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1. 发明授权

US5856200A Method and device for metering liquids 失效
标题翻译：液体计量方法和装置
公开(公告)号：US5856200A
公开(公告)日：1999-01-05
申请号：US634366
申请日：1996-04-18
申请人： Friedemann Krause , Sigmar Klose
发明人： Friedemann Krause , Sigmar Klose
IPC分类号： G01F11/00 , B01L3/02 , G01B11/10 , G01F1/66 , G01F3/00 , G01F13/00 , G01F22/00 , G01N33/48 , G01N35/10 , G06T1/00
CPC分类号： B01L3/0244 , G01F1/661 , G01F22/00 , G01F3/00 , G01N2035/1037 , Y10T436/2575
摘要： The present invention relates to a method and a device for metering liquids, wherein the volume of a droplet of a sample liquid is determined by means of optical measuring. The liquid to be metered is brought into contact with a transfer element so that a droplet adheres to the transfer element. The transfer element and the liquid adhering thereto are illuminated from one or several directions and the resulting images are displayed on an optical sensor. The liquid volume is determined on the basis of these images. Metering is accomplished by transferring the liquid volume adhering to the transfer element into an analysis vessel.
摘要翻译：本发明涉及一种用于计量液体的方法和装置，其中通过光学测量来确定样品液体的液滴的体积。要计量的液体与转印元件接触，使得液滴附着到转印元件上。传输元件和粘附在其上的液体从一个或多个方向照射，并将所得到的图像显示在光学传感器上。基于这些图像确定液体体积。通过将粘附到转移元件的液体体积转移到分析容器中来进行计量。

2. 发明授权

US4690899A Process and device for carrying out analytical determinations 失效
标题翻译：用于进行分析测定的过程和设备
公开(公告)号：US4690899A
公开(公告)日：1987-09-01
申请号：US751368
申请日：1985-07-02
申请人： Sigmar Klose , Manfred Pasch , Helmut Schlumberger , Wolfgang Kleemann , Friedhelm Vieth
发明人： Sigmar Klose , Manfred Pasch , Helmut Schlumberger , Wolfgang Kleemann , Friedhelm Vieth
IPC分类号： G01N33/48 , G01N21/07 , G01N33/543 , G01N33/563 , G01N33/68 , G01N21/11
CPC分类号： G01N21/07 , G01N33/54366 , G01N33/563 , G01N33/6857 , Y10T436/111666
摘要： In a process for carrying out an analytical determination by mixing and incubating a sample liquid with at least one dry reagent which is soluble therein to form a reaction mixture liquid and measuring a parameter in the reaction mixture liquid, the sample liquid is first transported along a transport path to the soluble dry reagent and the resulting reaction mixture liquid then further transported along the transport path. The further transporting of the reaction mixture liquid along the transport path is under the influence of a force-change cycle in which centrifugal force and a further force alternately predominate to determine the direction of the further transporting along the transport path. At least one further liquid is transported on another path, part of which is separate from and part of which is common with the transport path, by the force-change cycle in such a manner that at least two of the liquids pass through the common part of the transport path chronologically separated.
摘要翻译：在通过将样品液体与可溶于其中的至少一种干试剂混合并孵育以形成反应混合物液体并测量反应混合物液体中的参数的方法进行分析测定的过程中，首先将样品液体沿着向可溶性干试剂的输送路径和所得到的反应混合物液体进一步沿输送路径输送。反应混合物液体沿着输送路径的进一步输送受力变化循环的影响，其中离心力和进一步的力交替占主导地位，以确定沿输送路径进一步输送的方向。至少一个另外的液体在另一个路径上被传送，其中一部分液体通过力 - 变化循环分开并且其一部分与输送路径共同，使得至少两个液体通过公共部分的运输路径按时间顺序分隔。

