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1. 发明申请

US20120016106A1 ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS 有权
标题翻译：针对GDF-8的拮抗剂抗体和用于治疗ALS和其他GDF-8相关疾病的用途
公开(公告)号：US20120016106A1
公开(公告)日：2012-01-19
申请号：US13038954
申请日：2011-03-02
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L.F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L.F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
IPC分类号： C07K16/00 , C12N5/10 , C07H21/04 , C12N1/19 , C12N15/63 , C12P21/06 , C12N1/21
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译：本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。

2. 发明授权

US07910107B2 Antagonist antibodies against GDF-8 and uses in treatment of ALS and other GDF-8 associated disorders 有权
标题翻译：抗GDF-8抗体抗体，用于治疗ALS和其他GDF-8相关疾病
公开(公告)号：US07910107B2
公开(公告)日：2011-03-22
申请号：US12508618
申请日：2009-07-24
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley, legal representative , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译：本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。

3. 发明申请

US20090285827A1 ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS 有权
标题翻译：针对GDF-8的拮抗剂抗体和用于治疗ALS和其他GDF-8相关疾病的用途
公开(公告)号：US20090285827A1
公开(公告)日：2009-11-19
申请号：US12508618
申请日：2009-07-24
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
IPC分类号： A61K39/395 , G01N33/53
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译：本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。

4. 发明申请

US20070087000A1 Antagonist antibodies against GDF-8 and uses in treatment of ALS and other GDF-8-associated disorders 有权
标题翻译：抗GDF-8抗体抗体，用于治疗ALS和其他GDF-8相关疾病
公开(公告)号：US20070087000A1
公开(公告)日：2007-04-19
申请号：US11503062
申请日：2006-08-14
申请人： Frank Walsh , Margaret Zaleska , David Howland , Erika Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Kwak , Karen Wallace , Nicholas Weber , Menelas Pangalos , William Kelley
发明人： Frank Walsh , Margaret Zaleska , David Howland , Erika Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Kwak , Karen Wallace , Nicholas Weber , Menelas Pangalos , William Kelley
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译：本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。

5. 发明申请

US20090094048A1 System and Method For Facilitating The Introduction of Compatible Individuals Using Third Party Collaborative Tools 审中-公开
标题翻译：使用第三方协作工具促进兼容个人引入的系统和方法
公开(公告)号：US20090094048A1
公开(公告)日：2009-04-09
申请号：US12098983
申请日：2008-04-07
申请人： Karen Wallace , Suneet Wadhwa , Andrew Pickholtz
发明人： Karen Wallace , Suneet Wadhwa , Andrew Pickholtz
IPC分类号： G06Q99/00
CPC分类号： G06Q30/02 , G06Q50/01
摘要： A system and method for facilitating an online collaborative community for individuals to meet each other, make suggestions to members in their network of other individuals as potential matches, and introduce members to each other. A number of features are provided that promote collaboration among members of the online community with regard to suggested matches of potentially compatible individuals. A first feature enables a user to initiate a multi-party discussion concerning suggested matches for particular individuals. The user has the ability to attach a profile of the suggested match to the discussion, which may be retrieved and viewed by the invited parties to the discussion. Invited parties may be non-members as well as members of the online community. A “social feed” is provided to a user to inform the user of activities happening on the site that are related to the user or any friends to whom he/she is connected. A points system is provided to award points to users for participation in various categories of activities and actions that promote the advancement of the introduction and matching network. Various games modules are provided to encourage matchmaking activities by enhancing the entertainment value of site participation. A scoreboard is also provided, which lists the top-scoring users of the site.
摘要翻译：一种促进个人在线协作社区相互见面的系统和方法，向其他个人网络中的成员作为潜在的比赛提出建议，并将成员介绍给彼此。提供了一些功能，用于促进在线社区成员之间的协作关于潜在兼容个人的建议匹配。第一个功能使用户能够针对特定个人的建议匹配发起多方讨论。用户可以将建议匹配的配置文件附加到讨论中，这可以由被邀请方检索和查看。受邀各方可能是非会员以及在线社区的成员。向用户提供“社会饲料”，以向用户通知与用户或他/她所连接的任何朋友相关的网站上发生的活动。提供积分制度，以奖励用户参与促进引进和匹配网络进步的各类活动和行动。提供各种游戏模块，通过增强现场参与的娱乐价值来鼓励配对活动。还提供了一个记分牌，其中列出了该网站的得分最高的用户。

