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1. 发明授权

US10253309B2 Apparatus for separating fine particles using magnetophoresis, and method for separating fine particles using same 有权
公开(公告)号：US10253309B2
公开(公告)日：2019-04-09
申请号：US13821477
申请日：2011-08-19
申请人： Ki Ho Han , Hwan Yong Lee , Song I Han , Seon Young Kim , In Hak Choi
发明人： Ki Ho Han , Hwan Yong Lee , Song I Han , Seon Young Kim , In Hak Choi
IPC分类号： C12N13/00 , C07H1/08 , B03C1/033 , B03C1/32 , G01N27/74 , G01N15/10
摘要： The present invention relates to an apparatus for separating fine particles using magnetophoresis, and to a method for separating fine particles using same, and particularly, to an apparatus for separating fine particles using magnetophoresis, which includes a fine, patterned magnetic structure capable of quickly and efficiently separating even particles that are weakly magnetized and coupled to fine particles, and to a method for separating fine particles using same.

2. 发明授权

US08486905B2 Use of FLJ25416 gene 有权
标题翻译：使用FLJ25416基因
公开(公告)号：US08486905B2
公开(公告)日：2013-07-16
申请号：US12746722
申请日：2008-12-05
申请人： Misun Won , Kyung-Sook Chung , Young-Joo Kim , Shin-Jung Choi , Young Il Yeom , Seon-Young Kim , Kyung Bin Song , Hee Gu Lee , Eun Young Song , Young Ho Kim , Ho Kyung Chun , Chae-Ok Yun , Moon Hee Kim , Kyeong-Eun Jung , Sun-Jung Cho
发明人： Misun Won , Kyung-Sook Chung , Young-Joo Kim , Shin-Jung Choi , Young Il Yeom , Seon-Young Kim , Kyung Bin Song , Hee Gu Lee , Eun Young Song , Young Ho Kim , Ho Kyung Chun , Chae-Ok Yun , Moon Hee Kim , Kyeong-Eun Jung , Sun-Jung Cho
IPC分类号： C12N15/11 , C07H21/02
CPC分类号： G01N33/57484 , A61K31/7088 , A61K38/1709 , C12N15/1135 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2710/10343 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/00 , G01N2500/04
摘要： Provided are a composition for diagnosing cancer or screening an anticancer drug comprising an FLJ25416 gene or an antibody directed to a protein expressed from the FLJ25416 gene, a composition for treating cancer comprising an inhibitor of the gene or an inhibitor of the protein expressed from the gene and a pharmaceutically acceptable carrier, and a kit for diagnosing cancer comprising at least one of the FLJ25416 gene and the protein expressed from the FLJ25416 gene. The FLJ25416 gene is expressed at high level in specific cancer cells, and induces an increase in proliferation rate of normal cells. The expression of the gene is suppressed, which results in an inhibitory effect on cancer cell growth. Thus, the FLJ25416 gene can be used as a target gene for diagnosis or treatment of cancer.
摘要翻译：提供了用于诊断癌症或筛选包含FLJ25416基因或针对从FLJ25416基因表达的蛋白质的抗体的抗癌药物的组合物，用于治疗癌症的组合物，其包含该基因的抑制剂或从该基因表达的蛋白质的抑制剂和药学上可接受的载体，以及用于诊断癌症的试剂盒，其包含FLJ25416基因和从FLJ25416基因表达的蛋白质中的至少一种。 FLJ25416基因在特异性癌细胞中表达量高，诱导正常细胞增殖。该基因的表达被抑制，这导致对癌细胞生长的抑制作用。因此，FLJ25416基因可用作癌症诊断或治疗的靶基因。

