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1. 发明授权

US06264978B1 Transdermal application system containing acetylsalicylic acid for antithrombotic therapy and cancer prophylaxis 失效
标题翻译：含有乙酰水杨酸用于抗血栓治疗和癌症预防的透皮应用系统
公开(公告)号：US06264978B1
公开(公告)日：2001-07-24
申请号：US08256065
申请日：1994-08-04
申请人： Frank Becher , Thomas Kissel
发明人： Frank Becher , Thomas Kissel
IPC分类号： A61F1300
CPC分类号： A61K9/7061 , A61K9/7084 , A61K31/60
摘要： The invention concerns a transdermal application system for antithrombotic therapy and for the prophylaxis against cancer, respectively, containing as active substance acetylsalicylic acid and/or pharmaceutically acceptable salts thereof.
摘要翻译：本发明涉及分别含有作为活性物质乙酰水杨酸和/或其药学上可接受的盐的抗血栓治疗和预防癌症的透皮应用系统。

2. 发明授权

US5236421A Fixing system for fastening catheters, cannulas or the like to the skin surface and process for the sterile fastening thereof 失效
标题翻译：用于将导管，插管等紧固到皮肤表面的固定系统和用于其无菌紧固的过程
公开(公告)号：US5236421A
公开(公告)日：1993-08-17
申请号：US979412
申请日：1992-11-19
申请人： Frank Becher
发明人： Frank Becher
IPC分类号： A61M25/02
CPC分类号： A61M25/02 , A61M2025/0266
摘要： The invention relates to a fixing system for fixing catheters, cannulas, etc. with a skin film (3) coated with a skin adhesion layer (2) and having a cover film (1) and an overplaster (6) finished with a pressure sensitive adhesive layer (5) adhering to the skin film and having an overplaster cover layer (4), as well as to a process for the sterile fastening of a cannula to the skin with the following steps: application of a bacteria-tight skin film with skin adhesion layer to the skin in the insertion region of the cannula, passing the cannula through the skin film, applying an adhesive forming an elastic, bacteria-tight film adhering to the skin film region surrounding the insertion point and the cannula portion projecting out of the skin and sticking the overplaster over the cannula.
摘要翻译：本发明涉及一种固定导管，插管等的固定系统，其中涂有皮肤粘合层（2）并具有覆盖膜（1）和覆盖层（6）的皮膜（3）粘合剂层（5）粘附到皮肤膜并具有过度覆盖层（4），以及用于以下步骤将套管无菌地固定到皮肤的过程：将具有细菌的皮肤膜与皮肤粘合层到插管的插入区域中的皮肤，使套管穿过皮肤膜，施加粘合剂，形成粘附到插入点周围的皮肤膜区域的弹性细菌密封膜，以及从插入部分突出的套管部分皮肤并将覆盖物贴在套管上。

3. 发明授权

US08207159B2 Use of galanthamine for the treatment of pathological manifestations of the central nervous system based on intoxications with psychotropic substances 有权
标题翻译：使用加兰他敏治疗中枢神经系统的病理表现，基于与精神药物的中毒
公开(公告)号：US08207159B2
公开(公告)日：2012-06-26
申请号：US10475357
申请日：2002-04-18
申请人： Klaus Opitz , Joachim Moormann , Thomas Hille , Frank Becher
发明人： Klaus Opitz , Joachim Moormann , Thomas Hille , Frank Becher
IPC分类号： A61K31/55
CPC分类号： A61K31/55 , Y10S514/811
摘要： The invention relates to the use of galanthamine, as free base or as acid addition salt, for the treatment of cerebral, central nervous or psychiatric symptoms, defunctionalization manifestations or disorders occurring through intake of psychotropic substances as a consequence of occasional or chronic abuse of addictive substances, intoxicants or medicines, or as side effects of the use, especially repeated or prolonged, as intended of medicaments, or as an effect of use, in particular repeated or prolonged, not as intended of medicaments, or as a result of acute poisoning by psychotropic toxic substances, or as a result of chronic exposure to toxic substances with a psychotropic effect in humans or other vertebrates.
摘要翻译：本发明涉及作为游离碱或作为酸加成盐的雪花胺作为治疗脑，中枢神经或精神病症状的功能化表现或通过摄取精神药物而发生的紊乱的作用，因为偶尔或长期滥用上瘾物质，毒物或药物，或副作用，特别是重复或延长的药物意图，或作为使用的效果，特别是重复或延长的药物，或作为急性中毒的结果或由于在人类或其他脊椎动物中长期暴露于具有精神作用的有毒物质的结果。

