：US20060289341A1
公开(公告)日：2006-12-28
申请号：US10549886
申请日：2004-03-17
申请人： Torsten Muller , Thomas Schnelle , Rolf Hagedorn
发明人： Torsten Muller , Thomas Schnelle , Rolf Hagedorn
IPC分类号： B03C7/00 , B03B5/00
CPC分类号： B03C5/005
摘要： Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.
摘要翻译：描述了用于在流体微系统（100）的隔室（30）中分离颗粒（20,21,22）的方法和装置，其中液体（10）的运动，其中颗粒（20,21,22 ）以预定的流动方向悬挂通过隔室（30），并产生偏转电位，其中至少一部分颗粒（20,21,22）在偏转方向上相对于液体移动被设想为进一步产生至少一个聚焦电位，使得至少一部分颗粒在高频电场的作用下通过介电电泳相对于液体的偏转方向移动，并且引导颗粒在不同的流动区域（11,12）中发生不同的电，磁或几何特性。

10. 发明授权

US5948328A Shaping of microparticles in electric-field cages 失效
标题翻译：电场笼中微粒的形成
公开(公告)号：US5948328A
公开(公告)日：1999-09-07
申请号：US700395
申请日：1996-08-23
申请人： Stefan Fiedler , Andreas Voigt , Thomas Schnelle , Guenter Fuhr , Torsten Mueller , Rolf Hagedorn , Jan Hornung , Henning Glasser , Bernd Wagner
发明人： Stefan Fiedler , Andreas Voigt , Thomas Schnelle , Guenter Fuhr , Torsten Mueller , Rolf Hagedorn , Jan Hornung , Henning Glasser , Bernd Wagner
IPC分类号： B01J2/00 , B01J13/02 , B01J19/08
CPC分类号： B01J13/02 , B01J19/087 , B01J2/00
摘要： In the method proposed, microparticles suspended in a liquid or droplets suspended in a liquid with which they are immiscible are shaped by high-frequency electric fields in a three-dimensional electrode array of a size in the micrometer or submicrometer range and subsequently consolidated by prior art chemical bonding procedures or by physical methods. The disposition, geometry and control of the electrodes determine the shape of the particles. The particles themselves must have a conductivity and/or relative dielectric constant lower than the solution surrounding them. For some, this can be achieved only at certain frequencies in the kHz and MHz band which are determined by the passive electrical properties of the particles and the surrounding solution. The particles or droplets are repelled by the electrodes so that they are shaped in the free solution without making contact with any surface and can then be consolidated. This makes it possible to shape micrometer and submicrometer size particles of the kind required in chromatography, affinity biochemistry and medicine, as well as for filter systems.
摘要翻译： PCT No.PCT / DE95 / 00237 Sec。 371日期：1996年8月23日 102（e）日期1996年8月23日PCT提交1995年2月23日PCT公布。 WO95 / 23020 PCT公开号日期1995年8月31日在所提出的方法中，悬浮在液体中的微粒悬浮在与其不混溶的液体中的微滴通过在微米或亚微米范围内的尺寸的三维电极阵列中的高频电场并随后通过现有技术的化学键合方法或通过物理方法进行固结。电极的布置，几何形状和控制决定了颗粒的形状。颗粒本身必须具有低于围绕它们的溶液的导电性和/或相对介电常数。对于一些，这只能在通过颗粒和周围溶液的被动电特性确定的kHz和MHz频带的某些频率下实现。颗粒或液滴被电极排斥，使得它们在游离溶液中成形，而不与任何表面接触，然后可以被固结。这使得可以形成色谱，亲和力生物化学和药物所需类型的微米和亚微米尺寸的颗粒，以及过滤系统。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式