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1. 发明申请

US20110251097A1 DIAGNOSTIC KIT OF COLON CANCER USING COLON CANCER RELATED MARKER AND DIAGNOSTIC METHOD THEREOF 审中-公开
标题翻译：使用结肠癌的结肠癌诊断套件相关标记及其诊断方法
公开(公告)号：US20110251097A1
公开(公告)日：2011-10-13
申请号：US13126500
申请日：2009-04-20
申请人： Eun Young Song , Hee Gu Lee , Young Il Yeom , Jae Wha Kim , Na Young Ji , Kyung-Sook Chung , Misun Won , Seon-Young Kim , Joo Heon Kim , Young Ho Kim , Ho Kyung Chun
发明人： Eun Young Song , Hee Gu Lee , Young Il Yeom , Jae Wha Kim , Na Young Ji , Kyung-Sook Chung , Misun Won , Seon-Young Kim , Joo Heon Kim , Young Ho Kim , Ho Kyung Chun
IPC分类号： C40B30/04 , G01N33/53 , G01N33/566 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to a composition for diagnosing colon cancer. The composition comprises at least one marker for measuring an mRNA or protein expression level of at least one gene specific for colon cancer. It can screen the genes which are overexpressed specifically only in colon cancer tissues or blood. The present invention can quantitatively analyze both the mRNA expression levels of the genes and the expression levels of the proteins encoded by the gene at the same time, thereby diagnosing colon caner of an early stage with a high level of reliability.
摘要翻译：本发明涉及用于诊断结肠癌的组合物。组合物包含至少一种用于测量至少一种对结肠癌特异性基因的mRNA或蛋白质表达水平的标记物。它可以筛选出仅在结肠癌组织或血液中过度表达的基因。本发明可以同时定量分析基因的mRNA表达水平和基因编码的蛋白质的表达水平，从而以高可靠性诊断早期的结肠癌。

2. 发明申请

US20100248244A1 Characterization of ESM-1 as a Tumor Associated Marker of Colorectal Cancer 有权
标题翻译： ESM-1作为肿瘤相关标志物的结直肠癌的表征
公开(公告)号：US20100248244A1
公开(公告)日：2010-09-30
申请号：US12744223
申请日：2007-11-23
申请人： Eun Young Song , Mi Young Park , Hyang Sin Lee , Hee Gu Lee , Jae Wha Kim , In Seong Choe , Min A. Kang , Mi Sun Won , Kyung Sook Chung , Young Ho Kim , Ho Kyung Chun , Young Il Yeom , Seon-Young Kim
发明人： Eun Young Song , Mi Young Park , Hyang Sin Lee , Hee Gu Lee , Jae Wha Kim , In Seong Choe , Min A. Kang , Mi Sun Won , Kyung Sook Chung , Young Ho Kim , Ho Kyung Chun , Young Il Yeom , Seon-Young Kim
IPC分类号： C12Q1/68 , C07H21/00 , C07K16/18 , G01N33/48 , G01N33/53 , C07H21/02
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Disclosed herein is a colorectal cancer marker for diagnosing colorectal cancer based on ESM-I overexpression in tissues, cells or body fluids of colorectal cancer patients. Disclosed also is the use of the colorectal cancer marker in the development of therapeutic agents for cancer and in the diagnosis and treatment of colorectal cancer.
摘要翻译：本文公开了一种基于ESM-1在结肠直肠癌患者的组织，细胞或体液中过度表达的用于诊断结肠直肠癌的结肠直肠癌标志物。还公开了结肠直肠癌标志物在癌症治疗剂的开发和结肠直肠癌的诊断和治疗中的应用。

