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1. 发明专利

JPH01175836A MANUFACTURE FOR BIOINDUCTION ELECTRODE 失效
公开(公告)号：JPH01175836A
公开(公告)日：1989-07-12
申请号：JP33606887
申请日：1987-12-29
申请人： FUKUDA DENSHI KK , RIKEN KK
发明人： MINAGAWA SAKAE , KOIKE MASAO , ISHII HIROYOSHI , TEJIMA IWAO , SHIMIZU TADAHARU
IPC分类号： A61B5/0408 , A61B5/04
摘要： PURPOSE:To manufacture a bioinduction electrode efficiently in a short time by pressurizing a supporting base material, fixing an electrode element and an electrolyte, adhesive base material, provided with a separator, and a cover in a piled condition, and giving an ultrasonic vibration to simultaneously connect the adhesive base material to the supporting base material and the separator to the cover. CONSTITUTION:A bioinduction electrode A is constituted of an electrode element 1, adhesive base material 2, supporting base material 3, electrolyte 4, etc. The electrode element 1 is constituted of a head part 11 mounting a lead wire terminal, neck part 12 and a bottom part 13, using synthetic resin for a base material 14, and its peripheral surface is coated with metal dust as a coating layer 15 being given conductivity. Manufacture for the bioinduction electrode A sets up the electrode element 1, adhesive base material 2, supporting base material 3, electrolyte 4, separator 5 and a cover 6 to an electrode storage port 8a of an anvil 8. An ultrasonic phone 7, having a ring- shaped point end 7a, is piled on thereafter adapted to the anvil 8, and giving an ultrasonic vibration in the vertical direction under a suitable pressure, the supporting base material, fixing the electrode element and the electrolyte, adhesive base material, provided with the separator, and the cover are connected.

2. 发明专利

JPH06307226A DETECTING METHOD FOR PARTICLE-LIKE MATERIAL DEPOSITION DENSITY DISTRIBUTION OF FILTER/AND DETECTING DEVICE THEREOF 失效
公开(公告)号：JPH06307226A
公开(公告)日：1994-11-01
申请号：JP9312393
申请日：1993-04-20
申请人： RIKEN KK
发明人： OHASHI SATOSHI , SHITO KAZUYUKI , MINAGAWA SAKAE
IPC分类号： F01N3/02
摘要： PURPOSE:To easily detect the deposition density distribution of particle-like materials in a filter by inserting capacitively coupled load and determining the deposition density of local particle-like materials from the transmission ratio of high frequency. CONSTITUTION:A front stage element 20 and a rear stage element 30 for carrying out the capacitive coupling in the high frequency range are parallely inserted inside a pipe of a filter 16 so as to be along the wall. High frequency wave having the fixed frequency is supplied to the load from a diode switch 24. A reference detector 50 forms a reference signal for indicating the strength of high frequency before being conveyed to the capacitively coupled load. A signal detector forms a receiving signal for indicating the strength of high frequency transmitted through the capacitively coupled load. A control unit 70 detects the transmission ratio of high frequency by comparing the reference signal with the receiving signal and determines the deposition density of partial particle-like materials from the transmission ratio. Thus the deposition density distribution of particle-like materials in the filter can be easily detected.

3. 发明专利

JPH05137802A THERMOTHERAPY ELEMENT TO BE INFUSED IN LIVING BODY 失效
公开(公告)号：JPH05137802A
公开(公告)日：1993-06-01
申请号：JP32963791
申请日：1991-11-20
申请人： RIKEN KK
发明人： MINAGAWA SAKAE , HENMI KOJI
IPC分类号： A61N1/40
摘要： PURPOSE:To provide a thermotherapy element capable of being used for an inplant material to heat the affected part and being infused in a living body by the use of a specified magnetic oxide material. CONSTITUTION:A disk-shaped element 1 should have 1-10 of the aspect ratio of the maximum diameter 2 to the thickness 3. If the ratio is 1 or less, the heat generating speed gets slow when a high frequency magnetic field is applied, and if the ratio is 10 or more, the fluidity of the element is degraded to make difficult the injection of the element through an injector. Also, if a grain size of the element are 30mum or less, the heat generating speed gets slow when a high frequency magnetic field is applied, and if 100mum or more, the fluidity of the element is degraded, the element gets difficult to infuse through the injector and if the element is coated with a carcinostatic substance, the infusion through the injector gets difficult. Further, the Qurie temperature of magnetic oxide powder should fall within the range of 42-90 deg.C. In 42 deg.C or less of the Qurie temperature, the powder cannot be heated up to the treatment temperature region effective in the thermotherapy, and in 90 deg.C or more the powder exceeds the treatment temperature region of the thermotherapy to be overheated.

