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1. 发明申请

US20120165626A1 DEVICES, METHODS, AND KITS FOR DETERMINING ANALYTE CONCENTRATIONS 审中-公开
标题翻译：用于确定分析浓度的装置，方法和试剂盒
公开(公告)号：US20120165626A1
公开(公告)日：2012-06-28
申请号：US13383809
申请日：2010-07-01
申请人： Finkelshtein V. Irina , James W. Moyer , Russell O. Potts , Burton H. Sage , Robert J. Shartie , Donald R. Wilson , Bruce D. Wong
发明人： Finkelshtein V. Irina , James W. Moyer , Russell O. Potts , Burton H. Sage , Robert J. Shartie , Donald R. Wilson , Bruce D. Wong
IPC分类号： A61B5/1455 , A61B5/145
CPC分类号： C12Q1/006 , A61B5/14517 , A61B5/14532 , A61B5/1455 , A61B10/0064 , G01N21/78 , G01N21/8483 , G01N33/52 , G01N2021/7786
摘要： Devices, methods, and kits for measuring or otherwise evaluating the concentration of one or more analytes in a body fluid are described. The devices, methods, and/or kits may be non-invasive. In some variations, a method for measuring the concentration of an analyte in sweat of a subject may comprise contacting a colorimetric membrane with a skin surface of the subject so that the membrane collects a volume of sweat from the skin surface, and analyzing the colorimetric membrane to determine the concentration of the analyte in the collected volume of sweat.
摘要翻译：描述了用于测量或以其它方式评价体液中一种或多种分析物的浓度的装置，方法和试剂盒。装置，方法和/或试剂盒可以是非侵入性的。在一些变型中，用于测量受试者汗液中分析物浓度的方法可以包括使比色膜与受试者的皮肤表面接触，使得膜从皮肤表面收集体积的汗液，并分析比色膜以确定所收集体积的汗液中分析物的浓度。

2. 发明申请

US20090126343A1 Internal Detonation Reciprocating Engine 审中-公开
标题翻译：内爆式往复式发动机
公开(公告)号：US20090126343A1
公开(公告)日：2009-05-21
申请号：US11941741
申请日：2007-11-16
申请人： Frank K. Lu , Philip K. Panicker , Donald R. Wilson , Wei-Hsiang Lai , Jiun-Ming Li
发明人： Frank K. Lu , Philip K. Panicker , Donald R. Wilson , Wei-Hsiang Lai , Jiun-Ming Li
IPC分类号： F02K5/02
CPC分类号： F02B23/08 , Y02T10/125
摘要： A method of rotating a crank shaft and in internal detonation engine are provided. The internal detonation engine comprises a deflagration to detonation transition section. The deflagration to detonation transition section is connected to a main cylinder, which houses a piston. Inducing a detonation wave from the deflagration wave and passing the detonation wave through a fluid, gives rise to high pressure and temperature in a cylinder and pushes a piston towards bottom dead center. An internal detonation reciprocating engine may be a single cylinder and may be either a two or four stroke engine. A two-stroke internal detonation reciprocating engine is similar to a four-stroke internal detonation reciprocating engine but has different valve placements. Detonations produce a more thorough combustion of the fuel and may, thereby, yield reduced emissions of carbon monoxide as compared to internal combustion engines.
摘要翻译：提供了一种旋转曲柄轴和内部爆震引擎的方法。内爆式发动机包括爆燃过渡段。爆燃过渡段的爆燃与主缸相连，主缸装有活塞。从爆燃波引起爆震波并将爆震波通过流体，引起气缸中的高压和温度，并将活塞推向下死点。内部爆震往复发动机可以是单缸，并且可以是二冲程发动机或四冲程发动机。二冲程内爆炸往复式发动机类似于四冲程内爆炸往复式发动机，但具有不同的阀门布置。爆炸产生燃料的更彻底的燃烧，从而与内燃机相比可减少一氧化碳的排放。