3. 发明授权

US08314082B2 Stilbene derivatives for ADP-ribosyl cyclase inhibitors 有权
标题翻译： ADP-核糖基环化酶抑制剂的二苯乙烯衍生物
公开(公告)号：US08314082B2
公开(公告)日：2012-11-20
申请号：US13149166
申请日：2011-05-31
申请人： Uh-Hyun Kim , Ho-Jeong Kwon , Mie-Jae Im , Seon-Young Kim , Kwang-Hyun Park , So-Young Rah , Tae-Sik Nam , Byung-Ju Kim , Gul Rukhsana
发明人： Uh-Hyun Kim , Ho-Jeong Kwon , Mie-Jae Im , Seon-Young Kim , Kwang-Hyun Park , So-Young Rah , Tae-Sik Nam , Byung-Ju Kim , Gul Rukhsana
IPC分类号： A61K31/05
CPC分类号： C07C245/08 , C07C39/215
摘要： The present disclosure relates to bisphenyl compounds that are useful for inhibiting the ADP-ribosyl cyclase (ADPR-cyclase). More particularly, the disclosed compounds can be used for treatment and prevention of hypertension, hypertensive cardiac hypertrophy, diabetes, and diabetic nephropathy, in which pathogenesis ADPR-cyclase is involved. The compounds and compositions of the invention can be used for treatment and prevention of cardiovascular disease and related disease states, particularly, hypertension or diabetes related disorders, such as, hypertensive cardiac hypertrophy, diabetic nephropathy, and the like.
摘要翻译：本公开涉及可用于抑制ADP-核糖基环化酶（ADPR-环化酶）的双苯基化合物。更具体地，所公开的化合物可用于治疗和预防涉及发病机制ADPR-环化酶的高血压，高血压心脏肥大，糖尿病和糖尿病性肾病。本发明的化合物和组合物可用于治疗和预防心血管疾病和相关疾病状态，特别是高血压或糖尿病相关疾病，例如高血压心脏肥大，糖尿病性肾病等。

4. 发明申请

US20110008370A1 NOVEL USE OF FLJ25416 GENE 有权
标题翻译： FLJ25416基因的新用途
公开(公告)号：US20110008370A1
公开(公告)日：2011-01-13
申请号：US12746722
申请日：2008-12-05
申请人： Misun Won , Kyung-Sook Chung , Young-Joo Kim , Shin-Jung Choi , Young Il Yeom , Seon-Young Kim , Kyung Bin Song , Hee Gu Lee , Eun Young Song , Young Ho Kim , Ho Kyung Chun , Chae-Ok Yun , Moon Hee Kim , Kyeong-Eun Jung , Sun-Jung Cho
发明人： Misun Won , Kyung-Sook Chung , Young-Joo Kim , Shin-Jung Choi , Young Il Yeom , Seon-Young Kim , Kyung Bin Song , Hee Gu Lee , Eun Young Song , Young Ho Kim , Ho Kyung Chun , Chae-Ok Yun , Moon Hee Kim , Kyeong-Eun Jung , Sun-Jung Cho
IPC分类号： A61K39/395 , C07H21/02 , A61K31/713 , C07H21/00 , C07K16/18 , C07K14/47 , C12Q1/68 , G01N33/574 , A61P35/00
CPC分类号： G01N33/57484 , A61K31/7088 , A61K38/1709 , C12N15/1135 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2710/10343 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/00 , G01N2500/04
摘要： Provided are a composition for diagnosing cancer or screening an anticancer drug comprising an FLJ25416 gene or an antibody directed to a protein expressed from the FLJ25416 gene, a composition for treating cancer comprising an inhibitor of the gene or an inhibitor of the protein expressed from the gene and a pharmaceutically acceptable carrier, and a kit for diagnosing cancer comprising at least one of the FLJ25416 gene and the protein expressed from the FLJ25416 gene. The FLJ25416 gene is expressed at high level in specific cancer cells, and induces an increase in proliferation rate of normal cells. The expression of the gene is suppressed, which results in an inhibitory effect on cancer cell growth. Thus, the FLJ25416 gene can be used as a target gene for diagnosis or treatment of cancer.
摘要翻译：提供了用于诊断癌症或筛选包含FLJ25416基因或针对由FLJ25416基因表达的蛋白质的抗体的抗癌药物的组合物，用于治疗癌症的组合物，其包含该基因的抑制剂或从该基因表达的蛋白质的抑制剂和药学上可接受的载体，以及用于诊断癌症的试剂盒，其包含FLJ25416基因和从FLJ25416基因表达的蛋白质中的至少一种。 FLJ25416基因在特异性癌细胞中表达量高，诱导正常细胞增殖。该基因的表达被抑制，这导致对癌细胞生长的抑制作用。因此，FLJ25416基因可用作癌症诊断或治疗的靶基因。

