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1. 发明申请

US20080183208A1 Inorganic-organic melt-extruded hybrid yarns and fibrous composite medical devices thereof 有权
标题翻译：无机 - 有机熔融挤出混合纱线及其纤维复合医疗装置
公开(公告)号：US20080183208A1
公开(公告)日：2008-07-31
申请号：US11880993
申请日：2007-07-25
申请人： Shalaby W. Shalaby , Kenneth W. Clinkscales , Kimberly A. Carpenter
发明人： Shalaby W. Shalaby , Kenneth W. Clinkscales , Kimberly A. Carpenter
IPC分类号： A61L17/00 , D02G3/04 , D03D15/00
CPC分类号： D01F1/10 , A61F2/0063 , A61L17/005 , A61L17/10 , A61L17/145 , A61L31/127 , A61L31/128 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/622 , A61L2300/624 , D01F6/62 , D01F6/625 , D01F6/64 , D01F6/86 , D02G3/04 , D02G3/38 , D02G3/448 , Y10T428/249938 , Y10T428/29 , Y10T428/2913 , Y10T428/2915 , Y10T428/2931 , Y10T428/298 , Y10T442/105 , Y10T442/3146 , Y10T442/3154 , Y10T442/3171 , Y10T442/3301 , Y10T442/425 , Y10T442/431 , Y10T442/438 , Y10T442/444
摘要： Composite fibrous constructs are made of combinations of inorganic-organic hybrid monofilament or multifilament yarns containing at least 6 weight percent of inorganic micro-/nanoparticles and organic monofilament or multifilament yarn with typical examples of the hybrid yarn matrix made of absorbable or non-absorbable thermoplastic polymers and final constructs being in the form of knitted or woven meshes and braided ligatures intended to perform under specific mechanically, biologically, and/or radiologically related functions.
摘要翻译：复合纤维构造物由含有至少6重量％的无机微/纳米颗粒和有机单丝或多丝纱的无机 - 有机杂化单丝或复丝纱的组合制成，具有由可吸收或不可吸收的热塑性塑料制成的混合纱线基质的典型实例聚合物和最终构造物是针织或梭织网格和编织结扎的形式，旨在在特定的机械，生物学和/或放射学相关功能下进行。

2. 发明授权

US08986393B2 Radiation and radiochemically sterilized fiber-reinforced, composite urinogenital stents 有权
公开(公告)号：US08986393B2
公开(公告)日：2015-03-24
申请号：US13301894
申请日：2011-11-22
申请人： Shalaby W. Shalaby , Kenneth W. Clinkscales , Kenneth D. Gray
发明人： Shalaby W. Shalaby , Kenneth W. Clinkscales , Kenneth D. Gray
IPC分类号： A61F2/04 , A61F2/06 , A61L31/12 , A61L31/14 , A61L31/16 , A61L31/18 , A61M27/00 , A61F2/94 , A61M25/01
CPC分类号： A61F2/86 , A61F2/04 , A61F2/94 , A61F2210/0004 , A61F2210/0076 , A61L31/048 , A61L31/129 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/404 , A61L2300/416 , A61M25/0108 , A61M27/008
摘要： A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.

3. 发明申请

US20120083897A1 RADIATION AND RADIOCHEMICALLY STERILIZED FIBER-REINFORCED, COMPOSITE URINOGENITAL STENTS 审中-公开
标题翻译：辐射和无机化学灭菌纤维增强复合尿素
公开(公告)号：US20120083897A1
公开(公告)日：2012-04-05
申请号：US13301894
申请日：2011-11-22
申请人： Shalaby W. Shalaby , Kenneth W. Clinkscales , Kenneth David Gray
发明人： Shalaby W. Shalaby , Kenneth W. Clinkscales , Kenneth David Gray
IPC分类号： A61F2/04
CPC分类号： A61F2/86 , A61F2/04 , A61F2/94 , A61F2210/0004 , A61F2210/0076 , A61L31/048 , A61L31/129 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/404 , A61L2300/416 , A61M25/0108 , A61M27/008
摘要： A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.
摘要翻译：辐射和放射化学消毒的多组分纤维增强复合材料，可吸收/分解的尿道内支架，如输尿管内支架，根据用于灭菌的高能量辐射剂量，在生物部位的放射性调节停留时间为1至10周。

