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1. 发明授权

US5512293A Oral sustained release drug delivery device 失效
标题翻译：口服持续释放药物输送装置
公开(公告)号：US5512293A
公开(公告)日：1996-04-30
申请号：US164181
申请日：1993-12-09
申请人： Felix A. Landrau , Patricia S. Campbell , Arthur W. Hall , Juan M. E. Harrison
发明人： Felix A. Landrau , Patricia S. Campbell , Arthur W. Hall , Juan M. E. Harrison
IPC分类号： A61K9/00 , A61K9/20 , A61L15/24 , A61K9/70 , A61K47/32
CPC分类号： A61K9/0004 , A61K9/006 , A61K9/2027
摘要： This invention pertains to a sustained release delivery device for delivering a beneficial agent into the oral cavity of a patient. More particularly, the invention relates to a device comprising about 0.1% to about 20% by weight beneficial agent, about 40% to about 95% by weight ethylene vinyl acetate copolymer having a vinyl acetate content of about 4% to about 80% and about 1% to about 60% by weight polyvinyl pyrrolidone.
摘要翻译：本发明涉及一种用于将有益药物输送到患者的口腔中的持续释放递送装置。更具体地说，本发明涉及包含约0.1％至约20％重量的有益剂，约40％至约95％重量的乙酸乙烯酯含量为约4％至约80％的乙烯 - 乙酸乙烯酯共聚物和约 1％至约60％重量的聚乙烯吡咯烷酮。

2. 发明授权

US5462745A Subsaturated transdermal therapeutic system having improved release characteristics 失效
标题翻译：具有改善的释放特性的亚饱和透皮治疗系统
公开(公告)号：US5462745A
公开(公告)日：1995-10-31
申请号：US297739
申请日：1994-08-30
申请人： David J. Enscore , Patricia S. Campbell , James L. Osborne , Melinda K. Smart , Su I. Yum
发明人： David J. Enscore , Patricia S. Campbell , James L. Osborne , Melinda K. Smart , Su I. Yum
IPC分类号： A61K9/70 , A61K31/46 , A61F13/02
CPC分类号： A61K9/7084 , A61K31/46
摘要： Rate controlled transdermal delivery devices are disclosed which utilize an in-line adhesive to maintain the device on the skin and deliver an agent which is a solvent or a plasticizer for the in-line adhesive. The initial equilibrated concentration of the agent in the agent reservoir and the adhesive is below saturation, and the reservoir comprises the agent dissolved in a solvent with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of the agent in reservoir is sufficient to prevent the activity of the agent in the reservoir from decreasing by more than about 50% and preferably no more than about 25% during the predetermined period of administration: and the thicknesses of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and preferably at least 75% initial equilibrated agent loading is in the reservoir layer. The devices are usable to deliver agents which are liquid at body temperatures such as benztropine, secoverine, nicotine, arecoline, polyethylene glycol monolaurate, glycerol monolaurate, glycerol monooleate and ethanol, for example.
摘要翻译：公开了速率控制的透皮递送装置，其使用直列粘合剂将装置保持在皮肤上并输送作为在线粘合剂的溶剂或增塑剂的试剂。试剂储存器和粘合剂中试剂的初始平衡浓度低于饱和，并且储存器包含溶解在溶剂中的试剂，其中装置的速率控制元件基本上不可渗透。在优选实施方案中，试剂在储存器中的初始加载量足以防止储存器中的试剂在给定施用期间的活性降低超过约50％，优选不超过约25％选择粘合剂，速率控制膜和储存层，使得至少50％，优选至少75％的初始平衡剂负载在储层中。这些装置可用于例如递送在体温下为液体的药剂，例如苯托品，脱毛，尼古丁，槟榔碱，聚乙二醇单月桂酸酯，甘油单月桂酸酯，甘油单油酸酯和乙醇。

3. 发明授权

US4832953A Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix 失效
标题翻译：用于防止在单水基质中的液体分散体中形成结晶水合物的方法
公开(公告)号：US4832953A
公开(公告)日：1989-05-23
申请号：US85052
申请日：1987-08-13
申请人： Patricia S. Campbell , David J. Enscore , Robert M. Gale , Arnold Kaufman
发明人： Patricia S. Campbell , David J. Enscore , Robert M. Gale , Arnold Kaufman
IPC分类号： A61K9/70
CPC分类号： A61K9/7053 , A61K9/7084
摘要： A method for preventing the formation of crystalline hydrates in a dispersion of a hydratable liquid in a nonaqueous matrix is disclosed. The method is particularly useful in the manufacture of laminated items formed from such dispersions and comprises forming individual subunits from such dispersions, heating the subunits, preferably after they have been packed in sealed containers, to a temperature high enough to melt the crystalline hydrate, maintaining said subunits at such temperature for a time sufficient to melt all the crystalline hydrate present and to prevent the occurrence of crystals for an extended period of time after cooling and cooling subunits to ambient conditions. The use of the method in the manufacture of transdermal delivery devices for the delivery of scopolamine base is described.

