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1. 发明授权

US5436244A Indane derivatives and analgesic and diuretic compositions thereof 失效
标题翻译：吲哚衍生物及其镇痛和利尿组合物
公开(公告)号：US5436244A
公开(公告)日：1995-07-25
申请号：US96034
申请日：1993-07-22
申请人： Francois Clemence , Michel Fortin , Gilles Hamon , Odile Le Martret , Anne M. Moura
发明人： Francois Clemence , Michel Fortin , Gilles Hamon , Odile Le Martret , Anne M. Moura
IPC分类号： C07D207/06 , A61K31/165 , A61K31/255 , A61P7/10 , C07C233/41 , C07C233/79 , C07C235/14 , C07C235/44 , C07C307/02 , C07D295/135 , C07D307/52 , A61K31/34 , A61K31/495 , C07D241/04
CPC分类号： C07D295/135 , C07D307/52 , C07C2102/08
摘要： Novel indanes in all possible stereoisomer forms of the formula ##STR1## wherein the substituents are as defined in the specification and their non-toxic, pharmaceutically acceptable acid addition salts and their hydrates having central analgesic properties as well as antiarrhythmic and diuretic activities.
摘要翻译：所有可能的式I的立体异构体形式的新型茚满酮，其中取代基如说明书中所定义，及其无毒的药学上可接受的酸加成盐及其具有中枢镇痛特性以及抗心律不齐和利尿活性的水合物。

2. 发明授权

US5348971A Indanes useful as analgesics 失效
标题翻译：吲哚可用作镇痛药
公开(公告)号：US5348971A
公开(公告)日：1994-09-20
申请号：US105329
申请日：1993-08-09
申请人： Francois Clemence , Michel Fortin , Gilles Hamon , Odile Le Martret , Anne-Marie Moura
发明人： Francois Clemence , Michel Fortin , Gilles Hamon , Odile Le Martret , Anne-Marie Moura
IPC分类号： C07D295/135 , C07D307/52 , A61K31/40 , C07D295/073
CPC分类号： C07D295/135 , C07D307/52 , C07C2102/08
摘要： Novel indanes in all possible stereoisomer forms of the formula ##STR1## wherein the substrates are as defined in the application and their non-toxic, pharmaceutically acceptable acid addition salts and their hydrates are disclosed as having central analgesic properties as well as antiarrhythmic and diuretic activities.
摘要翻译：式中所有可能的立体异构体形式的新型茚满酮其中底物如本申请中所定义，并且它们的无毒，药学上可接受的酸加成盐及其水合物被公开为具有中枢镇痛特性以及抗心律不齐和利尿活动

3. 发明授权

US4877796A Decahydroquinolines and central analgesic method of use thereof 失效
标题翻译：十氢喹啉和中枢镇痛药的使用方法
公开(公告)号：US4877796A
公开(公告)日：1989-10-31
申请号：US084456
申请日：1987-08-12
申请人： Francois Clemence , Odile Le Martret , Francoise Delevallee , Michel Fortin
发明人： Francois Clemence , Odile Le Martret , Francoise Delevallee , Michel Fortin
IPC分类号： A61K31/47 , A61P7/06 , A61P7/10 , A61P9/06 , A61P9/12 , A61P25/04 , C07D215/40 , C07D401/12 , C07D409/12
CPC分类号： C07D215/40
摘要： A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms of a decahydroquinoline of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 5 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen and akyl of 1 to 5 carbon atoms, A is selected from the group consisting of --(CH.sub.2).sub.n --, --CH.sub.2 O-- and alkylene substituted with alkyl having a total of 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, optionally substituted naphthyl, optionally substituted indenyl, optionally substituted heteromonocycle of 5 to 6 members and optionally substituted heterobicycle with the proviso that when Z is o-alkoxy-phenyl, A is not --(CH.sub.2).sub.n -- in which n is O, and their non-toxic, pharmaceutically acceptable acid addition salts and their quaternary ammonium salts and intermediates having analgesic, diuretic, hypotensive, anti-arrithmic and anti-cerebral-ischaemic properties.
摘要翻译：选自下式的化合物：其中R 1为1至5个碳原子的烷基，R 2选自氢和1至5个碳原子的烷基的所有对映异构体和非对映异构体形式的十氢喹啉的化合物原子，A选自 - （CH 2）n - ， - CH 2 O-和被具有总共2至8个碳原子的烷基取代的亚烷基，n是0至5的整数，Z选自由任选取代的苯基，任选取代的萘基，任选取代的茚基，任选取代的5至6个成员的异单环和任选取代的杂双环，条件是当Z是邻 - 烷氧基 - 苯基时，A不是 - （CH2）n-，其中 n是O，它们的无毒的药学上可接受的酸加成盐及其季铵盐和具有止痛，利尿，降压，抗对数和抗脑缺血性质的中间体。

