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1. 发明授权

US08088605B2 Exopolysaccharides delivery system for active molecules 失效
标题翻译：活性分子的多糖递送系统
公开(公告)号：US08088605B2
公开(公告)日：2012-01-03
申请号：US10537118
申请日：2003-12-04
申请人： Nicolas Beaudet , Claude Dupont , Pierre Lemieux , Eric Simard , Philippe Goyette
发明人： Nicolas Beaudet , Claude Dupont , Pierre Lemieux , Eric Simard , Philippe Goyette
IPC分类号： C12P19/04 , A61K31/715
CPC分类号： A61K9/1075 , A61K9/0014 , A61K9/0019 , A61K9/2009 , A61K31/337 , A61K31/425 , A61K31/715 , A61K47/36
摘要： The present invention relates to a delivery system for delivery of an active molecule to a patient, the delivery system comprising a population of exopolysaccharide micelles, each micelle defining a core for containing the active molecule.
摘要翻译：本发明涉及一种用于将活性分子递送至患者的递送系统，所述递送系统包含一群外多糖胶束，每个胶束限定含有活性分子的核心。

2. 发明申请

US20060057131A1 Malleable protein matrix and uses thereof 审中-公开
标题翻译：可塑性蛋白质基质及其用途
公开(公告)号：US20060057131A1
公开(公告)日：2006-03-16
申请号：US10499313
申请日：2002-12-20
申请人： Eric Simard , Dominique Pilote , Claude DuPont , Nathalie Lajoie , Marcel Paquet , Pierre Lemieux , Philippe Goyette
发明人： Eric Simard , Dominique Pilote , Claude DuPont , Nathalie Lajoie , Marcel Paquet , Pierre Lemieux , Philippe Goyette
IPC分类号： A61K35/74 , C12N1/20
CPC分类号： A61K35/74 , A23C9/1307 , A23C9/1315 , A23C13/14 , A23C15/16 , A23J3/00 , A23J3/08 , A23J3/22 , A23L27/60 , A23L33/135 , A23V2002/00 , A23Y2220/47 , A61K8/64 , A61K8/99 , A61K9/0014 , A61K9/1658 , A61K35/20 , A61K35/742 , A61K35/744 , A61K35/745 , A61K35/747 , A61K36/064 , A61K38/00 , A61K47/42 , A61K2800/85 , A61Q1/02 , A61Q19/00 , C12N1/20 , C12N11/02 , C12N15/63 , A23V2200/242 , A23V2250/54252 , A23V2200/124
摘要： The present invention relates to a malleable protein matrice (MPM), which is the reaction product of the agglomeration of proteins after a fermentation process and is exhibiting biological activities and is suitable for the incorporation (or encapsulation) of various hydrophilic or lipophylic substances. The present invention also relates to the process for the preparation of the malleable protein matrice and its usages.
摘要翻译：本发明涉及可发育的蛋白质基质（MPM），其是发酵过程后蛋白质聚集并且具有生物活性并且适于掺入（或包封）各种亲水或亲脂物质的反应产物。本发明还涉及可塑性蛋白质基质的制备方法及其用途。

3. 发明申请

US20060051354A1 Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof 审中-公开
标题翻译：化疗剂作为抗癌疫苗佐剂及其治疗方法
公开(公告)号：US20060051354A1
公开(公告)日：2006-03-09
申请号：US10508738
申请日：2003-03-25
申请人： Eric Simard , Philippe Goyette , Pierre Lemieux
发明人： Eric Simard , Philippe Goyette , Pierre Lemieux
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： A61K39/39 , A61K39/0011 , A61K2039/5152 , A61K2039/55511 , A61K2039/55555 , Y02A50/41
摘要： The present invention relates to an anti-cancer vaccine composition comprising an antigen in association with an effective amount of at least one immunomodulator chemotherapeutic adjuvant eliciting an immune response in a patient and a pharmaceutically acceptable carrier. It also relates to method of preventing tumor growth and reducing tumor growth using the anti-cancer vaccine composition of the present invention.
摘要翻译：本发明涉及一种抗癌疫苗组合物，其包含与有效量的至少一种在患者和药学上可接受的载体中引起免疫应答的免疫调节剂化学治疗剂的抗原。本发明还涉及使用本发明的抗癌疫苗组合物来预防肿瘤生长和减少肿瘤生长的方法。

4. 发明申请

US20110002994A1 METHOD OF REGULATING THE TH17 PATHWAY AND ITS ASSOCIATED METABOLIC IMPACT 审中-公开
标题翻译：调节TH17途径及其相关代谢影响的方法
公开(公告)号：US20110002994A1
公开(公告)日：2011-01-06
申请号：US12681294
申请日：2008-10-02
申请人： Josee Beaulieu , Jean-Francois Lapointe , Claude Dupont , Pierre Lemieux , Eric Simard , Eric Trottier
发明人： Josee Beaulieu , Jean-Francois Lapointe , Claude Dupont , Pierre Lemieux , Eric Simard , Eric Trottier
IPC分类号： A61K9/00 , A61K38/02 , C07K14/00 , A61K39/395 , A61K8/64 , A61P3/00 , A61P9/12 , A61P17/06 , A61P19/02 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/00 , A61P35/00 , A61P37/02 , A61Q90/00 , A61P1/00
CPC分类号： A61K38/018
摘要： It is disclosed a method of immunomodulating an immune response in a subject comprising administering to a subject a malleable protein matrix (MPM), from fermented whey, in an amount effective to modulate the biological activity of Th17 cells, and its associated metabolic pathway, for a preventative or a therapeutic purpose of a variety of health applications in the field of immunity or obesity related diseases.
摘要翻译：公开了一种在受试者中免疫调节免疫应答的方法，其包括以有效调节Th17细胞及其相关代谢途径的生物活性的量向受试者施用来自发酵乳清的可延展蛋白质基质（MPM）及其相关代谢途径，用于在免疫或肥胖相关疾病领域中的各种健康应用的预防或治疗目的。

