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1. 发明授权

US5070188A Acylated epidermal growth factor 失效
标题翻译： ACYLATED EPIDERMAL GROWTH FACTOR
公开(公告)号：US5070188A
公开(公告)日：1991-12-03
申请号：US383518
申请日：1989-07-24
申请人： Francois K. Njieha , Shalaby W. Shalaby
发明人： Francois K. Njieha , Shalaby W. Shalaby
IPC分类号： A61K38/22 , A61K38/00 , A61P1/04 , A61P17/00 , A61P43/00 , C07K1/113 , C07K14/485 , C07K14/52
CPC分类号： C07K14/485 , A61K38/00
摘要： The present invention provides acylated epidermal growth factor derivatives, methods of making the derivatives and pharmaceutical compositions containing the derivatives.

2. 发明授权

US08865205B2 Bioswellable sutures 有权
标题翻译：生物可维护的缝线
公开(公告)号：US08865205B2
公开(公告)日：2014-10-21
申请号：US12229142
申请日：2008-08-20
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61K9/14 , A61K9/70 , A61L27/34 , A61L17/14 , A61L29/08 , A61B17/06 , A61B17/00
CPC分类号： A61B17/06166 , A61B2017/00889 , A61L17/145 , A61L27/34 , A61L29/085
摘要： Swellable, coated sutures have a swellable polymeric coating and a fibrous component, wherein the coating is formed of an absorbable or non-absorbable polymer, while the fibrous component is formed of a synthetic absorbable or non-absorbable monofilament yarn, synthetic absorbable or non-absorbable braided multifilament yarn, braided silk multifilament yarn or combinations thereof. In certain instances, the coating is used as a carrier for the controlled delivery of different types of bioactive agents, including those having antimicrobial, anti-inflammatory, anesthetic, tissue growth-promoting, and antineoplastic activities.
摘要翻译：可膨胀的涂层缝合线具有可溶胀的聚合物涂层和纤维组分，其中涂层由可吸收或不可吸收的聚合物形成，而纤维组分由合成的可吸收或不可吸收的单丝纱线，合成的可吸收或不可吸收的聚合物形成，可吸收编织复丝纱，编织丝复丝纱或其组合。在某些情况下，涂层用作用于受控递送不同类型的生物活性剂的载体，包括具有抗微生物，抗炎，麻醉，组织生长促进和抗肿瘤活性的生物活性剂。

3. 发明授权

US07842749B2 Tissue protecting spray-on copolymeric film composition 有权
标题翻译：组织保护喷雾共聚膜组成
公开(公告)号：US07842749B2
公开(公告)日：2010-11-30
申请号：US11175636
申请日：2005-07-05
申请人： Shalaby W. Shalaby , James M. Lindsey, III
发明人： Shalaby W. Shalaby , James M. Lindsey, III
IPC分类号： C08L31/00
CPC分类号： A61L26/0014 , A61L26/0076 , C08F293/005 , C08L53/00 , C08L2666/02
摘要： This invention deals with a tissue protecting, spray-on film composition comprising an amphiphilic film-forming, segmented/block copolymer derived form at least one water-soluble monomer and at least another water-insoluble monomer, wherein the film can be formed from a water soluble organic solvent such as 2-propanol, acetone, and ethyl acetate. The film can contain a bioactive agent including those to have antimicrobial, anesthetic, anti-inflammatory, and wound-healing activities.
摘要翻译：本发明涉及包含形成至少一种水溶性单体和至少另一种水不溶性单体的两亲成膜，分段/嵌段共聚物的组织保护喷涂膜组合物，其中该膜可由水溶性有机溶剂如2-丙醇，丙酮和乙酸乙酯。该膜可以含有包括具有抗微生物剂，麻醉剂，抗炎和伤口愈合活性的生物活性剂。

4. 发明申请

US20090264555A1 Cyanoacrylate tissue adhesive formulations with multipurpose rheology modifiers 有权
标题翻译：具有多用途流变改性剂的氰基丙烯酸酯组织粘合剂配方
公开(公告)号：US20090264555A1
公开(公告)日：2009-10-22
申请号：US12386401
申请日：2009-04-18
申请人： Shalaby W. Shalaby , Michael Aaron Vaughn , James M. Lindsey, III
发明人： Shalaby W. Shalaby , Michael Aaron Vaughn , James M. Lindsey, III
IPC分类号： A61L24/04
CPC分类号： A61L24/06 , A61L24/04 , A61K6/0017 , C08L33/14 , A61K6/0023
摘要： Absorbable and non-absorbable cyanoacrylate tissue adhesive/sealant formulations include at least one multipurpose carboxylic, acid-bearing C-succinylated polymeric rheology modifier capable of increasing the viscosity of the liquid formulation, while controlling the anionic polymerization of the cyanoacrylate monomers and increasing the compliance of the cured solid adhesive.
摘要翻译：可吸收和不可吸收的氰基丙烯酸酯组合粘合剂/密封剂制剂包括至少一种多功能羧酸，含酸的C琥珀酰化聚合物流变改性剂，其能够增加液体制剂的粘度，同时控制氰基丙烯酸酯单体的阴离子聚合并增加顺应性的固化固体粘合剂。

