专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012158818A2 MULTI-SPECIFIC FAB FUSION PROTEINS AND METHODS OF USE 审中-公开
标题翻译：多特异性FAB融合蛋白及其使用方法
公开(公告)号：WO2012158818A2
公开(公告)日：2012-11-22
申请号：PCT/US2012038177
申请日：2012-05-16
申请人： FABION PHARMACEUTICALS INC , ZHOU HONGXING
发明人： ZHOU HONGXING
CPC分类号： C07K16/2809 , C07K14/705 , C07K16/30 , C07K2317/31 , C07K2317/55 , C07K2319/00 , C07K2319/74
摘要： The present disclosure relates generally to multi-specific Fab fusion proteins (MSFP) which comprise an antibody Fab fragment with both N-termini fused to a fusion moiety (fusion moiety A or B). MSFP containing the Fab fragment exhibit significantly reduced binding ability of the Fab fragment to the Fab target. Binding of the Fab to its target is restored when the MSFP is clustered on a cell surface by binding of the fusion moieties to their target. The reduced binding of the Fab to its target, especially when presented on a cell surface in its native state, absent fusion moiety binding provides advantages such as: reduced side effects and allows desirable pharmacological effects of selectivity and specificity in a controlled manner.
摘要翻译：本公开一般涉及多特异性Fab融合蛋白（MSFP），其包含与融合部分（融合部分A或B）融合的N-末端的抗体Fab片段。包含Fab片段的MSFP显示出Fab片段与Fab靶标的结合能力显着降低。当通过将融合部分与其靶标结合将MSFP聚集在细胞表面上时，还原Fab与靶标的结合。 Fab与其靶的减少的结合，特别是当呈现在其天然状态的细胞表面时，没有融合部分结合提供了优点，例如：减少的副作用并且以受控的方式允许选择性和特异性的期望的药理作用。

2. 发明公开

EP0712660A4 BIFUNCTIONAL CATALYST CONTAINING MULTIMETAL OXIDES 失效
标题翻译： MULTIMETALLHALTIGER双功能催化剂
公开(公告)号：EP0712660A4
公开(公告)日：1997-02-04
申请号：EP94922817
申请日：1994-07-29
申请人： ZHOU HONGXING
发明人： ZHOU HONGXING
IPC分类号： B01D53/86 , B01D53/94 , B01J21/12 , B01J23/83 , B01J23/86 , B01J23/889 , B01J37/02 , B01J37/08 , B01D53/60
CPC分类号： B01D53/945 , B01D53/865 , B01J21/12 , B01J23/83 , B01J23/868 , B01J23/8892 , B01J37/0203 , Y02T10/22
摘要： This invention provides a bifunctional catalyst containing multimetal oxides, and a method for preparing the same. Said catalyst comprises a support of moulded mixture of silica and alumina in the weight ratio of 1:1.2-2.5, and upon said support is deposited 3-30 % by weight of metal oxides based on the total weight of said catalyst. The metal elements of the metal oxides are at least two selected from transition metal of periodic group 4 and lanthanide. Said metal oxides of the catalyst exist in the state of non-composite oxides.

3. 发明专利

IL175362A ANTIBODIES THAT BIND INTERLEUKIN-4 RECEPTOR, NUCLEIC ACIDS ENCODING SAME, COMPOSITIONS COMPRISING SAME AND METHODS OF MAKING AND USING SAME 未知
公开(公告)号：IL175362A
公开(公告)日：2012-02-29
申请号：IL17536206
申请日：2006-05-01
申请人： IMMUNEX CORP , CARTER PAUL J , ZHOU HONGXING
发明人： CARTER PAUL J , ZHOU HONGXING
IPC分类号： C07K16/28
摘要： The present invention relates to antibodies that bind to the IL-4 receptor, fragments, muteins, and derivatives of such antibodies, nucleic acids encoding such antibodies, fragments, muteins and derivatives, and methods of making and using such antibodies, fragments, muteins, derivatives and nucleic acids. Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 receptor binding antibody, or an IL-4 receptor binding fragment, mutein, or derivative of an IL-4 receptor binding antibody, to a patient afflicted with such a condition. Particular antibodies provided herein include human monoclonal antibodies. Certain of the antibodies inhibit both IL-4-induced and IL-13-induced biological activities.