4. 发明授权

US07763274B2 Administration form with active substance-containing particles, for application on the skin or mucosa 失效
标题翻译：给药形式含有活性物质的颗粒，适用于皮肤或粘膜
公开(公告)号：US07763274B2
公开(公告)日：2010-07-27
申请号：US10484895
申请日：2002-07-11
申请人： Frank Becher
发明人： Frank Becher
IPC分类号： A61F13/00
CPC分类号： A61K9/1611 , A61K9/006 , A61K9/1652 , A61K9/1694 , A61K9/7023
摘要： Administration forms for application to the skin or mucosa, comprising a carrier matrix and at least one active substance, are characterized in that the carrier matrix has a plurality of particles having open pores or containing capillary spaces, said particles serving as active substance reservoir and containing at least one active substance.
摘要翻译：包含载体基质和至少一种活性物质的施用于皮肤或粘膜的给药形式的特征在于，所述载体基质具有多个具有开放孔或含有毛细管空间的颗粒，所述颗粒用作活性物质储库并含有至少一种活性物质。

5. 发明授权

US07011843B2 Method for protecting a human being against health impairment by ingestion of a transdermal therapeutic system 有权
公开(公告)号：US07011843B2
公开(公告)日：2006-03-14
申请号：US10152413
申请日：2002-05-21
申请人： Frank Becher , Ann-Katrin Klink
发明人： Frank Becher , Ann-Katrin Klink
IPC分类号： A61F13/00 , A61L15/16
CPC分类号： A61K9/7023
摘要： A method for the protection of a human being against any health impairment as a result of the ingestion of the whole or parts of a transdermal therapeutic system containing at least one pharmacologically active ingredient, which is toxic or induces nausea or addiction at oral, but not at transdermal administration is disclosed. The method comprises adding to said transdermal therapeutic system a substance being able to keep off a human being from said ingestion.

6. 发明授权

US6143320A Method for the application of an active substance patch for controlling or alleviating an addiction 失效
标题翻译：用于控制或缓解成瘾的活性物质贴剂的应用方法
公开(公告)号：US6143320A
公开(公告)日：2000-11-07
申请号：US173804
申请日：1998-10-16
申请人： Frank Becher , Werner Wessling
发明人： Frank Becher , Werner Wessling
IPC分类号： A61K9/70 , A61F13/00 , A01N43/42
CPC分类号： A61K9/7023
摘要： A method for the application of an active substance patch for controlling or alleviating an addiction such as drug addiction, addiction to pills or analgesia is characterized in that two or more active substance patches are applied simultaneously, sequentially or alternately within a given therapy plan under surveillance of the blood level of the active substance in a way that allows the achievement of an active substance blood level which is high enough for a successful suppression of the addiction and remains constantly effective throughout a useful period of administration.
摘要翻译：用于控制或缓解成瘾如药物成瘾，丸剂或镇痛成瘾的活性物质贴剂的方法的特征在于，在监视的给定治疗计划中同时，依次或交替地施用两种或更多种活性物质贴剂活性物质的血液水平以允许实现足够高的活性物质血液水平的方式来成功抑制成瘾，并且在整个有效的给药期间保持有效。

7. 发明授权

US06853395B1 Process and device for inscription of a sheet-like adhesive system of a polymer, especially of a transdermal therapeutic system 有权
标题翻译：用于记录聚合物片状粘合剂体系的方法和装置，特别是透皮治疗系统
公开(公告)号：US06853395B1
公开(公告)日：2005-02-08
申请号：US09980917
申请日：2000-04-08
申请人： Frank Becher
发明人： Frank Becher
IPC分类号： A61K9/70 , B23K26/00 , B41J2/44 , B41J3/407 , B41M5/24 , B41M5/26 , C09J7/02 , G09F3/02 , B41J2/47 , B23K26/08
CPC分类号： G09F3/02 , A61K9/7023 , B41J2/442 , B41J3/407 , B41M5/24 , B41M5/267
摘要： A process for inscription of a sheet-like adhesive system of a polymer, preferably on the adhesive-free side thereof, with information is characterized in that the inscription is carried out with the aid of a movably guided laser beam in such a manner that a detrimental influence on the ingredients contained in the system, in particular by heat generated by the laser beam or by detrimental perforation of a backing layer impermeable to ingredients or water vapour, is avoided, and that to this end the intensity and penetration depth of the laser beam is adjusted according to the material properties of the system in such a way that the laser beam does not penetrate far enough to reach an ingredient-containing layer of the system.
摘要翻译：聚合物的片状粘合剂体系（优选在其无粘合剂侧）上记录信息的方法的特征在于，借助于可移动引导的激光束进行铭文，使得避免了对系统中所含成分的不利影响，特别是通过激光束产生的热或对成分或水蒸气不可渗透的背衬层的不利穿孔，并且为此，激光的强度和穿透深度根据系统的材料性质调节光束，使得激光束不能穿透足够远以到达系统的成分含有层。