5. 发明申请

US20100075334A1 METHYLATION BIOMARKER FOR EARLY DETECTION OF GASTRIC CANCER 审中-公开
标题翻译：甲状腺生物标志物早期检测胃癌
公开(公告)号：US20100075334A1
公开(公告)日：2010-03-25
申请号：US12596245
申请日：2008-04-15
申请人： Yong Sung Kim , Seung Moo Noh , Hyang Sook Yoo , Jeong Hwan Kim , Mi Rang Kim , Hay Ran Jang , Kyu Sang Song , June Sik Cho , Seon-Young Kim , Hyun Yong Jeong
发明人： Yong Sung Kim , Seung Moo Noh , Hyang Sook Yoo , Jeong Hwan Kim , Mi Rang Kim , Hay Ran Jang , Kyu Sang Song , June Sik Cho , Seon-Young Kim , Hyun Yong Jeong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： The present application describes a method of diagnosing gastric cancer or a stage in the progression of the cancer in a subject comprising assaying for loss of expression of a marker gene such as POPDC3, CCDC67, LRRC3B, PRKD1, CYP1B1, LIMS2, DCBLD2, LOC149351, ADCY8, BACH2, ALOX5, TCF4, CXXC4, CAMK2N2, EMX1, KCNK9, NCAM2, AMPD3, NOG, SP6, LOC100128675, or CHSY3, or a combination thereof.
摘要翻译：本申请描述了一种诊断受试者胃癌或癌症进展阶段的方法，包括测定标记基因如POPDC3，CCDC67，LRRC3B，PRKD1，CYP1B1，LIMS2，DCBLD2，LOC149351， ADCY8，BACH2，ALOX5，TCF4，CXXC4，CAMK2N2，EMX1，KCNK9，NCAM2，AMPD3，NOG，SP6，LOC100128675或CHSY3，或其组合。

6. 发明申请

US20130190200A1 SNP FOR PREDICTING THE SENSITIVITY TO ANTICANCER TARGETED THERAPEUTIC FORMULATION 审中-公开
标题翻译：用于预测抗精神病药物治疗药物灵敏度的SNP
公开(公告)号：US20130190200A1
公开(公告)日：2013-07-25
申请号：US13704423
申请日：2010-12-08
申请人： Jin Cheon Kim , Yong Sung Kim , Seon Young Kim , Dong Hyung Cho
发明人： Jin Cheon Kim , Yong Sung Kim , Seon Young Kim , Dong Hyung Cho
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： The present invention relates to a single nucleotide polymorphism (SNP) for predicting the sensitivity to an anticancer targeted therapeutic formulation, a polynucleotide containing the same, and a method for predicting the sensitivity to an anticancer targeted therapeutic formulation. According to the present invention, it is possible to predict the sensitivity of each individual to a certain anticancer targeted therapeutic formulation, using a small amount of a sample taken from a patient and thus to select a most suitable targeted therapeutic formulation over the entire duration of treatment for the patient.
摘要翻译：本发明涉及用于预测对抗癌靶向治疗制剂的敏感性的单核苷酸多态性（SNP），含有该制剂的多核苷酸，以及预测对抗癌靶向治疗剂型的敏感性的方法。根据本发明，可以使用少量来自患者的样品来预测每个个体对某种抗癌靶向治疗剂型的敏感性，从而在整个持续时间内选择最合适的靶向治疗制剂治疗病人。

7. 发明申请

US20100069619A1 STILBENE DERIVATIVES FOR ADP-RIBOSYL CYCLASE INHIBITORS 审中-公开
标题翻译： ADP-RIBOSYL CYCLASE INHIBITORS的STILBENE衍生物
公开(公告)号：US20100069619A1
公开(公告)日：2010-03-18
申请号：US12520391
申请日：2007-12-28
申请人： Uh-Hyun Kim , Ho-Jeong Kwon , Mie-Jae Im , Seon-Young Kim , Kwang-Hyun Park , So-Young Rah , Tae-Sik Nam , Byung-Ju Kim , Gul Rukhsana
发明人： Uh-Hyun Kim , Ho-Jeong Kwon , Mie-Jae Im , Seon-Young Kim , Kwang-Hyun Park , So-Young Rah , Tae-Sik Nam , Byung-Ju Kim , Gul Rukhsana
IPC分类号： C07C245/08 , C07C39/21
CPC分类号： C07C245/08 , C07C39/215
摘要： The present disclosure relates to bisphenyl compounds that are useful for inhibit the ADP-ribosyl cyclase (ADPR-cyclase). More particularly, the disclosed compounds can be used for treatment and prevention of hypertension, hypertensive cardiac hypertrophy, diabetes, and diabetic nephropathy, in which pathogenesis ADPR-cyclase is involved. The compounds and compositions of the invention can be used for treatment and prevention of cardiovascular disease and related disease states, particularly, hypertension or diabetes related disorders, such as, hypertensive cardiac hypertrophy, diabetic nephropathy, and the like.
摘要翻译：本公开涉及可用于抑制ADP-核糖基环化酶（ADPR-环化酶）的双苯基化合物。更具体地，所公开的化合物可用于治疗和预防涉及发病机制ADPR-环化酶的高血压，高血压心脏肥大，糖尿病和糖尿病性肾病。本发明的化合物和组合物可用于治疗和预防心血管疾病和相关疾病状态，特别是高血压或糖尿病相关疾病，例如高血压心脏肥大，糖尿病性肾病等。