3. 发明授权

US4329062A Polychromatic photometer 失效
标题翻译：多色光度计
公开(公告)号：US4329062A
公开(公告)日：1982-05-11
申请号：US164520
申请日：1980-07-02
申请人： Hans-Peter Haar , Hermann Edelmann , Sigmar Klose
发明人： Hans-Peter Haar , Hermann Edelmann , Sigmar Klose
IPC分类号： G01N21/27 , G01N21/13 , G01N21/25
CPC分类号： G01N21/13 , G01N21/253
摘要： In a polychromatic photometer a sample wheel containing angularly spaced sample compartments and a filter wheel containing angularly spaced filters are rotated by a common drive arrangement so that the sample compartments and filters are in turn rotated through and aligned with the optical path of a photometric measuring device. The number of sample compartments is different from the number of filters. The number of sample compartments and the number of filters are not evenly divisible by a common integer. The ratio of the angular velocity of the sample wheel to the angular velocity of the filter wheel is substantially equal to the ratio of the number of filters to the number of sample compartments.
摘要翻译：在多色光度计中，包含角度间隔开的样品室和包含角度间隔开的滤光器的滤光轮的样品轮通过公共驱动装置旋转，使得样品室和滤光器又旋转通过并与光度测量装置的光路对准。样品室的数量与过滤器的数量不同。样本室的数量和过滤器的数量不能被公共整数均分。样品轮的角速度与滤光轮的角速度的比率基本上等于滤光片数与样品室数之比。

4. 发明授权

US4268628A Method for the determination of .alpha.-amylase 失效
标题翻译：测定α-淀粉酶的方法
公开(公告)号：US4268628A
公开(公告)日：1981-05-19
申请号：US22011
申请日：1979-03-19
申请人： Sigmar Klose , Hans-Georg Batz , Michael Stoltz , Alexander Hagen , Gunter Weimann
发明人： Sigmar Klose , Hans-Georg Batz , Michael Stoltz , Alexander Hagen , Gunter Weimann
IPC分类号： G01N33/50 , C08B31/00 , C12Q1/40 , G01N33/02
CPC分类号： C08B31/00 , C12Q1/40 , C12Q2334/00 , Y10S435/805
摘要： Novel method for the determination of .alpha.-amylase which method comprises contacting a sample suspected of containing .alpha.-amylase with a starch derivative carrying a substituent capable of dyestuff-forming coupling; separating from the resulting starch-containing phase the low molecular weight soluble fission products formed by splitting of said starch derivative by .alpha.-amylase; coupling the said couplable substituent with another dyestuff forming component; and measuring the dyestuff so formed as a measure of the initial .alpha.-amylase content.
摘要翻译：用于测定α-淀粉酶的新方法，该方法包括使怀疑含有α-淀粉酶的样品与携带能够进行染料形成偶联的取代基的淀粉衍生物接触; 从所得含淀粉相中分离出由α-淀粉酶分解所述淀粉衍生物形成的低分子量可溶裂解产物; 将所述可连接取代基与另一种形成染料的成分偶联; 并测量如此形成的染料作为初始α-淀粉酶含量的量度。

5. 发明授权

US4814144A Centrifugal analyzer rotor unit and insert elements 失效
标题翻译：离心分析仪转子单元和插入元件
公开(公告)号：US4814144A
公开(公告)日：1989-03-21
申请号：US559521
申请日：1983-12-08
申请人： Hermann Edelmann , Anton Pasch , Sigmar Klose , Hans-Peter Haar , Karlheinz Mann
发明人： Hermann Edelmann , Anton Pasch , Sigmar Klose , Hans-Peter Haar , Karlheinz Mann
IPC分类号： G01N33/48 , B01F5/06 , B01F13/00 , B04B5/04 , G01N21/07 , G01N35/00 , G01N37/00
CPC分类号： B01L3/5027 , B01F15/0233 , B01F5/0641 , B01F5/0682 , B01F5/0694 , B04B5/0407 , G01N21/07 , B01F13/0059 , B01L2200/028 , B01L2200/16 , B01L2300/021 , B01L2300/0806 , B01L2400/0409
摘要： A rotor unit for a centrifugal analyzer comprises a rotatably-driven circular rotor base; and a rotor head comprising a plurality of insert elements each having at least one chamber sample for the reception of a sample liquid, at least one measuring chamber radially outwardly from the associated sample chamber for the measurement of characteristic parameters for the detection of components of the sample, at least one liquid channel connecting the sample chamber with the measuring chamber and each insert element is releasably mounted on the rotor base at any one of a plurality of different selectable angular positions wherein the insert element is positionally stable when the rotor base is rotating.
摘要翻译：用于离心分析器的转子单元包括可旋转驱动的圆形转子基座; 以及转子头，其包括多个插入元件，每个插入元件具有至少一个用于接收样品液体的室样品，至少一个从相关联的样品室径向向外的测量室，用于测量用于检测样品的组分的特征参数样品，将样品室与测量室连接的至少一个液体通道和每个插入元件可以以多个不同的可选角度位置中的任何一个可释放地安装在转子基座上，其中当转子基座旋转时，插入元件位置稳定。

