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1. 发明专利

JP2005239737A Method for producing new pharmaceutical composition for ameliorating quality of life and use of the composition 审中-公开
标题翻译：生产用于调节生活质量和组合物使用的新药物组合物的方法
公开(公告)号：JP2005239737A
公开(公告)日：2005-09-08
申请号：JP2005152478
申请日：2005-05-25
申请人： Freunt Ind Co Ltd , Nrl Pharma Inc , フロイント産業株式会社 , 株式会社Nrlファーマ
发明人： ANDO KUNIO , SUZUKI SEIKICHI , FUKUDA AKIO , KAWAI JURI , OGASAWARA TOSHICHIKA , IGUSA KAZUO
IPC分类号： A61K47/32 , A61K9/30 , A61K9/32 , A61K9/36 , A61K9/38 , A61K9/50 , A61K38/00 , A61K38/46 , A61K38/55 , A61K39/395 , A61K47/38 , A61K47/42 , A61K47/46 , A61P1/04 , A61P3/04 , A61P3/10 , A61P9/12 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/22 , A61P35/00 , A61P37/02
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a medicinal composition passing through, without being decomposed, the stomach causing decomposition therein and first dissolved in the duodenum when orally administering a bioactive protein as an active ingredient to improve clinical conditions and to promote health. SOLUTION: The method for producing an enteric coated preparation comprises covering the surface layer of powder, granule or tablet containing, as an active ingredient, one or more selected from bioactive proteins such as enzyme, lactoferrin, immunoglobulin, lysozyme, amylase inhibitor of protein, protease inhibitor of protein, and the like, with an enteric coating film using a material selected, as a raw material of the covering coating film, from zein, shellac, hydroxymethylcellulose-phthalate, carboxymethylethylcellulose, cellulose acetate phthalate, methacrylate copolymer, water-insoluble ethyl cellulose, and aminoalkylmethacrylate copolymer. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：待解决的问题：提供一种药物组合物的制备方法，其通过而不分解胃，引起其中的分解，并且当口服施用生物活性蛋白作为活性成分时首先溶解在十二指肠中，以改善临床条件，促进健康。解决方案：肠溶包衣制剂的制备方法包括将含有活性成分的一种或多种选自生物活性蛋白如酶，乳铁蛋白，免疫球蛋白，溶菌酶，淀粉酶抑制剂的粉末，颗粒或片剂的表面层蛋白质的蛋白酶抑制剂等，使用选自玉米蛋白，虫胶，羟甲基纤维素邻苯二甲酸酯，羧甲基乙基纤维素，乙酸邻苯二甲酸纤维素，甲基丙烯酸酯共聚物等作为覆盖涂膜的原料的肠溶衣膜，水不溶性乙基纤维素和氨基烷基甲基丙烯酸酯共聚物。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2010229102A Sleep disorder-improving agent 审中-公开
标题翻译：睡眠障碍改善剂
公开(公告)号：JP2010229102A
公开(公告)日：2010-10-14
申请号：JP2009079832
申请日：2009-03-27
申请人： Nrl Pharma Inc , 株式会社Nrlファーマ
发明人： KOBAYASHI YUKITAKA , SHIMIZU TOMO , TAMAOKI YUKIMICHI , ANDO KUNIO
IPC分类号： A61K38/16 , A61K8/64 , A61K47/10 , A61K47/26 , A61P3/04 , A61P17/02 , A61P17/06 , A61P17/16 , A61P25/20 , A61P37/08 , A61Q19/00 , A61Q19/10
摘要： PROBLEM TO BE SOLVED: To provide a sleep disorder-improving agent which can safely mitigate sleep disorder and sleep abnormality, exhibit a leaning effect and a skin care effect, and prevent/treat intractable skin diseases.
SOLUTION: This sleep disorder-improving agent prepared into bathing agents and cosmetics or external preparations is characterized by containing lactoferrin having a skin temperature-rising action and skin immune system-activating and normalizing action as an active ingredient. In addition, it is preferable to use together with a saccharide such as sucrose, maltose, lactose, glucose, fructose, mannitol, maltitol, sorbitol and xylose.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供可以安全地减轻睡眠障碍和睡眠异常的睡眠障碍改善剂，具有倾斜效果和护肤效果，并且预防/治疗难治性皮肤病。解决方案：制备成洗浴剂和化妆品或外用制剂的睡眠障碍改善剂的特征在于含有具有皮肤升温作用的乳铁蛋白和作为活性成分的皮肤免疫系统活化和正常化作用。此外，优选与蔗糖，麦芽糖，乳糖，葡萄糖，果糖，甘露糖醇，麦芽糖醇，山梨糖醇，木糖等糖类一起使用。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2005112835A Method for producing new medicinal composition and processed food for treating hypertension 审中-公开
标题翻译：用于生产新药物组合物的方法和加工食品用于治疗高血压
公开(公告)号：JP2005112835A
公开(公告)日：2005-04-28
申请号：JP2003383113
申请日：2003-10-08
申请人： Nrl Pharma Inc , 株式会社Nrlファーマ
发明人： HARADA YOSHIMORI , HAYASHIDA KENICHIRO , TAKEUCHI TAKASHI , SHIMIZU HIROHIKO , ANDO KUNIO
IPC分类号： A23L1/30 , A23L1/302 , A23L1/305 , A61K31/201 , A61K31/355 , A61K31/375 , A61K33/06 , A61K35/60 , A61K36/00 , A61K36/18 , A61K36/896 , A61K38/00 , A61P9/12 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To create a new hypotensive drug based on a new mechanism of action. SOLUTION: By using rats as model animals, the administration of lactoferrin significantly lowers blood pressure dose dependently without affecting the number of heart beats. This hypotensive effect of the lactoferrin which is a part of researches of its physiological activities, is a new finding which has not been described in any of research reports and patent literatures associated with the lactoferrin, and is useful for the blood pressure control of hypertensive patients. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：根据新的行动机制创造一种新的降血压药物。
解决方案：通过使用大鼠作为模型动物，乳铁蛋白的施用显着降低血压剂量依赖性而不影响心跳次数。作为其生理活动研究的一部分的乳铁蛋白的这种降血压作用是在与乳铁蛋白相关的研究报告和专利文献中没有描述的新发现，并且可用于高血压患者的血压控制。版权所有（C）2005，JPO＆NCIPI

