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1. 发明申请

US20080046070A1 CHEMICALLY TREATED EXTRACELLULAR MATRICES FOR AFFECTING THE CELLULAR RESPONSE 审中-公开
标题翻译：用于影响细胞响应的化学处理细胞外基质
公开(公告)号：US20080046070A1
公开(公告)日：2008-02-21
申请号：US11694328
申请日：2007-03-30
申请人： F. Obermiller , Michael Hiles
发明人： F. Obermiller , Michael Hiles
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0066 , A61F2220/0075
摘要： Described are preferred prosthetic valve devices including an extracellular matrix (ECM) material coated with a microtubule inhibiting agent and affixed to a stent. The stent is configured such that the coated ECM material is formed into one or more leaflets. In preferred embodiments, the prosthetic valve devices are configured for use in vascular applications.
摘要翻译：描述了优选的人工瓣膜装置，其包括涂覆有微管抑制剂并固定在支架上的细胞外基质（ECM）材料。支架构造成使得涂覆的ECM材料形成为一个或多个传单。在优选实施例中，假体瓣膜装置被配置用于血管应用。

2. 发明申请

US20060116548A1 Methods for treating valve-associated regions of vascular vessels 有权
标题翻译：治疗血管血管相关区域的方法
公开(公告)号：US20060116548A1
公开(公告)日：2006-06-01
申请号：US11266166
申请日：2005-11-03
申请人： Brian Case , Jacob Flagle , Michael Hiles , F. Obermiller , Umesh Patel
发明人： Brian Case , Jacob Flagle , Michael Hiles , F. Obermiller , Umesh Patel
IPC分类号： A61F2/00 , A61F13/00
CPC分类号： A61F2/2475 , A61L27/3604 , A61L27/3633 , A61L27/3641 , A61L27/3645 , A61L27/3839
摘要： This invention relates in one aspect to the treatment of a valve-associated region of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
摘要翻译：本发明在一个方面涉及用生物材料治疗血管血管的瓣膜相关区域。生物材料可以是加强和/或支持血管壁的可重塑材料。另外，生物材料可以包括多种天然存在或添加的生物活性剂和/或活细胞群体。

3. 发明申请

US20060136047A1 Tissue graft prosthesis devices containing juvenile or small diameter submucosa 审中-公开
标题翻译：包含少年或小直径粘膜下层的组织移植假体装置
公开(公告)号：US20060136047A1
公开(公告)日：2006-06-22
申请号：US10523892
申请日：2003-09-04
申请人： F. Obermiller , Michael Hiles , Jason Hodde
发明人： F. Obermiller , Michael Hiles , Jason Hodde
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2/0077 , A61F2/07 , A61F2002/075
摘要： Described are preferred tissue graft materials that incorporate juvenile submucosa tissue from a warm-blooded vertebrate. Preferred materials incorporate juvenile small intestinal submucosa tissue from a mammal such as a porcine mammal, and the constructs are preferably in tubular form and utilized the isolated submucosa tissue in its native, intact tubular form. More preferred devices are multi-laminate and include the juvenile submucosa tissue in addition to at least one, and preferably several other layers providing increased strength or other advantageous properties to the construct.
摘要翻译：描述的是优选的组织移植材料，其包含来自温血脊椎动物的幼年粘膜下层组织。优选的材料包括来自哺乳动物如猪哺乳动物的幼年小肠粘膜下层组织，并且构建体优选为管状形式，并以其天然的完整管状形式使用分离的粘膜下层组织。更优选的装置是多层压的，并且除了至少一个，优选几个其它层之外还包括少年粘膜下层组织，为构建体提供增强的强度或其它有利的性质。

