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1. 发明授权

US06955884B2 Methods for identifying compounds that inhibit CD38 activity 失效
标题翻译：鉴定抑制CD38活性的化合物的方法
公开(公告)号：US06955884B2
公开(公告)日：2005-10-18
申请号：US09982616
申请日：2001-10-17
申请人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sánchez
发明人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sánchez
IPC分类号： G01N33/50 , C07K14/435 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/24 , C12N15/09 , C12Q1/02 , C12Q1/25 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/573 , C12N5/00 , C12N5/02
CPC分类号： C07K14/4354 , C12N9/2497 , C12Y302/02005
摘要： The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, eosinophils, macrophages and dentritic cells. The invention further relates to drug screening assays designed to identify compounds that modulate the ADP-ribosyl cyclase activity of CD38 and the use of such compounds in the treatment of disorders involving CD38 modulated cell migration. The invention is based on the discovery that CD38 ADP-ribosyl cyclase activity is required for chemotaxis. Furthermore, the invention relates to methods for identifying compounds that modulate the enzyme activity of the S. mansoni CD38 homologue and using those compounds in the treatment of pathologic disorders caused by helminth infection. This is based on the discovery that helminths such as S. mansoni express CD38 homologues.
摘要翻译：本发明涉及调节表达CD38的细胞的迁移活性的方法，用于治疗疾病，包括但不限于炎症，局部缺血，哮喘，自身免疫疾病，糖尿病，关节炎，过敏，病原体感染和移植排斥。这样的细胞包括例如嗜中性粒细胞，淋巴细胞，嗜酸性粒细胞，巨噬细胞和牙髓细胞。本发明还涉及设计用于鉴定调节CD38的ADP-核糖基环化酶活性的化合物的药物筛选试验，以及这些化合物在治疗涉及CD38调节的细胞迁移的疾病中的用途。本发明基于发现趋化性所需的CD38 ADP-核糖基环化酶活性。此外，本发明涉及用于鉴定调节曼氏血清CD38同源物的酶活性并使用这些化合物治疗由蠕虫感染引起的病理性疾病的化合物的方法。这是基于以下发现：蠕虫如曼氏男性表达CD38同源物。

2. 发明授权

US08084035B2 CD38 modulated chemotaxis 失效
标题翻译： CD38调节趋化性
公开(公告)号：US08084035B2
公开(公告)日：2011-12-27
申请号：US12703062
申请日：2010-02-09
申请人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sanchez
发明人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sanchez
IPC分类号： A61K39/00 , A61K39/385 , G01N33/53 , C07K14/52
CPC分类号： C07K14/4354 , C12N9/2497 , C12Y302/02005
摘要： The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms, such as parasites, and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, eosinophils, macrophages and dentritic cells. The invention further relates to drug screening assays designed to identify compounds that modulate the ADP-ribosyl cyclase activity of CD38 and the use of such. compounds in the treatment of disorders involving CD38 modulated cell migration. Additionally, the invention relates to the isolation and characterization of a CD38 homologue from the parasitic flatworm, Schistosoma mansoni.
摘要翻译：本发明涉及调节表达CD38的细胞的迁移活性的方法，用于治疗疾病，包括但不限于炎症，局部缺血，哮喘，自身免疫疾病，糖尿病，关节炎，过敏，病原体感染等寄生虫，移植排斥。这样的细胞包括例如嗜中性粒细胞，淋巴细胞，嗜酸性粒细胞，巨噬细胞和牙髓细胞。本发明还涉及设计用于鉴定调节CD38的ADP-核糖基环化酶活性的化合物的药物筛选测定及其用途。治疗涉及CD38调节细胞迁移的疾病的化合物。此外，本发明涉及从寄生扁丝虫曼氏血吸虫分离和表征CD38同系物。

3. 发明申请

US20100297148A1 CD38 MODULATED CHEMOTAXIS 失效
标题翻译： CD38调节化学
公开(公告)号：US20100297148A1
公开(公告)日：2010-11-25
申请号：US12703062
申请日：2010-02-09
申请人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sanchez
发明人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sanchez
IPC分类号： A61K39/00 , A61K38/47 , C07K16/40 , A61K38/02 , A01N63/00 , A61K39/395 , A61K31/7088 , A01N57/16 , A01P1/00 , A61P33/10 , C12N9/14 , C12Q1/34
CPC分类号： C07K14/4354 , C12N9/2497 , C12Y302/02005
摘要： The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms, such as parasites, and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, eosinophils, macrophages and dentritic cells. The invention further relates to drug screening assays designed to identify compounds that modulate the ADP-ribosyl cyclase activity of CD38 and the use of such. compounds in the treatment of disorders involving CD38 modulated cell migration. Additionally, the invention relates to the isolation and characterization of a CD38 homologue from the parasitic flatworm, Schistosoma mansoni.
摘要翻译：本发明涉及调节表达CD38的细胞的迁移活性的方法，用于治疗疾病，包括但不限于炎症，局部缺血，哮喘，自身免疫疾病，糖尿病，关节炎，过敏，病原体感染等寄生虫，移植排斥。这样的细胞包括例如嗜中性粒细胞，淋巴细胞，嗜酸性粒细胞，巨噬细胞和牙髓细胞。本发明还涉及设计用于鉴定调节CD38的ADP-核糖基环化酶活性的化合物的药物筛选测定及其用途。治疗涉及CD38调节细胞迁移的疾病的化合物。此外，本发明涉及从寄生扁丝虫曼氏血吸虫分离和表征CD38同系物。

