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1. 发明授权

US4816258A Transdermal contraceptive formulations 失效
标题翻译：透皮避孕配方
公开(公告)号：US4816258A
公开(公告)日：1989-03-28
申请号：US19163
申请日：1987-02-26
申请人： Diane E. Nedberge , Patricia S. Campbell , Robert M. Gale , Su I. Yum
发明人： Diane E. Nedberge , Patricia S. Campbell , Robert M. Gale , Su I. Yum
IPC分类号： A61K9/70 , A61K31/565
CPC分类号： A61K9/7053 , A61K31/565 , A61K31/567 , A61K9/7076 , A61K9/7084 , Y10S424/14 , Y10S514/841 , Y10S514/874
摘要： A transdermal delivery system for the administering of ethinyl estradiol and levonorgestrel, in combination, utilizing a polymer matrix having the drug formulation along with a permeation enhancer dispersed throughout.

2. 发明授权

US5376377A Transdermal contraceptive formulations, methods and devices 失效
标题翻译：透皮避孕配方，方法和装置
公开(公告)号：US5376377A
公开(公告)日：1994-12-27
申请号：US994055
申请日：1992-12-17
申请人： Robert M. Gale , Diane E. Nedberge , Linda E. Atkinson
发明人： Robert M. Gale , Diane E. Nedberge , Linda E. Atkinson
IPC分类号： A61K9/00 , A61K9/70 , A61K31/565 , A61K47/14 , A61F13/02
CPC分类号： A61K9/7084 , A61K31/565 , A61K31/567 , A61K47/14 , A61K9/0014 , Y10S514/843 , Y10S514/947
摘要： The present invention provides compositions and methods for the transdermal administration of a contraceptively effective amount of gestodene and an estrogen, such as ethinyl estradiol, in combination, together with a suitable permeation enhancer.
摘要翻译：本发明提供组合物和合适的透皮给药避孕有效量的孕二烯酮和雌激素（例如乙炔雌二醇）的组合物和方法以及合适的渗透促进剂。

3. 发明授权

US5314694A Transdermal formulations, methods and devices 失效
标题翻译：透皮制剂，方法和装置
公开(公告)号：US5314694A
公开(公告)日：1994-05-24
申请号：US39593
申请日：1993-03-26
申请人： Robert M. Gale , Diane E. Nedberge , Linda E. Atkinson
发明人： Robert M. Gale , Diane E. Nedberge , Linda E. Atkinson
IPC分类号： A61K9/00 , A61K9/70 , A61K31/57 , A61K47/14 , A61F13/02
CPC分类号： A61K31/57 , A61K47/14 , A61K9/0014 , A61K9/7084 , Y10S514/946 , Y10S514/947
摘要： The present invention provides compositions and methods for the transdermal administration of a therapeutically effective amount of a synthetic 19-nor-progesterone (ST-1435) and an estrogen, in combination, together with, optionally, a suitable permeation enhancer.
摘要翻译：本发明提供组合物和任选的合适的渗透促进剂经皮给药治疗有效量的合成的19-去甲孕酮（ST-1435）和雌激素的组合物和方法。

4. 发明授权

US5122382A Transdermal contraceptive formulations, methods and devices 失效
标题翻译：转基因制剂，方法和装置
公开(公告)号：US5122382A
公开(公告)日：1992-06-16
申请号：US605726
申请日：1990-10-29
申请人： Robert M. Gale , Diane E. Nedberge , Linda E. Atkinson
发明人： Robert M. Gale , Diane E. Nedberge , Linda E. Atkinson
IPC分类号： A61K9/00 , A61K9/70 , A61K31/00 , A61K31/565 , A61K31/57 , A61K47/14 , A61P15/00 , A61P15/18
CPC分类号： A61K9/7084 , A61K31/57 , A61K47/14 , A61K9/0014
摘要： The present invention provides compositions and methods for the transdermal administration of a contraceptively effective amount of a synthetic 19-nor-progesterone (ST-1435) and an estrogen, in combination, together with a suitable permeation enhancer.
摘要翻译：本发明提供组合物和合适的渗透促进剂经皮给药避孕有效量的合成的19-去甲孕酮（ST-1435）和雌激素的组合物和方法。