4. 发明申请

US20070004961A1 Methods for modifying vascular vessel walls 有权
标题翻译：改变血管壁的方法
公开(公告)号：US20070004961A1
公开(公告)日：2007-01-04
申请号：US11295866
申请日：2005-12-07
申请人： Brian Case , Michael Hiles , Jacob Flagle , F. Obermiller , Umesh Patel
发明人： Brian Case , Michael Hiles , Jacob Flagle , F. Obermiller , Umesh Patel
IPC分类号： A61F2/00
CPC分类号： A61L27/3633 , A61F2/2475 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3839
摘要： This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
摘要翻译：本发明在一个方面涉及用生物材料治疗血管血管。生物材料可以是加强和/或支持血管壁的可重塑材料。另外，生物材料可以包括多种天然存在或添加的生物活性剂和/或活细胞群体。

5. 发明申请

US20080004657A1 Volumetric grafts for treatment of fistulae and related methods and systems 有权
标题翻译：用于治疗瘘的体积移植物及相关方法和系统
公开(公告)号：US20080004657A1
公开(公告)日：2008-01-03
申请号：US11415403
申请日：2006-05-01
申请人： F. Obermiller , Michael Hiles , Matthew Graham , Clay Fette
发明人： F. Obermiller , Michael Hiles , Matthew Graham , Clay Fette
IPC分类号： A61F2/04
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00641 , A61B2017/00654 , A61M27/00
摘要： Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.
摘要翻译：描述了可用于治疗瘘的装置，方法和系统，并且在某些实施例中，具有延伸进入消化道的开口的那些，诸如肛门直肠瘘。说明性地，可以通过将体积结构置于瘘的主要开口内来治疗肛门直肠瘘。在某些实施方案中，体积构造可以包括经加工以形成基本上单体的卷状可重塑材料。有益的这种可重塑材料可以包括胶原细胞外基质材料，如小肠粘膜下层。

6. 发明申请

US20060251702A1 Implantable materials and methods for inhibiting tissue adhesion formation 审中-公开
标题翻译：用于抑制组织粘连形成的植入材料和方法
公开(公告)号：US20060251702A1
公开(公告)日：2006-11-09
申请号：US11429662
申请日：2006-05-05
申请人： Abram Janis , Michael Hiles , Jason Hodde
发明人： Abram Janis , Michael Hiles , Jason Hodde
IPC分类号： A61F2/00 , A61K31/192
CPC分类号： A61L31/16 , A61F2/0063 , A61F2/0095 , A61F2/06 , A61F2210/0004 , A61F2250/0067 , A61K31/192 , A61L27/3633 , A61L27/38 , A61L27/54 , A61L31/005 , A61L31/042 , A61L31/048 , A61L2300/30 , A61L2300/41 , A61L2300/412 , C08L5/08 , C08L23/12
摘要： Described are materials and methods for inhibiting the formation of tissue adhesions. In one aspect, a prosthetic tissue support mesh, and especially such a mesh comprised of a remodelable material that promotes tissue ingrowth, incorporates an effective amount of an anti-inflammatory compound such as a non-steroidal anti-inflammatory drug (NSAID) to inhibit the formation of tissue adhesions to the mesh and/or to surrounding tissues when implanted in a patient. Also described are materials and methods for increasing the length of persistence of implanted resorbable materials, and especially implanted bioremodelable materials, using an anti-inflammatory compound such as an NSAID.
摘要翻译：描述了用于抑制组织粘连形成的材料和方法。在一个方面，假体组织支撑网，特别是由促进组织向内生长的可重塑材料组成的网，结合有效量的抗炎化合物，例如非甾体抗炎药（NSAID）以抑制当植入患者时，对网状物和/或周围组织的组织粘连的形成。还描述了使用抗炎化合物如NSAID来增加植入的可再吸收材料的持久性长度，特别是植入的生物可重塑材料的材料和方法。