6. 发明授权

US4101381A Method and reagent for the determination of substances forming hydrogen peroxide 失效
标题翻译：用于测定形成过氧化氢的物质的方法和试剂
公开(公告)号：US4101381A
公开(公告)日：1978-07-18
申请号：US754878
申请日：1976-12-27
申请人： Sigmar Klose , Ulfert Deneke , Erich Haid , Gunter Weimann
发明人： Sigmar Klose , Ulfert Deneke , Erich Haid , Gunter Weimann
IPC分类号： G01N33/50 , C12Q1/26 , C12Q1/28 , C12Q1/60 , G01N33/00 , G01N31/14
CPC分类号： C12Q1/60 , C12Q1/28 , C12Q2326/00 , C12Q2326/32
摘要： In a conventional method for the quantitative determination of substances, particularly in serum, which, by action of an oxidase thereon, combine with oxygen to form hydrogen peroxide and wherein the hydrogen peroxide formed is converted, in the presence of methanol and catalase, to formaldehyde, the formaldehyde is reacted with hydrazone in the presence of ferric chloride, and the dye thus formed is determined photometrically, the improvement comprising using as the hydrazone, 3-methyl-2-sulfonylbenzothiazolone-hydrazone; use of this hydrazone results in the formation of a very easily soluble dye and is suited for use in automatic analyzers.
摘要翻译：在用于定量测定物质的常规方法中，特别是在血清中，通过其上的氧化酶的作用与氧结合形成过氧化氢，并且其中形成的过氧化氢在甲醇和过氧化氢酶存在下转化成甲醛，在氯化铁存在下，甲醛与腙反应，由此形成的染料用光度法测定，其改进包括使用3-甲基-2-磺酰基苯并噻唑酮 - 腙; 使用该腙导致形成非常容易溶解的染料，并且适用于自动分析仪。

7. 发明授权

US5338688A Method for the metered application of a biochemical analytical liquid to a target 失效
标题翻译：将生化分析液计量应用于目标的方法
公开(公告)号：US5338688A
公开(公告)日：1994-08-16
申请号：US19828
申请日：1993-02-19
申请人： Rolf Deeg , Eberhard Maurer , Reiner Babiel , Sigmar Klose , Bernhard Kopfer
发明人： Rolf Deeg , Eberhard Maurer , Reiner Babiel , Sigmar Klose , Bernhard Kopfer
IPC分类号： C12M1/34 , B01L3/02 , C12Q1/26 , C12Q1/28 , C40B60/14 , G01N1/00 , G01N33/543 , G01N35/00 , G01N35/10 , G01N1/10
CPC分类号： B01L3/0268 , B82Y30/00 , G01N35/1002 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00677 , C40B60/14 , G01N2035/1041 , G01N35/00009 , G01N35/0099 , Y10T436/110833 , Y10T436/112499 , Y10T436/2575
摘要： A method for the metered application of a biochemical analytical liquid to a target, wherein the liquid is ejected in small quantities on to the target through a jet from a jet chamber by a procedure in which a partial volume of the liquid in the jet chamber is evaporated and expanded for a short time whenever a quantity of the liquid is to be ejected. The invention further relates to a device with a disposable jet element which contains prepackaged analytical liquid.
摘要翻译：一种用于向目标物质计量施用生物化学分析液体的方法，其中通过喷射室中的液体的部分体积是通过喷射室的射流将液体少量喷射到靶上的方法每当要排出一定量的液体时，蒸发并膨胀短时间。本发明还涉及一种具有一次性喷射元件的装置，其包含预包装的分析液体。

8. 发明授权

US4985204A Device for carrying out a heterogeneous reaction 失效
标题翻译：用于进行异质反应的装置
公开(公告)号：US4985204A
公开(公告)日：1991-01-15
申请号：US159253
申请日：1988-02-23
申请人： Sigmar Klose , Klaus Erler , Wolfgang Uhl , Manfred Baier
发明人： Sigmar Klose , Klaus Erler , Wolfgang Uhl , Manfred Baier
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： B01L3/502 , G01N33/54366
摘要： The present invention provides a device for carrying out a heterogeneous reaction for the determination of a component of a sample liquid on a first capillary action carrier present in a measurement chamber, to which carrier adheres at least one non-soluble reagent, wherein at least one soluble reagent is present on a second capillary action carrier in a first pre-chamber, which carrier is in capillary contact with the capillary action carrier in the measurement chamber, which first pre-chamber is connected via a first capillary with a first application chamber to be filled from outside through a filling opening and the measurement chamber is also connected with a waste chamber by a capillary arrangement through which can only flow a liquid under a predetermined gravitational force into the measurement chamber.
摘要翻译：本发明提供一种用于进行非均相反应的装置，用于确定存在于测量室中的第一毛细作用载体上的样品液体的组分，载体粘附至至少一种不溶性试剂，其中至少一种可溶性试剂存在于第一预处理室中的第二毛细管作用载体上，该第一预处理室与测量室中的毛细管作用载体毛细接触，该第一预先室经由第一毛细管与第一施加室连接，从外部通过填充开口填充，并且测量室还通过毛细管装置与废物室连接，通过该毛细管装置，只能将液体以预定重力流动到测量室中。

