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1. 发明申请

US20060116548A1 Methods for treating valve-associated regions of vascular vessels 有权
标题翻译：治疗血管血管相关区域的方法
公开(公告)号：US20060116548A1
公开(公告)日：2006-06-01
申请号：US11266166
申请日：2005-11-03
申请人： Brian Case , Jacob Flagle , Michael Hiles , F. Obermiller , Umesh Patel
发明人： Brian Case , Jacob Flagle , Michael Hiles , F. Obermiller , Umesh Patel
IPC分类号： A61F2/00 , A61F13/00
CPC分类号： A61F2/2475 , A61L27/3604 , A61L27/3633 , A61L27/3641 , A61L27/3645 , A61L27/3839
摘要： This invention relates in one aspect to the treatment of a valve-associated region of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
摘要翻译：本发明在一个方面涉及用生物材料治疗血管血管的瓣膜相关区域。生物材料可以是加强和/或支持血管壁的可重塑材料。另外，生物材料可以包括多种天然存在或添加的生物活性剂和/或活细胞群体。

2. 发明申请

US20070004961A1 Methods for modifying vascular vessel walls 有权
标题翻译：改变血管壁的方法
公开(公告)号：US20070004961A1
公开(公告)日：2007-01-04
申请号：US11295866
申请日：2005-12-07
申请人： Brian Case , Michael Hiles , Jacob Flagle , F. Obermiller , Umesh Patel
发明人： Brian Case , Michael Hiles , Jacob Flagle , F. Obermiller , Umesh Patel
IPC分类号： A61F2/00
CPC分类号： A61L27/3633 , A61F2/2475 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3839
摘要： This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
摘要翻译：本发明在一个方面涉及用生物材料治疗血管血管。生物材料可以是加强和/或支持血管壁的可重塑材料。另外，生物材料可以包括多种天然存在或添加的生物活性剂和/或活细胞群体。

3. 发明申请

US20060212111A1 Vascular valves having implanted and target configurations and methods of preparing the same 有权
标题翻译：具有植入和靶构造的血管瓣及其制备方法
公开(公告)号：US20060212111A1
公开(公告)日：2006-09-21
申请号：US11260770
申请日：2005-10-27
申请人： Brian Case , Jacob Flagle , Michael Garrison , F. Obermiller , Dusan Pavcnik
发明人： Brian Case , Jacob Flagle , Michael Garrison , F. Obermiller , Dusan Pavcnik
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2475 , A61F2210/0004 , A61F2220/0016 , A61F2250/0067
摘要： Described are vascular valve devices for implantation in a patient. The vascular valve devices are designed to compensate for the retraction characteristics of a remodelable material used to form one or more leaflets. Alternatively, or in addition, the devices are designed to reduce retraction of the remodelable leaflet-forming material. Further described are methods for preparing and using these vascular valve devices.
摘要翻译：描述了用于植入患者体内的血管瓣膜装置。血管瓣膜装置被设计成补偿用于形成一个或多个传单的可重塑材料的回缩特性。或者或另外，设备被设计成减少可重塑的小叶形成材料的缩回。进一步描述了制备和使用这些血管瓣膜装置的方法。

4. 发明申请

US20070106372A1 IMPLANTABLE MEDICAL DEVICE WITH CONSTRAINED EXPANSION 有权
标题翻译：具有约束扩张的可植入医疗装置
公开(公告)号：US20070106372A1
公开(公告)日：2007-05-10
申请号：US11539925
申请日：2006-10-10
申请人： Thomas Osborne , Brian Case , Jacob Flagle , Andrew Hoffa , Michael Garrison
发明人： Thomas Osborne , Brian Case , Jacob Flagle , Andrew Hoffa , Michael Garrison
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的医疗装置。根据本发明的医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植部件。支撑结构具有第一，未膨胀的构造和第二扩展构型。约束部分适于基本上防止支撑结构实现第二扩张构型。阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

