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1. 发明授权

US5820875A Device for administering drug transdermally with a controlled temporal change in skin flux 失效
标题翻译：用于通过皮肤通量控制的时间变化经皮给药的装置
公开(公告)号：US5820875A
公开(公告)日：1998-10-13
申请号：US211029
申请日：1994-03-16
申请人： Renee A. Fallon , Donald R. Wilson , Russell D. Beste
发明人： Renee A. Fallon , Donald R. Wilson , Russell D. Beste
IPC分类号： A61M37/00 , A61F13/00 , A61F13/02 , A61K9/70
CPC分类号： A61K9/703 , A61K9/7069 , A61K9/7084 , A61F2013/00553 , A61F2013/00604 , A61F2013/00646 , A61F2013/00906
摘要： A transdermal drug delivery device that administers drug in an initial pulse followed by a substantially lower continuous rate comprising a drug reservoir of the drug dissolved in a nonvolatile skin permeation enhancer and a volatile permeation enhancer confined between a backing that is permeable to the volatile permeation enhancer and an underlying substrate layer that is permeable to the drug and both enhancers. When the device is placed on the skin the volatile permeation enhancer is depleted from the reservoir by evaporation through the backing such that the magnitude and duration of the pulse is dependent upon the permeability of the backing layer to the volatile enhancer.
摘要翻译： PCT No.PCT / US92 / 08631 Sec。 371日期1994年3月16日 102（e）日期1994年3月16日PCT提交1992年10月9日PCT公布。出版物WO93 / 06803 日期1994年4月15日一种透皮药物递送装置，其以初始脉冲施用药物，然后以基本上较低的连续速率施用药物，其包含溶解在非挥发性皮肤渗透增强剂中的药物的药物储存器和限制在可渗透的背衬之间的挥发性渗透增强剂涉及挥发性渗透增强剂和可渗透药物和两种增强剂的下层基底层。当将装置放置在皮肤上时，挥发性渗透增强剂通过背衬蒸发从储存器中消耗，使得脉冲的幅度和持续时间取决于背衬层对挥发性增强剂的渗透性。

2. 发明授权

US06369354B1 Excimer laser ablation process control of multilaminate materials 失效
标题翻译：准分子激光烧蚀过程控制多层材料
公开(公告)号：US06369354B1
公开(公告)日：2002-04-09
申请号：US09616582
申请日：2000-07-14
申请人： Russell D. Beste
发明人： Russell D. Beste
IPC分类号： B23K2638
CPC分类号： B23K26/382 , B23K26/40 , B23K2103/16 , B23K2103/42 , B23K2103/50 , H05K3/0032
摘要： A method of ablating holes in a material, using a laminated material which includes first and second layers. The first and second layers have different coefficients of thermal expansion. The first layer has a hole within it surrounding a target region of the second layer in the laminated material. Thus, the target region is not laminated to the second layer but is surrounded entirely by laminated regions wherein the first layer is laminated to the second layer. A laser source producing energy of a wavelength and a power level that can ablate material from the first layer is directed toward the target region after and/or during changing the temperature of the laminated material so as to place the target region under tension, thereafter ablation of the target region produces the desired holes.
摘要翻译：使用包括第一层和第二层的层压材料来消除材料中的孔的方法。第一层和第二层具有不同的热膨胀系数。第一层在其周围具有围绕层压材料中的第二层的目标区域的孔。因此，目标区域不层叠到第二层，而是被第一层层叠到第二层的层叠区域完全包围。在层叠材料的温度变化之后和/或改变层叠材料的温度之间，产生能够从第一层吸收材料的波长能量和功率水平的激光源朝向目标区域，以使靶区域处于张力状态，然后消融的目标区域产生所需的孔。