5. 发明申请

US20090177286A1 Radiation and radiochemically sterilized fiber-reinforced, composite urinogenital stents 有权
标题翻译：辐射和放射化学灭菌的纤维增强，复合尿殖器支架
公开(公告)号：US20090177286A1
公开(公告)日：2009-07-09
申请号：US12378221
申请日：2009-02-12
申请人： Shalaby W. Shalaby , Kenneth W. Clinkscales , Kenneth David Gray
发明人： Shalaby W. Shalaby , Kenneth W. Clinkscales , Kenneth David Gray
IPC分类号： A61F2/04
CPC分类号： A61F2/86 , A61F2/04 , A61F2/94 , A61F2210/0004 , A61F2210/0076 , A61L31/048 , A61L31/129 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/404 , A61L2300/416 , A61M25/0108 , A61M27/008
摘要： A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.
摘要翻译：辐射和放射化学消毒的多组分纤维增强复合材料，可吸收/分解的尿道内支架，如输尿管内支架，根据用于灭菌的高能量辐射剂量，在生物部位的放射性调节停留时间为1至10周。

6. 发明申请

US20080220045A1 Self-setting polymeric cyanoacrylate composites 有权
标题翻译：自制聚合氰基丙烯酸酯复合材料
公开(公告)号：US20080220045A1
公开(公告)日：2008-09-11
申请号：US12080649
申请日：2008-04-04
申请人： Shalaby W. Shalaby , Michael Aaron Vaughn , Shawn J. Peniston , Sheila Nagatomi
发明人： Shalaby W. Shalaby , Michael Aaron Vaughn , Shawn J. Peniston , Sheila Nagatomi
IPC分类号： A61F2/28
CPC分类号： A61L24/0084 , A61L24/0042 , A61L24/0089 , A61L27/446 , A61L27/46 , A61L27/58 , A61L2430/02 , C08L35/04
摘要： Self-setting, absorbable bioactive polycyanoacrylate-based composites include at least one inorganic phosphate salt or a combination of at least one inorganic phosphate salt and calcium silicate in a cyanoacrylate matrix. The composites can be reinforced with single- or multicomponent absorbable, warp-knitted mesh, thus producing a broad range of absorbable, bioactive biomaterials suitable for use not only as preferred absorbable alternatives to the commercial non-absorbable polymethyl methacrylate bone cements, but also for repairing or replacing cranial and maxillofacial bone defects and other complex defects through guided bone regeneration.
摘要翻译：自制的可吸收的生物活性聚氰基丙烯酸酯复合材料包括氰基丙烯酸酯基体中的至少一种无机磷酸盐或至少一种无机磷酸盐和硅酸钙的组合。复合材料可以用单组分或多组分可吸收的经编织物加强，从而产生广泛范围的可吸收的生物活性生物材料，不仅适用于商业上不可吸收的聚甲基丙烯酸甲酯骨水泥的优选可吸收替代物，而且适用于通过引导骨再生修复或替代颅面和颌面骨缺损及其他复杂缺陷。

7. 发明授权

US07416559B2 Micromantled drug-eluting stent 有权
标题翻译：微胶囊药物洗脱支架
公开(公告)号：US07416559B2
公开(公告)日：2008-08-26
申请号：US11390403
申请日：2006-03-27
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： C08F265/04
CPC分类号： A61L17/12 , A61F2/82 , A61F2250/0067 , A61L31/06 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/00 , C08G63/08 , C08G63/64 , C08L67/04
摘要： Pharmacologically active, easy-to-deploy, biomechanically compatible, inflatable endovascular, drug-eluting stent are formed of a primary expandable polymeric or metallic construct, intimately mantled with a biomechanically compatible, polymeric microporous, microfibrous, compliant, stretchable fabric formed by direct electrospinning onto the outside surface of the primary construct using at least one polymer solution containing at least one active compound, selected from those expected to control key biological events leading to in-stent restenosis.
摘要翻译：药物活性，易于部署，生物力学兼容，可充气的血管内药物洗脱支架由主要的可扩张聚合物或金属构造体形成，与生物力学相容的聚合物微孔，微纤维，柔顺的可伸缩织物紧密结合，通过直接静电纺丝形成使用至少一种含有至少一种活性化合物的聚合物溶液在主要构建体的外表面上，所述活性化合物选自预期控制导致支架内再狭窄的关键生物学事件的活性化合物。

