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1. 发明授权

US10253309B2 Apparatus for separating fine particles using magnetophoresis, and method for separating fine particles using same 有权
公开(公告)号：US10253309B2
公开(公告)日：2019-04-09
申请号：US13821477
申请日：2011-08-19
申请人： Ki Ho Han , Hwan Yong Lee , Song I Han , Seon Young Kim , In Hak Choi
发明人： Ki Ho Han , Hwan Yong Lee , Song I Han , Seon Young Kim , In Hak Choi
IPC分类号： C12N13/00 , C07H1/08 , B03C1/033 , B03C1/32 , G01N27/74 , G01N15/10
摘要： The present invention relates to an apparatus for separating fine particles using magnetophoresis, and to a method for separating fine particles using same, and particularly, to an apparatus for separating fine particles using magnetophoresis, which includes a fine, patterned magnetic structure capable of quickly and efficiently separating even particles that are weakly magnetized and coupled to fine particles, and to a method for separating fine particles using same.

2. 发明授权

US08486905B2 Use of FLJ25416 gene 有权
标题翻译：使用FLJ25416基因
公开(公告)号：US08486905B2
公开(公告)日：2013-07-16
申请号：US12746722
申请日：2008-12-05
申请人： Misun Won , Kyung-Sook Chung , Young-Joo Kim , Shin-Jung Choi , Young Il Yeom , Seon-Young Kim , Kyung Bin Song , Hee Gu Lee , Eun Young Song , Young Ho Kim , Ho Kyung Chun , Chae-Ok Yun , Moon Hee Kim , Kyeong-Eun Jung , Sun-Jung Cho
发明人： Misun Won , Kyung-Sook Chung , Young-Joo Kim , Shin-Jung Choi , Young Il Yeom , Seon-Young Kim , Kyung Bin Song , Hee Gu Lee , Eun Young Song , Young Ho Kim , Ho Kyung Chun , Chae-Ok Yun , Moon Hee Kim , Kyeong-Eun Jung , Sun-Jung Cho
IPC分类号： C12N15/11 , C07H21/02
CPC分类号： G01N33/57484 , A61K31/7088 , A61K38/1709 , C12N15/1135 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2710/10343 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/00 , G01N2500/04
摘要： Provided are a composition for diagnosing cancer or screening an anticancer drug comprising an FLJ25416 gene or an antibody directed to a protein expressed from the FLJ25416 gene, a composition for treating cancer comprising an inhibitor of the gene or an inhibitor of the protein expressed from the gene and a pharmaceutically acceptable carrier, and a kit for diagnosing cancer comprising at least one of the FLJ25416 gene and the protein expressed from the FLJ25416 gene. The FLJ25416 gene is expressed at high level in specific cancer cells, and induces an increase in proliferation rate of normal cells. The expression of the gene is suppressed, which results in an inhibitory effect on cancer cell growth. Thus, the FLJ25416 gene can be used as a target gene for diagnosis or treatment of cancer.
摘要翻译：提供了用于诊断癌症或筛选包含FLJ25416基因或针对从FLJ25416基因表达的蛋白质的抗体的抗癌药物的组合物，用于治疗癌症的组合物，其包含该基因的抑制剂或从该基因表达的蛋白质的抑制剂和药学上可接受的载体，以及用于诊断癌症的试剂盒，其包含FLJ25416基因和从FLJ25416基因表达的蛋白质中的至少一种。 FLJ25416基因在特异性癌细胞中表达量高，诱导正常细胞增殖。该基因的表达被抑制，这导致对癌细胞生长的抑制作用。因此，FLJ25416基因可用作癌症诊断或治疗的靶基因。