4. 发明授权

US07695933B2 SM38 nucleic acid molecules 失效
标题翻译： SM38核酸分子
公开(公告)号：US07695933B2
公开(公告)日：2010-04-13
申请号：US11058924
申请日：2005-02-15
申请人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sanchez
发明人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sanchez
IPC分类号： C12P21/06 , C12N1/20 , C12N15/63 , C07H21/04
CPC分类号： C07K14/4354 , C12N9/2497 , C12Y302/02005
摘要： The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms, such as parasites, and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, eosinophils, macrophages and dentritic cells. The invention further relates to drug screening assays designed to identify compounds that modulate the ADP-ribosyl cyclase activity of CD38 and the use of such compounds in the treatment of disorders involving CD38 modulated cell migration. Additionally, the invention relates to the isolation and characterization of a CD38 homologue from the parasitic flatworm, Schistosoma mansoni.
摘要翻译：本发明涉及调节表达CD38的细胞的迁移活性的方法，用于治疗疾病，包括但不限于炎症，局部缺血，哮喘，自身免疫疾病，糖尿病，关节炎，过敏，病原体感染等寄生虫，移植排斥。这样的细胞包括例如嗜中性粒细胞，淋巴细胞，嗜酸性粒细胞，巨噬细胞和牙髓细胞。本发明还涉及设计用于鉴定调节CD38的ADP-核糖基环化酶活性的化合物的药物筛选试验，以及这些化合物在治疗涉及CD38调节的细胞迁移的疾病中的用途。此外，本发明涉及从寄生扁丝虫曼氏血吸虫分离和表征CD38同系物。

5. 发明申请

US20120094937A1 MAMMALIAN CELL SURFACE ANTIGENS; RELATED REAGENTS 审中-公开
标题翻译： MAMMALIAN细胞表面抗原相关试剂
公开(公告)号：US20120094937A1
公开(公告)日：2012-04-19
申请号：US13331879
申请日：2011-12-20
申请人： Daniel M. Gorman , Troy D. Randall , Albert Zlotnik
发明人： Daniel M. Gorman , Troy D. Randall , Albert Zlotnik
IPC分类号： A61K38/16 , C12N9/02 , C12N9/38 , A61P37/04 , C12N9/26 , C12N9/30 , C07K1/14 , A61P37/02 , C07K14/47 , C12N9/86
CPC分类号： A61K39/39 , A61K38/00 , A61K2039/55516 , C07K14/47 , C07K14/705 , C07K14/70578 , C07K16/28 , C07K16/2878 , C07K2317/70 , C07K2319/00 , Y10S435/81 , Y10S435/975
摘要： Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译：提供了编码来自哺乳动物的T细胞表面抗原的纯化基因，与其相关的试剂，包括纯化蛋白质，特异性抗体和编码该抗原的核酸。还提供了使用所述试剂和诊断试剂盒的方法。

6. 发明授权

US07025962B1 Mammalian cell surface antigens; related reagents 失效
公开(公告)号：US07025962B1
公开(公告)日：2006-04-11
申请号：US09545998
申请日：2000-04-10
申请人： Daniel M. Gorman , Troy D. Randall , Albert Zlotnik
发明人： Daniel M. Gorman , Troy D. Randall , Albert Zlotnik
IPC分类号： A61K39/395 , A61K39/44 , C07K16/28
CPC分类号： A61K39/39 , A61K38/00 , A61K2039/55516 , C07K14/47 , C07K14/705 , C07K14/70578 , C07K16/28 , C07K16/2878 , C07K2317/70 , C07K2319/00 , Y10S435/81 , Y10S435/975
摘要： Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.

7. 发明授权

US6111090A Mammalian cell surface antigens; related reagents 失效
公开(公告)号：US6111090A
公开(公告)日：2000-08-29
申请号：US911423
申请日：1997-08-14
申请人： Daniel M. Gorman , Troy D. Randall , Albert Zlotnik
发明人： Daniel M. Gorman , Troy D. Randall , Albert Zlotnik
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C07H21/04 , C12N5/10 , C12N15/63
CPC分类号： A61K39/39 , C07K14/47 , C07K14/705 , C07K14/70578 , C07K16/28 , C07K16/2878 , A61K2039/55516 , A61K38/00 , C07K2317/70 , C07K2319/00 , Y10S435/81 , Y10S435/975
摘要： Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.

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