8. 发明申请

US20080183208A1 Inorganic-organic melt-extruded hybrid yarns and fibrous composite medical devices thereof 有权
标题翻译：无机 - 有机熔融挤出混合纱线及其纤维复合医疗装置
公开(公告)号：US20080183208A1
公开(公告)日：2008-07-31
申请号：US11880993
申请日：2007-07-25
申请人： Shalaby W. Shalaby , Kenneth W. Clinkscales , Kimberly A. Carpenter
发明人： Shalaby W. Shalaby , Kenneth W. Clinkscales , Kimberly A. Carpenter
IPC分类号： A61L17/00 , D02G3/04 , D03D15/00
CPC分类号： D01F1/10 , A61F2/0063 , A61L17/005 , A61L17/10 , A61L17/145 , A61L31/127 , A61L31/128 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/622 , A61L2300/624 , D01F6/62 , D01F6/625 , D01F6/64 , D01F6/86 , D02G3/04 , D02G3/38 , D02G3/448 , Y10T428/249938 , Y10T428/29 , Y10T428/2913 , Y10T428/2915 , Y10T428/2931 , Y10T428/298 , Y10T442/105 , Y10T442/3146 , Y10T442/3154 , Y10T442/3171 , Y10T442/3301 , Y10T442/425 , Y10T442/431 , Y10T442/438 , Y10T442/444
摘要： Composite fibrous constructs are made of combinations of inorganic-organic hybrid monofilament or multifilament yarns containing at least 6 weight percent of inorganic micro-/nanoparticles and organic monofilament or multifilament yarn with typical examples of the hybrid yarn matrix made of absorbable or non-absorbable thermoplastic polymers and final constructs being in the form of knitted or woven meshes and braided ligatures intended to perform under specific mechanically, biologically, and/or radiologically related functions.
摘要翻译：复合纤维构造物由含有至少6重量％的无机微/纳米颗粒和有机单丝或多丝纱的无机 - 有机杂化单丝或复丝纱的组合制成，具有由可吸收或不可吸收的热塑性塑料制成的混合纱线基质的典型实例聚合物和最终构造物是针织或梭织网格和编织结扎的形式，旨在在特定的机械，生物学和/或放射学相关功能下进行。

9. 发明授权

US07138464B2 Functionalized, absorbable, segmented copolyesters and related copolymers 有权
标题翻译：官能化的，可吸收的，分段的共聚酯和相关的共聚物
公开(公告)号：US07138464B2
公开(公告)日：2006-11-21
申请号：US10693361
申请日：2003-10-24
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： C08F20/00
CPC分类号： C08G63/912 , C08G63/64 , C08G63/664
摘要： Absorbable heterochain polymers carrying acid or basic groups, capable of ionic conjugation with basic or acidic bioactive agents, respectively, are produced by free-radical addition of unsaturated functional monomers onto absorbable liquid polymers and subsequent generation of reactive functionality or by direct copolymerization of a carboxylic initiator with cyclic monomers to produce liquid carboxyl-bearing copolyesters or polyester carbonates.
摘要翻译：通过将不饱和官能单体自由基添加到可吸收的液体聚合物上并随后产生反应性官能团或通过直接共聚羧基来产生携带酸或碱性基团的能够与碱性或酸性生物活性剂离子缀合的可吸收的杂链聚合物引发剂与环状单体产生液体含羧基的共聚酯或聚酯碳酸酯。

10. 发明授权

US07048753B2 Coated, slow-absorbing textile constructs for sutures and tissue engineering 有权
标题翻译：用于缝线和组织工程的涂层缓慢吸收的纺织结构
公开(公告)号：US07048753B2
公开(公告)日：2006-05-23
申请号：US10086312
申请日：2002-03-01
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61B17/04
CPC分类号： C08G63/08 , A61L17/12 , A61L27/18 , A61L31/06 , C08G63/64 , C08L69/00 , C08L67/04
摘要： The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably ε-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150° C. and a crystallinity of at least 20%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1.1 dl/g. A variety of surgical constructs may be formed from the present copolymers. Disclosed are coated surgical constructs including sutures made of multifilament yarns of the present copolymers and coated with nitrogenous copolyesters which will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.
摘要翻译：本发明涉及1-丙交酯和少部分环状单体的结晶共聚物，优选ε-己内酯或三亚甲基碳酸酯或两者。本共聚物的熔融温度至少为150℃，结晶度至少为20％。优选的是具有至少1.1dl / g的特性粘度的高分子量共聚物。各种手术构建体可以由本发明的共聚物形成。公开了包括本发明共聚物的复丝纱线的缝合线的涂层手术构造物，并且涂覆有含氮共聚酯，其将在不到3年的时间内生物吸收，并且将在手术后三周保持其初始强度的至少50％。

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