3. 发明授权

US08314082B2 Stilbene derivatives for ADP-ribosyl cyclase inhibitors 有权
标题翻译： ADP-核糖基环化酶抑制剂的二苯乙烯衍生物
公开(公告)号：US08314082B2
公开(公告)日：2012-11-20
申请号：US13149166
申请日：2011-05-31
申请人： Uh-Hyun Kim , Ho-Jeong Kwon , Mie-Jae Im , Seon-Young Kim , Kwang-Hyun Park , So-Young Rah , Tae-Sik Nam , Byung-Ju Kim , Gul Rukhsana
发明人： Uh-Hyun Kim , Ho-Jeong Kwon , Mie-Jae Im , Seon-Young Kim , Kwang-Hyun Park , So-Young Rah , Tae-Sik Nam , Byung-Ju Kim , Gul Rukhsana
IPC分类号： A61K31/05
CPC分类号： C07C245/08 , C07C39/215
摘要： The present disclosure relates to bisphenyl compounds that are useful for inhibiting the ADP-ribosyl cyclase (ADPR-cyclase). More particularly, the disclosed compounds can be used for treatment and prevention of hypertension, hypertensive cardiac hypertrophy, diabetes, and diabetic nephropathy, in which pathogenesis ADPR-cyclase is involved. The compounds and compositions of the invention can be used for treatment and prevention of cardiovascular disease and related disease states, particularly, hypertension or diabetes related disorders, such as, hypertensive cardiac hypertrophy, diabetic nephropathy, and the like.
摘要翻译：本公开涉及可用于抑制ADP-核糖基环化酶（ADPR-环化酶）的双苯基化合物。更具体地，所公开的化合物可用于治疗和预防涉及发病机制ADPR-环化酶的高血压，高血压心脏肥大，糖尿病和糖尿病性肾病。本发明的化合物和组合物可用于治疗和预防心血管疾病和相关疾病状态，特别是高血压或糖尿病相关疾病，例如高血压心脏肥大，糖尿病性肾病等。

4. 发明申请

US20110008370A1 NOVEL USE OF FLJ25416 GENE 有权
标题翻译： FLJ25416基因的新用途
公开(公告)号：US20110008370A1
公开(公告)日：2011-01-13
申请号：US12746722
申请日：2008-12-05
申请人： Misun Won , Kyung-Sook Chung , Young-Joo Kim , Shin-Jung Choi , Young Il Yeom , Seon-Young Kim , Kyung Bin Song , Hee Gu Lee , Eun Young Song , Young Ho Kim , Ho Kyung Chun , Chae-Ok Yun , Moon Hee Kim , Kyeong-Eun Jung , Sun-Jung Cho
发明人： Misun Won , Kyung-Sook Chung , Young-Joo Kim , Shin-Jung Choi , Young Il Yeom , Seon-Young Kim , Kyung Bin Song , Hee Gu Lee , Eun Young Song , Young Ho Kim , Ho Kyung Chun , Chae-Ok Yun , Moon Hee Kim , Kyeong-Eun Jung , Sun-Jung Cho
IPC分类号： A61K39/395 , C07H21/02 , A61K31/713 , C07H21/00 , C07K16/18 , C07K14/47 , C12Q1/68 , G01N33/574 , A61P35/00
CPC分类号： G01N33/57484 , A61K31/7088 , A61K38/1709 , C12N15/1135 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2710/10343 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/00 , G01N2500/04
摘要： Provided are a composition for diagnosing cancer or screening an anticancer drug comprising an FLJ25416 gene or an antibody directed to a protein expressed from the FLJ25416 gene, a composition for treating cancer comprising an inhibitor of the gene or an inhibitor of the protein expressed from the gene and a pharmaceutically acceptable carrier, and a kit for diagnosing cancer comprising at least one of the FLJ25416 gene and the protein expressed from the FLJ25416 gene. The FLJ25416 gene is expressed at high level in specific cancer cells, and induces an increase in proliferation rate of normal cells. The expression of the gene is suppressed, which results in an inhibitory effect on cancer cell growth. Thus, the FLJ25416 gene can be used as a target gene for diagnosis or treatment of cancer.
摘要翻译：提供了用于诊断癌症或筛选包含FLJ25416基因或针对由FLJ25416基因表达的蛋白质的抗体的抗癌药物的组合物，用于治疗癌症的组合物，其包含该基因的抑制剂或从该基因表达的蛋白质的抑制剂和药学上可接受的载体，以及用于诊断癌症的试剂盒，其包含FLJ25416基因和从FLJ25416基因表达的蛋白质中的至少一种。 FLJ25416基因在特异性癌细胞中表达量高，诱导正常细胞增殖。该基因的表达被抑制，这导致对癌细胞生长的抑制作用。因此，FLJ25416基因可用作癌症诊断或治疗的靶基因。

