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1. 发明授权

US06452005B1 JAK-3 inhibitors for treating allergic disorders 失效
标题翻译：用于治疗过敏性疾病的JAK-3抑制剂
公开(公告)号：US06452005B1
公开(公告)日：2002-09-17
申请号：US09791040
申请日：2001-02-22
申请人： Fatih M. Uckun , Ravi Malaviya , Elise A. Sudbeck
发明人： Fatih M. Uckun , Ravi Malaviya , Elise A. Sudbeck
IPC分类号： C07D23972
CPC分类号： A61K31/517
摘要： Inhibitors of JAK3 kinase for the treatment of allergy inhibit mast cell degranulation an dmediator release.
摘要翻译： JAK3激酶抑制剂治疗过敏抑制肥大细胞脱颗粒释放。

2. 发明授权

US06495556B2 Dimethoxy quinazolines for treating diabetes 失效
标题翻译：用于治疗糖尿病的二甲氧基喹唑啉
公开(公告)号：US06495556B2
公开(公告)日：2002-12-17
申请号：US09812098
申请日：2001-03-19
申请人： Fatih M. Uckun , Elise A. Sudbeck , Marina Cetkovic , Ravi Malaviya , Xing-Ping Liu
发明人： Fatih M. Uckun , Elise A. Sudbeck , Marina Cetkovic , Ravi Malaviya , Xing-Ping Liu
IPC分类号： A61K3152
CPC分类号： A61K31/00 , A61K31/505 , A61K31/517 , C07D239/74 , C07D239/94
摘要： The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
摘要翻译：本发明提供了可用于治疗白血病和淋巴瘤的新型JAK-3抑制剂。这些化合物也可用于治疗或预防皮肤癌，以及晒伤和UVB诱导的皮肤炎症。此外，本发明的化合物可防止UVB辐射的免疫抑制作用，并且可用于治疗或预防自身免疫性疾病，炎症和移植排斥。本发明还提供了包含本发明化合物的药物组合物，以及它们使用的治疗方法。

3. 发明授权

US06469013B2 Therapeutic compounds 失效
公开(公告)号：US06469013B2
公开(公告)日：2002-10-22
申请号：US09858824
申请日：2001-05-16
申请人： Fatih M. Uckun , Elise A. Sudbeck , Marina Cetkovic , Ravi Malaviya , Xing-Ping Liu
发明人： Fatih M. Uckun , Elise A. Sudbeck , Marina Cetkovic , Ravi Malaviya , Xing-Ping Liu
IPC分类号： A61K31517
CPC分类号： A61K31/00 , A61K31/505 , A61K31/517 , C07D239/74 , C07D239/94
摘要： The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.

4. 发明授权

US06313130B1 JAK-3 inhibitors for treating allergic disorders 失效
标题翻译：用于治疗过敏性疾病的JAK-3抑制剂
公开(公告)号：US06313130B1
公开(公告)日：2001-11-06
申请号：US09627342
申请日：2000-07-28
申请人： Fatih M. Uckun , Ravi Malaviya , Elise A. Sudbeck
发明人： Fatih M. Uckun , Ravi Malaviya , Elise A. Sudbeck
IPC分类号： A61K31505
CPC分类号： A61K31/517
摘要： Inhibitors of JAK3 kinase for the treatment of allergy inhibit mast cell degranulation an dmediator release.
摘要翻译： JAK3激酶抑制剂治疗过敏抑制肥大细胞脱颗粒释放。

5. 发明授权

US06313129B1 Therapeutic compounds 失效
标题翻译：治疗化合物
公开(公告)号：US06313129B1
公开(公告)日：2001-11-06
申请号：US09378093
申请日：1999-08-20
申请人： Fatih M. Uckun , Elise A. Sudbeck , Marina Cetkovic , Ravi Malaviya , Xing-Ping Liu
发明人： Fatih M. Uckun , Elise A. Sudbeck , Marina Cetkovic , Ravi Malaviya , Xing-Ping Liu
IPC分类号： A61K31517
CPC分类号： A61K31/00 , A61K31/505 , A61K31/517 , C07D239/74 , C07D239/94
摘要： The invention provides novel JAK-3 inhibitors that are useful for treating leukemia and lymphoma. The compounds are also useful to treat or prevent skin cancer, as well as sunburn and UVB-induced skin inflammation. In addition, the compounds of the present invention prevent the immunosuppressive effects of UVB radiation, and are useful to treat or prevent autoimmune diseases, inflammation, and transplant rejection. The invention also provides pharmaceutical compositions comprising compounds of the invention, as well as therapeutic methods for their use.
摘要翻译：本发明提供了可用于治疗白血病和淋巴瘤的新型JAK-3抑制剂。这些化合物也可用于治疗或预防皮肤癌，以及晒伤和UVB诱导的皮肤炎症。此外，本发明的化合物可防止UVB辐射的免疫抑制作用，并且可用于治疗或预防自身免疫性疾病，炎症和移植排斥。本发明还提供了包含本发明化合物的药物组合物，以及它们使用的治疗方法。

