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1. 发明申请

US20090285827A1 ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS 有权
标题翻译：针对GDF-8的拮抗剂抗体和用于治疗ALS和其他GDF-8相关疾病的用途
公开(公告)号：US20090285827A1
公开(公告)日：2009-11-19
申请号：US12508618
申请日：2009-07-24
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L. F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
IPC分类号： A61K39/395 , G01N33/53
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译：本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。

2. 发明申请

US20120016106A1 ANTAGONIST ANTIBODIES AGAINST GDF-8 AND USES IN TREATMENT OF ALS AND OTHER GDF-8 ASSOCIATED DISORDERS 有权
标题翻译：针对GDF-8的拮抗剂抗体和用于治疗ALS和其他GDF-8相关疾病的用途
公开(公告)号：US20120016106A1
公开(公告)日：2012-01-19
申请号：US13038954
申请日：2011-03-02
申请人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L.F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
发明人： Frank S. Walsh , Margaret M. Zaleska , David S. Howland , Erika L.F. Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , William Kelley , Xiang-Yang Tan , Seung Poon Kwak , Karen Wallace , Nicholas Weber , Menelas N. Pangalos
IPC分类号： C07K16/00 , C12N5/10 , C07H21/04 , C12N1/19 , C12N15/63 , C12P21/06 , C12N1/21
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译：本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。

3. 发明申请

US20070087000A1 Antagonist antibodies against GDF-8 and uses in treatment of ALS and other GDF-8-associated disorders 有权
标题翻译：抗GDF-8抗体抗体，用于治疗ALS和其他GDF-8相关疾病
公开(公告)号：US20070087000A1
公开(公告)日：2007-04-19
申请号：US11503062
申请日：2006-08-14
申请人： Frank Walsh , Margaret Zaleska , David Howland , Erika Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Kwak , Karen Wallace , Nicholas Weber , Menelas Pangalos , William Kelley
发明人： Frank Walsh , Margaret Zaleska , David Howland , Erika Holzbaur-Howland , Lioudmila Tchistiakova , Riyez Karim , Pamela Kelley , Xiang-Yang Tan , Seung Kwak , Karen Wallace , Nicholas Weber , Menelas Pangalos , William Kelley
IPC分类号： A61K39/395 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/24 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N33/74 , G01N2333/475 , G01N2800/2835 , G01N2800/50 , G01N2800/52
摘要： The disclosure provides novel molecules related to growth and differentiation factor-8 (GDF-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit GDF-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (ALS). In addition, the disclosure provides pharmaceutical compositions for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.
摘要翻译：本公开提供了与生长和分化因子-8（GDF-8）特别是小鼠和人源化抗体以及抗体片段相关的新分子，包括在体外和/或体内抑制GDF-8活性和信号传导的抗体片段。本公开还提供了用于诊断，治疗，改善，预防，预后或监测肌肉，骨骼和胰岛素代谢等的退行性顺序，特别是肌萎缩性侧索硬化（ALS）的方法。此外，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种病症的药物组合物。

4. 发明申请

US20060072505A1 Distributed networking agent and method of making and using the smae 有权
标题翻译：分布式网络代理和制造和使用smae的方法
公开(公告)号：US20060072505A1
公开(公告)日：2006-04-06
申请号：US11217677
申请日：2005-09-02
申请人： Steve Carrillo , Paul Bristow , Alan Stewart , Richard Stewart , William Kelley
发明人： Steve Carrillo , Paul Bristow , Alan Stewart , Richard Stewart , William Kelley
IPC分类号： H04Q7/00
CPC分类号： H04W16/18 , H04L41/042 , H04L41/046 , H04L41/083 , H04L41/12 , H04L41/145 , H04L41/5003 , H04L41/5009 , H04L43/0829 , H04L43/0852 , H04L43/16 , H04W24/02 , H04W24/04 , H04W28/16 , H04W40/18 , H04W40/38
摘要： The present invention relates to an agent for distributed networking and a processor-readable software code. The agent may include, for example, a cosite analyzer, an EMI sniffer, an asset controller module, an asset discovery module, and a link negotiator. The agent may be configured to initiate and optimize network configurations for radio communications systems based on parameters. The software code may receive data associated with a network plan, may determine if any planned links are included in the network plan and may establish connectivity of a confirmed link between at least two nodes in the network. Additionally, the software code may determine if a non-planned link should be added to the network and may establish connectivity for the non-planned link based on a priority associated with the non-planned link.
摘要翻译：本发明涉及一种用于分布式网络的代理和一种处理器可读软件代码。代理可以包括例如电话分析器，EMI嗅探器，资产控制器模块，资产发现模块和链接协商者。代理可以被配置为基于参数来发起和优化用于无线电通信系统的网络配置。软件代码可以接收与网络规划相关联的数据，可以确定网络规划中是否包括任何预定链路，并且可以在网络中的至少两个节点之间建立确认链路的连通性。此外，软件代码可以确定是否应该将非计划链路添加到网络中，并且可以基于与非规划链路相关联的优先级为非规划链路建立连接。