6. 发明申请

US20060015369A1 Healthcare provider recommendation system 审中-公开
标题翻译：医疗保健提供者推荐系统
公开(公告)号：US20060015369A1
公开(公告)日：2006-01-19
申请号：US11181158
申请日：2005-07-13
申请人： Sonja Bachus , Michael Abreu , Jeff Bachus , Karen Wallace
发明人： Sonja Bachus , Michael Abreu , Jeff Bachus , Karen Wallace
IPC分类号： G06Q10/00
CPC分类号： G06Q50/22 , G06Q10/10 , G16H40/20
摘要： An online database of patient-to-patient healthcare provider recommendations is provided. This database may provide a resource for choosing a physician, and a community of support for those facing medical challenges. Patients who have had a positive experience with a physician can register this physician online, and subsequent patients can search for a physician by a variety of categories, such as, e.g., location, specialty, or physician name. Registrants may have the ability to recommend more than one physician if they so choose. All registrations may be verified by the online service for current license status, correct contact information, and for positive recommendations. This database may be provided and maintained by a central server and accessed by users over the world wide web using a conventional browser application.
摘要翻译：提供了病人对患者医疗服务提供者建议的在线数据库。该数据库可以提供用于选择医师的资源，以及面临医疗挑战的人的社区。对医生有积极经验的患者可以在线注册该医师，随后的患者可以通过各种类别（例如位置，专业或医师名称）搜索医生。如果他们这样选择，注册人可能有能力推荐多位医生。所有注册可以通过在线服务验证当前许可证状态，正确的联系信息和积极的建议。该数据库可以由中央服务器提供和维护，并且可以由使用常规浏览器应用的万维网上的用户访问。

7. 发明申请

US20070106499A1 NATURAL LANGUAGE SEARCH SYSTEM 审中-公开
标题翻译：自然语言搜索系统
公开(公告)号：US20070106499A1
公开(公告)日：2007-05-10
申请号：US11463296
申请日：2006-08-08
申请人： Kathleen Dahlgren , Edward Stabler , Karen Wallace , Paul Deane
发明人： Kathleen Dahlgren , Edward Stabler , Karen Wallace , Paul Deane
IPC分类号： G06F17/21
CPC分类号： G06F16/36 , G06F16/243 , G06F16/3334
摘要： A natural language system searching system develops concept and string indexes of a textual database, such as a group of litigation documents, by breaking the text to be indexed into sentences, words, dates, names and places in a reader, identifying phrases in a phrase parser, recovering word stems in a morphology module and determining the sense of potentially ambiguous words in a sense selector, all in accordance with words and concepts (word senses) stored in lexicon database 9-32. A query may then be processed by the reader, phrase parser, morphology module, and sense selector to provide a text meaning output which can be compared with the concept and string indexes to identify, retrieve and display documents and/or portions of documents related to the query. A lexicon enhancer adds vocabulary semi-automatically.
摘要翻译：自然语言系统搜索系统通过将要索引到文本中的文本（例如一组诉讼文件）的文本数据库的概念和字符串索引开发成读者中的句子，单词，日期，名称和地点，识别短语中的短语解析器，在形态学模块中恢复词干，并根据存储在词典数据库9 - 32中的单词和概念（词义）确定感觉选择器中潜在的模糊词的感觉。然后可以由读者，短语解析器，形态学模块和感测选择器处理查询以提供文本含义输出，其可以与概念和字符串索引进行比较，以识别，检索和显示文档相关的文档和/或部分文档查询。词典增强器半自动添加词汇。

8. 发明申请

US20060287878A1 System and Method for Facilitating the Introduction of Compatible Individuals 审中-公开
标题翻译：促进引入兼容个人的制度和方法
公开(公告)号：US20060287878A1
公开(公告)日：2006-12-21
申请号：US11425390
申请日：2006-06-20
申请人： Suneet Wadhwa , Andrew Pickholtz , Karen Wallace
发明人： Suneet Wadhwa , Andrew Pickholtz , Karen Wallace
IPC分类号： G06Q99/00 , G07G1/00 , G06F17/30
CPC分类号： G06Q30/00 , G06Q30/0204 , G06Q50/01
摘要： A system and method for facilitating an online collaborative community for individuals to meet each other with the assistance of third party intermediaries or matchmakers. The system provides the intermediaries with a variety of features to participate and collaborate in the process of identifying potentially compatible individuals and arranging for the introduction of those individuals. For example, the intermediaries can provide profile information about individual participants, search for potentially compatible individuals for others, or introduce individuals to each other. The introductions can be of individuals who are already participating or who are subsequently invited to participate. Introductions may also be anonymous. Other features include a rating or ranking of intermediaries based on the quality of their introductions, a polling feature whereby users are asked to vote on potential matches for certain participants, and a real time event feature whereby participants may chat, research information on other participants, and identify potential participants for introduction. Still other features of the system are described herein.
摘要翻译：一种促使个人在线协作社区在第三方中间人或配对者协助下相互见面的系统和方法。该系统为中介机构提供了各种功能，以便参与和协调识别潜在相容的个人并安排引进这些个人的过程。例如，中间人可以提供关于个人参与者的个人资料信息，搜索潜在的与他人相容的个人，或者将个人彼此介绍。介绍可以是已经参加或随后被邀请参加的个人。介绍也可能是匿名的。其他功能包括基于其介绍质量的中介机构的评级或排名，轮询功能，用户被要求对某些参与者的潜在比赛进行投票，以及参与者可以聊天的实时事件特征，其他参与者的研究信息，并确定潜在参与者的介绍。本文描述了系统的其它特征。

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