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1. 发明授权

US5811047A Polyolefin packaging material for drug packaging, method of production thereof and containers for drug packaging 失效
标题翻译：用于药物包装的聚烯烃包装材料，其生产方法和用于药物包装的容器
公开(公告)号：US5811047A
公开(公告)日：1998-09-22
申请号：US617311
申请日：1996-03-18
申请人： Fujio Inoue , Masamitsu Izumi , Shigetoshi Kashiyama , Hiroshi Tanaka
发明人： Fujio Inoue , Masamitsu Izumi , Shigetoshi Kashiyama , Hiroshi Tanaka
IPC分类号： A61J1/00 , A61J1/05 , A61J1/10 , C08F6/00 , C08J5/18 , C08L23/08 , C08L23/12 , B01D3/06
CPC分类号： C08F6/005 , C08J5/18 , C08L23/0815 , A61J1/10 , C08J2323/08 , C08L23/12
摘要： The invention provides a polyolefin drug packaging material characterized in that the content, in the polyolefin, of substances containing 12 to 26 carbon atoms is not more than 150 ppm. The packaging material of the invention is useful because the risk of its reacting with and adversely affecting the drug packaged therewith is minimum.
摘要翻译：本发明提供一种聚烯烃药物包装材料，其特征在于聚烯烃中含有12-26个碳原子的物质的含量不超过150ppm。本发明的包装材料是有用的，因为其与包装的药物的反应和不利影响的风险是最小的。

2. 发明授权

US5423421A Containers having plurality of chambers 失效
标题翻译：具有多个室的容器
公开(公告)号：US5423421A
公开(公告)日：1995-06-13
申请号：US170215
申请日：1993-12-28
申请人： Fujio Inoue , Masamitsu Izumi , Shigetoshi Kashiyama
发明人： Fujio Inoue , Masamitsu Izumi , Shigetoshi Kashiyama
IPC分类号： A61J1/00 , B65D81/32
CPC分类号： A61J1/00 , B65D81/32
摘要： A container having a plurality of chambers chiefly for use in the field of medicine. The body of the container is made of flexible plastics and has partition means dividing the container body into the chambers and permitting communication between the chambers when required. At least one of the chambers is enclosed with a cover to form a closed space therein around the chamber. The cover is made of a flexible film having barrier properties against moisture and gas. The container is inexpensive, has high quality and is efficient to use and easy to dispose of.
摘要翻译： PCT No.PCT / JP93 / 00558 Sec。 371日期：1993年12月28日 102（e）日期1993年12月28日PCT提交1993年4月28日PCT公布。公开号WO93 / 21890 日期：1993年11月11日。具有主要用于医学领域的多个室的容器。容器的主体由柔性塑料制成，并且具有将容器主体分成室的分隔装置，并且当需要时允许室之间的连通。至少一个腔室被封闭以在腔室周围形成封闭的空间。该盖由具有防潮和气体阻隔性的柔性膜制成。容器便宜，质量好，使用方便，易于处理。

3. 发明授权

US06773775B2 Medical multilayer sealant films and methods for producing the same 失效
标题翻译：医用多层密封胶膜及其制造方法
公开(公告)号：US06773775B2
公开(公告)日：2004-08-10
申请号：US10330050
申请日：2002-12-30
申请人： Fujio Inoue , Masamitsu Izumi , Shigetoshi Kashiyama
发明人： Fujio Inoue , Masamitsu Izumi , Shigetoshi Kashiyama
IPC分类号： B32B2732
CPC分类号： B32B27/08 , A61J1/10 , A61J1/2024 , A61J1/2027 , A61J1/2093 , B32B7/12 , B32B27/18 , B32B27/306 , B32B27/32 , B32B2309/105 , B32B2323/046 , B32B2439/80 , Y10T428/1341 , Y10T428/1383 , Y10T428/24967 , Y10T428/24975 , Y10T428/2826 , Y10T428/31913 , Y10T428/31928 , Y10T428/31935
摘要： A multilayer sealant film for use in the medical field at least comprises as its innermost layer a first layer comprising at least one resin selected from the group consisting of linear low-density polyethylene, low-density polyethylene, polypropylene and polybutene-1, and a third layer comprising an ethylene-vinyl alcohol copolymer and laminated to the outer side of the first layer with a second layer serving as an adhesive layer and comprising a resin containing, as a main component, at least one of an amorphous polyolefin, adherent polyolefin and ethylene-vinyl acetate copolymer. The ethylene-vinyl alcohol copolymer forming the third layer functions as a barrier for preventing contaminants from migrating from outside of the third layer toward the first layer (innermost layer). Further, it is possible to improve the formability of the multilayer film since the difference in density between the resin for forming the first layer and the resin for forming the second layer is set to be 0.02 g/cm3 or less.
摘要翻译：用于医疗领域的多层密封膜至少包含最内层，该第一层包含至少一种选自线性低密度聚乙烯，低密度聚乙烯，聚丙烯和聚丁烯-1的树脂，和第三层，其包含乙烯 - 乙烯醇共聚物，并且层压到第一层的外侧，具有用作粘合剂层的第二层，并且包含含有非晶形聚烯烃，粘合性聚烯烃和非粘性聚烯烃中的至少一种的树脂，乙烯 - 乙酸乙烯酯共聚物。形成第三层的乙烯 - 乙烯醇共聚物用作防止污染物从第三层外侧朝向第一层（最内层）迁移的屏障。此外，由于用于形成第一层的树脂与用于形成第二层的树脂之间的密度差设定为0.02g / cm 3以下，所以可以提高多层膜的成形性。

