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1. 发明申请

WO2005063817A3 METHODS FOR IDENTIFYING FUNCTIONAL ANTIBODIES 审中-公开
标题翻译：识别功能抗体的方法
公开(公告)号：WO2005063817A3
公开(公告)日：2006-03-16
申请号：PCT/US2004042937
申请日：2004-12-21
申请人： AMGEN INC , YAN WEI , SHEN WENYAN , ZHOU HONGXING , ZHOU CHEN , COSMAN DAVID J , CARTER PAUL , MARTIN FRANCIS H
发明人： YAN WEI , SHEN WENYAN , ZHOU HONGXING , ZHOU CHEN , COSMAN DAVID J , CARTER PAUL , MARTIN FRANCIS H
IPC分类号： C07K16/00 , C07H21/04 , C07K16/06 , C07K16/18 , C07K16/28 , C12N5/10 , C12N15/10 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C07K16/005 , C07K16/2863 , C07K16/2866 , C07K16/2875 , C07K16/2878 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/80 , C07K2319/00 , C12N15/1037 , G01N33/6854
摘要： The invention provides methods for screening multimeric antibodies produced by mammalian cells to find those that exhibit a biological function. The methods can be used to screen large numbers of antibodies, which may be cell surface, secreted, or intracellular antibodies. Antibodies can be screened to find those that bind antigen more avidly or those that compete with a ligand that binds to the antigen for binding. Any biological function that can be tested in vitro can be used to screen the antibodies. Nucleic acids encoding the antibodies that exhibit the biological function can be obtained in a number of ways.
摘要翻译：本发明提供了筛选由哺乳动物细胞产生的多聚体抗体以找到表现出生物功能的抗体的方法。该方法可用于筛选大量抗体，其可以是细胞表面，分泌的或细胞内的抗体。可以筛选抗体以找到更加狂热地结合抗原的抗体或与结合抗原结合的配体竞争的抗体。可以在体外测试的任何生物学功能可用于筛选抗体。可以以多种方式获得编码表现出生物功能的抗体的核酸。

2. 发明申请

WO2010059981A3 HIGH COMPLEXITY MAMMALIAN DISPLAY LIBRARY AND METHODS OF SCREENING 审中-公开
标题翻译：高复杂性哺乳动物显示文库和筛选方法
公开(公告)号：WO2010059981A3
公开(公告)日：2010-08-12
申请号：PCT/US2009065393
申请日：2009-11-20
申请人： DGEN BIOTECH LTD , ZHOU CHEN
发明人： ZHOU CHEN
IPC分类号： C12Q1/68 , C12P19/34 , C40B30/04
CPC分类号： G01N33/6845 , C12N15/1037
摘要： Provided herein are methods of isolating a polynucleotide encoding a polypeptide such as an antibody with a desired property by way of mammalian display library screening and methods of generating a library of polynucleotides encoding polypeptides such as antibodies, wherein the polynucleotides collectively encode at least 109 different polypeptides. Also provided are kits for carry out the methods described herein, polynucleotides isolated by methods described herein, libraries encoding the antibody reservoir of different species including human, mouse, rabbit, and polypeptides encoded by the polynucleotides.
摘要翻译：本文提供了通过哺乳动物展示文库筛选分离编码具有期望特性的多肽例如抗体的多核苷酸的方法和产生编码多肽例如抗体的多核苷酸文库的方法，其中所述多核苷酸共同编码至少109种不同的多肽。还提供了用于实施本文所述方法的试剂盒，通过本文所述方法分离的多核苷酸，编码包括人，小鼠，兔在内的不同物种的抗体库和由所述多核苷酸编码的多肽的文库。