4. 发明专利

DE69429268T2 未知
公开(公告)号：DE69429268T2
公开(公告)日：2002-07-18
申请号：DE69429268
申请日：1994-07-29
申请人： ZHOU HONGXING
发明人： ZHOU HONGXING
IPC分类号： B01D53/86 , B01D53/94 , B01J21/12 , B01J23/83 , B01J23/86 , B01J23/889 , B01J37/02 , B01J37/08 , B01D53/60

5. 发明专利

DE69429268D1 未知
公开(公告)号：DE69429268D1
公开(公告)日：2002-01-10
申请号：DE69429268
申请日：1994-07-29
申请人： ZHOU HONGXING
发明人： ZHOU HONGXING
IPC分类号： B01D53/86 , B01D53/94 , B01J21/12 , B01J23/83 , B01J23/86 , B01J23/889 , B01J37/02 , B01J37/08 , B01D53/60

6. 发明申请

WO2005063817A3 METHODS FOR IDENTIFYING FUNCTIONAL ANTIBODIES 审中-公开
标题翻译：识别功能抗体的方法
公开(公告)号：WO2005063817A3
公开(公告)日：2006-03-16
申请号：PCT/US2004042937
申请日：2004-12-21
申请人： AMGEN INC , YAN WEI , SHEN WENYAN , ZHOU HONGXING , ZHOU CHEN , COSMAN DAVID J , CARTER PAUL , MARTIN FRANCIS H
发明人： YAN WEI , SHEN WENYAN , ZHOU HONGXING , ZHOU CHEN , COSMAN DAVID J , CARTER PAUL , MARTIN FRANCIS H
IPC分类号： C07K16/00 , C07H21/04 , C07K16/06 , C07K16/18 , C07K16/28 , C12N5/10 , C12N15/10 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C07K16/005 , C07K16/2863 , C07K16/2866 , C07K16/2875 , C07K16/2878 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/80 , C07K2319/00 , C12N15/1037 , G01N33/6854
摘要： The invention provides methods for screening multimeric antibodies produced by mammalian cells to find those that exhibit a biological function. The methods can be used to screen large numbers of antibodies, which may be cell surface, secreted, or intracellular antibodies. Antibodies can be screened to find those that bind antigen more avidly or those that compete with a ligand that binds to the antigen for binding. Any biological function that can be tested in vitro can be used to screen the antibodies. Nucleic acids encoding the antibodies that exhibit the biological function can be obtained in a number of ways.
摘要翻译：本发明提供了筛选由哺乳动物细胞产生的多聚体抗体以找到表现出生物功能的抗体的方法。该方法可用于筛选大量抗体，其可以是细胞表面，分泌的或细胞内的抗体。可以筛选抗体以找到更加狂热地结合抗原的抗体或与结合抗原结合的配体竞争的抗体。可以在体外测试的任何生物学功能可用于筛选抗体。可以以多种方式获得编码表现出生物功能的抗体的核酸。

