专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080114079A1 TRPM2-specfic inhibitors 审中-公开
标题翻译： TRPM2特异性抑制剂
公开(公告)号：US20080114079A1
公开(公告)日：2008-05-15
申请号：US11652265
申请日：2007-01-10
申请人： Frances E. Lund , Santiago Partida-Sanchez , Tim Walseth
发明人： Frances E. Lund , Santiago Partida-Sanchez , Tim Walseth
IPC分类号： A61K47/00 , C12N5/06 , C12Q1/02 , A61P9/00 , A61P1/00 , A61P19/00
CPC分类号： C07K14/705 , A61K31/365 , G01N33/6872 , G01N2500/04
摘要： The present invention relates to methods and compositions for modulating ADPR-mediated migratory activity of cells through regulation of the TRPM2 cation channel. Such methods and compositions may be used for the treatment of disorders including, but not limited to, inflammation, ischemia, atherosclerosis, asthma, autoimmune disease, diabetes, arthritis, allergies, and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, eosinophils, macrophages, monocytes and dendritic cells. The invention further relates to specific inhibition of TRPM2 by blocking the activity of ADPR. The invention also relates to drug screening assays designed to identify compounds that regulate TRPM2 and thereby also function to modulate ADPR-mediated cell migration. The invention is based on the discovery that, 8Br-ADPR, which specifically inhibits activation of TRPM2, acts to inhibit ADPR-mediated cell migration.
摘要翻译：本发明涉及通过调节TRPM2阳离子通道调节ADPR介导的细胞迁移活性的方法和组合物。这些方法和组合物可用于治疗疾病，包括但不限于炎症，缺血，动脉粥样硬化，哮喘，自身免疫性疾病，糖尿病，关节炎，过敏反应和移植排斥。这样的细胞包括例如嗜中性粒细胞，淋巴细胞，嗜酸性粒细胞，巨噬细胞，单核细胞和树突状细胞。本发明还涉及通过阻断ADPR的活性而对TRPM2的特异性抑制。本发明还涉及设计用于鉴定调节TRPM2的化合物并由此也可用于调节ADPR介导的细胞迁移的药物筛选测定。本发明基于以下发现：特异性抑制TRPM2激活的8Br-ADPR起抑制ADPR介导的细胞迁移的作用。

2. 发明申请

US20100297148A1 CD38 MODULATED CHEMOTAXIS 失效
标题翻译： CD38调节化学
公开(公告)号：US20100297148A1
公开(公告)日：2010-11-25
申请号：US12703062
申请日：2010-02-09
申请人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sanchez
发明人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sanchez
IPC分类号： A61K39/00 , A61K38/47 , C07K16/40 , A61K38/02 , A01N63/00 , A61K39/395 , A61K31/7088 , A01N57/16 , A01P1/00 , A61P33/10 , C12N9/14 , C12Q1/34
CPC分类号： C07K14/4354 , C12N9/2497 , C12Y302/02005
摘要： The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms, such as parasites, and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, eosinophils, macrophages and dentritic cells. The invention further relates to drug screening assays designed to identify compounds that modulate the ADP-ribosyl cyclase activity of CD38 and the use of such. compounds in the treatment of disorders involving CD38 modulated cell migration. Additionally, the invention relates to the isolation and characterization of a CD38 homologue from the parasitic flatworm, Schistosoma mansoni.
摘要翻译：本发明涉及调节表达CD38的细胞的迁移活性的方法，用于治疗疾病，包括但不限于炎症，局部缺血，哮喘，自身免疫疾病，糖尿病，关节炎，过敏，病原体感染等寄生虫，移植排斥。这样的细胞包括例如嗜中性粒细胞，淋巴细胞，嗜酸性粒细胞，巨噬细胞和牙髓细胞。本发明还涉及设计用于鉴定调节CD38的ADP-核糖基环化酶活性的化合物的药物筛选测定及其用途。治疗涉及CD38调节细胞迁移的疾病的化合物。此外，本发明涉及从寄生扁丝虫曼氏血吸虫分离和表征CD38同系物。

3. 发明授权

US07695933B2 SM38 nucleic acid molecules 失效
标题翻译： SM38核酸分子
公开(公告)号：US07695933B2
公开(公告)日：2010-04-13
申请号：US11058924
申请日：2005-02-15
申请人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sanchez
发明人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sanchez
IPC分类号： C12P21/06 , C12N1/20 , C12N15/63 , C07H21/04
CPC分类号： C07K14/4354 , C12N9/2497 , C12Y302/02005
摘要： The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms, such as parasites, and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, eosinophils, macrophages and dentritic cells. The invention further relates to drug screening assays designed to identify compounds that modulate the ADP-ribosyl cyclase activity of CD38 and the use of such compounds in the treatment of disorders involving CD38 modulated cell migration. Additionally, the invention relates to the isolation and characterization of a CD38 homologue from the parasitic flatworm, Schistosoma mansoni.
摘要翻译：本发明涉及调节表达CD38的细胞的迁移活性的方法，用于治疗疾病，包括但不限于炎症，局部缺血，哮喘，自身免疫疾病，糖尿病，关节炎，过敏，病原体感染等寄生虫，移植排斥。这样的细胞包括例如嗜中性粒细胞，淋巴细胞，嗜酸性粒细胞，巨噬细胞和牙髓细胞。本发明还涉及设计用于鉴定调节CD38的ADP-核糖基环化酶活性的化合物的药物筛选试验，以及这些化合物在治疗涉及CD38调节的细胞迁移的疾病中的用途。此外，本发明涉及从寄生扁丝虫曼氏血吸虫分离和表征CD38同系物。