4. 发明授权

US5520975A Medical multilayer film and containers having plurality of chambers 失效
标题翻译：具有多个室的医用多层膜和容器
公开(公告)号：US5520975A
公开(公告)日：1996-05-28
申请号：US313047
申请日：1994-10-04
申请人： Fujio Inoue , Masamitsu Izumi , Shigetoshi Kashiyama
发明人： Fujio Inoue , Masamitsu Izumi , Shigetoshi Kashiyama
IPC分类号： A61L15/24 , A61J1/00 , A61J1/10 , A61J1/20 , B32B27/32 , B65D65/40 , B29D22/00 , B29D23/00 , B32B1/08 , B65D30/02
CPC分类号： A61J1/2093 , B32B27/32 , A61J1/10 , A61J1/2024 , Y10T428/1359 , Y10T428/24992 , Y10T428/31909
摘要： A medical multilayer film chiefly for use in forming medical containers having a plurality of chambers comprises an inner layer, an intermediate layer and an outer layer each made primarily of a polyolefin, the inner layer being formed of resin mixture of an ethylene-alpha-olefin copolymer having a density of 0.930 to 0.945 g/cm.sup.3 and a polypropylene, the intermediate layer including at least one resin mixture layer of resin mixture of an ethylene-alpha-lefin copolymer having a density of 0.920 to 0.945 g/cm.sup.3 and an ethylene-alpha-olefin elastomer having a density of 0.880 to 0.890 g/cm.sup.3 in a mixing ratio by weight of 1:5 to 2:1, the resin mixture layer having a thickness of at least 85% of the overall thickness of the intermediate layer, the outer layer being formed of an ethylene-alpha-olefin copolymer having a density of 0.930 to 0.945 g/cm.sup.3. The film having this structure is excellent in any of heat resistance, transparency, flexibility, impact resistance and easily peelable sealing properties.
摘要翻译： PCT No.PCT / JP94 / 00143 Sec。 371日期：1994年10月4日 102（e）日期1994年10月4日PCT 1994年2月2日PCT PCT。公开号WO94 / 17772 日本1984年8月18日。主要用于形成具有多个室的医疗容器的医用多层膜包括主要由聚烯烃制成的内层，中间层和外层，内层由树脂混合物的密度为0.930至0.945g / cm3的乙烯-α-烯烃共聚物和聚丙烯，所述中间层包括至少一种密度为0.920至0.945的乙烯-α-烯烃共聚物的树脂混合物的树脂混合物层 g / cm 3，密度为0.880〜0.890g / cm 3的乙烯-α-烯烃弹性体，混合比例为1:5〜2:1，树脂混合层的厚度为85〜中间层的总厚度，外层由密度为0.930至0.945g / cm3的乙烯-α-烯烃共聚物形成。具有这种结构的膜在耐热性，透明性，柔韧性，耐冲击性和易剥离密封性方面都是优异的。