5. 发明申请

US20060259128A1 Method for implanting prosthetic valves 审中-公开
标题翻译：植入人工瓣膜的方法
公开(公告)号：US20060259128A1
公开(公告)日：2006-11-16
申请号：US11404439
申请日：2006-04-14
申请人： Dusan Pavcnik , Brian Case , Ram Paul , Jacob Flagle
发明人： Dusan Pavcnik , Brian Case , Ram Paul , Jacob Flagle
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2427 , A61F2/2475 , A61F2250/0002 , A61F2250/0096
摘要： Methods for implanting a prosthetic valve in a body vessel having a fluid flow therethrough are provided. One method includes identifying a position of an existing valve and determining a factor affecting fluid flow in at least one of a first direction and a second direction at the existing valve. The method includes selecting the implantation position for a prosthetic valve at a distance away from the existing valve position in consideration of the factor. The method further includes providing the prosthetic valve for delivery to the implantation position, delivering and implanting the prosthetic valve at the position. The prosthetic valve includes at least one flexible member movable between a first position that permits fluid flow in the first direction and the second position that substantially prevents fluid flow in a second direction.
摘要翻译：提供了将人造瓣植入具有流体流体的体内容器中的方法。一种方法包括识别现有阀的位置并且确定影响现有阀处的第一方向和第二方向中的至少一个中的流体流动的因素。该方法包括考虑到该因素，在离开现有阀位置的距离处选择假体瓣膜的植入位置。该方法还包括提供用于输送到植入位置的人造瓣膜，将该假体瓣膜输送和植入该位置。假体瓣膜包括至少一个柔性构件，其可在第一位置和第二位置之间移动，所述第一位置允许流体在第一方向上流动，而第二位置基本上防止流体沿第二方向流动。

6. 发明申请

US20060149309A1 Inverting occlusion devices, methods, and systems 有权
标题翻译：反相闭塞装置，方法和系统
公开(公告)号：US20060149309A1
公开(公告)日：2006-07-06
申请号：US11322145
申请日：2005-12-29
申请人： Ram Paul , Brian Case , Jacob Flagle
发明人： Ram Paul , Brian Case , Jacob Flagle
IPC分类号： A61M29/02
CPC分类号： A61B17/00008 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/12181 , A61B2017/1205
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the percutaneous delivery of an occlusion device inverted within a cannula, its deployment and filling, so as to occlude or obliterate a portion of a vascular vessel.
摘要翻译：描述了用于实现血管血管阻塞的装置，方法和系统。经皮手术可用于闭塞和闭塞较大的隐静脉，例如用于治疗由静脉回流引起的静脉曲张病变。某些实施方案包括在插管内反转的闭塞装置的经皮递送，其展开和填充，以封闭或消除血管容器的一部分。

7. 发明申请

US20060136045A1 Methods and systems for modifying vascular valves 有权
标题翻译：改变血管瓣膜的方法和系统
公开(公告)号：US20060136045A1
公开(公告)日：2006-06-22
申请号：US11260360
申请日：2005-10-27
申请人： Jacob Flagle , Brian Case
发明人： Jacob Flagle , Brian Case
IPC分类号： A61F2/06
CPC分类号： A61B17/00234 , A61B17/00491 , A61B17/064 , A61B17/122 , A61B18/1492 , A61B2017/00783 , A61F2/06 , A61F2/2475 , Y10S623/904
摘要： Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.
摘要翻译：描述了用于修改血管瓣膜以减少通过瓣膜的逆行血流量的方法和系统。优选的方法包括将血管瓣叶与至少一种可重塑材料连接，使得瓣膜小叶通过患者的天然组织的向内生长而变得熔化。优选的可重塑材料包括胶原细胞外基质材料，例如小肠粘膜下层。