4. 发明专利

JP2005068060A Pharmaceutical composition containing lactoferrin and method for producing processed food containing lactoferrin 审中-公开
标题翻译：含有LACTOFERRIN的药物组合物和生产含有LACTOFERRIN的加工食品的方法
公开(公告)号：JP2005068060A
公开(公告)日：2005-03-17
申请号：JP2003299214
申请日：2003-08-22
申请人： Nrl Pharma Inc , 株式会社Nrlファーマ
发明人： ANDO KUNIO
IPC分类号： A23L1/30 , A23L1/302 , A61K38/16 , A61K45/00 , A61P1/02 , A61P1/04 , A61P1/10 , A61P1/16 , A61P3/06 , A61P7/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P13/04 , A61P17/00 , A61P19/02 , A61P25/28 , A61P31/04 , A61P35/00 , A61P37/08 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a material capable of potentiating the efficacy of other medicinal ingredients used in alternative medicine. SOLUTION: An enteric preparation as a pharmaceutical composition is provided. This enteric preparation is obtained by incorporating an appropriate amount of lactoferrin in a combination of various active ingredients for alternative medicine, whose efficacies have been confirmed for morbid conditions respectively. This enteric preparation is highly effective in potentiating their efficacies. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供能够增强替代医学中使用的其它药物成分的功效的材料。提供作为药物组合物的肠溶制剂。这种肠溶制剂通过将适量的乳铁蛋白并入各种用于替代药物的活性成分的组合而获得，其功效已被证实为病态。这种肠溶制剂在增强其功效方面非常有效。版权所有（C）2005，JPO＆NCIPI