4. 发明授权

US08084035B2 CD38 modulated chemotaxis 失效
标题翻译： CD38调节趋化性
公开(公告)号：US08084035B2
公开(公告)日：2011-12-27
申请号：US12703062
申请日：2010-02-09
申请人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sanchez
发明人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sanchez
IPC分类号： A61K39/00 , A61K39/385 , G01N33/53 , C07K14/52
CPC分类号： C07K14/4354 , C12N9/2497 , C12Y302/02005
摘要： The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms, such as parasites, and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, eosinophils, macrophages and dentritic cells. The invention further relates to drug screening assays designed to identify compounds that modulate the ADP-ribosyl cyclase activity of CD38 and the use of such. compounds in the treatment of disorders involving CD38 modulated cell migration. Additionally, the invention relates to the isolation and characterization of a CD38 homologue from the parasitic flatworm, Schistosoma mansoni.
摘要翻译：本发明涉及调节表达CD38的细胞的迁移活性的方法，用于治疗疾病，包括但不限于炎症，局部缺血，哮喘，自身免疫疾病，糖尿病，关节炎，过敏，病原体感染等寄生虫，移植排斥。这样的细胞包括例如嗜中性粒细胞，淋巴细胞，嗜酸性粒细胞，巨噬细胞和牙髓细胞。本发明还涉及设计用于鉴定调节CD38的ADP-核糖基环化酶活性的化合物的药物筛选测定及其用途。治疗涉及CD38调节细胞迁移的疾病的化合物。此外，本发明涉及从寄生扁丝虫曼氏血吸虫分离和表征CD38同系物。

5. 发明申请

US20100061995A1 Immunotherapy To Treat Or Prevent Viral Infection 审中-公开
标题翻译：免疫治疗或预防病毒感染
公开(公告)号：US20100061995A1
公开(公告)日：2010-03-11
申请号：US12206157
申请日：2008-09-08
申请人： Damian Michael Carragher , Denise Ann Kaminski , Frances E. Lund , Troy Douglas Randall
发明人： Damian Michael Carragher , Denise Ann Kaminski , Frances E. Lund , Troy Douglas Randall
IPC分类号： A61K39/395 , A61P31/16 , A61K31/7088
CPC分类号： C07K16/1018 , A61K31/7088 , A61K2039/505
摘要： The prevention and treatment of influenza is described, by using passive immunization with antibodies (e.g. polyclonal, monoclonal, etc.) to one or more conserved influenza proteins. Both antibodies and fragments thereof are contemplated, raised against conserved proteins such as nucleoproteins.
摘要翻译：通过使用针对一种或多种保守的流感蛋白的抗体（例如多克隆，单克隆等）的被动免疫来描述流感的预防和治疗。考虑到抗体和其片段，针对保守的蛋白质例如核蛋白产生。

6. 发明授权

US06955884B2 Methods for identifying compounds that inhibit CD38 activity 失效
标题翻译：鉴定抑制CD38活性的化合物的方法
公开(公告)号：US06955884B2
公开(公告)日：2005-10-18
申请号：US09982616
申请日：2001-10-17
申请人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sánchez
发明人： Frances E. Lund , Troy D. Randall , Santiago Partida-Sánchez
IPC分类号： G01N33/50 , C07K14/435 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/24 , C12N15/09 , C12Q1/02 , C12Q1/25 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/573 , C12N5/00 , C12N5/02
CPC分类号： C07K14/4354 , C12N9/2497 , C12Y302/02005
摘要： The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms and transplant rejection. Such cells include, for example, neutrophils, lymphocytes, eosinophils, macrophages and dentritic cells. The invention further relates to drug screening assays designed to identify compounds that modulate the ADP-ribosyl cyclase activity of CD38 and the use of such compounds in the treatment of disorders involving CD38 modulated cell migration. The invention is based on the discovery that CD38 ADP-ribosyl cyclase activity is required for chemotaxis. Furthermore, the invention relates to methods for identifying compounds that modulate the enzyme activity of the S. mansoni CD38 homologue and using those compounds in the treatment of pathologic disorders caused by helminth infection. This is based on the discovery that helminths such as S. mansoni express CD38 homologues.
摘要翻译：本发明涉及调节表达CD38的细胞的迁移活性的方法，用于治疗疾病，包括但不限于炎症，局部缺血，哮喘，自身免疫疾病，糖尿病，关节炎，过敏，病原体感染和移植排斥。这样的细胞包括例如嗜中性粒细胞，淋巴细胞，嗜酸性粒细胞，巨噬细胞和牙髓细胞。本发明还涉及设计用于鉴定调节CD38的ADP-核糖基环化酶活性的化合物的药物筛选试验，以及这些化合物在治疗涉及CD38调节的细胞迁移的疾病中的用途。本发明基于发现趋化性所需的CD38 ADP-核糖基环化酶活性。此外，本发明涉及用于鉴定调节曼氏血清CD38同源物的酶活性并使用这些化合物治疗由蠕虫感染引起的病理性疾病的化合物的方法。这是基于以下发现：蠕虫如曼氏男性表达CD38同源物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式