3. 发明授权

US5820875A Device for administering drug transdermally with a controlled temporal change in skin flux 失效
标题翻译：用于通过皮肤通量控制的时间变化经皮给药的装置
公开(公告)号：US5820875A
公开(公告)日：1998-10-13
申请号：US211029
申请日：1994-03-16
申请人： Renee A. Fallon , Donald R. Wilson , Russell D. Beste
发明人： Renee A. Fallon , Donald R. Wilson , Russell D. Beste
IPC分类号： A61M37/00 , A61F13/00 , A61F13/02 , A61K9/70
CPC分类号： A61K9/703 , A61K9/7069 , A61K9/7084 , A61F2013/00553 , A61F2013/00604 , A61F2013/00646 , A61F2013/00906
摘要： A transdermal drug delivery device that administers drug in an initial pulse followed by a substantially lower continuous rate comprising a drug reservoir of the drug dissolved in a nonvolatile skin permeation enhancer and a volatile permeation enhancer confined between a backing that is permeable to the volatile permeation enhancer and an underlying substrate layer that is permeable to the drug and both enhancers. When the device is placed on the skin the volatile permeation enhancer is depleted from the reservoir by evaporation through the backing such that the magnitude and duration of the pulse is dependent upon the permeability of the backing layer to the volatile enhancer.
摘要翻译： PCT No.PCT / US92 / 08631 Sec。 371日期1994年3月16日 102（e）日期1994年3月16日PCT提交1992年10月9日PCT公布。出版物WO93 / 06803 日期1994年4月15日一种透皮药物递送装置，其以初始脉冲施用药物，然后以基本上较低的连续速率施用药物，其包含溶解在非挥发性皮肤渗透增强剂中的药物的药物储存器和限制在可渗透的背衬之间的挥发性渗透增强剂涉及挥发性渗透增强剂和可渗透药物和两种增强剂的下层基底层。当将装置放置在皮肤上时，挥发性渗透增强剂通过背衬蒸发从储存器中消耗，使得脉冲的幅度和持续时间取决于背衬层对挥发性增强剂的渗透性。

4. 发明授权

US5217718A Method and device for administering dexmedetomidine transdermally 失效
标题翻译：透皮给药右美托咪定的方法和装置
公开(公告)号：US5217718A
公开(公告)日：1993-06-08
申请号：US761408
申请日：1991-09-17
申请人： Kenneth J. Colley , Donald R. Wilson , Gary W. Cleary , Risto Lammintausta , Harry Jalonen
发明人： Kenneth J. Colley , Donald R. Wilson , Gary W. Cleary , Risto Lammintausta , Harry Jalonen
IPC分类号： A61K9/70 , A61K31/415
CPC分类号： A61K9/703 , A61K31/415 , A61K9/7084
摘要： Transdermal administration of dexmedetomidine, the dextrorotatory isomer of medetomidine, is described. The method involves sedating a patient by administering dexmedetomidine to a predetermined area of skin at an administration rate and for a time period effective to achieve the desired level of sedation. A therapeutic system for transdermally administering the drug is also provided. The therapeutic system is in the form of a skin patch which is a laminated composite of a backing layer, an optional anchor adhesive layer, a contact adhesive layer, and one or more additional layers.
摘要翻译：描述了右美托咪定的透皮给药，美托咪定的右旋异构体。该方法包括以给药速率和有效达到期望的镇静水平的时间段将右美托咪定投予皮肤的预定区域来镇静患者。还提供了用于经皮给药的治疗系统。治疗系统是皮肤贴片的形式，其是背衬层，任选的锚定粘合剂层，接触粘合剂层和一个或多个另外的层的层压复合材料。

5. 发明授权

US4405798A Acrylate and methacrylate monoesters of pentaerythritol and pentaerythritol orthoesters and polymers and copolymers derived therefrom 失效
公开(公告)号：US4405798A
公开(公告)日：1983-09-20
申请号：US248183
申请日：1981-03-30
申请人： Henry K. Hall , Donald R. Wilson
发明人： Henry K. Hall , Donald R. Wilson
IPC分类号： C07D493/08 , C08F20/28 , C07D319/14
CPC分类号： C07D493/08 , C08F20/28
摘要： Acrylate and methacrylate monoesters of pentaerythritol and pentaerythritol orthoesters are provided. These orthoesters are especially useful as monomers for the preparation of polymers and copolymers having a variety of industrial applications.

6. 发明授权

US07907038B2 Electromagnetic flow control, methods and uses 有权
标题翻译：电磁流量控制，方法和用途
公开(公告)号：US07907038B2
公开(公告)日：2011-03-15
申请号：US12100890
申请日：2008-04-10
申请人： Frank K. Lu , Donald R. Wilson , J. Craig Dutton
发明人： Frank K. Lu , Donald R. Wilson , J. Craig Dutton
IPC分类号： H01F3/00 , F16K31/02
CPC分类号： B64C21/00 , B64C23/005 , B64C2230/12 , Y02T50/166
摘要： Actuation for control of surfaces is provided through use of a conducting material comprising electrolyte particles electrically charged with electromagnetic fields in boundary layers. Interactions of the electrically charged particles with electromagnetic fields in boundary layers are coordinated for generation of control forces for various applications.
摘要翻译：通过使用包含在边界层中带有电磁场的电解质颗粒的导电材料来提供用于控制表面的致动。带电粒子与边界层中的电磁场的相互作用被协调以产生用于各种应用的控制力。