5. 发明申请

US20100075334A1 METHYLATION BIOMARKER FOR EARLY DETECTION OF GASTRIC CANCER 审中-公开
标题翻译：甲状腺生物标志物早期检测胃癌
公开(公告)号：US20100075334A1
公开(公告)日：2010-03-25
申请号：US12596245
申请日：2008-04-15
申请人： Yong Sung Kim , Seung Moo Noh , Hyang Sook Yoo , Jeong Hwan Kim , Mi Rang Kim , Hay Ran Jang , Kyu Sang Song , June Sik Cho , Seon-Young Kim , Hyun Yong Jeong
发明人： Yong Sung Kim , Seung Moo Noh , Hyang Sook Yoo , Jeong Hwan Kim , Mi Rang Kim , Hay Ran Jang , Kyu Sang Song , June Sik Cho , Seon-Young Kim , Hyun Yong Jeong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154
摘要： The present application describes a method of diagnosing gastric cancer or a stage in the progression of the cancer in a subject comprising assaying for loss of expression of a marker gene such as POPDC3, CCDC67, LRRC3B, PRKD1, CYP1B1, LIMS2, DCBLD2, LOC149351, ADCY8, BACH2, ALOX5, TCF4, CXXC4, CAMK2N2, EMX1, KCNK9, NCAM2, AMPD3, NOG, SP6, LOC100128675, or CHSY3, or a combination thereof.
摘要翻译：本申请描述了一种诊断受试者胃癌或癌症进展阶段的方法，包括测定标记基因如POPDC3，CCDC67，LRRC3B，PRKD1，CYP1B1，LIMS2，DCBLD2，LOC149351， ADCY8，BACH2，ALOX5，TCF4，CXXC4，CAMK2N2，EMX1，KCNK9，NCAM2，AMPD3，NOG，SP6，LOC100128675或CHSY3，或其组合。

6. 发明授权

US09075066B2 CST1, DCC1, IFITM1 or MELK as markers for diagnosing stomach cancer 有权
标题翻译： CST1，DCC1，IFITM1或MELK作为诊断胃癌的标记物
公开(公告)号：US09075066B2
公开(公告)日：2015-07-07
申请号：US12679879
申请日：2009-04-21
申请人： Hee Gu Lee , Eun Young Song , Min Ah Kang , Jong Tae Kim , Jae Wha Kim , Young Il Yeom , Seon Young Kim , Kyung Chan Park
发明人： Hee Gu Lee , Eun Young Song , Min Ah Kang , Jong Tae Kim , Jae Wha Kim , Young Il Yeom , Seon Young Kim , Kyung Chan Park
IPC分类号： G01N33/53 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/57446 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N2500/04
摘要： The present invention relates to a biomarker for gastric cancer, CST1 (cysteine proteinase inhibitor, type 2 family), DCC1 (Defective in sister chromatid cohesion homolog 1), IFITM1 (interferon induced transmembrane protein 1) or MELK (maternal embryonic leucine zipper kinase). More particularly, the present invention relates to a diagnostic composition for gastric cancer comprising an agent measuring the expression level of CST1, DCC1, IFITM1 or MELK, a kit comprising the composition, a method for detecting the marker, and a method for screening a therapeutic agent for gastric cancer using the marker.
摘要翻译：本发明涉及胃癌生物标志物，CST1（半胱氨酸蛋白酶抑制剂，2型家族），DCC1（姐妹染色单体内聚同系物1缺陷），IFITM1（干扰素诱导的跨膜蛋白1）或MELK（母体白蛋白亮氨酸拉链激酶）。更具体地，本发明涉及用于胃癌的诊断组合物，其包含测量CST1，DCC1，IFITM1或MELK的表达水平的试剂，包含该组合物的试剂盒，用于检测标记物的方法和用于筛选治疗使用标记的胃癌药物。