4. 发明专利

JPH0261036A TEMPERATURE SENSITIVE AMORPHOUS ALLOY 失效
公开(公告)号：JPH0261036A
公开(公告)日：1990-03-01
申请号：JP20984488
申请日：1988-08-24
申请人： RIKEN KK
发明人： MINAGAWA SAKAE , OOKA KOICHI , MATSUKI HIDETOSHI , MURAKAMI KOICHI
IPC分类号： C22C45/02 , C22C45/04
摘要： PURPOSE:To obtain a temperature sensitive amorphous alloy for hyperthermia having a specific Curie temp. and capable of easily applying induction heating to the deseased part to a temp. in the prescribed range by incorporating transition metals, such as Fe, Ni, and Co, and metalloids, such as P, C, Si, and B. CONSTITUTION:The temperature sensitive amorphous alloy for hyperthermia having a Curie temp. of 42-90 deg.C is obtained by incorporating one or more transition metals among Fe, Ni, and Co and one or more metalloids among P, C, Si, and B and further adding, it necessary, small amounts of Al. In the above alloy, proper content ot the above metalloids is about 10-30 atomic%% and also proper additive quantity of Al is about 2-5%. By the above addition of Al, even if Ni content is reduced, the Curie temp. can be lowered and lowering of saturation magnetic flux density can be avoided. The resulting amorphous alloy can be used as an implant material for local heating and can always apply induction heating to the deseased part up to a temp. in the prescribed range while obviating the necessity of special control.

5. 发明专利

JPH0252663A COMPOSITE MAGNETIC MATERIAL FOR THERMOTHERAPY 失效
公开(公告)号：JPH0252663A
公开(公告)日：1990-02-22
申请号：JP20103188
申请日：1988-08-13
申请人： RIKEN KK
发明人： MINAGAWA SAKAE , OOKA KOICHI , MATSUKI HIDETOSHI , MURAKAMI KOICHI
IPC分类号： A61L27/00 , A61L31/00 , A61N5/02
摘要： PURPOSE:To inductively heat an ill part always in a prescribed temp. range by combining transition metals, semimetals, heat sensitive amorphous alloy having a specific Curie temp., and other ferromagnetic materials. CONSTITUTION:The composite material magnetic for thermotherapy is obtd. by combining the transition metals of 1 or >=2 kinds among Fe, Ni and Co, the semimetals of 1 or >=2 kinds among P, C, Si, and B, the heat sensitive amorphous alloy contg. Cr and/or Mo and having 42-90 deg.C Curie temp., and the other magnetic materials. The heat sensitive amorphous alloy has the Curie point as low as 42-90 deg.C by addition of the Cr and/or Mo and, therefore, the alloy is prevented from being heated up to the prescribed temp. correlated with the Curie temp. or above even if external magnetic fields are increased. The temp. of the ill part of a cancer, etc., is, therefore, maintained always at a desired level without requiring specific control.

6. 发明专利

JPH05228219A CANCER TREATING THERMO-ELEMENT COMPOSITION 失效
公开(公告)号：JPH05228219A
公开(公告)日：1993-09-07
申请号：JP7297492
申请日：1992-02-26
申请人： RIKEN KK , SATO TOMOYA , MATSUKI HIDETOSHI
发明人： HENMI KOJI , MINAGAWA SAKAE
IPC分类号： A61N1/40
摘要： PURPOSE:To provide a cancer treating thermo-element composition capable of artificially controlling the local administration of an anticancer drug, being inserted with a catheter or a retention needle, and concurrently applying the cancer chemotherapy and thermotherapy requiring no electromagnetic wave output adjustment and no temperature measurement. CONSTITUTION:A cancer treating thermo-element composition is covered with a conducting metal film 2 of 0.5-3mum on the surface of magnetic powder having the curie temperature of 42-90 deg.C, an anti-cancer drug 3 is coated or stuck on it, and a thermosensitive macromolecule 4 meltable at 40-70 deg.C is coated on it.

7. 发明专利

JPH04180775A CANCER TREATING DEVICE FOR THERMOTHERAPY 失效
公开(公告)号：JPH04180775A
公开(公告)日：1992-06-26
申请号：JP30705290
申请日：1990-11-15
申请人： RIKEN KK
发明人： HENMI KOJI , MINAGAWA SAKAE , MATSUKI HIDETOSHI
IPC分类号： A61N1/40 , A61N5/02
摘要： PURPOSE:To allow the efficient heating of a local and deep part by adequately selecting the frequencies and alternate magnetic fields of a magnetic induction heating section. CONSTITUTION:This device consists of two sections; a power source section 1 for excitation and the magnetic induction heating section 2. A temp. measuring section 3 may be added at need. In addition, temp. sensitive amorphous alloy powder is used as an implant material. The power source 1 for excitation consists of a power source section 4, a frequency matching section 5 and a cooling water circulating section 6. The frequencies of 50 to 300KHz and the alternating magnetic fields of 0.5 to 20KA/m are impressed by the power source 1 for excitation having 3 phases, 200V, and 30KW. The temp. sensitive amorphous alloy powder to be used as the implant material is coated with a polymer or noble metal, such as gold which are harmless to a living organism, so that the this powder can be directly injected into the part to be treated. The local heating and deep part heating are efficiently executed in this way.

