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1. 发明申请

US20110275846A1 PRODUCTION OF OMEGA-3 FATTY ACIDS BY MYXOBACTERIA 审中-公开
标题翻译：通过MYXOBACTERIA生产OMEGA-3脂肪酸
公开(公告)号：US20110275846A1
公开(公告)日：2011-11-10
申请号：US13132052
申请日：2009-12-01
申请人： Ernst Roemer , Rolf Müller , Ronald O. Garcia , Mark Stadler , Dominik Pistorius , Alexander Brachmann
发明人： Ernst Roemer , Rolf Müller , Ronald O. Garcia , Mark Stadler , Dominik Pistorius , Alexander Brachmann
IPC分类号： C07C57/03 , C12N1/20 , C12P7/64
CPC分类号： C12P7/6427 , C12R1/01
摘要： The present invention provides a method for producing ω-3 polyunsaturated fatty acids by culturing specific myxobacterial stains and myxobacterial strains suitable for said method.
摘要翻译：本发明提供通过培养适用于所述方法的特异性粘液细菌染色剂和粘液菌菌株来生产ω-3多不饱和脂肪酸的方法。

2. 发明授权

US10364447B2 Production of omega-3 fatty acids by myxobacteria 有权
公开(公告)号：US10364447B2
公开(公告)日：2019-07-30
申请号：US13132052
申请日：2009-12-01
申请人： Ernst Roemer , Rolf Müller , Ronald O. Garcia , Mark Stadler , Dominik Pistorius , Alexander Brachmann
发明人： Ernst Roemer , Rolf Müller , Ronald O. Garcia , Mark Stadler , Dominik Pistorius , Alexander Brachmann
IPC分类号： C12P7/64 , C12R1/01
摘要： The present invention provides a method for producing ω-3 polyunsaturated fatty acids by culturing specific myxobacterial stains and myxobacterial strains suitable for said method.

3. 发明申请

US20130123360A1 METHODS AND USES RELATING TO THE IDENTIFICATION OF COMPOUND ASSOCIATED WITH BACTERIAL INFECTION 审中-公开
标题翻译：与细菌感染相关的化合物鉴定方法和用途
公开(公告)号：US20130123360A1
公开(公告)日：2013-05-16
申请号：US13812794
申请日：2011-07-25
申请人： Rolf Müller , Dominik Pistorius
发明人： Rolf Müller , Dominik Pistorius
IPC分类号： C12Q1/48
CPC分类号： C12Q1/48 , C12Q1/18 , G01N2333/21 , G01N2500/04
摘要： The present invention relates to a method of identifying a compound useful for the treating, reducing or preventing pathogenic infection caused by a microorganism and to the use of the PqsD protein or a functional fragment or variant thereof for the identification of a compound having said effect.
摘要翻译：本发明涉及鉴定可用于治疗，减少或预防由微生物引起的致病性感染的化合物的方法，以及使用PqsD蛋白或其功能片段或变体来鉴定具有所述作用的化合物。

4. 发明授权

US10253288B2 Receptacle for accepting nutrient media 有权
公开(公告)号：US10253288B2
公开(公告)日：2019-04-09
申请号：US12526200
申请日：2008-04-09
申请人： Rolf Müller
发明人： Rolf Müller
IPC分类号： C12M1/22 , C12M1/00 , C12M3/00
摘要： Disclosed is a receptacle for accepting nutrient media, especially for bacterial cultures. Said receptacle comprises a dish and a lid that covers the dish. The dish and the lid each have a circular bottom (dish bottom and lid bottom) and an annular wall (dish wall and lid wall) that projects from the bottom. One of the walls, preferably the lid wall, has an at least slightly larger internal diameter than the external diameter of the other wall, preferably the dish wall, such that one wall can be slid onto the other wall to close the dish. In order to be able to safely handle the receptacle, engaging means which prevent the dish and the lid from being accidentally released when the same are mutually engaged, are associated with the dish and the lid.