3. 发明申请

WO2008153893A3 METHODS AND SPECIES-SPECIFIC PRIMERS FOR DETECTION AND QUANTIFICATION OF STREPTOCOCCUS MUTANS AND STREPTOCOCCUS SANGUINIS IN MIXED BACTERIAL SAMPLES 审中-公开
标题翻译：用于检测和定量混合细菌样品中的杆菌和杆菌的方法和物种特异性引物
公开(公告)号：WO2008153893A3
公开(公告)日：2009-02-12
申请号：PCT/US2008007066
申请日：2008-06-04
申请人： UNIV NEW YORK SCHOOL MEDICINE , LI YIHONG , CAUFIELD PAGE W , SAXENA DEEPAK , ZHOU CHEN
发明人： LI YIHONG , CAUFIELD PAGE W , SAXENA DEEPAK , ZHOU CHEN
IPC分类号： C12Q1/68 , C12Q1/14
CPC分类号： C12Q1/689 , C12Q2600/16
摘要： Dental caries is a polymicrobial infectious disease. Of the hundreds of bacteria present in the biofilms coating teeth, the Streptococcus mutans (S. mutans) remain strongly linked to caries and dental disease. Streptococcus sanguinis (S. sanguinis) may serve a protective or antagonistic role against the cariogenic bacterium S. mutans. In the present invention, exemplary sets of species-specific PCR primers are provided for the identification and quantification of S. mutans and of S. sanguinis in clinical samples, including the simultaneous and sensitive analysis of both bacterial species. Assays, kits and methods for determining the presence and amount of S. mutans and/or S. sanguinis are provided. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods for determining and evaluating an individual's oral bacteria, risk for caries, and effects of prevention and treatment modalities, are provided.
摘要翻译：牙龋是一种多微生物感染性疾病。在生物膜涂覆牙齿中存在的数百种细菌中，变形链球菌（变形链球菌）与龋齿和牙齿疾病密切相关。血清链球菌（S.sanguinis）可能对致龋菌细菌变形链球菌起保护作用或拮抗作用。在本发明中，提供了典型的物种特异性PCR引物组用于在临床样品中鉴定和定量变形链球菌和血清芽孢杆菌，包括对这两种细菌物种的同时和敏感的分析。提供了用于确定变形链球菌和/或血清血友病的存在和量的测定，试剂盒和方法。描述了用于测定，试剂盒和方法的寡核苷酸探针和引物。提供了确定和评估个人口腔细菌，龋风险和预防和治疗方式的影响的方法和方法。

4. 发明申请

US20130108037A1 SUPPORTING DEVICE AND TELEPHONE DEVICE 失效
标题翻译：支持设备和电话设备
公开(公告)号：US20130108037A1
公开(公告)日：2013-05-02
申请号：US13596105
申请日：2012-08-28
申请人： ZHOU CHEN
发明人： ZHOU CHEN
IPC分类号： H04M1/00
CPC分类号： H04M1/06 , H04M1/02 , H04M1/08
摘要： A telephone device comprises a base, a handset, and a supporting device secured to the base. The base comprises a first receiving portion and a hang-up button protruding out of the first receiving portion. The hang-up button is used for ending a call when being pressed. The handset comprises an earpiece received in the first receiving portion. When the supporting device is in a resisting position, the supporting device extends into the first receiving portion for supporting the earpiece to prevent the earpiece from pressing the hang-up button. When the supporting device is in an unresisting position, the supporting device retracts into the base for allowing the earpiece to press the hang-up button.
摘要翻译：电话设备包括基座，手机和固定到基座的支撑装置。基座包括从第一接收部分突出的第一接收部分和挂起按钮。挂机按钮用于在按下时结束通话。听筒包括接收在第一接收部分中的听筒。当支撑装置处于抵抗位置时，支撑装置延伸到用于支撑耳机的第一容纳部分中，以防止耳机按压挂断按钮。当支撑装置处于未停留位置时，支撑装置缩回到基座中，以允许耳机按下挂断按钮。