8. 发明授权

US07275375B2 Regenerator and cryocooler using the same 有权
标题翻译：再生器和低温冷冻机使用相同
公开(公告)号：US07275375B2
公开(公告)日：2007-10-02
申请号：US10965918
申请日：2004-10-18
申请人： Seon-Young Kim
发明人： Seon-Young Kim
IPC分类号： F25B9/00 , F28D17/00
CPC分类号： F25B9/14 , F25B2309/001 , F25B2309/003 , F25B2309/1415
摘要： A regenerator includes a casing including a connection channel for making a high temperature part and a cooling part communicate with each other; and a thermal energy storage material inserted in the connection channel of the casing and made of an aramid fiber which stores/radiates heat of a working fluid flowing through the connection channel. A cryocooler includes the regenerator. Accordingly, regeneration performance of storing heat included in the working fluid and transmitting the stored heat to a working fluid is improved, and simultaneously a weight is decreased, thereby minimizing abrasion of components.
摘要翻译：再生器包括：壳体，其包括用于使高温部件和冷却部件相互连通的连接通道; 以及插入在壳体的连接通道中并由芳族聚酰胺纤维制成的热能储存材料，其存储/辐射流过连接通道的工作流体的热量。一个低温冷却器包括再生器。因此，提高了包含在工作流体中并将储存的热量传递到工作流体的再生性能，并且同时减轻了重量，从而使部件的磨损最小化。

9. 发明申请

US20050223715A1 Regenerator and cryocooler using the same 有权
标题翻译：再生器和低温冷冻机使用相同
公开(公告)号：US20050223715A1
公开(公告)日：2005-10-13
申请号：US10965918
申请日：2004-10-18
申请人： Seon-Young Kim
发明人： Seon-Young Kim
IPC分类号： F25B9/00 , C09K5/08 , F25B9/14
CPC分类号： F25B9/14 , F25B2309/001 , F25B2309/003 , F25B2309/1415
摘要： A regenerator includes a casing including a connection channel for making a high temperature part and a cooling part communicate with each other; and a thermal energy storage material inserted in the connection channel of the casing and made of an aramid fiber which stores/radiates heat of a working fluid flowing through the connection channel. A cryocooler includes the regenerator. Accordingly, regeneration performance of storing heat included in the working fluid and transmitting the stored heat to a working fluid is improved, and simultaneously a weight is decreased, thereby minimizing abrasion of components.
摘要翻译：再生器包括：壳体，其包括用于使高温部件和冷却部件相互连通的连接通道; 以及插入在壳体的连接通道中并由芳族聚酰胺纤维制成的热能储存材料，其存储/辐射流过连接通道的工作流体的热量。一个低温冷却器包括再生器。因此，提高了包含在工作流体中并将储存的热量传递到工作流体的再生性能，并且同时减轻了重量，从而使部件的磨损最小化。

10. 发明申请

US20130189755A1 APPARATUS FOR SEPARATING FINE PARTICLES USING MAGNETOPHORESIS, AND METHOD FOR SEPARATING FINE PARTICLES USING SAME 审中-公开
标题翻译：使用磁分离分离精细颗粒的装置以及使用其分离精细颗粒的方法
公开(公告)号：US20130189755A1
公开(公告)日：2013-07-25
申请号：US13821477
申请日：2011-08-19
申请人： Ki Ho Han , Hwan Yong Lee , Song l Han , Seon Young Kim , In Hak Choi
发明人： Ki Ho Han , Hwan Yong Lee , Song l Han , Seon Young Kim , In Hak Choi
IPC分类号： C12N13/00 , C07H1/08
CPC分类号： C12N13/00 , B03C1/0335 , B03C1/32 , B03C2201/18 , B03C2201/26 , C07H1/08 , G01N15/1056 , G01N27/745
摘要： The present invention relates to an apparatus for separating fine particles using magnetophoresis, and to a method for separating fine particles using same, and particularly, to an apparatus for separating fine particles using magnetophoresis, which includes a fine, patterned magnetic structure capable of quickly and efficiently separating even particles that are weakly magnetized and coupled to fine particles, and to a method for separating fine particles using same.
摘要翻译：本发明涉及使用磁电泳分离细颗粒的装置，以及使用其分离细颗粒的方法，特别涉及一种使用磁电泳分离细颗粒的装置，其包括精细的图案化磁结构，其能够快速和有效地分离微弱磁化并耦合到细颗粒的颗粒，以及使用其分离细颗粒的方法。

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