4. 发明授权

US5234944A Novel indanes 失效
标题翻译：新的indanes
公开(公告)号：US5234944A
公开(公告)日：1993-08-10
申请号：US970776
申请日：1992-11-03
申请人： Francois Clemence , Odile Le Martret , Francoise Delevallee , Michel Fortin
发明人： Francois Clemence , Odile Le Martret , Francoise Delevallee , Michel Fortin
IPC分类号： C07D295/135 , C07D311/96
CPC分类号： C07D295/135 , C07D311/96
摘要： A compound selected from the group consisting of enantiomers and diastereoisomer forms and mixtures thereof of the formula ##STR1## wherein R.sub.6 is selected from the group consisting of hydrogen, halogen and alkyl and alkoxy of 1 to 5 carbon atoms, R.sub.1 and R.sub.2 are individually hydrogen or alkyl of 1 to 5 carbon atoms or taken together with the carbon atoms to which they are attached form a cycloalkyl of 3 to 6 carbon atoms optionally containing a heteroatom selected from the group consisting of --S--, --O-- and --N--, one of A and B has the formula ##STR2## and the other has the formula ##STR3## R is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, Z is selected from the group consisting of --(CH.sub.2).sub.n --, branched alkylene of 2 to 8 carbon atoms and --CH.sub.2 O--, n is an integer of 0 to 5, X, X' and X" are individually selected from the group consisting of hydrogen, alkyl and alkoxy of 1 to 4 carbon atoms, halogen, --OH, --CF.sub.3, --NO.sub.2, --NH.sub.2, mono and dialkylamino of 1 to 4 alkyl carbon atoms and sulfamino, R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are attached form a 5 to 6 member heterocycle optionally containing a member of the group consisting of --O--, --S-- and ##STR4## R.sub.1 ' is hydrogen or alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having a strong affinity for optical receptors, central analgesic, diuretic, anti-arrythmic, hypotensive and cerebral anti-ischemic activity.
摘要翻译：选自下组的对映异构体和非对映异构体形式的化合物及其混合物，其中R 6选自氢，卤素和1至5个碳原子的烷基和烷氧基，R 1和R 2分别为氢或1至5个碳原子的烷基或与它们所连接的碳原子一起形成3至6个碳原子的环烷基，任选地含有选自-S - ， - O-和-N - ，A和B中的一个具有式，另一个具有式（Ia）的化合物，其选自氢和1至5个碳原子的烷基，Z选自 - （ CH 2）n支链亚烷基，-CH 2 O-，n为0〜5的整数，X，X'和X“分别选自氢，烷基和烷氧基的1 至4个碳原子，卤素，-OH，-CF 3，-NO 2，-NH 2，1至4个烷基的单和二烷基氨基碳原子和磺氨基，R3和R4分别选自氢和1至5个碳原子的烷基，或与它们所连接的氮原子一起形成5至6个成员杂环，任选地含有由-O-，-S-和R IMA'组成的基团是氢或1至4个碳原子的烷基，它们对光学受体具有强亲和力的无毒的药学上可接受的酸加成盐，中枢性镇痛药，利尿剂，抗焦虑，降压和脑抗缺血活性。