5. 发明授权

US5267646A Containers having plurality of chambers 失效
标题翻译：具有多个室的容器
公开(公告)号：US5267646A
公开(公告)日：1993-12-07
申请号：US861985
申请日：1992-06-30
申请人： Fujio Inoue , Yasuo Furuta , Shigetoshi Kashiyama
发明人： Fujio Inoue , Yasuo Furuta , Shigetoshi Kashiyama
IPC分类号： A61J1/00 , A61J1/10 , A61J1/20 , B65D30/22 , B65D81/26 , B65D81/32
CPC分类号： A61J1/2093 , B65D81/266 , B65D81/3261 , B65D81/3266 , A61J1/10 , A61J1/2024 , A61J1/2027 , A61J1/2034 , A61J1/2041
摘要： A container having a plurality of chambers chiefly for use in the field of medicine. The body of the container is made of flexible plastics and has partition means dividing the container body into the chambers and permitting communication between the chambers when required. The container body comprises container portions forming the plurality of chambers and including at least one container portion having no cover and at least one container portion having a cover. The cover encloses the container portion therewith to form a closed space therein around the container portion and is made of a flexible film having barrier properties against moisture and gas. At least one of a desiccant and an oxygen absorber can accommodated in the closes space. The container is inexpensive, has high quality and is efficient to use and easy to dispose of.
摘要翻译： PCT No.PCT / JP91 / 01465 Sec。 371日期：1992年6月30日 102（e）日期1992年6月30日PCT 1991年10月28日PCT公布。出版物WO92 / 08434 日期：1992年5月29日。具有主要用于医学领域的多个室的容器。容器的主体由柔性塑料制成，并且具有将容器主体分成室的分隔装置，并且当需要时允许室之间的连通。容器主体包括形成多个室的容器部分，并且包括至少一个没有盖的容器部分和至少一个具有盖的容器部分。盖子包围其容器部分以在容器部分周围形成封闭空间，并由具有防潮和气体阻挡性能的柔性膜制成。干燥剂和氧吸收剂中的至少一种可以容纳在封闭空间中。容器便宜，质量好，使用方便，易于处理。

6. 发明申请

US20060229583A1 Drug solution filling plastic ampoule and process for producing the same 有权
标题翻译：药液灌装塑胶安瓿及其制作方法
公开(公告)号：US20060229583A1
公开(公告)日：2006-10-12
申请号：US10554094
申请日：2004-04-19
申请人： Katsuyoshi Nagao , Hideshi Okamoto , Masamitsu Izumi , Fujio Inoue
发明人： Katsuyoshi Nagao , Hideshi Okamoto , Masamitsu Izumi , Fujio Inoue
IPC分类号： A61M35/00 , A61B19/00
CPC分类号： B65B3/022 , A61J1/067 , A61M2207/00 , B29C49/04 , B65D1/095
摘要： The present invention provides a drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption/adsorption preventing capability, and a production method for the plastic ampoule. The drug solution filling plastic ampoule (10) according to the present invention includes a container body (11), a fusion-bonded portion (13) which seals a mouth (12) of the container body, and a wrench-off holder tab (14) connected to the fusion-bonded portion. The ampoule (10) is formed from a parison including two or more layers, at least one of which is a functional layer having at least one characteristic property selected from the group consisting of a gas permeation preventing capability, a steam permeation preventing capability, a light ray permeation preventing capability, a drug permeation preventing capability and a drug absorption/adsorption preventing capability. That is, the parison is extruded from a multilayer blow forming die, and then held between lower split mold pieces to be formed into the container body (11). After a drug solution (15) is filled in the container body (11), the mouth (12) is held between upper split mold pieces to form the fusion-bonded portion (13) and the holder tab (14). Thus, the plastic ampoule is provided.
摘要翻译：本发明提供一种具有气体，蒸汽和光线阻隔性，药物渗透防止能力和吸收/吸附防止能力的药液填充塑料安瓿，以及塑料安瓿的制造方法。根据本发明的填充塑料安瓿（10）的药液包括容器主体（11），密封容器主体的口部（12）的熔接部分（13）和扳手保持器突片 14）连接到熔接部分。安瓿（10）由包括两层或更多层的型坯形成，其中至少一层是具有选自以下的至少一种特性的功能层：气体渗透防止能力，防蒸汽渗透能力，光线透过防止能力，药物渗透防止能力和药物吸收/吸附防止能力。也就是说，型坯从多层吹塑成形模挤出，然后保持在下成型模具片之间，形成容器本体（11）。在药液（15）被填充到容器主体（11）中之后，口（12）被保持在上模制件之间，以形成熔接部分（13）和夹持片（14）。因此，提供塑料安瓿。