4. 发明授权

US4816258A Transdermal contraceptive formulations 失效
标题翻译：透皮避孕配方
公开(公告)号：US4816258A
公开(公告)日：1989-03-28
申请号：US19163
申请日：1987-02-26
申请人： Diane E. Nedberge , Patricia S. Campbell , Robert M. Gale , Su I. Yum
发明人： Diane E. Nedberge , Patricia S. Campbell , Robert M. Gale , Su I. Yum
IPC分类号： A61K9/70 , A61K31/565
CPC分类号： A61K9/7053 , A61K31/565 , A61K31/567 , A61K9/7076 , A61K9/7084 , Y10S424/14 , Y10S514/841 , Y10S514/874
摘要： A transdermal delivery system for the administering of ethinyl estradiol and levonorgestrel, in combination, utilizing a polymer matrix having the drug formulation along with a permeation enhancer dispersed throughout.

5. 发明授权

US06174545B1 Drug delivery devices and process of manufacture 有权
标题翻译：药物输送装置及制造过程
公开(公告)号：US06174545B1
公开(公告)日：2001-01-16
申请号：US09243873
申请日：1999-02-03
申请人： David J. Enscore , Patricia S. Campbell , Diane Nedberge , Richard D. Frame
发明人： David J. Enscore , Patricia S. Campbell , Diane Nedberge , Richard D. Frame
IPC分类号： A61F1302
CPC分类号： A61K9/7084 , Y10S514/947
摘要： An improved process for manufacturing transdermal drug delivery devices and devices made therefrom. The invention provides a heat equilibration process for the manufacture of drug delivery devices which eliminates the need to preload the body contacting layer with a drug. The method has particular application in the manufacture of transdermal drug delivery devices including a drug reservoir comprising drug in excess of saturation.
摘要翻译：用于制造透皮药物递送装置和由其制成的装置的改进方法。本发明提供了用于制造药物递送装置的热平衡过程，其不需要用药物预加载身体接触层。该方法在制造透皮药物递送装置中具有特别的应用，其包括含有超过饱和的药物的药物储库。

6. 发明授权

US5990179A Composition and method of enhancing electrotransport agent delivery 失效
标题翻译：增强电转运剂递送的组合物和方法
公开(公告)号：US5990179A
公开(公告)日：1999-11-23
申请号：US431187
申请日：1995-04-28
申请人： J. Richard Gyory , Patricia S. Campbell
发明人： J. Richard Gyory , Patricia S. Campbell
IPC分类号： A61K9/00 , A61K9/08 , A61N1/30
CPC分类号： A61N1/0448 , A61K9/0009 , Y10S514/946 , Y10S514/947
摘要： A composition suitable for transdermal electrotransport delivery of an agent through a body surface comprises a free acid/base form of an agent to be delivered by transdermal electrotransport, and a salt form of the agent, and optionally a permeation enhancer. Methods of enhancing transdermal electrotransport delivery and of forming a composition for the enhancement of transdermal electrotransport drug delivery, and a transdermal electrotransport delivery device (10) utilizing the compositions of the invention are disclosed.
摘要翻译：适用于通过身体表面的药物透皮电转移递送的组合物包含通过透皮电转运递送的药物的游离酸/碱形式，以及任选的渗透促进剂的盐形式。公开了增强透皮电转移递送和形成用于增强透皮电转运药物递送的组合物的方法，以及利用本发明组合物的透皮电转运递装置（10）。

7. 发明授权

US5985316A Composition and method of enhancing electrotransport agent delivery 失效
标题翻译：增强电转运剂递送的组合物和方法
公开(公告)号：US5985316A
公开(公告)日：1999-11-16
申请号：US431188
申请日：1995-04-28
申请人： J. Richard Gyory , Patricia S. Campbell
发明人： J. Richard Gyory , Patricia S. Campbell
IPC分类号： A61K9/00 , A61K47/12 , A61N1/30 , A61M37/00
CPC分类号： A61K9/0009 , A61N1/30 , Y10S514/947
摘要： An electrotransport device (10) for transdermal delivery of an agent through a body surface has a donor reservoir (16) which contains a compound formed of the agent and a transdermal permeation enhancer, the compound being able to dissociate into an agent ion and an enhancer counter ion. Methods of enhancing transdermal electrotransport drug delivery and methods of forming a composition exhibiting enhanced transdermal electrotransport drug delivery are also provided.
摘要翻译：用于透皮通过身体表面递送药物的电输送装置（10）具有供体储存器（16），其包含由所述药剂和透皮渗透促进剂形成的化合物，所述化合物能够离解成药剂离子和增强剂抗衡离子还提供了增强透皮电转运药物递送的方法和形成表现出增强的透皮电转运药物递送的组合物的方法。