3. 发明申请

US20100086582A1 AMORPHOUS ROTIGOTINE TRANSDERMAL SYSTEM 审中-公开
标题翻译：非晶转运系统
公开(公告)号：US20100086582A1
公开(公告)日：2010-04-08
申请号：US12571509
申请日：2009-10-01
申请人： Jiansheng Tang , Joseph M. Deverich , Kenneth J. Miller, II , Russell D. Beste
发明人： Jiansheng Tang , Joseph M. Deverich , Kenneth J. Miller, II , Russell D. Beste
IPC分类号： A61K31/381 , A61K9/70 , A61P25/16
CPC分类号： A61K9/7038 , A61K31/381
摘要： The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of rotigotine substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing a supersaturated amount of rotigotine substantially in amorphous form. Further, the present invention refers to a method of stabilizing and a method of reestablishing the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.
摘要翻译：本发明涉及一种透皮递送装置，其包括背层，粘合剂基质层，其包含在粘合剂基质内基本上无定形形式的过饱和浓度的罗替戈汀和释放衬垫。本发明还涉及一种制备含有基本上无定形形式的过饱和量的罗替戈汀的粘合剂基质的方法。此外，本发明涉及一种稳定化方法和在其制造，储存，运输和处理过程中重新建立间 - 稳定非晶药物透皮系统的方法。

4. 发明授权

US06288360B1 Excimer laser ablation process control of multilaminate materials 有权
公开(公告)号：US06288360B1
公开(公告)日：2001-09-11
申请号：US09353125
申请日：1999-07-14
申请人： Russell D. Beste
发明人： Russell D. Beste
IPC分类号： B23K2638
CPC分类号： B23K26/382 , B23K26/40 , B23K2103/16 , B23K2103/42 , B23K2103/50 , H05K3/0032
摘要： The instant invention discloses a method of ablating holes in a material, using a laminated material comprising first and second layers, said first and second layers having different coefficients of thermal expansion, said first layer having within it a hole, wherein a target region of said second layer in said laminated material is not laminated to said first layer but is surrounded entirely by laminated regions wherein the first layer is laminated to the second layer; providing a laser source producing energy of a wavelength and a power level that can ablate material from said first layer; changing the temperature of the laminated material so as to place said target region under tension; and directing said laser source onto said target region and ablating a portion thereof.

5. 发明授权

US10632082B2 Process for the continuous manufacture of a polyisobutylene based transdermal patch 有权
公开(公告)号：US10632082B2
公开(公告)日：2020-04-28
申请号：US12838919
申请日：2010-07-19
申请人： Russell Adam Baird , Brad L. Barnett , Russell D. Beste
发明人： Russell Adam Baird , Brad L. Barnett , Russell D. Beste
IPC分类号： A61K9/70 , C09J123/22 , C08L23/22
CPC分类号： A61K9/7053 , C09J123/22 , C08L23/22 , C08L2205/02 , C08L2666/06 , C09J123/22 , C08L2666/06
摘要： The present invention is directed to a process for manufacturing a transdermal delivery device comprising a backing layer, a release liner, and an adhesive layer between the backing layer and release liner. More specifically, the invention is directed to a process of preparing an adhesive layer, wherein the adhesive layer is comprised of polyisobutylene and an active pharmaceutical ingredient.

6. 发明申请

US20110020426A1 PROCESS FOR THE CONTINUOUS MANUFACTURE OF A POLYISOBUTYLENE BASED TRANSDERMAL PATCH 审中-公开
标题翻译：基于聚异戊二烯的透皮贴片的连续制造工艺
公开(公告)号：US20110020426A1
公开(公告)日：2011-01-27
申请号：US12838919
申请日：2010-07-19
申请人： Russell Adam Baird , Brad L. Barnett , Russell D. Beste
发明人： Russell Adam Baird , Brad L. Barnett , Russell D. Beste
IPC分类号： A61K9/70 , A61K31/167 , A61P23/02 , B32B37/12
CPC分类号： A61K9/7053 , C08L23/22 , C08L2205/02 , C08L2666/06 , C09J123/22
摘要： The present invention is directed to a process for manufacturing a transdermal delivery device comprising a backing layer, a release liner, and an adhesive layer between the backing layer and release liner. More specifically, the invention is directed to a process of preparing an adhesive layer, wherein the adhesive layer is comprised of polyisobutylene and an active pharmaceutical ingredient.
摘要翻译：本发明涉及一种用于制造透皮递送装置的方法，其包括背衬层，剥离衬垫和在背衬层和剥离衬垫之间的粘合剂层。更具体地，本发明涉及制备粘合剂层的方法，其中粘合剂层由聚异丁烯和活性药物成分组成。