7. 发明授权

US5922461A Method for inhibiting adsorption of container-derived contaminants on drugs and contamination-inhibitory containers 失效
标题翻译：抑制容器来源的污染物对药物和污染抑制容器的吸附的方法
公开(公告)号：US5922461A
公开(公告)日：1999-07-13
申请号：US849618
申请日：1997-06-05
申请人： Fujio Inoue , Masamitsu Izumi , Satoru Hayashi , Chieko Yoshida
发明人： Fujio Inoue , Masamitsu Izumi , Satoru Hayashi , Chieko Yoshida
IPC分类号： A61J1/00 , B65D81/20 , B65D81/24 , C09K15/04
CPC分类号： B65D81/2069 , A61J1/00 , B65D81/24 , Y10S206/828 , Y10T428/1314 , Y10T428/1352 , Y10T428/292
摘要： This invention provides a method for inhibiting adsorption of container-derived contaminants on a powdery or solid drug which comprises establishing a lower alcohol vapor phase within a container made, at least in part, of rubber or a plastic material. The method inhibits adsorption of container-derived substances on a drug to preclude development of insoluble particulate matter owing to said adsorption in an aqueous solution prepared extemporaneously without causing loss of the drug and avoiding the toxic effect of decomposition or degradation of the drug, thus insuring a long-term trouble-free stable shelf-life of the drug.
摘要翻译： PCT No.PCT / JP95 / 02487。 371日期：1997年6月5日 102（e）日期1997年6月5日PCT提交1995年12月4日PCT公布。公开号WO96 / 17578 日期1996年6月13日本发明提供了一种抑制容器衍生的污染物对粉末或固体药物的吸附的方法，其包括在至少部分由橡胶或塑料材料制成的容器内建立低级醇汽相。该方法抑制容器衍生物质对药物的吸附，以防止由于在临时制备的水溶液中的所述吸附而引起的不溶性颗粒物质的发生，而不会引起药物的损失并避免药物的分解或降解的毒性作用，从而确保药物的长期无故障稳定保质期。

8. 发明授权

US5610170A Package form for bicarbonate-containing powdery pharmaceutical compositions and a method of stabilizing the compositions 失效
标题翻译：含碳酸氢盐粉末药物组合物的包装形式和稳定组合物的方法
公开(公告)号：US5610170A
公开(公告)日：1997-03-11
申请号：US307804
申请日：1995-03-14
申请人： Fujio Inoue , Masamitsu Izumi , Satoru Hayashi
发明人： Fujio Inoue , Masamitsu Izumi , Satoru Hayashi
IPC分类号： A61J1/00 , A61J3/07 , A61M1/16 , B65D75/38 , B65D81/24 , B65D81/26
CPC分类号： A61J1/00 , A61M1/167 , B65D75/38 , B65D81/24 , B65D81/266
摘要： The invention provides a method and a package form for insuring a stabilized bicarbonate-containing pharmaceutical composition, the method comprises filling the bicarbonate-containing powdery pharmaceutical composition in a moisture- and gas-permeable plastic container, wrapping the so-filled container in a moisture- and gas-impermeable plastic wrapper and carrying out at least one procedure selected from the group consisting of the procedure of introducing a carbon dioxide gas into a space between the container and wrapper, the procedure of disposing a carbon dioxide-liberating deoxygenating agent in the space and the procedure of disposing a desiccant previously saturated with carbon dioxide gas by way of adsorption in the space. In accordance with the invention, the inherent objects of incorporating the bicarbonate can be accomplished without inducing the aging and degradation of the bicarbonate-containing powdery pharmaceutical composition.
摘要翻译： PCT No.PCT / JP94 / 00041 Sec。 371日期：1995年3月14日 102（e）1995年3月14日PCT PCT 1994年1月14日PCT公布。 WO94 / 16663 PCT出版物日期1994年8月4日本发明提供了一种用于确保含稳定碳酸氢盐的药物组合物的方法和包装形式，所述方法包括将含碳酸氢盐的粉末状药物组合物填充在透湿气体的塑料容器中，填充容器在防潮和不透气的塑料包装中并且执行至少一种选自以下的步骤：将二氧化碳气体引入到容器和包装物之间的空间中的方法，将二氧化碳 - 在空间中释放脱氧剂，并且通过在空间中通过吸附处理先前饱和二氧化碳气体的干燥剂的步骤。根据本发明，可以在不引起含碳酸氢盐的粉末状药物组合物的老化和降解的情况下实现掺入碳酸氢盐的固有目的。