9. 发明授权

US4898832A Process for carrying out analytical determinations and means for carrying out this process 失效
标题翻译：进行分析确定的过程和进行此过程的手段
公开(公告)号：US4898832A
公开(公告)日：1990-02-06
申请号：US147610
申请日：1988-01-25
申请人： Sigmar Klose , Fritz Stahler
发明人： Sigmar Klose , Fritz Stahler
IPC分类号： G01N21/78 , B04B5/04 , C12Q1/00 , G01N33/53
CPC分类号： B01L3/5027 , B04B5/0407 , C12Q1/00 , G01N33/5302 , B01L2200/16 , B01L2300/0809 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0481 , B01L2400/0655 , B01L3/502738 , Y10T436/111666
摘要： A process for carrying out an analytical determination by mixing and incubating a sample solution with at least one reagent and measuring a parameter in the reaction mixture, the sample solution being transported from an application point to a measurement point, wherein a sample solution is first transported to a soluble dry reagent, with at least partial dissolving of the latter, and then further transported to a measurement point, the transport taking place by two different forces, whereby, at least on a part of the transport path, it is brought about by a surface force acting on the solution as a first force, which, for the regulation of the transport velocity or transport direction, is superimposed by a centrifugal force and/or pressure force as a second force which, depending upon which transport state of the fluid is to be adjusted, is made greater or smaller than the first force.
摘要翻译：一种用于通过将样品溶液与至少一种试剂混合并培养并测量反应混合物中的参数进行分析测定的方法，所述样品溶液从应用点运送到测量点，其中样品溶液首先运输到可溶性干试剂，至少部分溶解后者，然后进一步输送到测量点，运输通过两个不同的力进行，由此至少在输送路径的一部分上由作为第一力的作用于溶液的表面力，其用于调节输送速度或输送方向，通过作为第二力的离心力和/或压力力叠加，这取决于流体的哪个输送状态要被调整，比第一力更大或更小。

10. 发明授权

US4670383A Immune-chemical measurement process for haptens and proteins 失效
标题翻译：半抗原和蛋白质的免疫化学测量方法
公开(公告)号：US4670383A
公开(公告)日：1987-06-02
申请号：US775596
申请日：1985-09-13
申请人： Manfred Baier , Helmut Jering , Sigmar Klose
发明人： Manfred Baier , Helmut Jering , Sigmar Klose
IPC分类号： G01N33/541 , G01N33/543 , G01N33/563 , G01N33/564 , G01N33/94 , G01N33/53 , G01N33/537
CPC分类号： G01N33/564 , G01N33/541 , G01N33/54306 , G01N33/563 , G01N33/9453 , Y10S435/81 , Y10S435/962 , Y10S435/971 , Y10S435/975 , Y10S436/808 , Y10S436/824
摘要： This invention describes a process for immuno-chemical quantitative determination of immunologically active substances. The method involves a first incubation of a sample containing the active substance with a labelled binder, which contains an antibody or antibody fragment. After complexing has taken place, solid phase bound active substance identical to the substance being quantitatively determined is added. The solid phase bound substance binds with free binder, and the solid and liquid phases are separated. A second antibody which is specific either to antibody or the solid phase antibody-substance complex is then added to the liquid phase. This second antibody is non cross-reactive with individual complex components. The amount of labelled first antibody bound to second antibody is then determined.
摘要翻译：本发明描述了免疫学定量测定免疫活性物质的方法。该方法包括将含有活性物质的样品与含有抗体或抗体片段的标记的粘合剂进行第一次孵育。发生络合后，加入与待定量物质相同的固相结合活性物质。固相结合的物质与游离的粘合剂结合，并分离固相和液相。然后将与抗体或固相抗体 - 物质复合物特异性的第二抗体加入到液相中。该第二抗体与单个复合组分是非交叉反应的。然后测定与第二抗体结合的标记的第一抗体的量。

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