3. 发明授权

US08283129B2 Characterization of ESM-1 as a tumor associated marker of colorectal cancer 有权
标题翻译： ESM-1作为结肠直肠癌肿瘤相关标志物的表征
公开(公告)号：US08283129B2
公开(公告)日：2012-10-09
申请号：US12744223
申请日：2007-11-23
申请人： Eun Young Song , Mi Young Park , Hyang Sin Lee , Hee Gu Lee , Jae Wha Kim , In Seong Choe , Min A Kang , Mi Sun Won , Kyung-Sook Chung , Young Ho Kim , Ho Kyung Chun , Young Il Yeom , Seon-Young Kim
发明人： Eun Young Song , Mi Young Park , Hyang Sin Lee , Hee Gu Lee , Jae Wha Kim , In Seong Choe , Min A Kang , Mi Sun Won , Kyung-Sook Chung , Young Ho Kim , Ho Kyung Chun , Young Il Yeom , Seon-Young Kim
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Disclosed herein is a colorectal cancer marker for diagnosing colorectal cancer based on ESM-I overexpression in tissues, cells or body fluids of colorectal cancer patients. Disclosed also is the use of the colorectal cancer marker in the development of therapeutic agents for cancer and in the diagnosis and treatment of colorectal cancer.
摘要翻译：本文公开了一种基于ESM-1在结肠直肠癌患者的组织，细胞或体液中过度表达的用于诊断结肠直肠癌的结肠直肠癌标志物。还公开了结肠直肠癌标志物在癌症治疗剂的开发和结肠直肠癌的诊断和治疗中的应用。

4. 发明授权

US08486905B2 Use of FLJ25416 gene 有权
标题翻译：使用FLJ25416基因
公开(公告)号：US08486905B2
公开(公告)日：2013-07-16
申请号：US12746722
申请日：2008-12-05
申请人： Misun Won , Kyung-Sook Chung , Young-Joo Kim , Shin-Jung Choi , Young Il Yeom , Seon-Young Kim , Kyung Bin Song , Hee Gu Lee , Eun Young Song , Young Ho Kim , Ho Kyung Chun , Chae-Ok Yun , Moon Hee Kim , Kyeong-Eun Jung , Sun-Jung Cho
发明人： Misun Won , Kyung-Sook Chung , Young-Joo Kim , Shin-Jung Choi , Young Il Yeom , Seon-Young Kim , Kyung Bin Song , Hee Gu Lee , Eun Young Song , Young Ho Kim , Ho Kyung Chun , Chae-Ok Yun , Moon Hee Kim , Kyeong-Eun Jung , Sun-Jung Cho
IPC分类号： C12N15/11 , C07H21/02
CPC分类号： G01N33/57484 , A61K31/7088 , A61K38/1709 , C12N15/1135 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2710/10343 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/00 , G01N2500/04
摘要： Provided are a composition for diagnosing cancer or screening an anticancer drug comprising an FLJ25416 gene or an antibody directed to a protein expressed from the FLJ25416 gene, a composition for treating cancer comprising an inhibitor of the gene or an inhibitor of the protein expressed from the gene and a pharmaceutically acceptable carrier, and a kit for diagnosing cancer comprising at least one of the FLJ25416 gene and the protein expressed from the FLJ25416 gene. The FLJ25416 gene is expressed at high level in specific cancer cells, and induces an increase in proliferation rate of normal cells. The expression of the gene is suppressed, which results in an inhibitory effect on cancer cell growth. Thus, the FLJ25416 gene can be used as a target gene for diagnosis or treatment of cancer.
摘要翻译：提供了用于诊断癌症或筛选包含FLJ25416基因或针对从FLJ25416基因表达的蛋白质的抗体的抗癌药物的组合物，用于治疗癌症的组合物，其包含该基因的抑制剂或从该基因表达的蛋白质的抑制剂和药学上可接受的载体，以及用于诊断癌症的试剂盒，其包含FLJ25416基因和从FLJ25416基因表达的蛋白质中的至少一种。 FLJ25416基因在特异性癌细胞中表达量高，诱导正常细胞增殖。该基因的表达被抑制，这导致对癌细胞生长的抑制作用。因此，FLJ25416基因可用作癌症诊断或治疗的靶基因。