5. 发明申请

US20130260824A1 PORTABLE ELECTRONIC DEVICE WITH DISTANCE MEASURING DEVICE 有权
标题翻译：具有距离测量装置的便携式电子设备
公开(公告)号：US20130260824A1
公开(公告)日：2013-10-03
申请号：US13572818
申请日：2012-08-13
申请人： ZHOU CHEN
发明人： ZHOU CHEN
IPC分类号： H04W88/02
CPC分类号： G01S17/08 , G01S17/74
摘要： A portable electronic device includes a main body, a display and a distance measuring device. The distance measuring device includes a first distance measuring member and a second distance measuring member. The first distance measuring member includes a first signal emitting/receiving module and an arithmetic module. The second distance measuring member includes a second signal emitting/receiving module and a control module. The first signal emitting/receiving module is for receiving an alignment signal, emitting a measuring signal, and receiving a feedback of a measuring signal. The arithmetic module is for calculating the distance between the first distance measuring member and the second distance measuring member. The distance is displayed. The second signal emitting/receiving module is for emitting the alignment signal, receiving the measuring signal, and emitting the feedback of the measuring signal. The present disclosure further provides a distance measuring method for a device.
摘要翻译：便携式电子设备包括主体，显示器和测距装置。距离测量装置包括第一距离测量构件和第二距离测量构件。第一测距构件包括第一信号发射/接收模块和运算模块。第二距离测量构件包括第二信号发射/接收模块和控制模块。第一信号发射/接收模块用于接收对准信号，发射测量信号，并接收测量信号的反馈。算术模块用于计算第一距离测量构件和第二距离测量构件之间的距离。显示距离。第二信号发射/接收模块用于发射对准信号，接收测量信号，并发出测量信号的反馈信号。本公开还提供了一种用于装置的距离测量方法。

6. 发明申请

US20130257376A1 CHARGING DOCK FOR PORTABLE ELECTRONIC DEVICE 有权
标题翻译：为便携式电子设备充电
公开(公告)号：US20130257376A1
公开(公告)日：2013-10-03
申请号：US13527876
申请日：2012-06-20
申请人： HAI-QIAN GE , TAI-SHAN ZHU , ZHOU CHEN , CHE-YU CHOU
发明人： HAI-QIAN GE , TAI-SHAN ZHU , ZHOU CHEN , CHE-YU CHOU
IPC分类号： H02J7/00
CPC分类号： H02J7/0044 , H02J2007/0062
摘要： A charging dock includes a base, a charging cable and a retractable wire reel module received in the base. A wall of the base is concaved downward to form a charging space including an opening in a cavity of the base. The charging cable includes a power wire, a charging and a power connector interfaces. The charging interface is received in the base. The power interface is positioned out of the base. The retractable wire reel module includes a guiding shaft positioned, a coil spring member and a sleeve member. The sleeve member rotatably sleeves on the guiding shaft via the coil spring member. The power wire is wound on the sleeve member, the coil spring member is connected with the guiding shaft and the sleeve member. The power wire retracts in the base via the sleeve member driven to rotate by the coil spring member.
摘要翻译：充电座包括底座，充电电缆和容纳在基座中的伸缩线卷筒模块。基部的壁向下凹入以形成包括基座的空腔中的开口的充电空间。充电电缆包括电源线，充电和电源连接器接口。充电接口在基座中接收。电源接口位于基座外。可伸缩线卷盘模块包括定位的导向轴，螺旋弹簧构件和套筒构件。套筒构件通过螺旋弹簧构件可旋转地套在引导轴上。电源线缠绕在套筒构件上，螺旋弹簧构件与引导轴和套筒构件连接。电源线通过被螺旋弹簧构件驱动旋转的套筒构件在基座中缩回。

7. 发明申请

US20130155584A1 SLIDING MECHANISM AND ELECTRONIC DEVICE USING SAME 有权
标题翻译：使用相同的滑动机构和电子设备
公开(公告)号：US20130155584A1
公开(公告)日：2013-06-20
申请号：US13631886
申请日：2012-09-29
申请人： ZHOU CHEN
发明人： ZHOU CHEN
IPC分类号： H05K5/03
CPC分类号： G06F1/1624 , H04M1/0237
摘要： A sliding mechanism is for sliding a cover relative to a body of an electronic device to close and open the electronic device. The sliding mechanism includes a driving assembly capable of sliding between a first position and a second position different from the first position, and an abutting assembly engaging with the driving assembly and capable of sliding between a closed position and an open position. When the driving assembly is driven to slide from the first position to the second position, the abutting assembly is driven to rotate from the closed position to the open position to open the electronic device. When the driving assembly slides back to the first position, the abutting assembly is driven to rotate from the open position to the closed position to close the electronic device. An electronic device using the sliding mechanism is also provided.
摘要翻译：滑动机构用于相对于电子设备的主体滑动盖子以关闭和打开电子设备。滑动机构包括能够在第一位置和与第一位置不同的第二位置之间滑动的驱动组件，以及与驱动组件接合并能够在关闭位置和打开位置之间滑动的抵接组件。当驱动组件被驱动以从第一位置滑动到第二位置时，抵靠组件被驱动以从关闭位置旋转到打开位置以打开电子设备。当驱动组件滑回到第一位置时，抵靠组件被驱动以从打开位置旋转到关闭位置以关闭电子设备。还提供了使用滑动机构的电子装置。