5. 发明专利

JP2010138160A Liver function protecting pharmaceutical formulation 审中-公开
标题翻译：肝功能保护药物制剂
公开(公告)号：JP2010138160A
公开(公告)日：2010-06-24
申请号：JP2009156312
申请日：2009-06-30
申请人： Nrl Pharma Inc , Tottori Univ , 国立大学法人鳥取大学 , 株式会社Nrlファーマ
发明人： TAKEUCHI TAKASHI , SUGIYAMA AKIHIKO , ANDO KUNIO , SHIMIZU HIROHIKO
IPC分类号： A61K38/16 , A61K47/34 , A61K47/48 , A61P1/16
摘要： PROBLEM TO BE SOLVED: To provide a lactoferrin conjugate having reduced antigenicity, pepsin resistance, and a prolonged in-vivo lifetime and being highly clinically useful as a liver function protecting pharmaceutical formulation.
SOLUTION: A branched non-peptidic hydrophilic polymer/lactoferrin conjugate represented by the formula (wherein LF is lactoferrin; NHS is an N-hydroxysuccinimidyl group; POLY is a poly(alkylene glycol) having a molecular weight (number-average molecular weight) of 10,000-60,000 (Da); and n is an integer of 1-10).
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供具有降低的抗原性，胃蛋白酶抗性和延长的体内寿命的乳铁蛋白缀合物，并且作为保护药物制剂的肝功能在临床上是有用的。解决方案：由式（其中LF是乳铁蛋白; NHS是N-羟基琥珀酰亚胺基）代表的支链非肽亲水性聚合物/乳铁蛋白缀合物; POLY是具有分子量（数均分子量重量）为10,000-60,000（Da）; n为1-10的整数）。版权所有（C）2010，JPO＆INPIT