5. 发明授权

US4788062A Transdermal administration of progesterone, estradiol esters, and mixtures thereof 失效
标题翻译：透皮给药孕酮，雌二醇酯及其混合物
公开(公告)号：US4788062A
公开(公告)日：1988-11-29
申请号：US19162
申请日：1987-02-26
申请人： Robert M. Gale , David J. Enscore , Diane E. Nedberge , Melinda Nelson , Yu-Ling Cheng , Shari B. Libicki
发明人： Robert M. Gale , David J. Enscore , Diane E. Nedberge , Melinda Nelson , Yu-Ling Cheng , Shari B. Libicki
IPC分类号： A61K9/00 , A61K9/70 , A61K31/565 , A61K31/57 , A61K47/14 , A61K47/26 , A61F13/00
CPC分类号： A61K9/7053 , A61K31/565 , A61K31/57 , A61K47/14 , A61K47/26 , A61K9/0014 , A61K9/7076 , A61K9/7084
摘要： A transdermal delivery system for the administering of progesterone and an estradiol ester alone or in combination utilizing a polymer matrix having the drug(s) along with a permeation enhancer dispersed throughout.

6. 发明授权

US5320850A Transdermal delivery of the gestogen ST-1435 and devices therefor 失效
标题翻译： Gestogen ST-1435的透皮输送及其装置
公开(公告)号：US5320850A
公开(公告)日：1994-06-14
申请号：US16627
申请日：1993-02-12
申请人： Robert M. Gale , Diane E. Nedberge , Linda E. Atkinson
发明人： Robert M. Gale , Diane E. Nedberge , Linda E. Atkinson
IPC分类号： A61K9/00 , A61K9/70 , A61K31/57 , A61K47/14 , A61F13/00
CPC分类号： A61K9/7084 , A61K31/57 , A61K47/14 , A61K9/0014 , Y10S514/843 , Y10S514/946 , Y10S514/947
摘要： The present invention provides compositions and methods for the transdermal administration of a therapeutically effective amount of a synthetic 19-nor-progesterone (ST-1435) together with, optionally, a suitable permeation enhancer.
摘要翻译：本发明提供用于经皮给药治疗有效量的合成的19-去甲孕酮（ST-1435）以及任选的合适的渗透增强剂的组合物和方法。

7. 发明授权

US5512292A Transdermal contraceptive formulations methods and devices 失效
标题翻译：透皮避孕配方法及装置
公开(公告)号：US5512292A
公开(公告)日：1996-04-30
申请号：US361356
申请日：1994-12-21
申请人： Robert M. Gale , Diane E. Nedberge , Linda E. Atkinson
发明人： Robert M. Gale , Diane E. Nedberge , Linda E. Atkinson
IPC分类号： A61K9/00 , A61K9/70 , A61K31/565 , A61K47/14 , A61F13/02
CPC分类号： A61K9/7084 , A61K31/565 , A61K31/567 , A61K47/14 , A61K9/0014 , Y10S514/843 , Y10S514/947
摘要： The present invention provides compositions and methods for the transdermal administration of a contraceptively effective amount of gestodene and estrogen, such as ethinyl estradiol, in combination, together with a suitable permeation enhancer. The amount of the estrogen codelivered is kept at an about constant and contraceptively effective rate while the amount of gestogen codelivered varies depending on the phase of the menstrual cycle but remains at a contraceptively effective rate. The size of the system may also vary depending on the amount of gestogeno be delivered.
摘要翻译：本发明提供组合物和合适的透皮给药避孕有效量的孕二烯酮和雌激素（例如乙炔雌二醇）的组合物和方法以及合适的渗透增强剂。雌激素编码的数量保持在大约恒定和避孕有效率，而代谢产物的数量根据月经周期的相位而变化，但仍然是避孕有效率。系统的尺寸也可以根据递送的gestogeno的量而变化。