4. 发明授权

US08252064B2 Fiber-reinforced composite absorbable endoureteral stent 有权
标题翻译：纤维增强复合材料吸收性输尿管支架
公开(公告)号：US08252064B2
公开(公告)日：2012-08-28
申请号：US11346117
申请日：2006-02-02
申请人： Shalaby W. Shalaby , Kenneth W. Clinkscales
发明人： Shalaby W. Shalaby , Kenneth W. Clinkscales
IPC分类号： A61F2/06 , A61F2/04 , A61M5/00
CPC分类号： A61F2/90 , A61F2002/821 , A61L31/06 , A61L31/128 , A61M25/0041 , A61M27/008 , C08L71/02
摘要： Absorbable/disintegratable endourological stents, specifically endoureteral stents, and applicators for their introduction into the biological site, are formed from fiber-reinforced elastomeric films configured to prevent their migration from the application site.
摘要翻译：可吸收/可分解的内科支架，特别是输尿管内支架，以及用于引入生物部位的敷料器，由纤维增强的弹性膜形成，以防止其从应用部位迁移。

5. 发明申请

US20090177286A1 Radiation and radiochemically sterilized fiber-reinforced, composite urinogenital stents 有权
标题翻译：辐射和放射化学灭菌的纤维增强，复合尿殖器支架
公开(公告)号：US20090177286A1
公开(公告)日：2009-07-09
申请号：US12378221
申请日：2009-02-12
申请人： Shalaby W. Shalaby , Kenneth W. Clinkscales , Kenneth David Gray
发明人： Shalaby W. Shalaby , Kenneth W. Clinkscales , Kenneth David Gray
IPC分类号： A61F2/04
CPC分类号： A61F2/86 , A61F2/04 , A61F2/94 , A61F2210/0004 , A61F2210/0076 , A61L31/048 , A61L31/129 , A61L31/148 , A61L31/16 , A61L31/18 , A61L2300/404 , A61L2300/416 , A61M25/0108 , A61M27/008
摘要： A radiation and radiochemically sterilized, multi-component, fiber-reinforced composite, absorbable/disintegratable urinogenital stent, such as an endoureteral stent, with radiomodulated residence time in the biological site of 1 to 10 weeks depending on the high energy radiation dose used for sterilization.
摘要翻译：辐射和放射化学消毒的多组分纤维增强复合材料，可吸收/分解的尿道内支架，如输尿管内支架，根据用于灭菌的高能量辐射剂量，在生物部位的放射性调节停留时间为1至10周。

6. 发明授权

US09011439B2 Selectively absorbable/biodegradable, fibrous composite constructs and applications thereof 有权
标题翻译：选择性吸收/可生物降解的纤维复合结构及其应用
公开(公告)号：US09011439B2
公开(公告)日：2015-04-21
申请号：US11983321
申请日：2007-11-08
申请人： Shalaby W. Shalaby , Shawn Peniston , Kimberly A. Carpenter
发明人： Shalaby W. Shalaby , Shawn Peniston , Kimberly A. Carpenter
IPC分类号： A61B17/04 , A61B17/56 , A61L27/48 , A61L27/58 , C08L23/06
CPC分类号： A61L27/48 , A61L27/54 , A61L27/58 , C08L23/06 , C08L2203/12 , C08L67/04
摘要： A family of selectively absorbable/biodegradable, fibrous composite constructs includes different combinations of biostable and absorbable/biodegradable yarns assembled as initially interdependent, load-bearing components, transitioning to exhibit independent functional properties during in vivo end-use. The family of constructs consists of two groups, one group is made of fiber-reinforced composites of high compliance, absorbable matrices of segmented polyaxial copolyesters reinforced with multifilament yarn constructs, which are combinations of ultrahigh molecular weight polyethylene fibers and at least one absorbable/biodegradable fiber selected from silk fibers and multifilament yarns made from linear segmented, l-lactide copolyesters and poly (3-hydroxyalkanoates, are useful in orthopedic, maxillofacial, urological, vascular, hernial repair and tissue engineering applications. The second group is made of coated and uncoated, warp-knitted mesh constructs for use in hernial, vascular, and urological tissue repair and tissue engineering.
摘要翻译：一系列可选择性吸收/可生物降解的纤维复合材料构造包括生物稳定和可吸收/可生物降解的纱线的不同组合，其组装为最初相互依赖的承载组分，在体内最终用途中转变为显示独立的功能特性。构建体组由两组组成，一组由高柔顺性的纤维增强复合材料制成，由多丝纱构造物增强的分段多轴共聚酯的可吸收基质，其是超高分子量聚乙烯纤维和至少一种可吸收/可生物降解的组合纤维选自由线性分段的丙交酯共聚酯和聚（3-羟基链烷酸酯）制成的丝纤维和复丝纱，可用于矫形，颌面，泌尿，血管，疝修补和组织工程应用中，第二组由涂层和用于疝，血管和泌尿组织修复和组织工程的无涂层，经编网眼构造物。