6. 发明专利

JP2006219415A Age-related eye disease ameliorant, medicine composition, food and beverage, cosmetic and feed containing the same 有权
标题翻译：与年龄相关的眼睛疾病，药物组合物，食品和饮料，化妆品和含有它们的饲料
公开(公告)号：JP2006219415A
公开(公告)日：2006-08-24
申请号：JP2005033913
申请日：2005-02-10
申请人： Nrl Pharma Inc , Tokyo Medical & Dental Univ , 国立大学法人東京医科歯科大学 , 株式会社Nrlファーマ
发明人： YAMASHITA YASUO , ITO KEIKO , ANDO KUNIO , SHIMIZU TOMO
IPC分类号： A61K38/00 , A23K1/16 , A23L1/30 , A61K8/00 , A61K8/96 , A61P27/02 , A61P27/06 , A61P27/12
摘要： PROBLEM TO BE SOLVED: To obtain a medicine, which is effective for preventing or treating eye diseases caused by or related to age (called age-related eye diseases) such as asthenopia, age-related retinal macular degeneration, glaucoma, cataract, dry eye, presbyopia, etc., and has high safety, especially a medicine for preventing or treating eye diseases, which does not cause eye diseases by interference in the process of aging, prevents function reduction or tissue injury by aging or reverses aging reduction and rejuvenates the eyes, a medicine composition, a food and beverage, a cosmetic and a feed that comprise the medicine and prevent or treat age-related eye diseases. SOLUTION: The age-related eye disease ameliorant comprises lactoferrin as an active ingredient. The age-related eye disease ameliorant is effective against one or more age-related eye diseases of asthenopia, age-related retinal macular degeneration, glaucoma, cataract, dry eye and presbyopia. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：获得一种有效预防或治疗由年龄相关的眼睛疾病（称为年龄相关性眼病）如眼疲劳，年龄相关性视网膜黄斑变性，青光眼，白内障的眼部疾病有效的药物，干眼症，老花眼等，并且具有高安全性，特别是用于预防或治疗眼部疾病的药物，其不会通过干扰老化过程而引起眼睛疾病，通过老化或逆转衰老减少功能降低或组织损伤并使眼睛复原，药物组合物，食品和饮料，化妆品和饲料，其包含药物和预防或治疗年龄相关的眼睛疾病。解决方案：年龄相关的眼部疾病改善剂包括乳铁蛋白作为活性成分。与年龄相关的眼睛疾病改善剂对于一种或多种年龄相关的眼疲劳，视网膜黄斑变性，青光眼，白内障，干眼症和老花眼的眼睛疾病有效。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2006213644A Ap-1 activity inhibitor 审中-公开
标题翻译： AP-1活性抑制剂
公开(公告)号：JP2006213644A
公开(公告)日：2006-08-17
申请号：JP2005028133
申请日：2005-02-03
申请人： Nrl Pharma Inc , 株式会社Nrlファーマ
发明人： CHAN YUNCHA , PARK KANKUU , LEE INSON , UMATAI JUNJI , ANDO KUNIO
IPC分类号： A61K31/122 , A61K31/192 , A61K31/216 , A61K31/341 , A61K31/443 , A61K31/455 , A61P1/02 , A61P1/04 , A61P1/14 , A61P3/10 , A61P3/14 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P33/06 , A61P35/00 , A61P35/04 , A61P37/06 , A61P43/00
CPC分类号： Y02A50/411
摘要： PROBLEM TO BE SOLVED: To provide a highly safe AP-1 (activator protein-1) activity inhibitor carrying out prophylaxis or amelioration of diseases (metastasis, etc., of cancer) caused by activation of MMP (matrix metalloprotease), to provide a gene expression inhibitor and to provide a pharmaceutical composition.
SOLUTION: The AP-1 activity inhibitor comprises a compound represented by ascochlorin, 4-O-methylascochlorin, 4-O-carboxymethylascochlorin, 4-O-methoxycarbonyloxyascochlorin, 4-O-(2-ethoxycarbonyloxy)ethylascochlorin, 4-O-nicotinoylascochlorin, ascofuranone, 4-O-methylascofuranone, 4-O-carboxymethylascofuranone, 4-O-methoxycarbonyloxyascofuranone, 4-O-(2-ethoxycarbonyloxy)ethylascofuranone or 4-O-nicotinoylascofuranone or a compound producing the compound in vivo or a pharmacologically acceptable salt thereof as an active ingredient.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种高度安全的AP-1（活化蛋白-1）活性抑制剂，其进行由MMP（基质金属蛋白酶）的激活引起的疾病（癌症的转移等）的预防或改善，以提供基因表达抑制剂并提供药物组合物。解决方案：AP-1活性抑制剂包括由低聚赖氨酸，4-O-甲基加氢氯仿，4-O-羧甲基乙醇胺，4-O-甲氧基羰基氧基苯甲酮，4-O-（2-乙氧基羰基氧基）乙基乙醇胺，4-O - 烟酰基苯乙酮，甲基呋喃酮，4-O-甲基异硬体呋喃酮，4-O-羧甲基甲基呋喃酮，4-O-甲氧基羰基氧基甲基呋喃酮，4-O-（2-乙氧基羰基氧基）乙基甲基砜或4-O-烟酰基甲基呋喃酮或者在体内或药理学上制备该化合物的化合物可接受的盐作为活性成分。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2010248219A Method for producing new pharmaceutical composition and new food for improving quality of life and use thereof 审中-公开
标题翻译：生产新型药物组合物的方法和新型食品，用于改善生活质量和使用寿命
公开(公告)号：JP2010248219A
公开(公告)日：2010-11-04
申请号：JP2010139616
申请日：2010-06-18
申请人： Nrl Pharma Inc , 株式会社Nrlファーマ
发明人： ANDO KUNIO , SUZUKI SEIKICHI , FUKUDA AKIO , KAWAI JURI , OGASAWARA TOSHICHIKA , IGUSA KAZUO
IPC分类号： A61K9/30 , A23L33/00 , A61K9/52 , A61K38/16 , A61K39/395 , A61K47/12 , A61K47/32 , A61K47/38 , A61P1/04 , A61P1/18 , A61P3/04 , A61P3/10 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/12 , A61P17/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/06
摘要： PROBLEM TO BE SOLVED: To provide a solid preparation for oral administration containing a protein exhibiting its physiological activity in digestive tracts lower than duodenum. SOLUTION: The preparation for oral administration is produced by coating a lactoferrin which is a physiologically active protein activating immunological competence and exhibiting analgesic anti-inflammatory action, immunoglobulin, lysozyme, etc., with an enteric coating film containing a base agent selected from a group consisting of shellac, zein, hydroxypropyl methylcellulose phthalate, carboxymethyl ethyl cellulose, cellulose acetate phthalate, methacrylic acid copolymer, water-insoluble ethylcellulose and aminoalkyl methacrylate copolymer. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供一种含有在低于十二指肠的消化道中显示其生理活性的蛋白质的口服给药的固体制剂。解决方案：口服给药的制剂是通过将含有选择的基础药物的肠溶衣膜包被作为生理活性蛋白激活免疫学能力的乳铁蛋白并显示出止痛抗炎作用，免疫球蛋白，溶菌酶等产生的来自由虫胶，玉米醇溶蛋白，羟丙基甲基纤维素邻苯二甲酸酯，羧甲基乙基纤维素，乙酸邻苯二甲酸纤维素，甲基丙烯酸共聚物，水不溶性乙基纤维素和甲基丙烯酸氨烷基酯共聚物组成的组。版权所有（C）2011，JPO＆INPIT

