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1. 发明申请

US20080058518A1 Process and intermediates for the synthesis of (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives and intermediates 有权
标题翻译：合成（3-烷基-5-哌啶-1-基-3,3a-二氢 - 吡唑并[1,5-a]嘧啶-7-基） - 氨基衍生物和中间体的方法和中间体
公开(公告)号：US20080058518A1
公开(公告)日：2008-03-06
申请号：US11893857
申请日：2007-08-17
申请人： Frank Chen , Kartik Keertikar , Shen-Chun Kuo , Hong-Chang Lee , Ramani Raghavan , George Wu , Ji Xie
发明人： Frank Chen , Kartik Keertikar , Shen-Chun Kuo , Hong-Chang Lee , Ramani Raghavan , George Wu , Ji Xie
IPC分类号： C07D487/00
CPC分类号： C07D487/04
摘要： This application discloses a novel process to synthesize (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives, and intermediates useful in the synthesis thereof. The subject (3-alkyl-5-piperidin-1-yl-3,3a-dihydro-pyrazolo[1,5-a]pyrimidin-7-yl)-amino derivatives are useful as cyclin-dependent kinase inhibitor compounds (CDK inhibitors) in pharmaceutical preparations.
摘要翻译：本申请公开了一种合成（3-烷基-5-哌啶-1-基-3,3a-二氢 - 吡唑并[1,5-a]嘧啶-7-基） - 氨基衍生物的新方法和用于合成。主题（3-烷基-5-哌啶-1-基-3,3a-二氢 - 吡唑并[1,5-a]嘧啶-7-基） - 氨基衍生物可用作细胞周期蛋白依赖性激酶抑制剂化合物（CDK抑制剂）在药物制剂中。

2. 发明申请

US20060247450A1 Exo- and diastereo- selective syntheses of himbacine analogs 有权
公开(公告)号：US20060247450A1
公开(公告)日：2006-11-02
申请号：US11331324
申请日：2006-01-12
申请人： George Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa Nguyen , Ngiap Lim
发明人： George Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram Thiruvengadam , Jing Liao , Ilia Zavialov , Hoa Nguyen , Ngiap Lim
IPC分类号： C07D307/02
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:

3. 发明申请

US20140058116A1 PROCESS FOR PREPARING INHIBITORS OF THE HEPATITIS C VIRUS 审中-公开
标题翻译：制备丙型肝炎病毒的抑制剂的方法
公开(公告)号：US20140058116A1
公开(公告)日：2014-02-27
申请号：US14114251
申请日：2012-05-02
申请人： Ji Xie , George Wu , Joseph Lamberson , Marc Poirier , Frank Chen
发明人： Ji Xie , George Wu , Joseph Lamberson , Marc Poirier , Frank Chen
IPC分类号： C07D209/52
CPC分类号： A61K9/00 , A61K38/005 , A61K38/06 , C07D209/52 , C07K1/36
摘要： The present invention relates to synthetic processes useful in the preparation of compounds of Formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease and have application in the treatment of conditions caused by HCV. In particular, the present invention relates to novel oxidation processes useful for preparing compounds of Formula (I) and related compounds, including pharmaceutically acceptable salts, hydrates and solvates thereof, and including stereoisomers thereof.
摘要翻译：本发明涉及用于制备式（I）化合物的合成方法，其可用作丙型肝炎病毒（HCV）NS3蛋白酶的抑制剂，并且可用于治疗由HCV引起的病症。特别地，本发明涉及可用于制备式（I）化合物和相关化合物的新型氧化方法，包括其药学上可接受的盐，水合物和溶剂合物，并包括它们的立体异构体。