5. 发明申请

US20110008370A1 NOVEL USE OF FLJ25416 GENE 有权
标题翻译： FLJ25416基因的新用途
公开(公告)号：US20110008370A1
公开(公告)日：2011-01-13
申请号：US12746722
申请日：2008-12-05
申请人： Misun Won , Kyung-Sook Chung , Young-Joo Kim , Shin-Jung Choi , Young Il Yeom , Seon-Young Kim , Kyung Bin Song , Hee Gu Lee , Eun Young Song , Young Ho Kim , Ho Kyung Chun , Chae-Ok Yun , Moon Hee Kim , Kyeong-Eun Jung , Sun-Jung Cho
发明人： Misun Won , Kyung-Sook Chung , Young-Joo Kim , Shin-Jung Choi , Young Il Yeom , Seon-Young Kim , Kyung Bin Song , Hee Gu Lee , Eun Young Song , Young Ho Kim , Ho Kyung Chun , Chae-Ok Yun , Moon Hee Kim , Kyeong-Eun Jung , Sun-Jung Cho
IPC分类号： A61K39/395 , C07H21/02 , A61K31/713 , C07H21/00 , C07K16/18 , C07K14/47 , C12Q1/68 , G01N33/574 , A61P35/00
CPC分类号： G01N33/57484 , A61K31/7088 , A61K38/1709 , C12N15/1135 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2710/10343 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/00 , G01N2500/04
摘要： Provided are a composition for diagnosing cancer or screening an anticancer drug comprising an FLJ25416 gene or an antibody directed to a protein expressed from the FLJ25416 gene, a composition for treating cancer comprising an inhibitor of the gene or an inhibitor of the protein expressed from the gene and a pharmaceutically acceptable carrier, and a kit for diagnosing cancer comprising at least one of the FLJ25416 gene and the protein expressed from the FLJ25416 gene. The FLJ25416 gene is expressed at high level in specific cancer cells, and induces an increase in proliferation rate of normal cells. The expression of the gene is suppressed, which results in an inhibitory effect on cancer cell growth. Thus, the FLJ25416 gene can be used as a target gene for diagnosis or treatment of cancer.
摘要翻译：提供了用于诊断癌症或筛选包含FLJ25416基因或针对由FLJ25416基因表达的蛋白质的抗体的抗癌药物的组合物，用于治疗癌症的组合物，其包含该基因的抑制剂或从该基因表达的蛋白质的抑制剂和药学上可接受的载体，以及用于诊断癌症的试剂盒，其包含FLJ25416基因和从FLJ25416基因表达的蛋白质中的至少一种。 FLJ25416基因在特异性癌细胞中表达量高，诱导正常细胞增殖。该基因的表达被抑制，这导致对癌细胞生长的抑制作用。因此，FLJ25416基因可用作癌症诊断或治疗的靶基因。

6. 发明授权

US5823757A Axial sealing apparatus for scroll type compressor 失效
标题翻译：涡旋式压缩机推力密封装置
公开(公告)号：US5823757A
公开(公告)日：1998-10-20
申请号：US765647
申请日：1996-12-31
申请人： Seon-Young Kim
发明人： Seon-Young Kim
IPC分类号： F04C18/02 , F04C27/00 , F04C18/04
CPC分类号： F04C27/005
摘要： An improved axial sealing apparatus for a scroll type apparatus which is capable of constantly maintaining pressure in a back pressure chamber by forming a back pressure hole at a predetermined portion in which the back pressure hole is opened before a compressed gas is discharged and the back pressure hole is closed after the compressed gas is substantially closed, whereby a more stable axial direction sealing can be obtained throughout the entire operation time of a scroll compressor, which includes a stationary scroll; a rotational scroll engaged at a lower portion of the stationary scroll so as to form a compression chamber therebetween; and a back pressure chamber having a back pressure hole formed at a predetermined position in which the back pressure hole is opened whereby the compression chamber and the back pressure chamber become communicated with each other before a refrigerant gas compressed in the compression chamber is discharged to the discharging chamber and in which the back pressure hole is closed after the refrigerant gas is discharged to the discharging chamber, whereby an intermediate pressure having a greater pressure than the suction gas pressure and having a lower pressure than the discharging gas pressure is introduced into the back pressure chamber.
摘要翻译： PCT No.PCT / KR96 / 00064 Sec。 371日期1996年12月31日第 102（e）日期1996年12月31日PCT提交1996年5月2日PCT公布。公开号WO96 / 35056 日期：1996年11月7日改进的涡旋式装置的轴向密封装置，其能够通过在压缩气体之前在背压孔打开的预定部分形成背压孔而不断地保持背压室中的压力在压缩气体基本上封闭之后，背压孔关闭，从而在包括固定涡旋件的涡旋压缩机的整个运行时间内可以获得更稳定的轴向密封; 旋转涡旋盘，其在固定涡旋件的下部接合，以在其间形成压缩室; 以及背压室，其具有形成在背压孔打开的预定位置的背压孔，从而压缩室和背压室在压缩室内压缩的制冷剂气体排出之前彼此连通排出室，并且在制冷剂气体排放到排出室之后背压孔关闭，由此将具有比吸入气体压力更大的压力并且具有比排出气体压力更低的压力的中间压力引入到后部压力室。