9. 发明专利

JP2010229101A Composition for skin 审中-公开
标题翻译：皮肤组合物
公开(公告)号：JP2010229101A
公开(公告)日：2010-10-14
申请号：JP2009079824
申请日：2009-03-27
申请人： Nrl Pharma Inc , 株式会社Nrlファーマ
发明人： KOBAYASHI YUKITAKA , SHIMIZU TOMO , TAMAOKI YUKIMICHI , ANDO KUNIO
IPC分类号： A61K38/16 , A23L1/30 , A23L1/305 , A61P17/00 , A61P17/04 , A61P17/06
摘要： PROBLEM TO BE SOLVED: To provide an agent for preventing or treating itching skin diseases, which inhibits itches accompanied by itching skin diseases, such as atopic dermatitis, hives, contact dermatitis, psoriasis vulgaris, xeroderma, and prurigo, especially an agent for preventing or treating the atopic dermatitis, and is safe. SOLUTION: It has been found that lactoferrin inhibits peripheral sensory nerve elongation caused by making a nerve growth factor to act on PC12 cells. The lactoferrin exhibits an effect for treating and preventing the pruritus of NC mouse which is a model animal of the atopic dermatitis. It is also found that an effect for clearly improving the skin symptoms of a patient in a therapeutic experiment performed under the agreement of the patient suffering from the atopic dermatitis has been shown. Namely, the composition for the skin safely and quickly inhibits itches accompanied by itching skin diseases such as intractable atopic dermatitis, hives, contact dermatitis, psoriasis vulgaris, xeroderma, and prurigo. Thereby, the composition for the skin, containing the lactoferrin as an active ingredient can safely treat and prevent the skin diseases accompanied by an intractable itching sense, including the atopic dermatitis. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种预防或治疗瘙痒皮肤疾病的药剂，其抑制伴随瘙痒的皮肤疾病如特应性皮炎，荨麻疹，接触性皮炎，寻常型牛皮癣，干燥性皮炎和痒疹，特别是药剂用于预防或治疗特应性皮炎，并且是安全的。解决方案：已经发现乳铁蛋白通过使神经生长因子作用于PC12细胞而抑制外周感觉神经伸长。乳铁蛋白具有治疗和预防作为特应性皮炎模型动物的NC小鼠瘙痒的作用。还发现，在患有特应性皮炎的患者的同意下进行的治疗实验中显示出改善患者皮肤症状的效果已被证明。也就是说，皮肤的组合物安全，快速地抑制瘙痒伴随着皮肤疾病如顽固性特应性皮炎，荨麻疹，接触性皮炎，寻常型牛皮癣，干燥性皮炎和痒疹。因此，含有乳铁蛋白作为活性成分的皮肤组合物可以安全地治疗和预防伴有难治性瘙痒感的皮肤病，包括特应性皮炎。版权所有（C）2011，JPO＆INPIT

10. 发明专利

JP2009102353A New pharmaceutical composition and processed food treating or preventing dry eye 有权
标题翻译：新型药物组合物和加工食品处理或预防干眼症
公开(公告)号：JP2009102353A
公开(公告)日：2009-05-14
申请号：JP2008318445
申请日：2008-12-15
申请人： Nrl Pharma Inc , 株式会社Nrlファーマ
发明人： ANDO KUNIO
IPC分类号： A61K38/00 , A23L1/305 , A61P11/06 , A61P17/00 , A61P19/02 , A61P27/02 , A61P27/16 , A61P29/00 , A61P37/08
摘要： PROBLEM TO BE SOLVED: To find out a material healing or improving dry eye without decreasing quality of life, and to produce new medicines and new processed food comprising the found out material as the active ingredient. SOLUTION: The new enteric preparation for treating or preventing dry eye comprises lactoferrin as an active ingredient and the new processed food comprises the preparation. COPYRIGHT: (C)2009,JPO&INPIT

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