8. 发明申请

US20130258102A1 MONITORING CAMERA DEVICE WITH WIRELESS CONTROL 有权
标题翻译：监控无线控制相机设备
公开(公告)号：US20130258102A1
公开(公告)日：2013-10-03
申请号：US13559565
申请日：2012-07-26
申请人： ZHOU CHEN
发明人： ZHOU CHEN
IPC分类号： H04N7/18
CPC分类号： G03B17/02 , G03B17/561 , G08C17/00 , H04N5/2252 , H04N5/23206
摘要： A monitoring camera device includes an exterior casing made of elastic material, an interior casing made of rigid material and attached to an inner surface of the exterior casing, and a number of camera assemblies received in the interior casing. The exterior casing is elastically deformed when pushed by a flat surface, such that the air between the exterior casing and the flat surface is drawn out of the exterior casing, thereby allowing the exterior casing to be firmly attached to the flat surface and the camera of each camera assembly.
摘要翻译：监控摄像机装置包括由弹性材料制成的外壳，由刚性材料制成并附接到外壳的内表面的内壳以及容纳在内壳中的多个相机组件。当外部壳体被平坦表面推压时，外部壳体弹性变形，使得外部壳体和平坦表面之间的空气被拉出外部壳体，从而允许外部壳体牢固地附接到平坦表面，并且相机每个相机组件。

9. 发明申请

US20130163170A1 ELECTRONIC DEVICE 有权
标题翻译：电子设备
公开(公告)号：US20130163170A1
公开(公告)日：2013-06-27
申请号：US13631885
申请日：2012-09-29
申请人： ZHOU CHEN
发明人： ZHOU CHEN
IPC分类号： H05K5/02
CPC分类号： G03B29/00 , G06F1/16 , G06F1/1605 , G06F2200/1631
摘要： An electronic device comprises a main body, an operating mechanism secured to the main body; and a camera mechanism. The main body defines an opening. The camera mechanism is capable of being received in the opening. The operating mechanism is operable to drive the camera mechanism protruding out of the opening, and allows the camera mechanism to be retracted into and received in the opening.
摘要翻译：电子设备包括主体，固定到主体的操作机构; 和相机机构。主体定义一个开口。相机机构能够被接收在开口中。操作机构可操作地驱动从开口突出的相机机构，并且允许相机机构缩回并接收在开口中。

10. 发明申请

US20130153451A1 PROTECTION CASE FOR ELECTRONIC DEVICE 有权
标题翻译：电子设备保护箱
公开(公告)号：US20130153451A1
公开(公告)日：2013-06-20
申请号：US13587977
申请日：2012-08-17
申请人： ZHOU CHEN
发明人： ZHOU CHEN
IPC分类号： B65D85/00
CPC分类号： A45C13/002 , G06F2200/1633
摘要： A protection case for protecting an electronic device is disclosed. The protection case includes a main body. The main body defines a receiving cavity for accommodating the electronic device and a plurality of connecting through holes for exposing a plurality of interface ports of the electronic device. The main body defines a number of grooves encircling the connecting through holes for receiving moisture in the air.
摘要翻译：公开了一种用于保护电子设备的保护壳体。保护壳包括主体。主体限定用于容纳电子装置的容纳腔和用于暴露电子装置的多个接口端口的多个连接通孔。主体限定环绕连接通孔的多个槽，用于接收空气中的水分。

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