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1. 发明授权

US07271311B2 Mammalian model for diabetes 失效
标题翻译：哺乳动物模型糖尿病
公开(公告)号：US07271311B2
公开(公告)日：2007-09-18
申请号：US10252111
申请日：2002-09-23
申请人： Fumitoshi Ishino , Naoki Miyoshi , Tomoko Ishino , Minesuke Yokoyama , Shigeharu Wakana
发明人： Fumitoshi Ishino , Naoki Miyoshi , Tomoko Ishino , Minesuke Yokoyama , Shigeharu Wakana
IPC分类号： G01N33/00 , A01K67/27 , A01K67/33
CPC分类号： C12N15/8509 , A01K67/0273 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0306 , C07K14/4705
摘要： An object of the present invention is to provide a model mammal for diabetes onset, being useful for elucidating the onset mechanism of diabetes caused by a blockage of signal transduction from insulin, and for the development of a remedy for said diabetes, and to provide a screening method of a remedy for said diabetes. A diabetic-prone transgenic mouse is prepared in a process comprising the steps of: a transgene that contains a Meg1/Grb10 gene, an imprinted gene exhibiting maternal expression, or a human GRB10 gene in the downstream of a chicken β-actin promoter and in the upstream of a rabbit β-globin poly A is constructed, and subsequently the transgene is microinjected into a male proneucleus of a mouse fertilized egg; thus obtained egg cell is cultured and then transplanted into an oviduct of a pseudopregnant female mouse; after rearing up the recipient animal, baby mice that have the above-mentioned cDNA are selected from the mice born from the recipient animal.
摘要翻译：本发明的目的是提供一种用于糖尿病发作的模型哺乳动物，可用于阐明由胰岛素信号传导阻断引起的糖尿病发病机制，以及用于开发所述糖尿病的治疗方法，并提供一种所述糖尿病治疗方法的筛选方法。制备具有糖尿病倾向的转基因小鼠，该方法包括以下步骤：在鸡β-肌动蛋白启动子的下游含有Meg1 / Grb10基因，表达母体表达的印记基因或人GRB10基因的转基因构建了兔β-珠蛋白聚A的上游，随后将转基因显微注射入小鼠受精卵的雄性易位; 由此获得的卵细胞被培养，然后移植到假孕女性小鼠的输卵管中; 在饲养受体动物后，具有上述cDNA的婴儿小鼠选自从受体动物出生的小鼠。

2. 发明申请

US20070177295A1 Information processing apparatus having built-in hard disk drive and head retraction processing method of built-in hard disk drive 有权
标题翻译：具有内置硬盘驱动器和内置硬盘驱动器的磁头缩回处理方法的信息处理装置
公开(公告)号：US20070177295A1
公开(公告)日：2007-08-02
申请号：US11643625
申请日：2006-12-21
申请人： Naoki Miyoshi , Keisuke Koide
发明人： Naoki Miyoshi , Keisuke Koide
IPC分类号： G11B21/02
CPC分类号： G11B21/12 , G11B19/02 , G11B19/04
摘要： An information processing apparatus includes a hard disk drive, an acceleration sensor, and a determination section. The hard disk drive is capable of moving a head of the hard disk drive to a data-free landing zone. The acceleration sensor detects acceleration. The determination section obtains a low frequency component from the detected acceleration and determines whether it is necessary to move the head of the hard disk drive to the data-free landing zone based on the low frequency component.
摘要翻译：信息处理装置包括硬盘驱动器，加速度传感器和判定部。硬盘驱动器能够将硬盘驱动器的头部移动到无数据的着陆区域。加速度传感器检测加速度。确定部分从检测到的加速度中获得低频分量，并且基于低频分量确定是否需要将硬盘驱动器的头部移动到无数据着陆区域。