7. 发明申请

WO2012009544A3 DOMAIN INSERTION IMMUNOGLOBULIN 审中-公开
标题翻译：域插入免疫球蛋白
公开(公告)号：WO2012009544A3
公开(公告)日：2012-04-05
申请号：PCT/US2011044020
申请日：2011-07-14
申请人： AMGEN INC , ZHOU HONGXING
发明人： ZHOU HONGXING
IPC分类号： C12P21/08 , A61K39/00 , C07H21/04 , C07K16/00 , C12N5/00 , C12P21/06
CPC分类号： C07K16/468 , C07K16/244 , C07K16/2878
摘要： Described herein is an antibody format, which is amenable to bispecific antibody creation. This format is referred to herein as "Domain Insertion Immunoglobulin G" or "(Di-IgG)". The Di-IgG molecules are capable of specifically binding two different antigens simultaneously, show high level recombinant expression, and are sufficiently aggregation-free to be amenable to commercial production. Further described herein are, Di-IgG-encoding nucleic acids and vectors, host cells for making Di-IgGs, Di-IgG pharmaceutical compositions, and methods of treatment.
摘要翻译：本文描述的是抗体形式，其可适用于双特异性抗体的产生。该格式在本文中称为“域插入免疫球蛋白G”或“（Di-IgG）”。 Di-IgG分子能够同时特异性结合两种不同的抗原，显示出高水平的重组表达，并且足够的聚合不易于商业化生产。本文进一步描述的是编码Di-IgG的核酸和载体，用于制备Di-IgG的宿主细胞，Di-IgG药物组合物和治疗方法。

8. 发明申请

WO2007120766A2 ERYTHROPOIETIN RECEPTOR AGONISTS 审中-公开
标题翻译： ERYTHROPOIETIN受体激动剂
公开(公告)号：WO2007120766A2
公开(公告)日：2007-10-25
申请号：PCT/US2007009030
申请日：2007-04-13
申请人： AMGEN INC , BORGES LUIS , KETCHEM RANDAL R , LIM AI CHING , MEHLIN CHRISTOPHER , ZHOU HONGXING
发明人： BORGES LUIS , KETCHEM RANDAL R , LIM AI CHING , MEHLIN CHRISTOPHER , ZHOU HONGXING
IPC分类号： C07K14/505
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/75 , C07K2317/92
摘要： Antibodies that bind erythropoeitin receptor are provided. Methods of making and using such antibodies are also provided. Kits containing such antibodies are also provided.
摘要翻译：提供了结合红细胞生成素受体的抗体。还提供了制备和使用这些抗体的方法。还提供了含有此类抗体的试剂盒。

9. 发明申请

WO2005047331A3 ANTIBODIES THAT BIND INTERLEUKIN-4 RECEPTOR 审中-公开
标题翻译：阻断白细胞介素-4受体的抗体
公开(公告)号：WO2005047331A3
公开(公告)日：2005-11-03
申请号：PCT/US2004037242
申请日：2004-11-04
申请人： IMMUNEX CORP , CARTER PAUL J , ZHOU HONGXING
发明人： CARTER PAUL J , ZHOU HONGXING
IPC分类号： C07K16/28 , A61P35/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76
摘要： The present invention relates to antibodies that bind to the IL-4 receptor, fragments, muteins, and derivatives of such antibodies, nucleic acids encoding such antibodies, fragments, muteins and derivatives, and methods of making and using such antibodies, fragments, muteins, derivatives and nucleic acids. Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 receptor binding antibody, or an IL-4 receptor binding fragment, mutein, or derivative of an IL-4 receptor binding antibody, to a patient afflicted with such a condition. Particular antibodies provided herein include human monoclonal antibodies. Certain of the antibodies inhibit both IL-4-induced and IL-13-induced biological activities.
摘要翻译：本发明涉及结合IL-4受体的抗体，这些抗体的片段，突变蛋白和衍生物，编码这些抗体，片段，突变蛋白和衍生物的核酸，以及制备和使用这些抗体，片段，突变蛋白，衍生物和核酸。用于治疗由白细胞介素-4诱导的医学病症的方法包括向患有这种病症的患者施用IL-4受体结合抗体或IL-4受体结合片段，突变蛋白或IL-4受体结合抗体的衍生物。本文提供的特异性抗体包括人单克隆抗体。某些抗体抑制IL-4诱导的和IL-13诱导的生物活性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式