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1. 发明授权

US06387047B1 Low profile support member for a surgical retraction apparatus 有权
标题翻译：用于外科收缩装置的低轮廓支撑构件
公开(公告)号：US06387047B1
公开(公告)日：2002-05-14
申请号：US09560835
申请日：2000-04-28
申请人： Francis G. Duhaylongsod , Janice Lee Rullo , William John Koteles
发明人： Francis G. Duhaylongsod , Janice Lee Rullo , William John Koteles
IPC分类号： A61B1702
CPC分类号： A61B17/0281 , A61B17/02 , A61B90/50 , A61B2017/0287
摘要： In one embodiment, the present invention relates to a low profile support member for a surgical retraction apparatus which includes a support member in which a lower portion of the support member has a rectilinear portion for insertion into an anchoring receptacle; an upper portion of the support member has a first horizontal extension; a splined coupling adaptor connects together the lower and upper portions, in which the splined coupling adaptor includes a splined segment having a key-like splined portion and a lock-like splined portion; and an extender portion having both a vertical extension and a second horizontal extension. The extender portion is mountable on the first horizontal extension. In one embodiment, the present invention relates to a method of providing surgical retraction to a patient positioned relative to a support platform, including steps of mounting upper and lower portions of a support member with respect to each other by a lock-and-key-like splined connection and with respect to the platform, in which the upper portion includes a first horizontal extension; mounting on the first horizontal extension an extender portion which has both a vertical extension and a second horizontal extension; positioning a lifting device above the patient by mounting the lifting device with respect to the second horizontal extension; and applying retraction to the patient.
摘要翻译：在一个实施例中，本发明涉及一种用于外科收缩装置的低轮廓支撑构件，其包括支撑构件，支撑构件的下部具有用于插入锚定容器的直线部分; 支撑构件的上部具有第一水平延伸部; 花键联接适配器将下部和上部连接在一起，其中花键联接适配器包括具有键状花键部分和锁定状花键部分的花键片段; 以及具有垂直延伸部和第二水平延伸部的延伸部分。扩展器部分可安装在第一个水平延伸部分上。在一个实施例中，本发明涉及一种向相对于支撑平台定位的患者提供外科收缩的方法，包括通过锁定键相对于彼此安装支撑构件的上部和下部的步骤，类似花键连接并且相对于平台，其中上部包括第一水平延伸部; 在所述第一水平延伸部上安装有具有垂直延伸部和第二水平延伸部分的延伸部分; 通过相对于第二水平延伸部安装提升装置来将升降装置定位在患者上方; 并对患者进行收缩。

2. 发明授权

US06043273A Compositions, apparatus and methods for facilitating surgical procedures 有权
公开(公告)号：US06043273A
公开(公告)日：2000-03-28
申请号：US379180
申请日：1999-08-23
申请人： Francis G. Duhaylongsod
发明人： Francis G. Duhaylongsod
IPC分类号： A61B17/00 , A61K31/00 , A61K31/138 , A61K31/27 , A61K45/06 , A61M25/00 , A61P9/04 , A01N47/10
CPC分类号： A61K31/27 , A61K31/00 , A61K45/06 , A61M2210/125 , Y10S514/922
摘要： Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a .beta.-blocker are provided, wherein the .beta.-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing system, thereby to maintain the patient's blood circulation. The electrical pacing then is selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and compositions advantageously may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.