7. 发明申请

US20100069619A1 STILBENE DERIVATIVES FOR ADP-RIBOSYL CYCLASE INHIBITORS 审中-公开
标题翻译： ADP-RIBOSYL CYCLASE INHIBITORS的STILBENE衍生物
公开(公告)号：US20100069619A1
公开(公告)日：2010-03-18
申请号：US12520391
申请日：2007-12-28
申请人： Uh-Hyun Kim , Ho-Jeong Kwon , Mie-Jae Im , Seon-Young Kim , Kwang-Hyun Park , So-Young Rah , Tae-Sik Nam , Byung-Ju Kim , Gul Rukhsana
发明人： Uh-Hyun Kim , Ho-Jeong Kwon , Mie-Jae Im , Seon-Young Kim , Kwang-Hyun Park , So-Young Rah , Tae-Sik Nam , Byung-Ju Kim , Gul Rukhsana
IPC分类号： C07C245/08 , C07C39/21
CPC分类号： C07C245/08 , C07C39/215
摘要： The present disclosure relates to bisphenyl compounds that are useful for inhibit the ADP-ribosyl cyclase (ADPR-cyclase). More particularly, the disclosed compounds can be used for treatment and prevention of hypertension, hypertensive cardiac hypertrophy, diabetes, and diabetic nephropathy, in which pathogenesis ADPR-cyclase is involved. The compounds and compositions of the invention can be used for treatment and prevention of cardiovascular disease and related disease states, particularly, hypertension or diabetes related disorders, such as, hypertensive cardiac hypertrophy, diabetic nephropathy, and the like.
摘要翻译：本公开涉及可用于抑制ADP-核糖基环化酶（ADPR-环化酶）的双苯基化合物。更具体地，所公开的化合物可用于治疗和预防涉及发病机制ADPR-环化酶的高血压，高血压心脏肥大，糖尿病和糖尿病性肾病。本发明的化合物和组合物可用于治疗和预防心血管疾病和相关疾病状态，特别是高血压或糖尿病相关疾病，例如高血压心脏肥大，糖尿病性肾病等。

8. 发明授权

US07275375B2 Regenerator and cryocooler using the same 有权
标题翻译：再生器和低温冷冻机使用相同
公开(公告)号：US07275375B2
公开(公告)日：2007-10-02
申请号：US10965918
申请日：2004-10-18
申请人： Seon-Young Kim
发明人： Seon-Young Kim
IPC分类号： F25B9/00 , F28D17/00
CPC分类号： F25B9/14 , F25B2309/001 , F25B2309/003 , F25B2309/1415
摘要： A regenerator includes a casing including a connection channel for making a high temperature part and a cooling part communicate with each other; and a thermal energy storage material inserted in the connection channel of the casing and made of an aramid fiber which stores/radiates heat of a working fluid flowing through the connection channel. A cryocooler includes the regenerator. Accordingly, regeneration performance of storing heat included in the working fluid and transmitting the stored heat to a working fluid is improved, and simultaneously a weight is decreased, thereby minimizing abrasion of components.
摘要翻译：再生器包括：壳体，其包括用于使高温部件和冷却部件相互连通的连接通道; 以及插入在壳体的连接通道中并由芳族聚酰胺纤维制成的热能储存材料，其存储/辐射流过连接通道的工作流体的热量。一个低温冷却器包括再生器。因此，提高了包含在工作流体中并将储存的热量传递到工作流体的再生性能，并且同时减轻了重量，从而使部件的磨损最小化。

