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1. 发明申请

US20140323946A1 PHOSPHORS AND SCINTILLATORS FOR LIGHT STIMULATION WITHIN A MEDIUM 有权
标题翻译：用于中等光刺激的磷光体和扫描仪
公开(公告)号：US20140323946A1
公开(公告)日：2014-10-30
申请号：US14131564
申请日：2012-07-09
申请人： Frederic A. Bourke, JR. , Harold Walder , Zakaryae Fathi , Michael J. Therien , Mark W. Dewhirst , Ian N. Stanton , Jennifer Ann Ayres , Diane Renee Fels , Joseph A. Herbert
发明人： Frederic A. Bourke, JR. , Harold Walder , Zakaryae Fathi , Michael J. Therien , Mark W. Dewhirst , Ian N. Stanton , Jennifer Ann Ayres , Diane Renee Fels , Joseph A. Herbert
IPC分类号： A61N5/06 , A61N5/10
CPC分类号： A61N5/062 , A61K41/0085 , A61N5/0622 , A61N5/1077 , A61N2005/0661 , A61N2005/1091 , A61N2005/1098
摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.
摘要翻译：介质内光刺激的系统和方法。该系统具有被配置为从等于或低于105kVp的施加阴极施加电压产生X射线的低电压x射线源，以及介质中的多个能量发射粒子，其在来自X射线源的辐射以比x射线源低的能量辐射以与介质中的至少一种可光活化剂相互作用。该方法将多个能量发射粒子引入到介质中，用等于或低于105kVp的施加阴极电压产生的x射线照射介质中的能量发射粒子; 并且发射比x射线源更低的能量以与介质或介质中的至少一种可光活化剂相互作用。

2. 发明申请

US20110117202A1 UP AND DOWN CONVERSION SYSTEMS FOR PRODUCTION OF EMITTED LIGHT FROM VARIOUS ENERGY SOURCES INCLUDING RADIO FREQUENCY, MICROWAVE ENERGY AND MAGNETIC INDUCTION SOURCES FOR UPCONVERSION 有权
标题翻译：用于生产来自各种能量源的发射光的UP和DOWN转换系统，包括无线电频率，微波能量和用于上变换的磁感应源
公开(公告)号：US20110117202A1
公开(公告)日：2011-05-19
申请号：US12943787
申请日：2010-11-10
申请人： Frederic A. Bourke, JR. , Zakaryae Fathi , Ian Nicholas Stanton , Michael J. Therien , Paul Rath Stauffer , Paolo MacCarini , Katherine Sarah Hansen , Diane Renee Fels , Cory Robert Wyatt , Mark Wesley Dewhirst
发明人： Frederic A. Bourke, JR. , Zakaryae Fathi , Ian Nicholas Stanton , Michael J. Therien , Paul Rath Stauffer , Paolo MacCarini , Katherine Sarah Hansen , Diane Renee Fels , Cory Robert Wyatt , Mark Wesley Dewhirst
IPC分类号： A61N5/00 , H01J61/00 , H01J61/20 , B01J8/18 , B01J19/08 , A61K9/14 , A61K38/20 , A61K39/395 , A61K38/44 , A61K33/00 , A61K33/38 , A61K33/24 , A61K38/28 , A61K38/22 , A61K38/14 , A61K31/7052 , A61K31/7084 , A61K31/655 , A61K31/5415 , A61K31/525 , A61K31/473 , A61K31/47 , A61K31/40 , A61K31/405 , A61K31/352 , A61K31/122 , A61K31/015 , C08G77/00 , A61L2/10 , G21G5/00 , A61M37/00 , B01J19/12 , C23C14/28 , B32B37/00 , B29C65/14 , B82Y15/00 , B82Y25/00 , B82Y99/00
CPC分类号： H05B41/2806 , A61L2/10 , A61N1/40 , A61N1/44 , A61N2/00 , A61N5/10 , C02F1/32 , H01J65/042 , Y02B20/22 , Y02W10/37
摘要： Methods and systems for producing a change in a medium. A first method and system (1) place in a vicinity of the medium at least one upconverter including a gas for plasma ignition, with the upconverter being configured, upon exposure to initiation energy, to generate light for emission into the medium, and (2) apply the initiation energy from an energy source including the first wavelength λ1 to the medium, wherein the emitted light directly or indirectly produces the change in the medium. A second method and system (1) place in a vicinity of the medium an agent receptive to microwave radiation or radiofrequency radiation, and (2) apply as an initiation energy the microwave radiation or radiofrequency radiation by which the agent directly or indirectly generates emitted light in the infrared, visible, or ultraviolet range to produce at least one of physical and biological changes in the medium.
摘要翻译：用于产生介质变化的方法和系统。第一种方法和系统（1）在介质附近放置至少一个包括用于等离子体点火的气体的上变频器，其中上变频器被配置为在暴露于引发能量时产生用于发射到介质中的光，和（2 ）将包括第一波长λ1的能量源的引发能量施加到介质，其中发射的光直接或间接地产生介质中的变化。第二种方法和系统（1）在介质附近放置接收微波辐射或射频辐射的试剂，以及（2）作为引发能量施加微波辐射或射频辐射，其中所述试剂直接或间接产生发射光在红外线，可见光或紫外线范围内产生介质中物理和生物变化中的至少一种。