7. 发明授权

US5124157A Method and device for administering dexmedetomidine transdermally 失效
标题翻译：用于施用德美塞米星转铁蛋白的方法和装置
公开(公告)号：US5124157A
公开(公告)日：1992-06-23
申请号：US395717
申请日：1989-08-18
申请人： Kenneth J. Colley , Donald R. Wilson , Gary W. Cleary , Risto Lammintausta , Harry Jalonen
发明人： Kenneth J. Colley , Donald R. Wilson , Gary W. Cleary , Risto Lammintausta , Harry Jalonen
IPC分类号： A61K31/4965 , A61K9/20 , A61K9/70 , A61K31/415 , A61K31/45 , A61L15/44
CPC分类号： A61K9/7061 , A61K31/415 , A61K9/7069 , A61K9/7084
摘要： Transdermal administration of dexmedetomidine, the dextrorotatory isomer of medetomidine, is described. The method involves sedating a patient by administering dexmedetomidine to a predetermined area of skin at an administration rate and for a time period effective to achieve the desired level of sedation. A therapeutic system for transdermally administering the drug is also provided. The therapeutic system is in the form of a skin patch which is a laminated composite of a backing layer, an optional anchor adhesive layer, a contact adhesive layer, and one or more additional layers.

8. 发明授权

US4314103A Telephone answering system with simulated dial tone disconnect protection 失效
标题翻译：具有模拟拨号音断开保护的电话应答系统
公开(公告)号：US4314103A
公开(公告)日：1982-02-02
申请号：US151295
申请日：1980-05-19
申请人： Donald R. Wilson
发明人： Donald R. Wilson
IPC分类号： H04M1/654 , H04M1/65
CPC分类号： H04M1/654
摘要： An automatic telephone answering system wherein disconnection from the telephone line following calling party hang up is in response to the detection of dial tone, utilizes a signal detector responsive to voice and steady tone signals for providing an indication of the status of an incoming signal on the telephone line, and a processor for monitoring line signal status to determine the presence of dial tone. Following a determination of the presence of dial tone as an incoming line signal, the processor acts to automatically disconnect the system from the telephone line by opening a telephone line connection relay. The determination of dial tone is made based upon the continuous existence, over a predetermined time interval, of an incoming line signal status representative of a steady tone signal, rather than an absolute, single event detection. An automatic telephone answering and message recording system having remote access message playback, and which disconnects from the telephone line in response to dial tone, further includes processor actuated circuitry for inserting a blank interval in an incoming line signal prior to being recorded. The circuitry is actuated upon a determination by the processor that the incoming line signal is a steady tone signal, the determination being made based upon the existence, over a predetermined time interval, of an incoming line signal status representative of a steady tone signal. The duration of the time interval for such determination being a shorter period than the duration of the time interval for a dial tone determination.
摘要翻译：一种自动电话应答系统，其中与呼叫方挂断之后的电话线路的断开是响应于拨号音的检测，利用响应于语音和稳定音调信号的信号检测器，以提供关于呼入信号的状态的指示电话线和处理器，用于监视线路信号状态，以确定拨号音的存在。在确定拨号音作为输入线路信号的确定之后，处理器通过打开电话线路连接中继器来自动断开系统与电话线的连接。拨号音的确定基于在预定时间间隔内连续存在表示稳定音调信号的输入线信号状态而不是绝对单个事件检测。具有远程访问消息回放并且响应于拨号音与电话线断开的自动电话应答和消息记录系统还包括处理器驱动的电路，用于在记录之前将空白间隔插入到输入行信号中。当处理器确定输入线路信号是稳定音信号时，电路被启动，该确定是基于在预定时间间隔内存在表示稳定音调信号的输入线信号状态进行的。这种确定的时间间隔的持续时间是比用于拨号音确定的时间间隔的持续时间更短的周期。