3. 发明授权

US6141589A Switch control for external pacing system 有权
标题翻译：外部起搏系统的开关控制
公开(公告)号：US6141589A
公开(公告)日：2000-10-31
申请号：US382705
申请日：1999-08-23
申请人： Francis G. Duhaylongsod
发明人： Francis G. Duhaylongsod
IPC分类号： A61B17/00 , A61K31/00 , A61K31/138 , A61K31/27 , A61K45/06 , A61M25/00 , A61P9/04 , A61N1/36
CPC分类号： A61K31/27 , A61K31/00 , A61K45/06 , A61M2210/125 , Y10S514/922
摘要： Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a .beta.-blocker are provided, wherein the .beta.-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing system, thereby to maintain the patient's blood circulation. The electrical pacing then is selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and compositions advantageously may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.
摘要翻译：提供了用于在患者中进行外科手术的方法，其中在外科手术过程中，自主心室电导率和逃逸搏动是可逆的和瞬时的抑制以便于外科手术。还提供了能够诱导患者心室停搏的组合物。组合物可以包括AV结节阻断剂。在一个实施方案中，提供包括房室（AV）节段阻断剂和β-阻断剂的组合物，其中所述β-阻断剂的存在量足以基本上减少在患者体内诱导室性心动过速所需的AV结节阻断剂的量。组合物和方法可以用于在搏动的心脏中诱导临时心室停搏，并且促进各种手术技术的执行，包括微创显微外科技术。提供了对人类患者进行外科手术的方法，其中例如通过冠状动脉内注射向心脏施用能够诱发暂时的可逆性心室停搏的组合物。然后使用电起搏系统对心脏进行电动起搏，从而维持患者的血液循环。然后选择性地间歇性地停止电起搏以允许发生心室停搏，并且在间歇性停止电起搏的时间期间进行手术或治疗程序的步骤，例如缝合。所述方法和组合物有利地可用于一系列不同的外科手术，包括心脏，血管和神经外科程序。

4. 发明授权

US6113588A Transillumination catheter and method 失效
标题翻译：透照导管及方法
公开(公告)号：US6113588A
公开(公告)日：2000-09-05
申请号：US42433
申请日：1998-03-13
申请人： Francis G. Duhaylongsod , Hugh L. Narciso, Jr.
发明人： Francis G. Duhaylongsod , Hugh L. Narciso, Jr.
IPC分类号： A61B5/00 , A61B18/18
CPC分类号： A61B5/0086 , A61B5/0084
摘要： A method of identifying vasculature including the steps of introducing an indicator in a peripheral vessel, and advancing a portion of the indicator into an internal vessel to identify said vessel. A catheter for identifying vasculature is also disclosed. The catheter is adapted to be introduced into a peripheral vessel and a portion thereof advanced into an internal vessel. The catheter includes a light delivery portion at a distal end thereof and an expandable member located proximal to the light delivery portion.
摘要翻译：一种识别脉管系统的方法，包括将指示器引入外周血管的步骤，以及使指示器的一部分进入内部容器以识别所述血管。还公开了用于识别脉管系统的导管。导管适于引入外周血管，其一部分进入内部血管。导管包括在其远端处的光输送部分和位于光输送部分附近的可扩张部件。

5. 发明授权

US06711436B1 Compositions, apparatus and methods for facilitating surgical procedures 有权
公开(公告)号：US06711436B1
公开(公告)日：2004-03-23
申请号：US09406333
申请日：1999-09-27
申请人： Francis G. Duhaylongsod
发明人： Francis G. Duhaylongsod
IPC分类号： A61N118
CPC分类号： A61K31/00 , A61K31/22 , A61K31/27 , A61K31/445 , A61K45/06 , A61M2210/125 , A61K31/135 , A61K2300/00
摘要： Methods are provided for conducting diagnostic or therapeutic medical or surgical procedures in a patient wherein, during the procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an atrioventricular (AV) node blocker. In one embodiment, compositions including an AV node blocker and a &bgr;-blocker are provided, wherein the &bgr;-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of techniques, including minimally invasive microsurgical techniques. Methods for performing a diagnostic or therapeutic procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. In one embodiment, the heart then is electrically paced using an electrical pacing system, thereby to maintain the patient's blood circulation. The electrical pacing then is selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the diagnostic or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. In one embodiment, pacing is not required, and at least one step of a procedure is conducted during a period of ventricular asystole. The methods and compositions advantageously may be used in a range of different diagnostic or therapeutic procedures including imaging procedures, placement of stents, grafts, and embolic devices, and cardiac, vascular and neurosurgical procedures.