7. 发明申请

US20080119848A1 Selectively absorbable/biodegradable, fibrous composite constructs and applications thereof 有权
标题翻译：选择性吸收/可生物降解的纤维复合结构及其应用
公开(公告)号：US20080119848A1
公开(公告)日：2008-05-22
申请号：US11983321
申请日：2007-11-08
申请人： Shalaby W. Shalaby , Shawn Peniston , Kimberly A. Carpenter
发明人： Shalaby W. Shalaby , Shawn Peniston , Kimberly A. Carpenter
IPC分类号： A61B17/04 , A61B17/56
CPC分类号： A61L27/48 , A61L27/54 , A61L27/58 , C08L23/06 , C08L2203/12 , C08L67/04
摘要： A family of selectively absorbable/biodegradable, fibrous composite constructs includes different combinations of biostable and absorbable/biodegradable yarns assembled as initially interdependent, load-bearing components, transitioning to exhibit independent functional properties during in vivo end-use. The family of constructs consists of two groups, one group is made of fiber-reinforced composites of high compliance, absorbable matrices of segmented polyaxial copolyesters reinforced with multifilament yarn constructs, which are combinations of ultrahigh molecular weight polyethylene fibers and at least one absorbable/biodegradable fiber selected from silk fibers and multifilament yarns made from linear segmented, l-lactide copolyesters and poly (3-hydroxyalkanoates, are useful in orthopedic, maxillofacial, urological, vascular, hernial repair and tissue engineering applications. The second group is made of coated and uncoated, warp-knitted mesh constructs for use in hernial, vascular, and urological tissue repair and tissue engineering.
摘要翻译：一系列可选择性吸收/可生物降解的纤维复合材料构造包括生物稳定和可吸收/可生物降解的纱线的不同组合，其组装为最初相互依赖的承载组分，在体内最终用途中转变为显示独立的功能特性。构建体组由两组组成，一组由高柔顺性的纤维增强复合材料制成，由多丝纱构造物增强的分段多轴共聚酯的可吸收基质，其是超高分子量聚乙烯纤维和至少一种可吸收/可生物降解的组合纤维选自由线性分段的丙交酯共聚酯和聚（3-羟基链烷酸酯）制成的丝纤维和复丝纱，可用于矫形，颌面，泌尿，血管，疝修补和组织工程应用中，第二组由涂层和用于疝，血管和泌尿组织修复和组织工程的无涂层，经编网眼构造物。