9. 发明授权

US5762944A Antithrombotic resin, antithrombotic tube, antithrombotic film and antithrombotic coat 失效
标题翻译：抗血栓形成树脂，抗血栓形成管，抗血栓膜和抗血栓外套
公开(公告)号：US5762944A
公开(公告)日：1998-06-09
申请号：US376431
申请日：1995-01-23
申请人： Fujio Inoue , Masamitsu Izumi , Satoru Hayashi , Nobuhisa Tsutsumi , Kunihiro Fukuoka
发明人： Fujio Inoue , Masamitsu Izumi , Satoru Hayashi , Nobuhisa Tsutsumi , Kunihiro Fukuoka
IPC分类号： A61L27/18 , A61L27/34 , A61L27/54 , A61L33/00 , C08G18/10 , C08G18/48
CPC分类号： C08G18/4854 , A61L27/18 , A61L27/34 , A61L27/54 , A61L33/0005 , A61L33/0041 , C08G18/10 , C08G18/4833 , C08G18/4841 , A61L2300/42 , Y10S514/822
摘要： The invention presents an antithrombotic resin which is prepared by blending at least one type of antithrombotics, in polyurethane or polyurethane urea polymerized by using at least one type of polyether diol selected from the group consisting of polyol containing a polyoxyethylene group expressed in formula (I) .paren open-st.CH.sub.2 CH.sub.2 O.paren close-st..sub.n (I) (where n is a number-average degree of polymerization of 1 to 100) and polyol containing a polyoxyethylene group expressed in formula (II) .paren open-st.CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 O.paren close-st..sub.m(II) (where m is a number-average degree of polymerization of 1 to 100). This antithrombotic resin is capable of eluting the antithrombotic in the blood for a long time at high concentration. By using the antithrombotic resin of the invention, antithrombotic tube, antithrombotic film, antithrombotic coat, and others are obtained.
摘要翻译：本发明提供一种抗血栓形成树脂，其通过使用至少一种选自由式（I）表示的聚氧乙烯基团的多元醇组成的组中的聚醚二醇聚合而成的聚氨酯或聚氨酯脲混合至少一种抗血栓形成剂， +545CH 2 CH 2 O + 546 n（I）（其中n是1〜100的数均聚合度）和式（II）表示的含有聚氧乙烯基团的多元醇+545CH 2 CH 2 CH 2 CH 2 O +546μm（II）（其中m为数均聚合度为1〜100）。该抗血栓树脂能够在高浓度下长时间洗脱血液中的抗血栓形成。通过使用本发明的抗血栓形成树脂，可以获得抗血栓形成管，抗血栓形成膜，抗血栓形成物等。

10. 发明授权

US08377029B2 Drug solution filling plastic ampoule and process for producing the same 有权
标题翻译：药液灌装塑胶安瓿及其制作方法
公开(公告)号：US08377029B2
公开(公告)日：2013-02-19
申请号：US10554094
申请日：2004-04-19
申请人： Katsuyoshi Nagao , Hideshi Okamoto , Masamitsu Izumi , Keiichi Kawakami , Fujio Inoue
发明人： Katsuyoshi Nagao , Hideshi Okamoto , Masamitsu Izumi , Keiichi Kawakami , Fujio Inoue
IPC分类号： A61B19/00 , A61M5/28 , A61M5/00 , B65D53/00 , B65D53/06 , B65D1/09
CPC分类号： B65B3/022 , A61J1/067 , A61M2207/00 , B29C49/04 , B65D1/095
摘要： A drug solution filling plastic ampoule having gas, steam and light ray barrier properties, a drug permeation preventing capability and an absorption/adsorption preventing capability, and a production method for the plastic ampoule. The drug solution filling plastic ampoule includes a container body, a fusion-bonded portion which seals a mouth of the container body, and a wrench-off holder tab connected to the fusion-bonded portion. The ampoule is formed from a parison including two or more layers, at least one of which is a functional layer having at least one characteristic property selected from the group consisting of a gas permeation preventing capability, a steam permeation preventing capability, a light ray permeation preventing capability, a drug permeation preventing capability and a drug absorption/adsorption preventing capability.
摘要翻译：填充具有气体，蒸汽和光线阻隔性能的药物溶液，药物渗透防止能力和吸收/吸附防止能力的药液以及塑料安瓿的制造方法。填充塑料安瓿的药液包括容器主体，密封容器主体的口部的熔接部分和连接到熔接部分的扳手保持片。安瓿由包括两层或更多层的型坯形成，其中至少一层是具有选自以下的至少一种特性的功能层：气体渗透防止能力，防蒸气渗透能力，光线渗透性防止能力，药物渗透防止能力和药物吸收/吸附防止能力。

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