3. 发明申请

US20120089180A1 ADHESIVE BONDING COMPOSITION AND METHOD OF USE 有权
标题翻译：胶粘剂组合物及其使用方法
公开(公告)号：US20120089180A1
公开(公告)日：2012-04-12
申请号：US13102277
申请日：2011-05-06
申请人： Zakaryae Fathi , James Clayton , Harold Walder , Frederic A. Bourke, JR. , Ian Stanton , Jennifer Ayres , Joshua T. Stecher , Michael Therien , Eric Toone , Dave Gooden , Mark Dewhirst , Joseph A. Herbert , Diane Fels , Katherine S. Hansen
发明人： Zakaryae Fathi , James Clayton , Harold Walder , Frederic A. Bourke, JR. , Ian Stanton , Jennifer Ayres , Joshua T. Stecher , Michael Therien , Eric Toone , Dave Gooden , Mark Dewhirst , Joseph A. Herbert , Diane Fels , Katherine S. Hansen
IPC分类号： A61B17/03 , G03F7/038 , C09D163/10 , H01B1/12 , C09D167/07 , G21K5/00 , B41J2/175 , H01L23/28 , B32B37/12 , B32B38/14 , B32B7/12 , C09D7/12 , C09D4/02 , B82Y30/00
CPC分类号： H01L24/83 , A61B17/0057 , A61L24/06 , B32B3/266 , B32B7/14 , B32B9/04 , B32B37/1284 , B32B37/18 , B32B38/0008 , B32B2037/1253 , B32B2457/00 , B32B2457/08 , B32B2457/14 , B41J2/17559 , C08K3/00 , C09J4/00 , C09J9/02 , C09J11/04 , C09J11/06 , C09J133/08 , C09K11/02 , C09K11/7769 , C09K11/777 , H01L23/5226 , H01L24/32 , H01L25/0657 , H01L25/50 , H01L2224/16225 , H01L2224/32225 , H01L2224/48091 , H01L2224/48227 , H01L2224/73204 , H01L2224/73253 , H01L2224/73265 , H01L2224/83192 , H01L2224/83855 , H01L2224/92125 , H01L2225/06524 , H01L2225/06589 , H01L2924/07811 , H01L2924/1461 , H01L2924/15311 , Y10T428/2852 , H01L2924/00014 , H01L2924/00
摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
摘要翻译：可聚合组合物包括至少一种单体，当暴露于光时能够引发单体聚合的光引发剂和当暴露于辐射（通常为X射线）时能产生光的荧光体）。该材料特别适用于在外部光源不能接合接合点的情况下在环境温度下结合部件。相关方法包括：将可聚合粘合剂组合物，包括光引发剂和能量转换材料（例如下变换磷光体）与要结合的至少两种组分接触以形成组件; 并且能够将第一波长的辐射照射到组件上，该辐射能够转换（由荧光体进行下变频）到能够激活光引发剂的第二波长，以制备诸如喷墨墨盒，晶片到晶片组件，半导体，集成电路等。

4. 发明申请

US20100003316A1 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS USING PLASMONICS ENHANCED PHOTOSPECTRAL THERAPY (PEPST) AND EXCITON-PLASMON ENHANCED PHOTOTHERAPY (EPEP) 有权
标题翻译：使用PLASMONICS增强光疗法（PEPST）和EXCITON-PLASMON增强型照相疗法（EPEP）治疗细胞增殖性疾病的方法和系统
公开(公告)号：US20100003316A1
公开(公告)日：2010-01-07
申请号：US12389946
申请日：2009-02-20
申请人： Tuan Vo Dinh , Frederic A. Bourke, JR.
发明人： Tuan Vo Dinh , Frederic A. Bourke, JR.
IPC分类号： A61K9/127 , A61K9/00 , A61K9/48 , A61K9/14 , A61K39/395 , A61K35/12 , A61K38/43 , A61K38/02 , A61K31/711 , A61K31/433 , A61K31/352 , A61K31/7105
CPC分类号： A61K41/0061 , A61K9/14 , A61K9/143 , A61K31/37 , A61K39/00 , A61K41/0028 , A61K41/0066 , A61K47/52 , A61K2039/57 , A61N5/06 , A61N5/062
摘要： The use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes used therein.
摘要翻译：使用等离子体激元增强光谱疗法（PEPST）和离子等离子体增强光疗法（EPEP）治疗各种细胞增殖障碍，以及其中使用的PEPST和EPEP试剂和探针。