5. 发明授权

US4888355A Indanes and their use as antiarrhythmic agents 失效
标题翻译：吲哚及其作为抗心律不齐剂的用途
公开(公告)号：US4888355A
公开(公告)日：1989-12-19
申请号：US136814
申请日：1987-12-22
申请人： Francois Clemence , Odile Le Martret , Michel Fortin , Francoise Delevallee
发明人： Francois Clemence , Odile Le Martret , Michel Fortin , Francoise Delevallee
IPC分类号： C07D209/42 , A61K31/165 , A61K31/33 , A61K31/34 , A61K31/343 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/47 , A61P3/04 , A61P7/10 , A61P9/00 , A61P9/06 , A61P9/12 , A61P25/04 , A61P25/06 , C07C67/00 , C07C209/00 , C07C209/16 , C07C209/60 , C07C209/62 , C07C211/42 , C07C213/00 , C07C215/44 , C07C217/74 , C07C231/00 , C07C231/02 , C07C233/11 , C07C233/23 , C07C233/41 , C07C233/62 , C07C233/65 , C07C233/74 , C07C233/79 , C07D215/14 , C07D215/48 , C07D235/04 , C07D263/54 , C07D277/64 , C07D295/12 , C07D295/135 , C07D295/155 , C07D307/79 , C07D333/24 , C07D333/54 , C07D403/12
CPC分类号： C07D295/135 , C07D295/155 , C07D333/24 , C07D333/54
摘要： A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms possible of compounds of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, halogen, and alkyl and alkoxy of 1 to 5 carbon atoms, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, one of A and B being ##STR2## and the other being ##STR3## R is hydrogen or alkyl of 1 to 5 carbon atoms, Z is --(CH.sub.2).sub.n -- or branched alkylene of 2 to 8 carbon atoms, n is an integer from 0 to 5, Y is selected from the group consisting of naphthyl, indenyl, heterobicyclics and heteromonocyclic containing 5 to 6 ring members, all optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, halogen, --OH, --CF.sub.3, --NO.sub.2, --NH.sub.2, monoalkylamino and dialkylamino of 1 to 4 alkyl carbon atoms and phenyl optionally substituted with at least one member of the group consisting of halogen and alkyl and alkoxy of 1 to 4 carbon atoms, R.sub.3 and R.sub.4 are individually hydrogen or alkyl of 1 to 5 carbon atoms or taken together with the nitrogen form a heterocyclic of 5 to 6 ring members and optionally containing --O--, --S-- or nitrogen in the ring and their non-toxic, pharmaceutically acceptable acid addition salts having central analgesic and antiarythmic activity among other activities.
摘要翻译：选自下列化合物的化合物的化合物：其中X选自氢，卤素和1至5个碳原子的烷基和烷氧基，R 1和R 2的所有对映异构体和非对映异构体形式分别选自氢和1至5个碳原子的烷基，A和B之一为“IMAGE”，另一个为R 1为氢或1至5个碳原子的烷基，Z为 - （ CH 2）2至8个碳原子的正或支链亚烷基，n为0至5的整数，Y选自萘基，茚基，异双环烯烃和含有5至6个环成员的杂单环，全部任选被由1至5个碳原子的烷基和烷氧基，卤素，-OH，-CF 3，-NO 2，-NH 2，1至4个烷基碳原子的一烷基氨基和二烷基氨基组成的组中的至少一个和任选被至少一个由卤素和卤素组成的组的成员具有1至4个碳原子的烷基和烷氧基，R 3和R 4分别是氢或1至5个碳原子的烷基或与氮一起形成5至6个环成员的杂环，并任选地含有-O - ， - S-或环中的氮和它们的无毒的药学上可接受的酸加成盐，具有其他活性的中枢镇痛和抗血液活性。

6. 发明授权

US5043347A Indanes and analgesic compositions and methods thereof 失效
标题翻译：吲哚和镇痛组合物及其方法
公开(公告)号：US5043347A
公开(公告)日：1991-08-27
申请号：US438526
申请日：1989-11-17
申请人： Francois Clemence , Odile Le Martret , Francoise Delevallee , Michel Fortin
发明人： Francois Clemence , Odile Le Martret , Francoise Delevallee , Michel Fortin
IPC分类号： C07D493/10 , A61K31/165 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/445 , A61K31/495 , A61P7/10 , A61P9/06 , A61P9/10 , A61P9/12 , A61P25/04 , C07C67/00 , C07C209/00 , C07C209/16 , C07C209/60 , C07C209/62 , C07C211/42 , C07C213/00 , C07C215/44 , C07C231/00 , C07C231/02 , C07C233/41 , C07C235/14 , C07C235/22 , C07C301/00 , C07C303/40 , C07C311/16 , C07C311/29 , C07D211/04 , C07D295/12 , C07D295/135 , C07D311/96 , C07D335/02
CPC分类号： C07D295/135 , C07D311/96
摘要： A compound selected from the group consisting of enantiomers and diastereoisomer forms and mixtures thereof of the formula ##STR1##
摘要翻译：选自对映异构体和非对映异构体形式的化合物及其具有式I的混合物

7. 发明授权

US4816465A Decahydroquinolines and analgesic use thereof 失效
标题翻译：十氢喹啉及其止痛用途
公开(公告)号：US4816465A
公开(公告)日：1989-03-28
申请号：US2778
申请日：1987-01-13
申请人： Francois Clemence , Michel Fortin , Odile Le Martret , Francoise Delevallee
发明人： Francois Clemence , Michel Fortin , Odile Le Martret , Francoise Delevallee
IPC分类号： A61K31/47 , A61K31/4709 , A61P9/00 , A61P9/06 , A61P25/04 , C07D215/18 , C07D215/40 , C07D333/00 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D401/02
CPC分类号： C07D401/06 , C07D215/18 , C07D215/40 , C07D409/06
摘要： Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected form a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of --(CH.sub.2).sub.n -- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceutically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.
摘要翻译：新颖的对映异构体和非对映异构形式的式Ⅰ'的十氢喹啉其中R 1和R 2分别选自氢和1至5个碳原子的烷基或与它们连接的氮原子一起形成5 至6元杂环，任选地包括另外的杂原子和任选取代的A选自 - （CH 2）n - 和被烷基取代并具有2-8个碳原子的亚烷基，n是0-5的整数，Z 选自5至6个成员的任选取代的苯基，萘基茚基，单环杂环和全部未被取代或被一个或多个取代基取代的双环杂环，及其无毒的药学上可接受的酸加成盐和季铵盐具有中枢镇痛特性。