6. 发明授权

US06248790B1 Treatment of inflammation with 2,4,6-trihydroxy-alpha-rho-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives 失效
标题翻译：用2,4,6-三羟基-α-对甲氧基苯乙酮或其药学上可接受的衍生物治疗炎症
公开(公告)号：US06248790B1
公开(公告)日：2001-06-19
申请号：US09606926
申请日：2000-06-29
申请人： Fatih M. Uckun , Ravi Malaviya
发明人： Fatih M. Uckun , Ravi Malaviya
IPC分类号： A61K3112
CPC分类号： A61K31/12
摘要： 2,4,6-trihydroxy-&agr;-p-methoxyphenylacetophenone (also identified herein as “D-58”), or its pharmaceutically acceptable derivatives such as salt and ester forms, is administered for inhibiting inflammatory reactions. The treatment can be remedial or prophylactic. Examples of the conditions that can be treated include acute inflammatory reactions and allergic inflammatory reactions, and specific examples include allergy, asthma, arthritis, psoriasis, skin sunburn, inflammatory pelvic disease, inflammatory bowel disease, urethritis, uvitis, senusitis, pneumonitis, encephalitis, meningitis, myocarditis, nephritis, osteomyelitis, myositis, hepatitis, gastritis, enteritis, dermatitis, gingivitis, appendicitis, pancreatitis, cholocystitis and cholangitis. The 2,4,6-trihydroxy-&agr;-p-methoxyphenylacetophenone can be administered by various routes as needed.
摘要翻译：施用2,4,6-三羟基-α-对甲氧基苯乙酮（本文中也称为“D-58”）或其药学上可接受的衍生物如盐和酯形式用于抑制炎性反应。治疗可以是补救或预防。可以治疗的病症的实例包括急性炎症反应和过敏性炎症反应，具体实例包括过敏，哮喘，关节炎，牛皮癣，皮肤晒伤，炎性骨盆疾病，炎性肠病，尿道炎，尿毒症，肾炎，肺炎，脑炎，脑膜炎，心肌炎，肾炎，骨髓炎，肌炎，肝炎，胃炎，肠炎，皮炎，牙龈炎，阑尾炎，胰腺炎，胆囊炎和胆管炎。 2,4,6-三羟基-α-对甲氧基苯乙酮可以根据需要通过各种途径施用。

7. 发明授权

US06753348B2 BTK inhibitors and methods for their identification and use 失效
标题翻译： BTK抑制剂及其鉴定和使用方法
公开(公告)号：US06753348B2
公开(公告)日：2004-06-22
申请号：US10115175
申请日：2002-04-02
申请人： Fatih M. Uckun , Ravi Malaviya
发明人： Fatih M. Uckun , Ravi Malaviya
IPC分类号： A61K31275
CPC分类号： A61K31/225 , A61K31/275 , A61K31/277 , A61K31/40 , A61K31/445 , A61K31/525
摘要： The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors, including allergy treatments.
摘要翻译：本发明提供了BTK抑制剂，其鉴定和使用方法，以及包含过敏治疗的包含BTK抑制剂的药物组合物。

8. 发明授权

US6066640A Hydroxy-halo-quinazolines for augmentation of mast cell bactericidal activity 失效
标题翻译：用于增强肥大细胞杀菌活性的羟基 - 卤代喹唑啉
公开(公告)号：US6066640A
公开(公告)日：2000-05-23
申请号：US264141
申请日：1999-03-05
申请人： Fatih M. Uckun , Ravi Malaviya
发明人： Fatih M. Uckun , Ravi Malaviya
IPC分类号： A61K31/517
CPC分类号： A61K31/517
摘要： Hydroxy-halo quinazolines for the augmentation of mast cell anti-microbial activity are disclosed.
摘要翻译：公开了用于增强肥大细胞抗微生物活性的羟基 - 卤代喹唑啉。

9. 发明授权

US06391921B1 Treatment of inflammation with 2,4,6-trihydroxy-&agr;-para-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives 有权
公开(公告)号：US06391921B1
公开(公告)日：2002-05-21
申请号：US09884245
申请日：2001-06-19
申请人： Fatih M. Uckun , Ravi Malaviya
发明人： Fatih M. Uckun , Ravi Malaviya
IPC分类号： A61K3112
摘要： 2,4,6-trihydroxy-&agr;-p-methoxyphenylacetophenone (also identified herein as “D-58”), or its pharmaceutically acceptable derivatives such as salt and ester forms, is administered for inhibiting inflammatory reactions. The treatment can be remedial or prophylactic. Examples of the conditions that can be treated include acute inflammatory reactions and allergic inflammatory reactions, and specific examples include allergy, asthma, arthritis, psoriasis, skin sunburn, inflammatory pelvic disease, inflammatory bowel disease, urethritis, uvitis, senusitis, pneumonitis, encephalitis, meningitis, myocarditis, nephritis, osteomyelitis, myositis, hepatitis, gastritis, enteritis, dermatitis, gingivitis, appendicitis, pancreatitis, cholocystitis and cholangitis. The 2,4,6-trihydroxy-&agr;-p-methoxyphenylacetophenone can be administered by various routes as needed.

10. 发明申请

US20060167090A1 BTK inhibitors 审中-公开
标题翻译： BTK抑制剂
公开(公告)号：US20060167090A1
公开(公告)日：2006-07-27
申请号：US10873769
申请日：2004-06-21
申请人： Fatih Uckun , Ravi Malaviya
发明人： Fatih Uckun , Ravi Malaviya
IPC分类号： A61K31/277
CPC分类号： A61K31/225 , A61K31/275 , A61K31/277 , A61K31/40 , A61K31/445 , A61K31/525
摘要： The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors, including allergy treatments.
摘要翻译：本发明提供了BTK抑制剂，其鉴定和使用方法，以及包含过敏治疗的包含BTK抑制剂的药物组合物。

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