7. 发明申请

US20100248244A1 Characterization of ESM-1 as a Tumor Associated Marker of Colorectal Cancer 有权
标题翻译： ESM-1作为肿瘤相关标志物的结直肠癌的表征
公开(公告)号：US20100248244A1
公开(公告)日：2010-09-30
申请号：US12744223
申请日：2007-11-23
申请人： Eun Young Song , Mi Young Park , Hyang Sin Lee , Hee Gu Lee , Jae Wha Kim , In Seong Choe , Min A. Kang , Mi Sun Won , Kyung Sook Chung , Young Ho Kim , Ho Kyung Chun , Young Il Yeom , Seon-Young Kim
发明人： Eun Young Song , Mi Young Park , Hyang Sin Lee , Hee Gu Lee , Jae Wha Kim , In Seong Choe , Min A. Kang , Mi Sun Won , Kyung Sook Chung , Young Ho Kim , Ho Kyung Chun , Young Il Yeom , Seon-Young Kim
IPC分类号： C12Q1/68 , C07H21/00 , C07K16/18 , G01N33/48 , G01N33/53 , C07H21/02
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： Disclosed herein is a colorectal cancer marker for diagnosing colorectal cancer based on ESM-I overexpression in tissues, cells or body fluids of colorectal cancer patients. Disclosed also is the use of the colorectal cancer marker in the development of therapeutic agents for cancer and in the diagnosis and treatment of colorectal cancer.
摘要翻译：本文公开了一种基于ESM-1在结肠直肠癌患者的组织，细胞或体液中过度表达的用于诊断结肠直肠癌的结肠直肠癌标志物。还公开了结肠直肠癌标志物在癌症治疗剂的开发和结肠直肠癌的诊断和治疗中的应用。

8. 发明授权

US5823757A Axial sealing apparatus for scroll type compressor 失效
标题翻译：涡旋式压缩机推力密封装置
公开(公告)号：US5823757A
公开(公告)日：1998-10-20
申请号：US765647
申请日：1996-12-31
申请人： Seon-Young Kim
发明人： Seon-Young Kim
IPC分类号： F04C18/02 , F04C27/00 , F04C18/04
CPC分类号： F04C27/005
摘要： An improved axial sealing apparatus for a scroll type apparatus which is capable of constantly maintaining pressure in a back pressure chamber by forming a back pressure hole at a predetermined portion in which the back pressure hole is opened before a compressed gas is discharged and the back pressure hole is closed after the compressed gas is substantially closed, whereby a more stable axial direction sealing can be obtained throughout the entire operation time of a scroll compressor, which includes a stationary scroll; a rotational scroll engaged at a lower portion of the stationary scroll so as to form a compression chamber therebetween; and a back pressure chamber having a back pressure hole formed at a predetermined position in which the back pressure hole is opened whereby the compression chamber and the back pressure chamber become communicated with each other before a refrigerant gas compressed in the compression chamber is discharged to the discharging chamber and in which the back pressure hole is closed after the refrigerant gas is discharged to the discharging chamber, whereby an intermediate pressure having a greater pressure than the suction gas pressure and having a lower pressure than the discharging gas pressure is introduced into the back pressure chamber.
摘要翻译： PCT No.PCT / KR96 / 00064 Sec。 371日期1996年12月31日第 102（e）日期1996年12月31日PCT提交1996年5月2日PCT公布。公开号WO96 / 35056 日期：1996年11月7日改进的涡旋式装置的轴向密封装置，其能够通过在压缩气体之前在背压孔打开的预定部分形成背压孔而不断地保持背压室中的压力在压缩气体基本上封闭之后，背压孔关闭，从而在包括固定涡旋件的涡旋压缩机的整个运行时间内可以获得更稳定的轴向密封; 旋转涡旋盘，其在固定涡旋件的下部接合，以在其间形成压缩室; 以及背压室，其具有形成在背压孔打开的预定位置的背压孔，从而压缩室和背压室在压缩室内压缩的制冷剂气体排出之前彼此连通排出室，并且在制冷剂气体排放到排出室之后背压孔关闭，由此将具有比吸入气体压力更大的压力并且具有比排出气体压力更低的压力的中间压力引入到后部压力室。