5. 发明授权

US4673374A Articulated limb assemby for figure toy 失效
标题翻译：铰链肢体搭配图形玩具
公开(公告)号：US4673374A
公开(公告)日：1987-06-16
申请号：US821950
申请日：1986-01-24
申请人： William Kelley
发明人： William Kelley
IPC分类号： A63H3/46
CPC分类号： A63H3/46
摘要： An articulated limb assembly for a figure toy which allows the limbs of the figure toy to be rotated about three different axes for the purpose of posing the limbs. The assembly includes a supporting track mounted within the hollow torso of the figure toy which is used to guide connectors coupled to the limbs. Heads attached to the connectors frictionally engage curve surfaces of the track allowing each limb to be rotated about a vertical axis. Each limb may also be frictionally rotated about a first horizontal axis or about the longitudinal axis of one of the connectors. Disk members attached to the connectors frictionally engage slots in the limbs allowing each limb to be frictionally rotated about a second horizontal axis. As a result, the limbs of the figure toy may be posed in a variety of different positions.
摘要翻译：用于图形玩具的铰接肢体组件，其允许图形玩具的肢体围绕三个不同的轴线旋转，以形成四肢。该组件包括安装在图形玩具的中空躯干内的支撑轨道，其用于引导连接到四肢的连接器。附接到连接器的头部摩擦地接合轨道的曲面，允许每个肢体围绕垂直轴线旋转。每个肢体还可以围绕第一水平轴线或围绕其中一个连接器的纵向轴线摩擦旋转。附接到连接器的盘构件摩擦地接合肢体中的槽，从而允许每个肢体围绕第二水平轴线摩擦旋转。因此，图形玩具的四肢可以呈现在各种不同的位置。

6. 发明申请

US20070032333A1 Integrated transaxle power take off 审中-公开
标题翻译：集成的变速驱动电源起飞
公开(公告)号：US20070032333A1
公开(公告)日：2007-02-08
申请号：US11197938
申请日：2005-08-05
申请人： William Kelley
发明人： William Kelley
IPC分类号： F16H48/06
CPC分类号： B60K17/344 , B60K17/35 , F16D27/004 , F16D27/115 , F16D48/064 , F16D2500/1022 , F16D2500/10431 , F16D2500/3108 , F16D2500/3144 , F16D2500/5075
摘要： A four wheel drive vehicle driveline includes a primary driveline having a prime mover on the transaxle and half shafts at the front of the vehicle and a secondary driveline including a prop shaft, friction clutch assembly, differential and half shafts at the rear of the vehicle. A bevel gear set and an offset chain drive assembly couple the transaxle output to the rear prop shaft.
摘要翻译：四轮驱动车辆传动系包括在驱动桥上具有原动机的主传动系和车辆前部的半轴，以及在车辆后部包括支柱，摩擦离合器组件，差速器和半轴的二次传动系。锥齿轮组和偏移链驱动组件将驱动桥输出耦合到后支轴。

7. 发明申请

US20050230217A1 Friction clutch pack having a motor driven ball ramp operator 有权
标题翻译：摩擦式离合器组件具有马达驱动的滚珠坡道操作器
公开(公告)号：US20050230217A1
公开(公告)日：2005-10-20
申请号：US10827657
申请日：2004-04-19
申请人： William Kelley
发明人： William Kelley
IPC分类号： B60K23/02 , F16D13/54 , F16D23/12 , F16D27/00 , F16H25/08
CPC分类号： F16D28/00 , F16D27/004
摘要： An electromagnetic clutch especially adapted for use in motor vehicle power trains includes a multiple plate friction clutch pack acted upon (compressed) by a ball ramp operator. The ball ramp operator includes two adjacent plates having opposed pairs of arcuate ramped recesses which receive a load transferring member such as a ball or roller bearing. Relative rotation of the plates is achieved through a worm gear drive from a bi-directional electric motor. Such relative rotation causes separation of the plates and compression of the friction clutch pack which transfers torque from the input to the output of the electromagnetic clutch.
摘要翻译：特别适用于机动车辆动力系的电磁离合器包括由滚珠斜坡操作器作用（压缩）的多板摩擦离合器组件。滚珠坡道操作器包括两个相邻的板，其具有相对的弓形斜坡凹槽对，其接收负载传递构件，例如滚珠或滚子轴承。通过来自双向电动机的蜗轮传动来实现板的相对旋转。这种相对旋转导致板的分离和摩擦离合器组件的压缩，其将扭矩从输入传递到电磁离合器的输出。