5. 发明申请

US20090130072A1 Use of Lactobacillus Kefiranofaciens as a Probiotic and a Synbiotic 审中-公开
标题翻译：使用乳酸杆菌作为益生菌和合生素
公开(公告)号：US20090130072A1
公开(公告)日：2009-05-21
申请号：US11884093
申请日：2006-02-10
申请人： Pierre Lemieux , Louis-Philippe Precourt , Eric Simard
发明人： Pierre Lemieux , Louis-Philippe Precourt , Eric Simard
IPC分类号： A61K35/74 , A61P29/00 , A61P37/00 , A61P3/00 , A61P19/00
CPC分类号： A61K35/747 , A23C9/1234 , A23C21/026
摘要： In accordance with the present invention, there is provided a probiotic composition comprising an effective amount of Lactobacillus kefiranofaciens in association with a suitable carrier. The probiotic composition has many probiotic effects such as intestinal adherence, intestinal persistence, positive modulation of the intestinal microflora, protection against intestinal pathogens, immunomodulation, protection against systemic inflammation, protection against intestinal inflammation, protection against allergies, protection against diarrhea, protection against diabetes, protection against hyperlipidemia and protection against colon cancer. In accordance with the present invention, there is also provided a method of treatment and/or prevention of a number of diseases for which the composition has a beneficial effect. For example, the composition is useful for fermenting a product which in turn finds utility in the treatment of hypertension, the treatment of weight disorder, the treatment of hyperlipidemia or the treatment of triglyceride disorder.
摘要翻译：根据本发明，提供一种益生菌组合物，其包含与合适的载体相关的有效量的胃酸乳杆菌（Lactobacillus kefiranafaciens）。益生菌组合物具有许多益生菌作用，例如肠粘连，肠持续性，肠道微生物群落的阳性调节，肠道病原体的保护，免疫调节，防止全身炎症，保护肠道炎症，防止过敏，防止腹泻，防止糖尿病，防止高脂血症和防止结肠癌。根据本发明，还提供了治疗和/或预防组合物具有有益效果的多种疾病的方法。例如，组合物可用于发酵产品，其又可用于治疗高血压，治疗体重紊乱，治疗高脂血症或治疗甘油三酸酯障碍。

6. 发明申请

US20130029906A1 METHOD OF REGULATING PPAR, OBESITY RELATED PATHWAYS AND THEIR ASSOCIATED METABOLIC IMPACT 审中-公开
标题翻译：调节PPAR，肥胖相关途径及其相关代谢影响的方法
公开(公告)号：US20130029906A1
公开(公告)日：2013-01-31
申请号：US13513442
申请日：2010-12-03
申请人： Eric Simard , Eric Trottier , Josée Beaulieu , Jean-Francois Lapointe , Pierre Lemieux
发明人： Eric Simard , Eric Trottier , Josée Beaulieu , Jean-Francois Lapointe , Pierre Lemieux
IPC分类号： A61K38/01 , A61P3/08
CPC分类号： A61K35/20 , A61K38/018
摘要： It is disclosed a method of modulating a peroxisome proliferator activated receptor (PPAR) activity in a patient comprising administering to said subject an effective amount of a malleable protein matrix (MPM), uses thereof and pharmaceutical compositions comprising MPM for treating obesity related disorders and their associated metabolic impact by modulating PPAR activity.
摘要翻译：公开了一种调节患者过氧化物酶体增殖物激活受体（PPAR）活性的方法，包括向所述受试者施用有效量的可延展蛋白质基质（MPM），其用途和包含MPM的药物组合物，用于治疗肥胖相关病症及其通过调节PPAR活性引起的相关代谢影响。

7. 发明申请

US20060154893A1 Exopolysaccharides delivery system for active molecules 失效
标题翻译：活性分子的多糖递送系统
公开(公告)号：US20060154893A1
公开(公告)日：2006-07-13
申请号：US10537118
申请日：2003-12-04
申请人： Nicolas Beaudet , Claude Dupont , Pierre Lemibuy , Eric Simard , Philippa Gorette
发明人： Nicolas Beaudet , Claude Dupont , Pierre Lemibuy , Eric Simard , Philippa Gorette
IPC分类号： A61K31/739 , A61K38/16 , A61K31/538 , A61K31/56
CPC分类号： A61K9/1075 , A61K9/0014 , A61K9/0019 , A61K9/2009 , A61K31/337 , A61K31/425 , A61K31/715 , A61K47/36
摘要： The present invention relates to a delivery system for delivery of an active molecule to a patient, the delivery system comprising a population of exopolysaccharide micelles, each micelle defining a core for containing the active molecule.
摘要翻译：本发明涉及一种用于将活性分子递送至患者的递送系统，所述递送系统包含一群外多糖胶束，每个胶束限定含有活性分子的核心。

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