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1. 发明申请

US20120225482A1 MAMMALIAN CX3C CHEMOKINE ANTIBODIES 失效
标题翻译： MAMMALIAN CX3C CHEMOKINE抗体
公开(公告)号：US20120225482A1
公开(公告)日：2012-09-06
申请号：US13453224
申请日：2012-04-23
申请人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , Bazan Fernando J. , Thomas P. Schall , Albert Zlotnik
发明人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , Bazan Fernando J. , Thomas P. Schall , Albert Zlotnik
IPC分类号： C12N5/02 , C07H21/04 , C07K16/24 , G01N33/566 , C07K14/52
CPC分类号： C07K14/521 , A61K38/00 , C07K2319/00 , Y10S435/81
摘要： Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
摘要翻译：描述了编码来自哺乳动物的新家族趋化因子，CX3C家族的核酸，与其相关的试剂，包括特异性抗体和纯化的蛋白质。还提供了使用所述试剂和相关诊断试剂盒的方法。

2. 发明申请

US20120094937A1 MAMMALIAN CELL SURFACE ANTIGENS; RELATED REAGENTS 审中-公开
标题翻译： MAMMALIAN细胞表面抗原相关试剂
公开(公告)号：US20120094937A1
公开(公告)日：2012-04-19
申请号：US13331879
申请日：2011-12-20
申请人： Daniel M. Gorman , Troy D. Randall , Albert Zlotnik
发明人： Daniel M. Gorman , Troy D. Randall , Albert Zlotnik
IPC分类号： A61K38/16 , C12N9/02 , C12N9/38 , A61P37/04 , C12N9/26 , C12N9/30 , C07K1/14 , A61P37/02 , C07K14/47 , C12N9/86
CPC分类号： A61K39/39 , A61K38/00 , A61K2039/55516 , C07K14/47 , C07K14/705 , C07K14/70578 , C07K16/28 , C07K16/2878 , C07K2317/70 , C07K2319/00 , Y10S435/81 , Y10S435/975
摘要： Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译：提供了编码来自哺乳动物的T细胞表面抗原的纯化基因，与其相关的试剂，包括纯化蛋白质，特异性抗体和编码该抗原的核酸。还提供了使用所述试剂和诊断试剂盒的方法。

3. 发明申请

US20110230502A1 MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH 有权
标题翻译：化学感受器的调节和与之相关的配体
公开(公告)号：US20110230502A1
公开(公告)日：2011-09-22
申请号：US13051586
申请日：2011-03-18
申请人： Catherine TACHDJIAN , Xiao-Qing Tang , Sara Werner , Marketa Rinnova , Qing Chen , Guy Servant , Xiaodong Li , Feng Zhang , Haitian Liu , Albert Zlotnik , Mark Zoller , Boris Klebansky , Richard Fine , Xinshan Kang
发明人： Catherine TACHDJIAN , Xiao-Qing Tang , Sara Werner , Marketa Rinnova , Qing Chen , Guy Servant , Xiaodong Li , Feng Zhang , Haitian Liu , Albert Zlotnik , Mark Zoller , Boris Klebansky , Richard Fine , Xinshan Kang
IPC分类号： A61K31/519 , A61K31/522 , A61K31/437 , A61K31/4355 , A61K31/4365 , A61P27/00
CPC分类号： C07D513/04 , A23L2/39 , A23L2/60 , A23L27/30 , A23L27/31 , A23L27/33 , A23L27/34 , A23L27/88 , C07D215/42 , C07D215/54 , C07D215/56 , C07D239/70 , C07D239/84 , C07D239/94 , C07D239/95 , C07D285/16 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/056 , C07D493/04 , C07D495/04 , C07D495/14 , C07D513/20 , G01N33/566
摘要： The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.
摘要翻译：本发明提供了用于鉴定化学感受器及其配体的调节剂的筛选方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获结构域内的一个或多个相互作用位点相互作用，以及能调节化学感受器及其配体。