4. 发明申请

US20070149459A1 Oxidation process for the preparation of N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-{N-[(tert-butylamino)carbonyl]-3-methyl-L-valyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide and related compounds 失效
标题翻译：制备N- [3-氨基-1-（环丁基甲基）-2,3-二氧代丙基] -3- {N - [（叔丁基氨基）羰基] -3-甲基-L-缬氨酰基} -6的氧化方法，6-二甲基-3-氮杂双环[3.1.0]己烷-2-甲酰胺及相关化合物
公开(公告)号：US20070149459A1
公开(公告)日：2007-06-28
申请号：US11598528
申请日：2006-11-13
申请人： George Wu , Ji Xie , Paitoon Rashatasakhon , Frank Chen , Marc Poirier , Victoria Sprague
发明人： George Wu , Ji Xie , Paitoon Rashatasakhon , Frank Chen , Marc Poirier , Victoria Sprague
IPC分类号： A61K38/05 , C07K5/08
CPC分类号： C07D209/52 , A61K38/00 , C07K5/0202
摘要： The present application relates to a process for preparing a compound of formula I: wherein R1 is alkyl; R2 is alkyl; and R3 is optionally substituted cycloalklylalkyl which comprises oxidizing a compound of the formula wherein R1, R2 and R3 are defined above to yield a compound of formula I.
摘要翻译：本申请涉及制备式I化合物的方法：其中R 1是烷基; R 2是烷基; 和R 3是任选取代的环烷基烷基，其包括将下式化合物其中R 1，R 2和R 3， SUP>如上定义，得到式I化合物。

5. 发明申请

US20080051579A1 Process for resolving chiral piperidine alcohol and process for synthesis of pyrazolo[1,5-a] pyrimidine derivatives using same 有权
标题翻译：用于拆分手性哌啶醇的方法和使用其合成吡唑并[1,5-a]嘧啶衍生物的方法
公开(公告)号：US20080051579A1
公开(公告)日：2008-02-28
申请号：US11893850
申请日：2007-08-17
申请人： Frank Chen , Maria Tamarez , Ji Xie
发明人： Frank Chen , Maria Tamarez , Ji Xie
IPC分类号： C07D487/00 , C07D211/00
CPC分类号： C07D487/04 , C07D211/22 , C07D471/04
摘要： The present invention provides a method of resolving piperdin-yl-alkylene-alcohols, in high yield at high enantiomeric purity, for example 2-piperidin-2-yl-ethanol.
摘要翻译：本发明提供以高对映体纯度的高收率例如2-哌啶-2-基 - 乙醇来分解哌啶基 - 亚烷基 - 醇的方法。

6. 发明申请

US20060074241A1 Enantioselective process 失效
公开(公告)号：US20060074241A1
公开(公告)日：2006-04-06
申请号：US11287041
申请日：2005-11-23
申请人： Frank Chen , Yee-Shing Wong , Feng Liang , Marc Poirier , George Wu
发明人： Frank Chen , Yee-Shing Wong , Feng Liang , Marc Poirier , George Wu
IPC分类号： C07D401/14
CPC分类号： C07D401/14 , C07D221/16
摘要： An enantioselective process for preparing intermediates useful in the preparation of the chiral tricyclic compound of formula I is disclosed.

7. 发明授权

US09862228B1 Caster structure 有权
公开(公告)号：US09862228B1
公开(公告)日：2018-01-09
申请号：US15485286
申请日：2017-04-12
申请人： Frank Chen
发明人： Frank Chen
IPC分类号： B60B33/00
CPC分类号： B60B33/006 , B60B33/0057 , B60B33/0068 , B60B2380/12 , Y10T16/186
摘要： A caster structure has a screw hole formed at the middle of a carrying plate and provided for passing, screwing, and pressing a screw, and then screwing and pressing tightly with a nut, so that the installed screw has a smaller thickness to lower the center of gravity of an installed wheel in addition to giving a dual nut fixing effect. The caster has bearings which are mainly thrust bearings for bearing a relatively larger axial gravity to prevent the bearing from being damaged by gravity and the balls from falling out. The bearings are limited and positioned securely to prevent installation gaps and dusts, to maintain a flexible rotation of the caster.