3. 发明授权

US07495858B2 Information processing apparatus having built-in hard disk drive and head retraction processing method of built-in hard disk drive 有权
标题翻译：具有内置硬盘驱动器和内置硬盘驱动器的磁头缩回处理方法的信息处理装置
公开(公告)号：US07495858B2
公开(公告)日：2009-02-24
申请号：US11643625
申请日：2006-12-21
申请人： Naoki Miyoshi , Keisuke Koide
发明人： Naoki Miyoshi , Keisuke Koide
IPC分类号： G11B21/02 , G11B33/14
CPC分类号： G11B21/12 , G11B19/02 , G11B19/04
摘要： An information processing apparatus includes a hard disk drive, an acceleration sensor, and a determination section. The hard disk drive is capable of moving a head of the hard disk drive to a data-free landing zone. The acceleration sensor detects acceleration. The determination section obtains a low frequency component from the detected acceleration and determines whether it is necessary to move the head of the hard disk drive to the data-free landing zone based on the low frequency component.
摘要翻译：信息处理装置包括硬盘驱动器，加速度传感器和判定部。硬盘驱动器能够将硬盘驱动器的头部移动到无数据的着陆区域。加速度传感器检测加速度。确定部分从检测到的加速度中获得低频分量，并且基于低频分量确定是否需要将硬盘驱动器的头部移动到无数据着陆区域。

4. 发明授权

US07474970B2 Information processing apparatus and head retraction processing method of built-in hard disk drive thereof 有权
标题翻译：信息处理装置及其内置硬盘驱动器的磁头缩回处理方法
公开(公告)号：US07474970B2
公开(公告)日：2009-01-06
申请号：US11635226
申请日：2006-12-06
申请人： Naoki Miyoshi , Keisuke Koide , Hirotaka Takahashi , Masaru Kawata
发明人： Naoki Miyoshi , Keisuke Koide , Hirotaka Takahashi , Masaru Kawata
IPC分类号： G06F19/00
CPC分类号： G11B19/04 , G06F11/004
摘要： An information processing apparatus is disclosed. The information processing apparatus includes a hard disk drive, an acceleration sensor, a determination section, and a threshold value setup section. The hard disk drive is capable of retracting a head to a data-free landing zone. The acceleration sensor detects acceleration. The determination section obtains high frequency components from acceleration information detected by the acceleration sensor, obtains a vibration level corresponding to the obtained high frequency components, compares the vibration level with a threshold value which has been set up, and determines whether or not there is a necessity to retract the head of the hard disk drive to the data-free landing zone. The threshold value setup section allows a user to change the threshold value and set up the changed threshold value.
摘要翻译：公开了一种信息处理装置。信息处理装置包括硬盘驱动器，加速度传感器，判定部和阈值设定部。硬盘驱动器能够将磁头缩回到无数据的着陆区域。加速度传感器检测加速度。确定部分从由加速度传感器检测到的加速度信息中获得高频分量，获得与获得的高频分量相对应的振动水平，将振动水平与已建立的阈值进行比较，并确定是否存在必须将硬盘驱动器的头部缩回到无数据的着陆区域。阈值设置部分允许用户改变阈值并设置改变的阈值。

5. 发明申请

US20070150211A1 Information processing apparatus and head retraction processing method of built-in hard disk drive thereof 有权
标题翻译：信息处理装置及其内置硬盘驱动器的磁头缩回处理方法
公开(公告)号：US20070150211A1
公开(公告)日：2007-06-28
申请号：US11635226
申请日：2006-12-06
申请人： Naoki Miyoshi , Keisuke Koide , Hirotaka Takahashi , Masaru Kawata
发明人： Naoki Miyoshi , Keisuke Koide , Hirotaka Takahashi , Masaru Kawata
IPC分类号： G01B3/44
CPC分类号： G11B19/04 , G06F11/004
摘要： An information processing apparatus is disclosed. The information processing apparatus includes a hard disk drive, an acceleration sensor, a determination section, and a threshold value setup section. The hard disk drive is capable of retracting a head to a data-free landing zone. The acceleration sensor detects acceleration. The determination section obtains high frequency components from acceleration information detected by the acceleration sensor, obtains a vibration level corresponding to the obtained high frequency components, compares the vibration level with a threshold value which has been set up, and determines whether or not there is a necessity to retract the head of the hard disk drive to the data-free landing zone. The threshold value setup section allows a user to change the threshold value and set up the changed threshold value.
摘要翻译：公开了一种信息处理装置。信息处理装置包括硬盘驱动器，加速度传感器，判定部和阈值设定部。硬盘驱动器能够将磁头缩回到无数据的着陆区域。加速度传感器检测加速度。确定部分从由加速度传感器检测到的加速度信息中获得高频分量，获得与获得的高频分量相对应的振动水平，将振动水平与已建立的阈值进行比较，并确定是否存在必须将硬盘驱动器的头部缩回到无数据的着陆区域。阈值设置部分允许用户改变阈值并设置改变的阈值。

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