9. 发明申请

US20050223715A1 Regenerator and cryocooler using the same 有权
标题翻译：再生器和低温冷冻机使用相同
公开(公告)号：US20050223715A1
公开(公告)日：2005-10-13
申请号：US10965918
申请日：2004-10-18
申请人： Seon-Young Kim
发明人： Seon-Young Kim
IPC分类号： F25B9/00 , C09K5/08 , F25B9/14
CPC分类号： F25B9/14 , F25B2309/001 , F25B2309/003 , F25B2309/1415
摘要： A regenerator includes a casing including a connection channel for making a high temperature part and a cooling part communicate with each other; and a thermal energy storage material inserted in the connection channel of the casing and made of an aramid fiber which stores/radiates heat of a working fluid flowing through the connection channel. A cryocooler includes the regenerator. Accordingly, regeneration performance of storing heat included in the working fluid and transmitting the stored heat to a working fluid is improved, and simultaneously a weight is decreased, thereby minimizing abrasion of components.
摘要翻译：再生器包括：壳体，其包括用于使高温部件和冷却部件相互连通的连接通道; 以及插入在壳体的连接通道中并由芳族聚酰胺纤维制成的热能储存材料，其存储/辐射流过连接通道的工作流体的热量。一个低温冷却器包括再生器。因此，提高了包含在工作流体中并将储存的热量传递到工作流体的再生性能，并且同时减轻了重量，从而使部件的磨损最小化。

10. 发明申请

US20110281826A1 STILBENE DERIVATIVES FOR ADP-RIBOSYL CYCLASE INHIBITORS 有权
标题翻译： ADP-RIBOSYL CYCLASE INHIBITORS的STILBENE衍生物
公开(公告)号：US20110281826A1
公开(公告)日：2011-11-17
申请号：US13149166
申请日：2011-05-31
申请人： Uh-Hyun Kim , Ho-Jeong Kwon , Mie-Jae Im , Seon-Young Kim , Kwang-Hyun Park , So-Young Rah , Tae-Sik Nam , Byung-Ju Kim , Gul Rukhsana
发明人： Uh-Hyun Kim , Ho-Jeong Kwon , Mie-Jae Im , Seon-Young Kim , Kwang-Hyun Park , So-Young Rah , Tae-Sik Nam , Byung-Ju Kim , Gul Rukhsana
IPC分类号： A61K31/655 , A61P13/12 , A61K31/05 , A61P9/00
CPC分类号： C07C245/08 , C07C39/215
摘要： The present disclosure relates to bisphenyl compounds that are useful for inhibiting the ADP-ribosyl cyclase (ADPR-cyclase). More particularly, the disclosed compounds can be used for treatment and prevention of hypertension, hypertensive cardiac hypertrophy, diabetes, and diabetic nephropathy, in which pathogenesis ADPR-cyclase is involved. The compounds and compositions of the invention can be used for treatment and prevention of cardiovascular disease and related disease states, particularly, hypertension or diabetes related disorders, such as, hypertensive cardiac hypertrophy, diabetic nephropathy, and the like.
摘要翻译：本公开涉及可用于抑制ADP-核糖基环化酶（ADPR-环化酶）的双苯基化合物。更具体地，所公开的化合物可用于治疗和预防涉及发病机制ADPR-环化酶的高血压，高血压心脏肥大，糖尿病和糖尿病性肾病。本发明的化合物和组合物可用于治疗和预防心血管疾病和相关疾病状态，特别是高血压或糖尿病相关疾病，例如高血压心脏肥大，糖尿病性肾病等。

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