6. 发明授权

US06241741B1 Anastomosis device and method 失效
标题翻译：吻合装置及方法
公开(公告)号：US06241741B1
公开(公告)日：2001-06-05
申请号：US09037113
申请日：1998-03-09
申请人： Francis G. Duhaylongsod , Fritz French
发明人： Francis G. Duhaylongsod , Fritz French
IPC分类号： A61B1700
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/1135
摘要： A method for coupling a first vessel and a second vessel in an anastomosis. The method includes providing a first vessel with a fastener coupled thereto, inserting at least a portion of the device into the second vessel with an end portion of the fastener extending generally longitudinally through the second vessel, and radially expanding at least a portion of the fastener to sealingly secure the first vessel to an inner wall of the second vessel. An anastomosis fastener for use in coupling the first and second vessels together is also disclosed. The second vessel has an opening formed in a side wall thereof for insertion of the device. The device includes a tubular member at least a portion thereof being radially expandable. The tubular member is preformed with a bend along its central longitudinal axis so that a portion of the tubular member extends out from the side wall of the second vessel while an end portion of the tubular member extends generally coaxially with the second vessel when the tubular member is inserted in the second vessel. The tubular member is sufficiently rigid to substantially retain the tubular member in its preformed configuration after the tubular member is expanded.
摘要翻译：一种在吻合中联接第一容器和第二容器的方法。该方法包括提供具有与之相连的紧固件的第一容器，将装置的至少一部分插入第二容器中，其中紧固件的端部大致纵向延伸穿过第二容器，并且径向扩张紧固件的至少一部分以将第一容器密封地固定到第二容器的内壁。还公开了用于将第一和第二容器联接在一起的吻合紧固件。第二容器具有形成在其侧壁中的用于插入装置的开口。该装置包括管状构件，其至少一部分是径向可扩张的。管状构件沿其中心纵向轴线弯曲成形，使得管状构件的一部分从第二容器的侧壁延伸出来，同时管状构件的端部与第二容器大致同轴地延伸时，当管状构件插入第二容器中。管状构件足够刚性，以便在管状构件膨胀之后基本上将管状构件保持在其预成形构型。

7. 发明授权

US6127410A Compositions, apparatus and methods for facilitating surgical procedures 有权
公开(公告)号：US6127410A
公开(公告)日：2000-10-03
申请号：US379179
申请日：1999-08-23
申请人： Francis G. Duhaylongsod
发明人： Francis G. Duhaylongsod
IPC分类号： A61B17/00 , A61K31/00 , A61K31/138 , A61K31/27 , A61K45/06 , A61M25/00 , A61P9/04 , A01N47/10 , A01N1/18 , A01N1/20 , A01N1/22 , A01N1/24
CPC分类号： A61K31/27 , A61K31/00 , A61K45/06 , A61M2210/125 , Y10S514/922
摘要： Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a .beta.-blocker are provided, wherein the .beta.-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing system, thereby to maintain the patient's blood circulation. The electrical pacing then is selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and compositions advantageously may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.

8. 发明授权

US6101412A Compositions, apparatus and methods for facilitating surgical procedures 有权
标题翻译：用于促进外科手术的组合物，装置和方法
公开(公告)号：US6101412A
公开(公告)日：2000-08-08
申请号：US469956
申请日：1999-12-21
申请人： Francis G. Duhaylongsod
发明人： Francis G. Duhaylongsod
IPC分类号： A61B17/00 , A61K31/00 , A61K31/138 , A61K31/27 , A61K45/06 , A61M25/00 , A61P9/04 , A61N1/00 , A61N1/18
CPC分类号： A61K31/27 , A61K31/00 , A61K45/06 , A61M2210/125 , Y10S514/922
摘要： Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compossitions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a .beta.-blocker are provided, wherein the .beta.-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing stysem, thereby to maintain the patient's blood circulation. The electrical pacing then is selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and comositions advantageously may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.
摘要翻译：提供了用于在患者中进行外科手术的方法，其中在外科手术过程中，自主心室电导率和逃逸搏动是可逆的和瞬时的抑制以便于外科手术。还提供了能够诱导患者心室停搏的组合物。压缩可以包括AV节点阻塞器。在一个实施方案中，提供包括房室（AV）节段阻断剂和β-阻断剂的组合物，其中所述β-阻断剂的存在量足以基本上减少在患者体内诱导室性心动过速所需的AV结节阻断剂的量。组合物和方法可以用于在搏动的心脏中诱导临时心室停搏，并且促进各种手术技术的执行，包括微创显微外科技术。提供了对人类患者进行外科手术的方法，其中例如通过冠状动脉内注射向心脏施用能够诱发暂时的可逆性心室停搏的组合物。然后心脏使用电起搏系统进行电动起搏，从而维持患者的血液循环。然后选择性地间歇性地停止电起搏以允许发生心室停搏，并且在间歇性停止电起搏的时间期间进行手术或治疗程序的步骤，例如缝合。方法和组合有利地可以用于一系列不同的外科手术，包括心脏，血管和神经外科程序。