8. 发明授权

US5198223A Transdermal formulations, methods and devices 失效
标题翻译：透皮制剂，方法和装置
公开(公告)号：US5198223A
公开(公告)日：1993-03-30
申请号：US848578
申请日：1992-03-09
申请人： Robert M. Gale , Diane E. Nedberge , Linda E. Atkinson
发明人： Robert M. Gale , Diane E. Nedberge , Linda E. Atkinson
IPC分类号： A61K9/00 , A61K9/70 , A61K31/57 , A61K47/14
CPC分类号： A61K9/7084 , A61K31/57 , A61K47/14 , A61K9/0014
摘要： The present invention provides compositions and methods for the transdermal administration of a therapeutically effective amount of a synthetic 19-nor-progesterone (ST-1435) and an estrogen, in combination, together with, optionally, a suitable permeation enhancer.
摘要翻译：本发明提供组合物和任选的合适的渗透促进剂经皮给药治疗有效量的合成的19-去甲孕酮（ST-1435）和雌激素的组合物和方法。

9. 发明授权

US5004610A Subsaturated nicotine transdermal therapeutic system 失效
标题翻译：亚饱和尼古丁透皮治疗系统
公开(公告)号：US5004610A
公开(公告)日：1991-04-02
申请号：US537672
申请日：1990-06-14
申请人： James L. Osborne , Melinda Nelson , David J. Enscore , Su I. Yum , Robert M. Gale
发明人： James L. Osborne , Melinda Nelson , David J. Enscore , Su I. Yum , Robert M. Gale
IPC分类号： A61K9/70 , A61K31/465
CPC分类号： A61K9/7084 , A61K31/465 , A61K9/7053 , A61K9/7069 , Y10S514/813
摘要： Rate controlled transdermal nicotine delivery systems are disclosed which utilize an in-line adhesive to maintain the systems on the skin. The initial equilibrated concentration of nicotine in the nicotine reservoir and the adhesive is below saturation, preferably at a thermodynamic activity no greater than 0.50, and the reservoir comprises the nicotine dissolved in a material with respect to which the rate controlling element of the device is substantially impermeable. In preferred embodiments the initial loading of nicotine in the reservoir is sufficient to prevent the activity of the nicotine in the reservoir from decreasing by more than about 75% and preferably no more than about 25% during the predetermined period of administration; and the thickness of the adhesive, rate controlling membrane and reservoir layers are selected so that at least 50% and, preferably at least 75% of the initial equilibrated nicotine loading is in the reservoir layer.
摘要翻译：公开了速率控制的透皮尼古丁递送系统，其利用直列粘合剂将系统保持在皮肤上。尼古丁储存器和粘合剂中尼古丁的初始平衡浓度低于饱和度，优选在不大于0.50的热力学活性下，并且储存器包含溶解在该装置的速率控制元件基本相当于的材料中的尼古丁不渗透在优选的实施方案中，储存器中尼古丁的初始加载量足以防止储存器中的尼古丁的活性在给定的给药期间减少超过约75％，优选不超过约25％; 并且选择粘合剂，速率控制膜和储存层的厚度，使得初始平衡的尼古丁负载的至少50％，优选至少75％在储层中。

10. 发明授权

US5633008A Method of administering nicotine transdermally 失效
标题翻译：透皮管理尼古丁的方法
公开(公告)号：US5633008A
公开(公告)日：1997-05-27
申请号：US105262
申请日：1993-08-12
申请人： James L. Osborne , Melinda K. Nelson , David J. Enscore , Su I. Yum , Robert M. Gale , Donna D. Causey
发明人： James L. Osborne , Melinda K. Nelson , David J. Enscore , Su I. Yum , Robert M. Gale , Donna D. Causey
IPC分类号： A61K9/70 , A61K31/465 , A61F13/00
CPC分类号： A61K9/7084 , A61K31/465 , A61K9/7053 , A61K9/7069 , Y10S514/813
摘要： A method of administering nicotine transdermally in which a nicotine patch, capable of administering nicotine for at least 16 hours at rates that are efficacious in smoking cessation therapy, is applied in the morning upon waking and removed prior to sleep. This method is effective even though nicotine is not essential during sleep and many smokers experience morning craving.
摘要翻译：一种经皮给药尼古丁的方法，其中可以在睡眠前醒来并在睡眠前去除能够以有效戒烟治疗的速率给尼古丁至少16小时的尼古丁贴片。即使尼古丁在睡眠中不是必需的，许多吸烟者也经历早晨的渴望，这种方法是有效的。

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