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    • 1. 发明申请
    • Pharmaceutical composition formulated for pre-gastric absorption of monoamine oxidase B inhibitors
    • 配制用于单胺氧化酶B抑制剂的胃前吸收的药物组合物
    • US20050106241A1
    • 2005-05-19
    • US10957947
    • 2004-10-04
    • Francesca BrewerEdward JohnsonAnthony Clarke
    • Francesca BrewerEdward JohnsonAnthony Clarke
    • A61K9/00A61K9/20A61K31/136A61K31/137
    • A61K9/0056A61K9/2095A61K31/136A61K31/137
    • The invention described herein provides a fast dispersing oral solid dosage form containing monoamine oxidase B inhibitor (MAO-B inhibitor) as the active ingredient, and method of treating disease therewith, such as Parkinson's disease. In one embodiment, the monoamine oxidase B inhibitor selegiline or its analogue can be the sole active ingredient in the composition administered. The dosage form composition is formulated to promote absorption through the buccal, sublingual, pharyngeal and/or esophageal mucous membrane tissue, such that at least 5% of the active ingredient is absorbed within one minute of placement in the oral cavity, as determined by a buccal absorption test. Monoamine oxidase B inhibitor compounds administered in accordance with the invention decrease the amount of undesirable metabolites associated with first pass effect of selegiline, for example, such as amphetamine and methamphetamine. The invention provides a number of other advantages over conventional orally administered tablet forms, including administration of monoamine oxidase B inhibitor compounds to patients that have difficulty swallowing.
    • 本文描述的本发明提供了含有单胺氧化酶B抑制剂(MAO-B抑制剂)作为活性成分的快速分散口服固体剂型,以及用于治疗疾病如帕金森病的方法。 在一个实施方案中,单胺氧化酶B抑制剂司来吉兰或其类似物可以是所施用组合物中的唯一活性成分。 配制剂型组合物以促进通过颊,舌下,咽和/或食管粘膜组织的吸收,使得至少5%的活性成分在放置在口腔中的一分钟内被吸收,如通过 颊吸收试验。 根据本发明施用的单胺氧化酶B抑制剂化合物减少与司来吉兰(例如苯丙胺和甲基苯丙胺)的首次通过效应相关的不合需要的代谢物的量。 本发明提供了与常规口服给药的片剂形式相比的许多其它优点,包括向吞咽困难的患者施用单胺氧化酶B抑制剂化合物。
    • 5. 发明申请
    • ANTIMICROBIAL ULTRAVIOLET LIGHT SYSTEM FOR REFRIGERATOR SANITATION
    • 用于制冷剂卫生的抗微生物超紫外光系统
    • US20120051030A1
    • 2012-03-01
    • US13035332
    • 2011-02-25
    • Edward Johnson
    • Edward Johnson
    • F21V33/00
    • F25D17/042F25D2317/0417
    • A refrigerator is adapted to include a plurality of ultraviolet light bars, which may be adjustably connected to sufficiently radiate UV light throughout the refrigerator compartment in connection with a control box and power cord which operate to control the bacterial level present on and around foodstuffs being stored therein. A series of UV light bars are capable of being arranged and plugged into one another by daisy chain to allow for a timer-controlled illumination of UV light to radiate throughout the compartment. Sensors in the control box signal the timer, and a wire ribbon extending from the control box provides a connection to the external power source without significantly affecting the seal of the refrigerator door. Power is supplied to the UV light sources via a ribbon-type power cable passing from the refrigerator interior compartment to the exterior by passing between the refrigerator and the refrigerator door and over the peripheral gasket, whereby power may be supplied to said control box by connection of said male electrical plug to an electrical outlet without significantly affecting the integrity of the thermal seal.
    • 冰箱适于包括多个紫外线灯条,其可调节地连接到与控制箱和电源线相连的整个冷藏室中充分辐射UV光,该控制箱和电源线用于控制存在于存储的食品上和周围的细菌水平 其中。 一系列UV灯条能够通过菊花链布置和相互插入,以允许定时器控制的UV光照射到整个隔间中。 控制箱中的传感器指示定时器,并且从控制箱延伸的丝带提供与外部电源的连接,而不会显着影响冰箱门的密封。 通过从冰箱内部隔间通过冰箱和冰箱门之间并在周边垫圈上方通过冰箱内部隔间的带式电力电缆向UV光源供电,从而可以通过连接将功率供应到所述控制箱 的所述阳电插头连接到电源插座,而不会显着影响热封的完整性。