8. 发明授权

US08865205B2 Bioswellable sutures 有权
标题翻译：生物可维护的缝线
公开(公告)号：US08865205B2
公开(公告)日：2014-10-21
申请号：US12229142
申请日：2008-08-20
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61K9/14 , A61K9/70 , A61L27/34 , A61L17/14 , A61L29/08 , A61B17/06 , A61B17/00
CPC分类号： A61B17/06166 , A61B2017/00889 , A61L17/145 , A61L27/34 , A61L29/085
摘要： Swellable, coated sutures have a swellable polymeric coating and a fibrous component, wherein the coating is formed of an absorbable or non-absorbable polymer, while the fibrous component is formed of a synthetic absorbable or non-absorbable monofilament yarn, synthetic absorbable or non-absorbable braided multifilament yarn, braided silk multifilament yarn or combinations thereof. In certain instances, the coating is used as a carrier for the controlled delivery of different types of bioactive agents, including those having antimicrobial, anti-inflammatory, anesthetic, tissue growth-promoting, and antineoplastic activities.
摘要翻译：可膨胀的涂层缝合线具有可溶胀的聚合物涂层和纤维组分，其中涂层由可吸收或不可吸收的聚合物形成，而纤维组分由合成的可吸收或不可吸收的单丝纱线，合成的可吸收或不可吸收的聚合物形成，可吸收编织复丝纱，编织丝复丝纱或其组合。在某些情况下，涂层用作用于受控递送不同类型的生物活性剂的载体，包括具有抗微生物，抗炎，麻醉，组织生长促进和抗肿瘤活性的生物活性剂。

9. 发明授权

US07842749B2 Tissue protecting spray-on copolymeric film composition 有权
标题翻译：组织保护喷雾共聚膜组成
公开(公告)号：US07842749B2
公开(公告)日：2010-11-30
申请号：US11175636
申请日：2005-07-05
申请人： Shalaby W. Shalaby , James M. Lindsey, III
发明人： Shalaby W. Shalaby , James M. Lindsey, III
IPC分类号： C08L31/00
CPC分类号： A61L26/0014 , A61L26/0076 , C08F293/005 , C08L53/00 , C08L2666/02
摘要： This invention deals with a tissue protecting, spray-on film composition comprising an amphiphilic film-forming, segmented/block copolymer derived form at least one water-soluble monomer and at least another water-insoluble monomer, wherein the film can be formed from a water soluble organic solvent such as 2-propanol, acetone, and ethyl acetate. The film can contain a bioactive agent including those to have antimicrobial, anesthetic, anti-inflammatory, and wound-healing activities.
摘要翻译：本发明涉及包含形成至少一种水溶性单体和至少另一种水不溶性单体的两亲成膜，分段/嵌段共聚物的组织保护喷涂膜组合物，其中该膜可由水溶性有机溶剂如2-丙醇，丙酮和乙酸乙酯。该膜可以含有包括具有抗微生物剂，麻醉剂，抗炎和伤口愈合活性的生物活性剂。

10. 发明申请

US20090264555A1 Cyanoacrylate tissue adhesive formulations with multipurpose rheology modifiers 有权
标题翻译：具有多用途流变改性剂的氰基丙烯酸酯组织粘合剂配方
公开(公告)号：US20090264555A1
公开(公告)日：2009-10-22
申请号：US12386401
申请日：2009-04-18
申请人： Shalaby W. Shalaby , Michael Aaron Vaughn , James M. Lindsey, III
发明人： Shalaby W. Shalaby , Michael Aaron Vaughn , James M. Lindsey, III
IPC分类号： A61L24/04
CPC分类号： A61L24/06 , A61L24/04 , A61K6/0017 , C08L33/14 , A61K6/0023
摘要： Absorbable and non-absorbable cyanoacrylate tissue adhesive/sealant formulations include at least one multipurpose carboxylic, acid-bearing C-succinylated polymeric rheology modifier capable of increasing the viscosity of the liquid formulation, while controlling the anionic polymerization of the cyanoacrylate monomers and increasing the compliance of the cured solid adhesive.
摘要翻译：可吸收和不可吸收的氰基丙烯酸酯组合粘合剂/密封剂制剂包括至少一种多功能羧酸，含酸的C琥珀酰化聚合物流变改性剂，其能够增加液体制剂的粘度，同时控制氰基丙烯酸酯单体的阴离子聚合并增加顺应性的固化固体粘合剂。

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