7. 发明申请

US20050187604A1 Cast bioremodelable graft 有权
标题翻译：铸造生物可重复移植
公开(公告)号：US20050187604A1
公开(公告)日：2005-08-25
申请号：US11054043
申请日：2005-02-09
申请人： Scott Eells , Michael Hiles , Thomas Osborne
发明人： Scott Eells , Michael Hiles , Thomas Osborne
IPC分类号： A61L27/36 , A61L27/50 , A61L27/58 , A61L31/00 , A61F2/06
CPC分类号： A61L27/507 , A61L27/3629 , A61L27/3633 , A61L27/58
摘要： A cast bioremodelable graft (22) comprising a cast tubular construct (33) of a bioremodelable substance (34). The bioremodelable substance is cast on or applied to a form and then vacuum pressed to dry or harden the substance. Expandable members (18) are disposed on, in, under or about the cast tubular construct to expand the graft when released from an endoluminal delivery system. A second layer (39) can be applied over the first layer (38) and the expandable stents to contain the stents there between without the need for any separate attachment. The graft is dehydrated and preferably vacuum pressed to harden the bioremodelable substance. The form is removed to form one or more lumens (23-25) in the graft, which is then loaded on an endoluminal delivery system.
摘要翻译：一种包含生物可重塑物质（34）的铸造管状构件（33）的浇注生物可重塑移植物（22）。将生物可重塑物质浇铸或施加到形式上，然后真空压制以干燥或硬化物质。可膨胀构件（18）设置在铸造管状结构的内部，下面或周围，以在从内腔输送系统释放时膨胀移植物。第二层（39）可以施加在第一层（38）上，并且可扩展支架在其间包含支架，而不需要任何单独的附接。将移植物脱水并优选真空压制以使生物可重塑物质硬化。去除形式以在移植物中形成一个或多个腔（23-25），然后将其装载在腔内递送系统上。

8. 发明申请

US20100106257A2 GRAFT PROSTHESIS, MATERIALS AND METHODS 审中-公开
公开(公告)号：US20100106257A2
公开(公告)日：2010-04-29
申请号：US11932000
申请日：2007-10-31
申请人： William Cook , Michael Hiles , Thomas Kozma , Umesh Patel
发明人： William Cook , Michael Hiles , Thomas Kozma , Umesh Patel
IPC分类号： A61F2/02 , A61K35/24
CPC分类号： A61L27/24 , A61F2/06 , A61F2/07 , A61L2/0088 , A61L27/3604 , A61L27/3662 , A61L27/3683 , A61L27/3695 , A61L27/3839 , A61L27/3843 , A61L27/386 , A61L29/005 , A61L31/005 , Y10S623/925
摘要： A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.

9. 发明申请

US20100106256A2 GRAFT PROSTHESIS, MATERIALS AND METHODS 有权
公开(公告)号：US20100106256A2
公开(公告)日：2010-04-29
申请号：US11931743
申请日：2007-10-31
申请人： William Cook , Michael Hiles , Thomas Kozma , Umesh Patel
发明人： William Cook , Michael Hiles , Thomas Kozma , Umesh Patel
IPC分类号： A61F2/02 , A61K35/24
CPC分类号： A61L27/24 , A61F2/06 , A61F2/07 , A61L2/0088 , A61L27/3604 , A61L27/3662 , A61L27/3683 , A61L27/3695 , A61L27/3839 , A61L27/3843 , A61L27/386 , A61L29/005 , A61L31/005 , Y10S623/925
摘要： A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.

10. 发明申请

US20080097585A1 VALVE REPAIR SYSTEMS AND METHODS 审中-公开
标题翻译：阀门维修系统和方法
公开(公告)号：US20080097585A1
公开(公告)日：2008-04-24
申请号：US11772438
申请日：2007-07-02
申请人： Richard Sisken , Michael Hiles , Neal Fearnot , Alan Leewood
发明人： Richard Sisken , Michael Hiles , Neal Fearnot , Alan Leewood
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2475
摘要： Medical device valve repair systems that include a stabilization member are provided. The stabilization member includes an engaging channel to contact the engaging surface of a valve holding valve leaflets in a position such that a tissue repair device may form a coaptation between the valve leaflets.
摘要翻译：提供包括稳定构件的医疗装置阀门维修系统。稳定构件包括接合通道，以将阀保持瓣膜小叶的接合表面接触在一个位置，使得组织修复装置可以在瓣膜单元之间形成接合。

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