8. 发明授权

US4460372A Percutaneous absorption enhancer dispenser for use in coadministering drug and percutaneous absorption enhancer 失效
标题翻译：用于联合给药和经皮吸收增强剂的经皮吸收增强剂分配器
公开(公告)号：US4460372A
公开(公告)日：1984-07-17
申请号：US481209
申请日：1983-04-01
申请人： Patricia S. Campbell , Santosh K. Chandrasekaran
发明人： Patricia S. Campbell , Santosh K. Chandrasekaran
IPC分类号： A61K9/70 , A61M37/00 , A61M7/00
CPC分类号： A61K9/7084 , A61M37/00
摘要： A dosage form that coadministers a drug and a percutaneous absorption enhancer to a defined area of the skin. The dosage form comprises a body that contains supplies of drug and enhancer and has a basal surface that contacts the area of skin and transmits the drug and enhancer to the area for absorption thereby. The drug is provided to the basal surface at a rate at least as great as the rate at which the skin is able to absorb the drug whereas the enhancer is via a rate controlling means at a substantially constant rate that increases the permeability of the treated area of skin to the drug to a level at which the drug is absorbed a therapeutically effective rate.
摘要翻译：将药物和经皮吸收增强剂共同施用于皮肤的限定区域的剂型。剂型包括含有药物和增强剂供应的身体，并具有与皮肤区域接触的基底表面，并将药物和增强剂传递到吸收区域。药物以至少与皮肤能够吸收药物的速率一样大的速率提供给基底表面，而增强剂通过速率控制装置以基本上恒定的速率提高，这增加了处理区域的渗透性的皮肤对药物的吸收水平达到治疗有效率。

9. 发明授权

US5865792A Reduction of skin irritation during electrotransport delivery 失效
标题翻译：电运输期间减少皮肤刺激
公开(公告)号：US5865792A
公开(公告)日：1999-02-02
申请号：US895096
申请日：1997-07-16
申请人： Philip W. Ledger , Michel J.N. Cormier , Patricia S. Campbell
发明人： Philip W. Ledger , Michel J.N. Cormier , Patricia S. Campbell
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0432 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/325 , A61N1/0436 , A61N1/0444
摘要： The invention is directed to a composition and product for use in an electrotransport device. The composition includes an ionized drug, an anti-inflammatory agent and a solvent. Preferably, the anti-inflammatory agent is hydrocortisone or esters thereof, and the solvent is an alcohol, a glycol, a glycerol, a cyclodextrin, a nonionic surfactant or mixtures thereof. The composition preferably further includes a gel matrix that is a swellable, hydrophilic polymer, a water soluble hydrophilic polymer or a solid polymer. A hydrophobic polymer and/or additives may also be included.
摘要翻译：本发明涉及一种用于电输送装置的组合物和产品。组合物包括电离药物，抗炎剂和溶剂。优选地，抗炎剂是氢化可的松或其酯，溶剂是醇，二醇，甘油，环糊精，非离子表面活性剂或其混合物。组合物优选还包括可溶胀亲水性聚合物，水溶性亲水聚合物或固体聚合物的凝胶基质。还可以包括疏水性聚合物和/或添加剂。

10. 发明授权

US5344656A Subsaturated transdermal therapeutic system having improved release characteristics 失效
公开(公告)号：US5344656A
公开(公告)日：1994-09-06
申请号：US78540
申请日：1993-06-16
申请人： David J. Enscore , Patricia S. Campbell , James L. Osborne , Melinda K. Smart , Su I. Yum
发明人： David J. Enscore , Patricia S. Campbell , James L. Osborne , Melinda K. Smart , Su I. Yum
IPC分类号： A61K9/70 , A61K31/46 , A61F13/02
CPC分类号： A61K9/7084 , A61K31/46
摘要： Rate controlled transdermal delivery devices are disclosed which utilize an in-line adhesive to maintain the device on the skin and deliver an agent which is a solvent or a plasticizer for the in-line adhesive. The initial equilibrated concentration of the agent in the agent reservoir and the adhesive is below saturation, and the reservoir comprises the agent dissolved in a solvent with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of the agent in reservoir is sufficient to prevent the activity of the agent in the reservoir from decreasing by more than about 50% and preferably no more than about 25% during the predetermined period of administration; and the thicknesses of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and preferably at least 75% initial equilibrated agent loading is in the reservoir layer. The devices are usable to deliver agents which are liquid at body temperatures such as benztropine, secoverine, nicotine, arecoline, polyethylene glycol monolaurate, glycerol monolaurate, glycerol monooleate and ethanol, for example.

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