5. 发明申请

US20110200541A1 RECOMBINANT PREPARATION OF BROMELAIN INHIBITORS AND BROMELAIN INHIBITOR PRECURSOR 审中-公开
标题翻译：溴化硼抑制剂和溴化硼抑制剂前体的重组制备
公开(公告)号：US20110200541A1
公开(公告)日：2011-08-18
申请号：US12993244
申请日：2009-07-27
申请人： Rolf Müller , Nora Luniak , Klaus Eschmann
发明人： Rolf Müller , Nora Luniak , Klaus Eschmann
IPC分类号： A61K38/02 , C07K14/00 , C12P21/02 , A61Q17/04 , A61Q19/08 , A61Q5/02 , A61P35/00 , A61P9/10 , A61P31/04 , A61P29/00 , A61P7/02 , A61P7/10
CPC分类号： C07K14/81 , A61K38/00 , Y02A50/473
摘要： The present invention pertains in general to Bromelain and particularly to the active compounds contained in this complex mixture of proteins. The present invention provides recombinant expressed Bromelain inhibitor precursor and Bromelain inhibitors, which are found in Bromelain. It has been found that the recombinant expressed inhibitors have superior effects in terms of treatment of disorders and conditions than Bromelain or its protein fractions from plant extracts.
摘要翻译：本发明一般涉及菠萝蛋白酶，尤其涉及这种复合蛋白质混合物中所含的活性化合物。本发明提供了在菠萝蛋白酶中发现的重组表达的菠萝蛋白酶抑制剂前体和菠萝蛋白酶抑制剂。已经发现重组表达的抑制剂在治疗疾病和病症方面比菠萝凝胶或其植物提取物的蛋白质级分具有优异的效果。

6. 发明申请

US20110124777A1 POLYSACCHARIDE BASED NETWORK AND METHOD FOR THE PRODUCTION THEREOF 有权
标题翻译：基于多糖的网络及其生产方法
公开(公告)号：US20110124777A1
公开(公告)日：2011-05-26
申请号：US12906710
申请日：2010-10-18
申请人： Rolf Müller , Federico Innerebner , Paul Smith , Theo A. Tervoort
发明人： Rolf Müller , Federico Innerebner , Paul Smith , Theo A. Tervoort
IPC分类号： C08B37/00 , C08B31/00 , C08L5/00
CPC分类号： C08L3/02 , A61J3/077 , A61K9/4816 , A61K9/5036 , C08B31/003 , C08L2666/02
摘要： The production of polysaccharide networks, especially starch networks, having a high network density, high solidity, a low swelling degree, and exhibiting reduced water absorption and to the uses thereof, especially, in the filed of biodegradable plastics.
摘要翻译：具有高网络密度，高固体度，低溶胀度和显示减少的吸水性的多糖网络，特别是淀粉网络的生产，尤其是在可生物降解的塑料领域。

7. 发明授权

US07650753B2 Arrangement for cooling exhaust gas and charge air 失效
标题翻译：冷却废气和增压空气的布置
公开(公告)号：US07650753B2
公开(公告)日：2010-01-26
申请号：US10587658
申请日：2005-02-01
申请人： Rolf Müller , Eberhard Pantow
发明人： Rolf Müller , Eberhard Pantow
IPC分类号： F02B29/04 , F02M25/07 , F02B33/00 , F01P5/10
CPC分类号： F02B29/0443 , F01P7/165 , F01P2060/02 , F02B29/0412 , F02B29/0493 , F02M26/05 , F02M26/06 , F02M26/15 , F02M26/24 , F02M26/25 , F02M26/28 , F23Q7/001 , F23Q2007/002 , Y02T10/146
摘要： The invention relates to an arrangement (A) for cooling recycled exhaust gas (AG) and charge air (LL) in a motor vehicle comprising a turbocharger respectively comprising at least one heat exchanger for the exhaust gas flow and a least one heat exchanger for the charge air flow. At least one heat exchanger for the exhaust gas flow and one heat exchanger for the charge air flow form part of a common low temperature cooling circuit (NK). The invention also relates to a method for operating one such arrangement (A).
摘要翻译：本发明涉及一种用于冷却机动车辆中的再循环废气（AG）和增压空气（LL）的装置（A），其包括分别包括用于排气流的至少一个热交换器的涡轮增压器和用于该废气流的至少一个热交换器充气流量。用于排气流的至少一个热交换器和用于增压空气流的一个热交换器形成常见的低温冷却回路（NK）的一部分。本发明还涉及一种用于操作一种这样的布置（A）的方法。