9. 发明申请

US20090322102A1 System and Method for Power Production Using a Hybrid Helical Detonation Device 有权
标题翻译：使用混合式螺旋爆轰装置进行电力生产的系统和方法
公开(公告)号：US20090322102A1
公开(公告)日：2009-12-31
申请号：US12552425
申请日：2009-09-02
申请人： Frank K. Lu , Philip K. Panicker , Donald R. Wilson , Jiun-Ming Li
发明人： Frank K. Lu , Philip K. Panicker , Donald R. Wilson , Jiun-Ming Li
IPC分类号： H02P9/04 , F02C5/02 , F02C7/00
CPC分类号： F02C5/12 , F05D2250/25 , F23R7/00 , Y02E20/14
摘要： The system and method described herein uses a hybrid pulsed detonation engine (PDE) system to drive a turbine that powers an electric generator. The combustion chamber of the PDE is shaped in a helical form, so that the external length of the section is reduced, while maintaining the distance for acceleration to detonation. This allows the achievement of deflagration to detonation transition without the help of turbulence enhancing obstacles, while keeping the overall size of the detonation tube small. The PDE output can be scaled by: increasing the cross sectional area of the detonation chamber; increasing the number of detonation tubes; and increasing the frequency of operation of the PDE. The replacement of conventional deflagrative internal combustion engines, including gas turbines and reciprocating engines, with pulsed detonation engines for electric power generation, may provide fuel savings and have a lower environmental impact.
摘要翻译：本文所述的系统和方法使用混合脉冲爆震发动机（PDE）系统来驱动对发电机供电的涡轮机。 PDE的燃烧室成形为螺旋形，从而减小了截面的外部长度，同时保持加速到爆炸的距离。这样就可以在不增加障碍物的紊流的帮助下实现爆燃转化，同时保持引爆管的整体尺寸。可以通过以下方式缩放PDE输出：增加爆震室的横截面积; 增加引爆管的数量; 并增加PDE的运行频率。用燃气涡轮机和往复式发动机代替用于发电的脉冲爆震发动机的常规爆燃内燃机可以提供燃料节约并且具有较低的环境影响。

10. 发明授权

US4756835A Permeable membranes having high flux-density and low fouling-propensity 失效
标题翻译：具有高通量密度和低污染倾向的渗透膜
公开(公告)号：US4756835A
公开(公告)日：1988-07-12
申请号：US901827
申请日：1986-08-29
申请人： Donald R. Wilson
发明人： Donald R. Wilson
IPC分类号： B32B3/30 , B01D53/22 , B01D61/08 , B01D61/18 , B01D63/00 , B01D69/00 , B01J19/24 , C12M1/12 , B01D13/00
CPC分类号： B01D63/082 , B01D53/22 , B01D63/10 , B01D65/08 , B01D69/00 , B01D69/02 , B01J19/2475 , B01D2321/2016 , B01D2325/08 , B01D2325/10
摘要： A permeable membrane system comprised of at least two sheets, at least one of the two sheets being a grooved permeable membrane having regularly spaced grooves on at least one surface, the grooves having a predetermined spacing factor, the grooved permeable membrane either having essentially no barrier layer or having a barrier layer on one grooved surface, the sheets being positioned in a configuration with the grooves of that one grooved surface of the grooved permeable membrane sheet forming feed channels with a surface of another sheet which covers that one grooved surface, the grooves being about 0.5 to about 100 mils wide and deep and the feed channels being used to deliver the feed stream to the membrane surface. Preferably, both sheets are permeable membranes. The grooves in the sheets are preferably about 5 to about 35 mils wide and deep for reverse osmosis, about 0.5 to about 20 mils wide and deep for gas separation, and about 15 to about 75 mils wide and deep for ultrafiltration. The grooves on one side of one sheet may be aligned with the grooves on one side of an adjacent sheet, whereby the grooves on one side of one sheet form parts of the feed channels and the corresponding grooves on one side of the other sheet form the other parts of the feed channels. Or, the grooved sheets may be alternated with planar sheets so that the grooves on one side of the grooved sheets form the feed channels with the adjacent surface of a planar sheet.
摘要翻译：一种可渗透膜系统，包括至少两个片材，所述两个片材中的至少一个片材是沟槽可渗透膜，其在至少一个表面上具有规则间隔的凹槽，所述凹槽具有预定的间隔因子，所述带槽的渗透膜基本上不具有屏障层或在一个沟槽表面上具有阻挡层，所述片被定位成具有沟槽的可渗透膜片的所述一个凹槽表面的槽的构造，其形成供给通道的另一片的表面覆盖所述一个凹槽表面，所述凹槽约0.5至约100密耳宽和深，并且进料通道用于将进料流输送到膜表面。优选地，两片都是可渗透膜。片材中的凹槽优选为约5至约35密耳宽，深度为反渗透，宽度为约0.5至约20密耳，气体分离深度大，而用于超滤的宽度为约15至约75密耳。一片的一侧上的槽可以与相邻片的一侧上的槽对准，由此一片的一侧上的槽形成供给通道的一部分，并且另一片的一侧的相应的槽形成饲料渠道的其他部分。或者，带槽的片材可以与平面片材交替，使得沟槽片材的一侧上的沟槽与平面片材的相邻表面形成馈送通道。

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