8. 发明授权

US4988810A Novel hydroquinolines useful as intermediates 失效
标题翻译：新型氢醌可用作中间体
公开(公告)号：US4988810A
公开(公告)日：1991-01-29
申请号：US389805
申请日：1989-08-04
申请人： Francois Clemence , Michel Fortin , Odile Le Martret , Francoise Delevallee
发明人： Francois Clemence , Michel Fortin , Odile Le Martret , Francoise Delevallee
IPC分类号： C07D215/18 , C07D215/40
CPC分类号： C07D215/18 , C07D215/40
摘要： Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected from a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of --(CH.sub.2).sub.n -- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceutically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.
摘要翻译：新颖的对映异构体和非对映异构体形式的式Ia的十氢喹啉其中R 1和R 2分别选自氢和1至5个碳原子的烷基或与它们连接的氮原子一起5 至6元杂环，任选地包括另外的杂原子和任选取代的A选自 - （CH 2）n - 和被烷基取代并具有2-8个碳原子的亚烷基，n是0-5的整数，Z 选自5至6个成员的任选取代的苯基，萘基茚基，单环杂环和全部未被取代或被一个或多个取代基取代的双环杂环，及其无毒的药学上可接受的酸加成盐和季铵盐具有中枢镇痛特性。

9. 发明授权

US4968700A 8-amino decahydroquinolines having central nervous system analgesic activity 失效
标题翻译：具有中枢神经系统止痛活性的8-氨基十氢喹啉
公开(公告)号：US4968700A
公开(公告)日：1990-11-06
申请号：US217834
申请日：1988-07-11
申请人： Francois Clemence , Michel Fortin , Odile Le Martret , Francoise Delevallee
发明人： Francois Clemence , Michel Fortin , Odile Le Martret , Francoise Delevallee
IPC分类号： A61K31/47 , A61K31/4709 , A61P9/00 , A61P9/06 , A61P25/04 , C07D215/18 , C07D215/40 , C07D333/00 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/06
CPC分类号： C07D401/06 , C07D215/18 , C07D215/40 , C07D409/06
摘要： Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected form a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of --(CH.sub.2).sub.n -- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceuically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.

10. 发明授权

US4950760A Decahydroquinolines and 5,6,7,8 tetrahydroquinolines 失效
标题翻译：十氢喹啉和5,6,7,8四氢喹啉
公开(公告)号：US4950760A
公开(公告)日：1990-08-21
申请号：US348766
申请日：1989-05-08
申请人： Francois Clemence , Odile Le Martret , Francoise Delevallee , Michel Fortin
发明人： Francois Clemence , Odile Le Martret , Francoise Delevallee , Michel Fortin
IPC分类号： C07D215/40
CPC分类号： C07D215/40
摘要： A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms of a decahydroquinoline of the formula ##STR1## wherein R.sub.1 is alkyl of 1 to 5 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, A is selected from the group consisting of --(CH.sub.2).sub.n --, --CH.sub.2 O-- and alkylene substituted with alkyl having a total of 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, optionally substituted naphthyl, optionally substituted indenyl, optionally substituted heteromonocycle of 5 to 6 members and optionally substituted heterobicycle with the proviso that when Z is o-alkoxy-phenyl, A is not --(CH.sub.2).sub.n -- in which n is O, and their non-toxic, pharmaceutically acceptable acid addition salts and their quaternary ammonium salts and intermediates having analgesic, diuretic, hypotensive, anti-arrithmic and anti-cerebral-ischaemic properties.
摘要翻译：选自下式的化合物：其中R 1为1至5个碳原子的烷基，R 2选自氢和1至5个碳原子的烷基的所有对映异构体和非对映异构形式的十氢喹啉的化合物原子，A选自 - （CH 2）n - ， - CH 2 O-和被具有总共2至8个碳原子的烷基取代的亚烷基，n是0至5的整数，Z选自由任选取代的苯基，任选取代的萘基，任选取代的茚基，任选取代的5至6个成员的异单环和任选取代的杂双环，条件是当Z是邻 - 烷氧基 - 苯基时，A不是 - （CH2）n-，其中 n是O，它们的无毒的药学上可接受的酸加成盐及其季铵盐和具有止痛，利尿，降压，抗对数和抗脑缺血性质的中间体。

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