8. 发明申请

US20070148220A1 Liposomes and liposomal compositions for vaccination and drug delivery 审中-公开
标题翻译：用于疫苗接种和药物递送的脂质体和脂质体组合物
公开(公告)号：US20070148220A1
公开(公告)日：2007-06-28
申请号：US10581844
申请日：2004-12-22
申请人： Rolf Müller , Andreas Graser , Abdo Konur , Sabine Muller-Brusselbach , Valerie Jerome
发明人： Rolf Müller , Andreas Graser , Abdo Konur , Sabine Muller-Brusselbach , Valerie Jerome
IPC分类号： A61K39/12 , A61K39/02 , A61K39/00 , A61K9/127 , A61K39/38
CPC分类号： A61K9/127 , Y02A50/463 , Y02A50/478 , Y02A50/48
摘要： The present invention relates to liposomes and compositions comprising liposomes, their production and use for the prevention and therapy of proliferative diseases, infectious diseases, vascular diseases, rheumatoid diseases, inflammatory diseases, immune diseases, and allergies.
摘要翻译：本发明涉及包含脂质体的脂质体和组合物，其生产和用途，用于预防和治疗增殖性疾病，感染性疾病，血管疾病，类风湿病，炎性疾病，免疫疾病和过敏。

9. 发明授权

US07084727B2 Switching device comprising a uniform control tile 有权
标题翻译：切换装置包括统一的控制瓦片
公开(公告)号：US07084727B2
公开(公告)日：2006-08-01
申请号：US10485354
申请日：2002-07-18
申请人： Markus Bauer , Peter Hartinger , Stefan Merz , Rolf Müller , Ludwig Niebler , Joe Rogers
发明人： Markus Bauer , Peter Hartinger , Stefan Merz , Rolf Müller , Ludwig Niebler , Joe Rogers
IPC分类号： H01H67/02
CPC分类号： H01H11/0031 , H01H71/08 , H01H71/1009
摘要： The aim of the invention is to provide a switching device (1) based on a uniform control tile, which is easy to produce and assemble, ensuring good electric insulation properties. To achieve this, the device comprises an adapter (12) with second contact means (13), arranged to form a connection between first contact means (7, 8) and a conductor (10) that is to be connected. Said adapter and second contact means have insulating isolating elements (18, 18a, 18b, 18c), at least bordering several sides, for defined creepage distances and clearances.
摘要翻译：本发明的目的是提供一种基于均匀控制瓦的开关装置（1），其易于制造和组装，确保良好的电绝缘性能。为了实现这一点，该装置包括具有第二接触装置（13）的适配器（12），其布置成在第一接触装置（7,8）和要连接的导体（10）之间形成连接。所述适配器和第二接触装置具有绝缘绝缘元件（18,18a，18b，18c），至少边界几边，用于限定的爬电距离和间隙。

10. 发明授权

US06495346B1 Complex-forming proteins 失效
标题翻译：复合物形成蛋白
公开(公告)号：US06495346B1
公开(公告)日：2002-12-17
申请号：US09481593
申请日：2000-01-12
申请人： Valerie Jerome , Hans-Harald Sedlacek , Rolf Müller
发明人： Valerie Jerome , Hans-Harald Sedlacek , Rolf Müller
IPC分类号： C12N1562
CPC分类号： C07K7/08 , A61K38/00 , C07K14/82 , C07K2319/00 , C07K2319/09 , C07K2319/50 , C07K2319/71 , C07K2319/73 , C07K2319/81 , C12N15/1055 , C12N15/62
摘要： The invention relates to a complex of specifically complex-forming proteins which are not naturally occurring, comprising the following components: a) at least one ligand specific for a target structure, b) at least one protein comprising a mutated dimerization domain, the mutated dimerization domain having been derived by mutation of a naturally occurring dimerization domain, it being possible for this mutated dimerization domain to interact specifically with component c) and the component b) being connected covalently to the component a), c) at least one protein comprising a mutated dimerization domain, the mutated dimerization domain having been derived by mutation of a naturally occurring dimerization domain, it being possible for this mutated dimerization domain to interact specifically with component b) and the component c) is linked covalently to the component d), and d) at least one effector. In addition, the invention relates to the use and preparation of these complexes, and to nucleic acid constructs coding for the proteins mentioned and use thereof.
摘要翻译：本发明涉及不是天然存在的特异性复合物形成蛋白质的复合物，其包含以下组分：a）至少一种对靶结构特异的配体，b）至少一种包含突变二聚化结构域的蛋白质，所述突变的二聚化已经通过天然存在的二聚化结构域的突变产生的结构域，该突变的二聚化结构域可能与组分c）特异性相互作用，并且组分b）与组分a）共价连接，c）至少一种蛋白质，其包含突变的二聚化结构域，突变的二聚化结构域是通过天然存在的二聚化结构域的突变产生的，该突变的二聚化结构域可能与组分b）特异性相互作用，并且组分c）与组分d）共价连接， d）至少一个效应器。此外，本发明涉及这些复合物的使用和制备，以及编码所述蛋白质的核酸构建体及其用途。

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