8. 发明专利

JPH04116146A TEMPERATURE-SENSITIVE AMORPHOUS ALLOY COATED WITH POLYMER 失效
公开(公告)号：JPH04116146A
公开(公告)日：1992-04-16
申请号：JP23248090
申请日：1990-09-04
申请人： RIKEN KK
发明人： HENMI KOJI , MINAGAWA SAKAE , MATSUKI HIDETOSHI
IPC分类号： A61N1/40 , A61N5/02 , C22C45/02
摘要： PURPOSE:To prevent an allay constituted of transition metals and semimetals and having a low Curie temp. from heating to a prescribed temp. or above when it is used for thermotherapy and to secure the safety of living bodies by coating the surface of the above alloy with a resin. CONSTITUTION:This amorphous allay is formed by coating the surface of an alloy with 42 to 90 deg.C Curie temp. with a polymer resin harmless to living bodies. The above alloy is formed from a compsn. constituted of transition metals selected from Fe, Ni and Co and semimetals selected from P, C, Si and B. At the time of using this amorphous alloy to an inplant material for local heating, even in the case an external magnetic field is increased, it is not heated to a prescribed temp. or above, and, by the coated resin, the flow of metallic ions into living bodies is prevented to secure the safety of living bodies.

9. 发明专利

JPH04116145A HEAT SENSITIVE AMORPHOUS ALLOY COATED WITH METAL 失效
公开(公告)号：JPH04116145A
公开(公告)日：1992-04-16
申请号：JP23247990
申请日：1990-09-04
申请人： RIKEN KK
发明人： HENMI KOJI , MINAGAWA SAKAE , MATSUKI HIDETOSHI
IPC分类号： A61N1/40 , A61N5/02 , C22C45/02
摘要： PURPOSE:To produce the heat sensitive amorphous alloy which can make induction heating to a prescribed temp. range at all times by coating the surface of an alloy contg. transition metals, such as Fe, Ni and Co and semimetals, such as P, C, Si, and B, and having a specific Curie temp. with a nonmagnetic metal. CONSTITUTION:The heat sensitive amorphous alloy for thermotherapy is produced by coating the surface of the alloy contg. one or >=2 kinds of the heat sensitive amorphous alloys, such as Fe, Ni and Co and one or, >=2 kinds of the semimetals, such as P, C, Si, and B, and having 42 to 90 deg.C Curie temp. with the nonmagnetic metal (metals, such as Cu, Ag and Au, having a good electric conductivity). The content of the above-mentioned semimetals is confined to about 10 to 30 atomic % in the alloy and the thickness of the film of the nonmagnetic metal is preferably about 5 to 10mum. The heat sensitive amorphous alloy which inductively heats an affected part to a prescribed temp. at all times is obtd. in this way without requiring special control and the stable thermotherapy is executed.

10. 发明专利

JPH0257264A COMPOSITE MAGNETIC BODY FOR HYPERTHERMIA 失效
公开(公告)号：JPH0257264A
公开(公告)日：1990-02-27
申请号：JP20984588
申请日：1988-08-24
申请人： RIKEN KK
发明人： MINAGAWA SAKAE , OOKA KOICHI , MATSUKI HIDETOSHI , MURAKAMI KOICHI
IPC分类号： A61L31/00 , A61N5/02
摘要： PURPOSE:To always bring the affected part to a predetermined temp. range by induction heating without requiring special control, in a composite magnetic body for hyperthermia composed of an amorphous alloy and other magnetic body, by increasing Ni-content in the amorphous alloy to lower Curie temp. to a desired level. CONSTITUTION:A temp.-sensitive amorphous alloy having Curie temp. of 42-90 deg.C containing one or more kind of a transition metal selected from Fe, Ni and Co and one or more kind of a semimetal selected from P, C, Si and B is combined with other magnetic body. Ni is an element added for the purpose of lowering Curie temp. and also imparts corrosion resistance at the same time. The lowering of Curie temp. is especially important as a magnetic material for soft heating, and local heating for obtaining the treatment temp. of a malignant tumor and the holding of said temp. are made possible. By adding Al to the above mentioned composition, Curie temp. can be further lowered. Therefore, even when the addition amount of Ni is suppressed in the case of the addition of Al, an amorphous alloy having low Curie temp. can be obtained.

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