8. 发明申请

US20050182483A1 Percutaneously placed prosthesis with thromboresistant valve portion 审中-公开
标题翻译：经皮放置假体与抗血栓阀部分
公开(公告)号：US20050182483A1
公开(公告)日：2005-08-18
申请号：US11056903
申请日：2005-02-11
申请人： Thomas Osborne , Brian Case , Jacob Flagle , Grant Hoffman
发明人： Thomas Osborne , Brian Case , Jacob Flagle , Grant Hoffman
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2424 , A61F2/2403 , A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0078 , A61F2230/008
摘要： A venous valve prosthesis having a substantially non-expandable, valve portion comprising a valve-closing mechanism, such as a pair of opposing leaflets; and an anchoring portion, such as one or more self-expanding frames or stents that are expandable to anchor the prosthesis at the implantation site. In one embodiment, the rigid valve portion includes a deposition of material such as pyrolitic carbon to reduce the thrombogenecity of the blood-contacting surfaces. The anchoring portions preferably include a covering, such as a tubular construct of synthetic or collagen-derived material (such as a bioremodelable ECM material), which attaches about the support structure such that blood flow is directed through the valve mechanism as it transitions from the larger diameter anchoring portion to the intermediate, smaller-diameter portion of the prosthesis. In another embodiment, the valve support housing and valve-closing elements are delivered in a collapsed, folded, and/or dissembled state sized for delivery, then manipulated in situ to the second expanded configured following deployment.
摘要翻译：一种静脉瓣膜假体，其具有基本上不可扩张的阀部分，其包括阀关闭机构，例如一对相对的传单; 以及锚固部分，例如一个或多个自扩张框架或支架，其可扩张以在植入部位处锚固假体。在一个实施例中，刚性瓣膜部分包括诸如热解碳的材料的沉积，以降低血液接触表面的血栓形成。锚定部分优选地包括覆盖物，例如由合成或胶原衍生的材料（例如生物可重构的ECM材料）组成的管状构件，其附接在支撑结构上，使得当血液流过较大直径的锚固部分到假体的中间较小直径部分。在另一个实施例中，阀支撑壳体和阀关闭元件以折叠，折叠和/或拆卸状态被输送，其尺寸适于输送，然后在原位操作到第二扩张配置的后续部署。

9. 发明申请

US20050085900A1 Prosthetic valve for implantation in a body vessel 有权
标题翻译：用于植入体内的假体瓣膜
公开(公告)号：US20050085900A1
公开(公告)日：2005-04-21
申请号：US10903907
申请日：2004-07-31
申请人： Brian Case , Thomas Osborne , Jacob Flagle , Fred Parker
发明人： Brian Case , Thomas Osborne , Jacob Flagle , Fred Parker
IPC分类号： A61F2/06 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Prosthetic valves for implantation in a body vessel are provided. Prosthetic valves according to the invention comprise first and second frame members and a graft member at least partially disposed between the first and second frame members. The graft member forms a valve that permits fluid flow through the body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的假体瓣膜。根据本发明的假体瓣膜包括第一和第二框架构件以及至少部分地设置在第一和第二框架构件之间的移植构件。移植物构件形成允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体血管。

10. 发明申请

US20080051879A1 METHODS OF TREATING VENOUS VALVE RELATED CONDITIONS WITH A FLOW-MODIFYING IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：用流动修改植入式医疗装置处理通气阀相关条件的方法
公开(公告)号：US20080051879A1
公开(公告)日：2008-02-28
申请号：US11844003
申请日：2007-08-23
申请人： Brian Case , Gary Shirley , Ram Paul , Jacob Flagle
发明人： Brian Case , Gary Shirley , Ram Paul , Jacob Flagle
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/07 , A61F2002/068
摘要： Implantable medical devices adapted to modify fluid flow within a body vessel are provided herein. The medical devices may include a fluid flow restricting channel configured to reduce longitudinal fluid flow in a retrograde direction or in an antegrade direction. Preferably, the medical devices are flow-modifying devices that reduce fluid flow through the medical device to a greater extent in a retrograde direction than in an antegrade direction. Methods of treatment comprising the step of implanting a flow-modifying medical device within a body vessel are also provided. Flow-modifying devices are useful, for example, in treating venous valve related conditions.
摘要翻译：本文提供了适于改变体内容器内的流体流动的植入式医疗装置。医疗装置可以包括流体流动限制通道，该流体流动限制通道构造成减小沿逆行方向或顺行方向的纵向流体流动。优选地，医疗装置是流动改变装置，其减少流体通过医疗装置的流体在逆行方向上比在顺行方向上更大程度地流动。还提供了包括在身体容器内植入流动改变医疗装置的步骤的治疗方法。流动改变装置例如在治疗静脉瓣相关病症中是有用的。

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