8. 发明授权

US6054196A Childproof package for active substance patches 失效
标题翻译：用于活性物质补丁的儿童防护包装
公开(公告)号：US6054196A
公开(公告)日：2000-04-25
申请号：US836098
申请日：1997-07-18
申请人： Reinhard Koch , Frank Muller , Frank Becher
发明人： Reinhard Koch , Frank Muller , Frank Becher
IPC分类号： B32B7/02 , B65D65/40 , B65D75/26 , A61L15/00 , B65D30/08
CPC分类号： B65D75/26 , B32B7/02 , B65D2215/00 , Y10S428/91 , Y10T428/1307 , Y10T428/1321 , Y10T428/1334 , Y10T428/1338 , Y10T428/1362 , Y10T428/1372
摘要： A childproof package for active substance patches is formed as primary package and comprises at least one mechanically tough, in particular tear-resistant layer.
摘要翻译： PCT No.PCT / EP95 / 04205 Sec。 371日期1997年7月18日 102（e）1997年7月18日PCT PCT 1995年10月26日PCT公布。公开号WO96 / 13445 日期1996年5月9日一种用于活性物质斑块的儿童防护包被形成为初级包装，并且包括至少一个机械坚韧的，特别是抗撕裂层。

9. 发明授权

US5902433A Process and a device for producing a transdermal therapeutic system for the administration of active substances to the skin in the form of a plane multichamber or multichamber-channel system 失效
标题翻译：制备用于以平面多室或多室通道系统的形式向皮肤施用活性物质的透皮治疗系统的方法和装置
公开(公告)号：US5902433A
公开(公告)日：1999-05-11
申请号：US553606
申请日：1996-05-02
申请人： Frank Becher , Walter Muller
发明人： Frank Becher , Walter Muller
IPC分类号： A61M37/00 , A61F13/02 , A61K9/70 , A61L15/44 , A61L15/64 , B29C35/16 , B29C65/02 , B29C65/08 , B29C65/14 , B29C65/16 , B29C65/18 , B29C65/48 , B29C65/50 , B29C65/52
CPC分类号： A61K9/703 , A61K9/7084 , A61K9/7092 , B29C65/02 , B29C65/526 , B29C66/436 , B29C2793/009 , B29C35/16 , B29C65/08 , B29C65/14 , B29C65/1412 , B29C65/1425 , B29C65/16 , B29C65/1603 , B29C65/18 , B29C65/4815 , B29C65/482 , B29C65/4825 , B29C65/483 , B29C65/486 , B29C65/5007 , B29C65/5057 , B29L2031/601 , B29L2031/712 , Y10T156/1023 , Y10T156/1041 , Y10T156/1054
摘要： In a process for the production of a transdermal therapeutic system for the administration of active substances to the skin in the form of a plane multichamber or multichamber-channel system an active substance-containing layer is introduced between top layer and bottom layer; subsequently top and bottom layer are squeezed at individual and/or coherent sites under displacement of the intermediary sites of the active substance-containing layer and formation of active substance-containing chambers or channels, and at the same time or after that top layer and bottom layer are bonded permanently at the squeezed places.
摘要翻译： PCT No.PCT / EP94 / 01278 Sec。 371日期：1996年5月2日 102（e）日期1996年5月2日PCT 1994年4月25日PCT PCT。第WO94 / 26346号公报日期1994年11月24日在制备用于以平面多室或多室通道系统形式向皮肤施用活性物质的透皮治疗系统的方法中，在顶层和底层之间引入含活性物质的层层; 随后在含活性物质层的中间位置置换的单个和/或连贯部位挤压顶层和底层，并形成含活性物质的腔室或通道，同时或之后的顶层和底层层在被挤压的地方永久地粘合。

10. 发明授权

US5066494A Transdermal therapeutic system 失效
标题翻译：变态治疗系统
公开(公告)号：US5066494A
公开(公告)日：1991-11-19
申请号：US327810
申请日：1989-04-03
申请人： Frank Becher
发明人： Frank Becher
IPC分类号： A61M37/00 , A61K9/70 , A61L15/16 , A61M20060101 , A61M35/00
CPC分类号： A61K9/703 , A61K9/7092
摘要： The invention relates to a transdermal therapeutic system for administering or applying active substances to the skin with a backing layer remote from the skin, an active substance depot, an active substance delivery control means controlling the delivery of the active substance through the system and a contact adhesive means for fixing the therapeutic system to the skin, in which the active substance depot is a multichamber system, in which discreet chambers contain one or more active substances.
摘要翻译： PCT No.PCT / DE88 / 00370 Sec。 371日期：1989年4月3日 102（e）日期1989年4月3日PCT Filed 1988年6月21日PCT公布。公开号WO89 / 00437 日本1989年1月26日。本发明涉及一种用于向远离皮肤的背衬层向皮肤施用或施用活性物质的透皮治疗系统，活性物质贮库，控制活性物质递送的活性物质输送控制装置物质通过系统和用于将治疗系统固定到皮肤的接触粘合剂装置，其中活性物质贮库是多室系统，其中谨慎的室含有一种或多种活性物质。

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