7. 发明授权

US06267984B1 Skin permeation enhancer compositions comprising a monoglyceride and ethyl palmitate 有权
标题翻译：包含单酸甘油酯和棕榈酸乙酯的皮肤渗透促进剂组合物
公开(公告)号：US06267984B1
公开(公告)日：2001-07-31
申请号：US09213835
申请日：1998-12-17
申请人： Russell D. Beste , Richard D. Hamlin
发明人： Russell D. Beste , Richard D. Hamlin
IPC分类号： A61K970
CPC分类号： A61K9/7069 , A61K9/0014 , A61K9/7084 , A61K47/14
摘要： Compositions, devices, and methods for transdermal administration of a drug are disclosed using a novel permeation enhancer mixture comprising a monoglyceride and ethyl palmitate. The monoglyceride/ethyl palmitate permeation enhancer is a potent permeation enhancer and provides stable systems which are more readily characterized. Additionally, ethyl palmitate cosolvent systems are more readily processed at manufacturing conditions thus providing further advantages over other cosolvents.
摘要翻译：使用包含单酸甘油酯和棕榈酸乙酯的新型渗透增强剂混合物公开了用于透皮给药药物的组合物，装置和方法。单酸甘油酯/棕榈酸乙酯渗透促进剂是一种有效的渗透促进剂，并提供更容易表征的稳定体系。另外，棕榈酸共溶剂系统在制造条件下更容易加工，从而提供优于其它共溶剂的进一步优势。

8. 发明申请

US20080226698A1 Amorphous drug transdermal systems, manufacturing methods, and stabilization 审中-公开
标题翻译：无定形药物透皮系统，制造方法和稳定性
公开(公告)号：US20080226698A1
公开(公告)日：2008-09-18
申请号：US11725159
申请日：2007-03-16
申请人： Jiansheng Tang , Joseph M. Deverich , Kenneth J. Miller , Russell D. Beste
发明人： Jiansheng Tang , Joseph M. Deverich , Kenneth J. Miller , Russell D. Beste
IPC分类号： A61K31/215 , A61F13/02 , A61K31/4353 , A61K31/4355 , A61K9/70 , A61P43/00
CPC分类号： A61K9/7053 , A61K9/7069
摘要： The present invention refers to a transdermal delivery device comprising a backing layer, an adhesive matrix layer comprising a supersaturated concentration of an active agent substantially in amorphous form within the adhesive matrix, and a release liner. The present invention also refers to a method of preparing an adhesive matrix containing at least one supersaturated active agent substantially in amorphous form. Further, the present invention refers to a method to stabilize and a method to reestablish the meta-stable amorphous-drug transdermal system during its manufacturing, storing, shipping and handling process.
摘要翻译：本发明涉及一种透皮递送装置，其包括背衬层，包含过饱和浓度的基本上为无定形形式的粘合剂基质中的活性剂的粘合剂基质层和释放衬垫。本发明还涉及制备含有至少一种基本上为无定形形式的过饱和活性剂的粘合剂基质的方法。此外，本发明涉及一种稳定化方法以及在其制造，储存，运输和处理过程中重新建立间 - 稳定非晶药物透皮系统的方法。

9. 发明授权

US5843468A Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate 失效
公开(公告)号：US5843468A
公开(公告)日：1998-12-01
申请号：US644922
申请日：1996-05-13
申请人： Terry L. Burkoth , Lina T. Taskovich , Russell D. Beste , Robert M. Gale , Eun Soo Lee , Richard D. Hamlin , Su LL Yum
发明人： Terry L. Burkoth , Lina T. Taskovich , Russell D. Beste , Robert M. Gale , Eun Soo Lee , Richard D. Hamlin , Su LL Yum
IPC分类号： A61K9/00 , A61K9/70 , A61K47/14 , A61F13/02
CPC分类号： A61K9/7053 , A61K47/14 , A61K9/0014 , A61K9/7069 , A61K9/7084 , Y10S514/946 , Y10S514/947
摘要： Compositions, devices, and methods for transdermal administration of an active agent are disclosed using a novel dual permeation enhancer mixture comprising lauryl acetate and a monoglyceride, preferably glycerol monolaurate. The dual permeation enhancer mixture comprising lauryl acetate is a potent permeation enhancer and provides stable systems which are more readily characterized.

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