4. 发明申请

US20090208946A1 Rationale, Methods, and Assays for Identifying Human and Non-Human Primate Taste Specific Genes and Use Thereof in Taste Modulator and Therapeutic Screening Assays 有权
标题翻译：用于鉴别人和非人灵长类特异性基因的原理，方法和分析及其在口味调节剂和治疗筛选试验中的用途
公开(公告)号：US20090208946A1
公开(公告)日：2009-08-20
申请号：US12134302
申请日：2008-06-06
申请人： Bryan Moyer , Albert Zlotnik , Peter Hevezi , Hortensia Soto , Dalia Kalabat , Min Lu , Na Gao , Evan Carl White
发明人： Bryan Moyer , Albert Zlotnik , Peter Hevezi , Hortensia Soto , Dalia Kalabat , Min Lu , Na Gao , Evan Carl White
IPC分类号： C12Q1/68 , C12Q1/02 , C12N5/08
CPC分类号： G01N33/566 , C12Q1/6806 , C12Q1/6876 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , C40B30/04 , C40B40/10 , G01N33/5005 , G01N33/5044 , G01N33/6872 , G01N2333/726 , G01N2500/10
摘要： This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related activities such as digestive function and digestive related diseases, taste cell turnover, immunoregulation of the oral and digestive tract, and metabolic regulation such as in diabetes and obesity, the genes identified using these methods, and assays for identifying taste modulators (enhancers or blockers) and potential therapeutics using these genes. These compounds have potential application in modulating (enhancing or blocking) taste perception, especially salty taste perception and as potential therapeutics. In addition, this invention relates to novel methods for identifying taste-specific genes that can be used as markers for different taste cell types, including sweet, bitter, umami, sour, salty, and other taste cells in mammals as well as assays that measure the activity of the sweet, bitter, umami, or sour receptor in the presence of these genes to identify modulators of sweet, bitter, umami, and sour taste and to identify therapeutics especially for treating digestive or metabolic disorders, taste loss, and oral infections. Particularly, the genes identified herein and antibodies or oligos thereto can be used as markers to identify and/or purify specific taste cells e.g., from taste cell suspensions by use of FACS or magnetic bead cell selection or other known cell purification and isolation procedures.
摘要翻译：本发明涉及用于鉴定人类和灵长类动物特异性基因的新的理论和方法，包括涉及咸味感知的基因，特别是人类咸味感知，以及参与甜味，苦味，鲜味和酸味感觉的基因以及基因参与其他味觉细胞或味觉受体相关活性，如消化功能和消化相关疾病，味觉细胞周转，口服和消化道的免疫调节，以及代谢调节，如糖尿病和肥胖症，使用这些方法鉴定的基因和测定用于鉴定使用这些基因的味觉调节剂（增强子或阻断剂）和潜在的治疗剂。这些化合物具有潜在的应用于调节（增强或阻断）味觉，特别是咸味感和作为潜在的疗法。此外，本发明涉及用于鉴定可用作哺乳动物中不同味道细胞类型（包括甜味，苦味，鲜味，酸味，咸味和其他味觉细胞）的标记的味道特异性基因的新方法，以及测量在这些基因存在下甜味，苦味，鲜味或酸性受体的活性，以鉴定甜味，苦味，鲜味和酸味的调节剂，并鉴定治疗剂，特别是用于治疗消化或代谢紊乱，口味丧失和口腔感染。特别地，本文鉴定的基因和其抗体或寡核苷酸可以用作标识物，以通过使用FACS或磁珠细胞选择或其他已知的细胞纯化和分离程序来鉴定和/或纯化特定味细胞，例如来自味细胞悬浮液。

5. 发明申请

US20080306053A1 MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH 有权
标题翻译：化学感受器的调节和与之相关的配体
公开(公告)号：US20080306053A1
公开(公告)日：2008-12-11
申请号：US11836074
申请日：2007-08-08
申请人： Catherine Tachdjian , Xiao-Qing Tang , Sara Werner , Marketa Rinnova , Qing Chen , Guy Servant , Xiaodong Li , Feng Zhang , Haitian Liu , Albert Zlotnik , Mark Zoller , Boris Klebansky , Richard Fine , Xinshan Kang
发明人： Catherine Tachdjian , Xiao-Qing Tang , Sara Werner , Marketa Rinnova , Qing Chen , Guy Servant , Xiaodong Li , Feng Zhang , Haitian Liu , Albert Zlotnik , Mark Zoller , Boris Klebansky , Richard Fine , Xinshan Kang
IPC分类号： A61K31/549 , C07D491/04 , C07D239/78 , C07D487/04 , C07D285/16 , C07D471/04 , A61K31/47 , C07D239/00 , C07D215/20 , A61K31/519 , A61K31/517 , A61K31/4985
CPC分类号： C07D513/04 , A23L2/39 , A23L2/60 , A23L27/30 , A23L27/31 , A23L27/33 , A23L27/34 , A23L27/88 , C07D215/42 , C07D215/54 , C07D215/56 , C07D239/70 , C07D239/84 , C07D239/94 , C07D239/95 , C07D285/16 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/056 , C07D493/04 , C07D495/04 , C07D495/14 , C07D513/20 , G01N33/566
摘要： The present invention provides screening methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors as well as modifiers capable of modulating chemosensory receptors and their ligands.
摘要翻译：本发明提供了用于鉴定化学感应受体及其配体的改性剂的筛选方法，例如通过确定测试实体是否适合与化学感应受体的金星蝇捕获结构域内的一个或多个相互作用位点相互作用，以及能够调节化学感受器及其配体。

6. 发明申请

US20080044835A1 MAMMALIAN CHEMOKINE REAGENTS 审中-公开
标题翻译： MAMMALIAN CHEMOKINE试剂
公开(公告)号：US20080044835A1
公开(公告)日：2008-02-21
申请号：US11847872
申请日：2007-08-30
申请人： Wei Wang , Kurt Gish , Thomas Schall , Alain Vicari , Albert Zlotnik
发明人： Wei Wang , Kurt Gish , Thomas Schall , Alain Vicari , Albert Zlotnik
IPC分类号： C07H21/04 , C07K16/00 , C12N15/00 , C12N5/00 , C12N5/04 , C12Q1/68 , G01N33/53
CPC分类号： C07K16/24 , C07K14/523 , C07K14/7158
摘要： Novel chemokines from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokines. Chemokine receptors are also provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译：来自哺乳动物的新型趋化因子，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码所述趋化因子的核酸。还提供趋化因子受体。还提供了使用所述试剂和诊断试剂盒的方法。