5. 发明申请

US20100266621A1 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS WITH PSORALEN DERIVATIVES 有权
标题翻译：用PSORALEN衍生物治疗细胞增殖障碍的方法和系统
公开(公告)号：US20100266621A1
公开(公告)日：2010-10-21
申请号：US12763404
申请日：2010-04-20
申请人： Eric Toone , David Gooden , Tuan Vo-Dinh , Frederic A. Bourke, JR.
发明人： Eric Toone , David Gooden , Tuan Vo-Dinh , Frederic A. Bourke, JR.
IPC分类号： A61K39/00 , C07D405/14 , A61K31/4433 , A61K31/453 , C07D211/22 , C07D215/38 , A61K31/4709 , A61P35/00
CPC分类号： C07D493/04 , A61K31/4433 , A61K31/453 , A61K31/4709 , A61K41/0066 , A61K45/06 , A61N5/062 , A61N5/10
摘要： Psoralen compounds of Formula (I): wherein (N+ Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: wherein R is C1-C30 hydrocarbyl, which may be linear, branched or cyclic and contains from 1 to 15 carbon-carbon double bonds, which may be conjugated or unconjugated with one another or may include an aryl ring, and may contain one or more substituents; R1 is hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, heterocyclyl, alkenyl, alkynyl, alkene-aryl, alkene-heteroaryl, alkene-heterocyclyl, alkene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclyheteroaryl, alkylene-fused cycloalkylaryl, alkylene-fused cycloalkylheteroaryl, alkylene-fused heterocyclylaryl, alkylene-fused heterocyclyheteroaryl; n is an integer from 1 to 8 and X is a pharmaceutically acceptable counter ion; and their use in methods for the treatment of a cell proliferation disorder in a subject, pharmaceutical compositions containing the psoralen derivatives, a kit for performing the method, and a method for causing an autovaccine effect in a subject using the method.
摘要翻译：式（I）的补骨脂素化合物：其中（N +芳基）是选自式（i） - （iii）的含氮芳族杂环的成员：其中Z是下式的基团：其中R是C1-C30 烃基，其可以是直链，支链或环状的并且含有1至15个碳 - 碳双键，其可以彼此共轭或非共轭或可以包括芳环，并且可以含有一个或多个取代基; R 1是氢，芳基，杂芳基，烷基，环烷基，杂环基，烯基，炔基，烯 - 芳基，烯 - 杂芳基，烯烃 - 杂环基，烯 - 环烷基，稠合环烷基芳基，稠合环烷基杂芳基，稠合杂环基芳基，稠合杂环杂芳基，亚烷基稠合环烷基芳基亚烷基稠合的环烷基杂芳基，亚烷基稠合的杂环基芳基，亚烷基稠合的杂环杂芳基; n为1〜8的整数，X为药学上可接受的抗衡离子; 及其在治疗受试者的细胞增殖障碍的方法中的用途，含有补骨脂素衍生物的药物组合物，用于进行该方法的试剂盒以及使用该方法在受试者中引起自身疫苗效应的方法。

6. 发明申请

US20110263920A1 ADVANCED METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS 有权
标题翻译：用于治疗细胞增殖障碍的先进方法和系统
公开(公告)号：US20110263920A1
公开(公告)日：2011-10-27
申请号：US13054279
申请日：2009-07-14
申请人： Frederic A. Bourke, JR. , Tuan Vo Dinh
发明人： Frederic A. Bourke, JR. , Tuan Vo Dinh
IPC分类号： A61N5/00 , A61K31/197 , G06F19/00 , A61P35/00 , A61N1/00 , A61K39/00 , A61K31/37
CPC分类号： A61N5/062 , A61K31/4427 , A61K31/7052 , A61K31/7056 , A61K41/008 , A61K47/55 , A61K47/551
摘要： The present invention relates to methods for treating cell proliferation disorders comprising (1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a predetermined cellular change when activated, (2) administering at least one plasmonics-active agent to the subject, and (3) applying an initiation energy from an initiation energy source to the subject, wherein the plasmonics-active agent enhances or modifies the applied initiation energy, such that the enhanced or modified initiation energy activates the activatable pharmaceutical agent by the simultaneous two photon absorption event in situ, thus causing the predetermined cellular change to occur, wherein said predetermined cellular change treats the cell proliferation related disorder, and the use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents and probes
摘要翻译：本发明涉及治疗细胞增殖紊乱的方法，其包括（1）向受试者施用至少一种能够同时进行两个光子吸收事件激活并可被激活时实现预定的细胞变化的可活化药剂，（2）向所述受试者施用至少一种等离子体激动剂活性剂，和（3）将来自起始能量源的引发能量施用于所述受试者，其中所述等离子体激活剂增强或改变所施加的引发能量，使得所述增强或修饰的引发能量通过原位同步双光子吸收事件激活可激活的药剂，从而导致发生预定的细胞变化，其中所述预定的细胞变化处理细胞增殖相关病症，以及使用等离子体激元增强光谱疗法（PEPST）和离开 - 增效光疗法（EPEP）治疗va 细胞增殖紊乱，PEPST和EPEP试剂和探针

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