8. 发明申请

US20050040000A1 Clutch and synchronizer having permanent magnet actuators 失效
标题翻译：离合器和同步器具有永磁执行器
公开(公告)号：US20050040000A1
公开(公告)日：2005-02-24
申请号：US10643661
申请日：2003-08-19
申请人： William Kelley , Andrew Joseph
发明人： William Kelley , Andrew Joseph
IPC分类号： B60K23/08 , F16D13/52 , F16D23/02 , F16D23/04 , F16D25/0638 , F16D27/01 , H02K49/04 , B60K17/34
CPC分类号： F16D25/0638 , B60K23/08 , F16D23/04 , F16D27/01 , H02K49/046
摘要： A friction clutch pack utilizes permanent magnets and induction rings to actuate a ball ramp actuator which come in turn, engages the friction clutch pack to transfer torque between drive and driven members in, for example, a motor vehicle transfer case. The permanent magnets and induction rings may also be utilized as a synchronizer to urge the speeds of two rotating members into synchronism to facilitate engagement of a direct coupling i.e., a dog clutch.
摘要翻译：摩擦离合器组件使用永磁体和感应环来致动一个滚珠斜坡致动器，该滑块致动器依次接合摩擦离合器组件，以在例如机动车辆移送壳体中的驱动部件和被驱动部件之间传递扭矩。永磁体和感应环也可以用作同步器，以促使两个旋转构件的速度同步，以便于直接联接即爪式离合器的接合。

9. 发明授权

US07742436B2 Distributed networking agent and method of making and using the same 有权
标题翻译：分布式网络代理及其制作和使用方法
公开(公告)号：US07742436B2
公开(公告)日：2010-06-22
申请号：US11217677
申请日：2005-09-02
申请人： Steve Carrillo , Paul Bristow , Alan Stewart , Richard Stewart , William Kelley
发明人： Steve Carrillo , Paul Bristow , Alan Stewart , Richard Stewart , William Kelley
IPC分类号： H04L12/28
CPC分类号： H04W16/18 , H04L41/042 , H04L41/046 , H04L41/083 , H04L41/12 , H04L41/145 , H04L41/5003 , H04L41/5009 , H04L43/0829 , H04L43/0852 , H04L43/16 , H04W24/02 , H04W24/04 , H04W28/16 , H04W40/18 , H04W40/38
摘要： The present invention relates to an agent for distributed networking and a processor-readable software code. The agent may include, for example, a cosite analyzer, an EMI sniffer, an asset controller module, an asset discovery module, and a link negotiator. The agent may be configured to initiate and optimize network configurations for radio communications systems based on parameters. The software code may receive data associated with a network plan, may determine if any planned links are included in the network plan and may establish connectivity of a confirmed link between at least two nodes in the network. Additionally, the software code may determine if a non-planned link should be added to the network and may establish connectivity for the non-planned link based on a priority associated with the non-planned link.
摘要翻译：本发明涉及一种用于分布式网络的代理和一种处理器可读软件代码。代理可以包括例如电话分析器，EMI嗅探器，资产控制器模块，资产发现模块和链接协商者。代理可以被配置为基于参数来发起和优化用于无线电通信系统的网络配置。软件代码可以接收与网络规划相关联的数据，可以确定网络规划中是否包括任何预定链路，并且可以在网络中的至少两个节点之间建立确认链路的连通性。此外，软件代码可以确定是否应该将非计划链路添加到网络中，并且可以基于与非规划链路相关联的优先级为非规划链路建立连接。

10. 发明申请

US20070174955A1 Cylindrical portable restroom 审中-公开
标题翻译：圆柱形便携式卫生间
公开(公告)号：US20070174955A1
公开(公告)日：2007-08-02
申请号：US11344743
申请日：2006-02-01
申请人： David Harris , William Kelley , Reginald Adams
发明人： David Harris , William Kelley , Reginald Adams
IPC分类号： A47K11/04
CPC分类号： E04H1/1216
摘要： A portable restroom facility is disclosed. The portable restroom facility includes a floor, a sidewall and a roof. The floor has a circular perimeter edge. The sidewall is curved and has a curved outer surface. A bottom edge of the sidewall is attached to the circular perimeter edge of the floor. A roof is attached to an upper edge of the sidewall. The roof has a perimeter rim having a radially extending flange and a downwardly extending flange and wherein the radially extending flange is positioned adjacent the upper edge of the sidewall and the downwardly extending flange overlaps a portion of the sidewall. Further, the portable restroom has an advertising sheet material having indicia indicative of a product or service being offered for sale to the sidewall of the portable restroom facility. Moreover, a feature is formed in a portion of the roof having indicia indicative of the product or service being offered for sale.
摘要翻译：公开了便携式洗手间设施。便携式洗手间设施包括地板，侧壁和屋顶。地板有一个圆周边。侧壁是弯曲的并且具有弯曲的外表面。侧壁的底部边缘附接到地板的圆周边缘。屋顶连接到侧壁的上边缘。屋顶具有周边边缘，其具有径向延伸的凸缘和向下延伸的凸缘，并且其中径向延伸凸缘定位成邻近侧壁的上边缘并且向下延伸的凸缘与侧壁的一部分重叠。此外，便携式洗手间具有广告片材料，其具有指示向便携式洗手间设施的侧壁提供出售的产品或服务的标记。此外，在屋顶的一部分中形成了一个特征，该部分具有指示要出售的产品或服务的标记。

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