7. 发明授权

US07276238B2 Methods for using chemokine teck 失效
标题翻译：使用趋化因子的方法
公开(公告)号：US07276238B2
公开(公告)日：2007-10-02
申请号：US10759860
申请日：2004-01-16
申请人： Wei Wang , Kurt C. Gish , Thomas J. Schall , Alain Vicari , Albert Zlotnik
发明人： Wei Wang , Kurt C. Gish , Thomas J. Schall , Alain Vicari , Albert Zlotnik
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/24 , C07K14/523 , C07K14/7158
摘要： Novel chemokines from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokines. Chemokine receptors are also provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译：来自哺乳动物的新型趋化因子，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码所述趋化因子的核酸。还提供趋化因子受体。还提供了使用所述试剂和诊断试剂盒的方法。

8. 发明申请

US20050181375A1 Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer 审中-公开
标题翻译：诊断转移性癌症的新方法，筛选转移癌调节剂的组合物和方法
公开(公告)号：US20050181375A1
公开(公告)日：2005-08-18
申请号：US10756149
申请日：2004-01-12
申请人： Natasha Aziz , Albert Zlotnik
发明人： Natasha Aziz , Albert Zlotnik
IPC分类号： C07H21/04 , C07K16/40 , C12N9/00 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/57423 , C12Q1/6837 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57415 , G01N2800/52
摘要： Described herein are methods and compositions that can be used for diagnosis and treatment of metastatic cancer. Also described herein are methods that can be used to identify modulators of metastatic cancer.
摘要翻译：本文描述了可用于诊断和治疗转移性癌症的方法和组合物。本文还描述了可用于鉴定转移性癌症调节剂的方法。

9. 发明授权

US06737252B2 7 transmembrane receptor family member BLRX 失效
标题翻译： 7跨膜受体家族成员BLRX
公开(公告)号：US06737252B2
公开(公告)日：2004-05-18
申请号：US09910695
申请日：2001-07-20
申请人： Joseph A. Hedrick , Bernhard Homey , Alain Vicari , Monica L. Zepeda , Albert Zlotnik
发明人： Joseph A. Hedrick , Bernhard Homey , Alain Vicari , Monica L. Zepeda , Albert Zlotnik
IPC分类号： C12N1512
CPC分类号： C07K14/521 , A61K39/00 , C07K14/522 , C07K14/705 , C07K14/7158
摘要： Novel chemokines and 7 transmembrane receptors from mammals, reagents related thereto, including purified proteins, specific antibodies, and nucleic acids encoding the chemokines and receptors are disclosed. Methods of using the chemokines, receptors, reagents and diagnostic kits are also provided.
摘要翻译：公开了来自哺乳动物的新趋化因子和7个跨膜受体，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码趋化因子和受体的核酸。还提供了使用趋化因子，受体，试剂和诊断试剂盒的方法。

10. 发明授权

US08541421B2 Methods of enhancing sweet taste of compositions using substituted thieno{2,3-D}pyrimidines 有权
标题翻译：使用取代的噻吩并[2,3-D]嘧啶提高组合物的甜味的方法
公开(公告)号：US08541421B2
公开(公告)日：2013-09-24
申请号：US13051586
申请日：2011-03-18
申请人： Catherine Tachdjian , Xiao-Qing Tang , Sara Werner , Marketa Rinnova , Qing Chen , Guy Servant , Xiaodong Li , Feng Zhang , Haitian Liu , Albert Zlotnik , Mark Zoller , Boris Klebansky , Richard Fine , Xinshan Kang
发明人： Catherine Tachdjian , Xiao-Qing Tang , Sara Werner , Marketa Rinnova , Qing Chen , Guy Servant , Xiaodong Li , Feng Zhang , Haitian Liu , Albert Zlotnik , Mark Zoller , Boris Klebansky , Richard Fine , Xinshan Kang
IPC分类号： A61K31/519
CPC分类号： C07D513/04 , A23L2/39 , A23L2/60 , A23L27/30 , A23L27/31 , A23L27/33 , A23L27/34 , A23L27/88 , C07D215/42 , C07D215/54 , C07D215/56 , C07D239/70 , C07D239/84 , C07D239/94 , C07D239/95 , C07D285/16 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/056 , C07D493/04 , C07D495/04 , C07D495/14 , C07D513/20 , G01N33/566
摘要： The present invention provides, in part, substituted thieno[2,3-d]pyrimidines and methods of contacting compositions with such compounds to enhance the sweet taste of said compositions.
摘要翻译：本发明部分地提供取代的噻吩并[2,3-d]嘧啶和使组合物与这些化合物接触以增强所述组合物的甜味的方法。

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