9. 发明授权

US06414018B1 Compositions, apparatus and methods for facilitating surgical procedures 有权
标题翻译：用于促进外科手术的组合物，装置和方法
公开(公告)号：US06414018B1
公开(公告)日：2002-07-02
申请号：US09494145
申请日：2000-01-28
申请人： Francis G. Duhaylongsod
发明人： Francis G. Duhaylongsod
IPC分类号： A01N4700
CPC分类号： A61K31/27 , A61K31/00 , A61K31/22 , A61K31/445 , A61K45/06 , A61M2210/125 , Y10S514/922 , A61K2300/00 , A61K31/135
摘要： Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a &bgr;-blocker are provided, wherein the &bgr;-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing system, thereby to maintain the patient's blood circulation. The electrical pacing then is selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and compositions advantageously may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.
摘要翻译：提供了用于在患者中进行外科手术的方法，其中在外科手术过程中，自主心室电导率和逃逸搏动是可逆的和瞬时的抑制以便于外科手术。还提供了能够诱导患者心室停搏的组合物。组合物可以包括AV结节阻断剂。在一个实施方案中，提供了包括房室（AV）节段阻滞剂和β-阻断剂的组合物，其中所述β-阻断剂的存在量足以基本上减少在患者体内诱导室性心动过速所需的AV结节阻滞剂的量。组合物和方法可以用于在搏动的心脏中诱导临时心室停搏，并且促进各种手术技术的执行，包括微创显微外科技术。提供了对人类患者进行外科手术的方法，其中例如通过冠状动脉内注射向心脏施用能够诱发暂时的可逆性心室停搏的组合物。然后使用电起搏系统对心脏进行电动起搏，从而维持患者的血液循环。然后选择性地间歇性地停止电起搏以允许发生心室停搏，并且在间歇性停止电起搏的时间期间进行手术或治疗程序的步骤，例如缝合。所述方法和组合物有利地可用于一系列不同的外科手术，包括心脏，血管和神经外科程序。

10. 发明授权

US6165196A Perfusion-occlusion apparatus 失效
标题翻译：灌注闭塞装置
公开(公告)号：US6165196A
公开(公告)日：2000-12-26
申请号：US161067
申请日：1998-09-25
申请人： Richard S. Stack , Francis G. Duhaylongsod , Harry R. Phillips, III , Troy Chapman , Michael Hogendijk , Hugh L. Narciso, Jr.
发明人： Richard S. Stack , Francis G. Duhaylongsod , Harry R. Phillips, III , Troy Chapman , Michael Hogendijk , Hugh L. Narciso, Jr.
IPC分类号： A61B17/11 , A61F2/06 , A61M29/02 , A61M29/00
CPC分类号： A61B17/11 , A61F2/064 , A61M2025/1052 , A61M2025/1097
摘要： A perfusion-occlusion catheter provides an occluded region in a vessel to facilitate, for example, an anastomosis in the region, while providing a path for perfusing fluid (blood) through the path for delivery in the vessel downstream from the occluded region. According to one aspect of the invention, at least a portion of the catheter that effects vessel occlusion comprises a shield that when exposed to suture needles or like piercing instruments deflects or resists perforation.
摘要翻译：灌注闭塞导管在血管中提供封闭区域，以促进例如该区域的吻合，同时提供通过路径灌注流体（血液）的路径以在封闭区域下游的血管输送。根据本发明的一个方面，导管的至少一部分实现血管闭塞包括一个屏蔽，当暴露于缝合针或类似的穿刺器械偏转或抵抗穿孔时。

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