9. 发明申请

US20130190200A1 SNP FOR PREDICTING THE SENSITIVITY TO ANTICANCER TARGETED THERAPEUTIC FORMULATION 审中-公开
标题翻译：用于预测抗精神病药物治疗药物灵敏度的SNP
公开(公告)号：US20130190200A1
公开(公告)日：2013-07-25
申请号：US13704423
申请日：2010-12-08
申请人： Jin Cheon Kim , Yong Sung Kim , Seon Young Kim , Dong Hyung Cho
发明人： Jin Cheon Kim , Yong Sung Kim , Seon Young Kim , Dong Hyung Cho
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/156
摘要： The present invention relates to a single nucleotide polymorphism (SNP) for predicting the sensitivity to an anticancer targeted therapeutic formulation, a polynucleotide containing the same, and a method for predicting the sensitivity to an anticancer targeted therapeutic formulation. According to the present invention, it is possible to predict the sensitivity of each individual to a certain anticancer targeted therapeutic formulation, using a small amount of a sample taken from a patient and thus to select a most suitable targeted therapeutic formulation over the entire duration of treatment for the patient.
摘要翻译：本发明涉及用于预测对抗癌靶向治疗制剂的敏感性的单核苷酸多态性（SNP），含有该制剂的多核苷酸，以及预测对抗癌靶向治疗剂型的敏感性的方法。根据本发明，可以使用少量来自患者的样品来预测每个个体对某种抗癌靶向治疗剂型的敏感性，从而在整个持续时间内选择最合适的靶向治疗制剂治疗病人。

10. 发明申请

US20100069619A1 STILBENE DERIVATIVES FOR ADP-RIBOSYL CYCLASE INHIBITORS 审中-公开
标题翻译： ADP-RIBOSYL CYCLASE INHIBITORS的STILBENE衍生物
公开(公告)号：US20100069619A1
公开(公告)日：2010-03-18
申请号：US12520391
申请日：2007-12-28
申请人： Uh-Hyun Kim , Ho-Jeong Kwon , Mie-Jae Im , Seon-Young Kim , Kwang-Hyun Park , So-Young Rah , Tae-Sik Nam , Byung-Ju Kim , Gul Rukhsana
发明人： Uh-Hyun Kim , Ho-Jeong Kwon , Mie-Jae Im , Seon-Young Kim , Kwang-Hyun Park , So-Young Rah , Tae-Sik Nam , Byung-Ju Kim , Gul Rukhsana
IPC分类号： C07C245/08 , C07C39/21
CPC分类号： C07C245/08 , C07C39/215
摘要： The present disclosure relates to bisphenyl compounds that are useful for inhibit the ADP-ribosyl cyclase (ADPR-cyclase). More particularly, the disclosed compounds can be used for treatment and prevention of hypertension, hypertensive cardiac hypertrophy, diabetes, and diabetic nephropathy, in which pathogenesis ADPR-cyclase is involved. The compounds and compositions of the invention can be used for treatment and prevention of cardiovascular disease and related disease states, particularly, hypertension or diabetes related disorders, such as, hypertensive cardiac hypertrophy, diabetic nephropathy, and the like.
摘要翻译：本公开涉及可用于抑制ADP-核糖基环化酶（ADPR-环化酶）的双苯基化合物。更具体地，所公开的化合物可用于治疗和预防涉及发病机制ADPR-环化酶的高血压，高血压心脏肥大，糖尿病和糖尿病性肾病。本发明的化合物和组合物可用于治疗和预防心血管疾病和相关疾病状态，特别是高血压或糖尿病相关疾病，例如高血压心脏肥大，糖尿病性肾病等。

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