8. 发明申请

US20120004897A1 Operation Training Simulation Apparatus for Computer Numerical Control Machine 审中-公开
标题翻译：计算机数控机床操作训练仿真装置
公开(公告)号：US20120004897A1
公开(公告)日：2012-01-05
申请号：US12672898
申请日：2008-08-19
申请人： Frank Chen
发明人： Frank Chen
IPC分类号： G06F13/10
CPC分类号： G09B25/02 , G09B19/24
摘要： An operation training simulation apparatus for a computer numerical control (CNC) machine includes a CNC casing assembly, a control panel device for inputting control and operation commands, a software simulator connected with the simulated control panel displayer, and a simulation displayer electrically connected to the software simulator. The casing assembly includes a CNC frame body. The control panel device is mounted on the casing assembly and has a realistic function control panel interface and a realistic operation control panel interface. The software simulator generates machining and operation simulations based on the inputted control and operation commands through the control panel device, and the simulation displayer visualizes the machining and operation simulations generated by the software simulator.
摘要翻译：一种用于计算机数控（CNC）机器的操作训练模拟装置，包括CNC壳体组件，用于输入控制和操作命令的控制面板装置，与仿真控制面板显示器连接的软件模拟器，以及与该模拟显示器电连接的模拟显示器软件模拟器。壳体组件包括CNC框体。控制面板装置安装在外壳组件上，具有逼真的功能控制面板界面和逼真的操作控制面板界面。软件模拟器通过控制面板设备根据输入的控制和操作命令生成加工和运行模拟，仿真显示器可以显示软件模拟器产生的加工和运行模拟。

9. 发明申请

US20110139359A1 IN-PRESS PROCESS FOR COATING COMPOSITE SUBSTRATES 有权
标题翻译：用于涂覆复合基材的印刷工艺
公开(公告)号：US20110139359A1
公开(公告)日：2011-06-16
申请号：US13033476
申请日：2011-02-23
申请人： Frank Chen , Greg Muselman , Travis W. Idol , David H. Nowak
发明人： Frank Chen , Greg Muselman , Travis W. Idol , David H. Nowak
IPC分类号： B44C1/17
CPC分类号： B05D7/54 , B05D3/0254 , B05D3/12 , B05D7/06 , B05D2203/20 , B27N3/06 , D21H19/16 , D21H27/18
摘要： An improved process for manufacture of polymer coated composite substrates is described. a coated composite substrate is prepared in the press by applying a layer of a primer coating composition to the surface of a compressible mat comprising fibers and/or particles and a resin binder. The primer coating composition is formulated preferably as a fast setting polymer latex capable of forming a chemically crosslinked polymer matrix when applied to the surface of a compressible mat. a thermosetting top coat composition can be applied directly over the wet primer coating composition before heat-processing the mat to improve surface quality and release characteristics. Compressing and heating the coated mat produces a primed composite substrate directly out of the press.
摘要翻译：描述了一种用于制造聚合物涂覆的复合基底的改进方法。在压制机中通过将一层底漆涂料组合物施加到包含纤维和/或颗粒的可压缩垫的表面和树脂粘合剂的表面上来制备涂覆的复合基材。底漆涂料组合物优选配制成能够在施加到可压缩垫的表面时形成化学交联的聚合物基质的快速凝固聚合物胶乳。热加工顶涂层组合物可以在热处理垫之前直接施加在湿底漆涂料组合物上，以改善表面质量和释放特性。压制和加热涂布的垫片直接从压机中产生底漆的复合基材。

10. 发明申请

US20100080060A1 DETERMINING MEMORY PAGE STATUS 有权
标题翻译：确定记忆页状态
公开(公告)号：US20100080060A1
公开(公告)日：2010-04-01
申请号：US12355934
申请日：2009-01-19
申请人： Frank Chen , Zhao Wei , Yuan Rong
发明人： Frank Chen , Zhao Wei , Yuan Rong
IPC分类号： G11C16/04 , G11C16/06 , G11C7/00
CPC分类号： G11C16/10 , G11C16/34 , G11C16/3436 , G11C2207/2245
摘要： The present disclosure includes methods, devices, modules, and systems for operating semiconductor memory. One method embodiment includes determining a status of a page of memory cells without using input/output (I/O) circuitry, and outputting the status through the I/O circuitry.
摘要翻译：本公开包括用于操作半导体存储器的方法，设备，模块和系统。一种方法实施例包括在不使用输入/输出（I / O）电路的情况下确定一页存储器单元的状态，并通过I / O电路输出状态。

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